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Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research

Delyth James, Joshua Smith, Emma Lane, Rhian Thomas Orcid Logo, Sarah Brown, Heidi Seage

Exploratory Research in Clinical and Social Pharmacy, Volume: 14

Swansea University Author: Rhian Thomas Orcid Logo

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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease which primarily presents with the core symptoms of rigidity, postural instability, tremor, and bradykinesia. Non-adherence to prescribed PD treatments can have significant ramifications, such as poor symptom control and greater...

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Published in: Exploratory Research in Clinical and Social Pharmacy
ISSN: 2667-2766
Published: Elsevier BV 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa67319
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Reasons for poor adherence are multifaceted, particularly when medication regimens are complex and often based on perceptual and practical barriers. Additionally, engaging fully non-adherent patients in research is challenging since they may have dropped out of service provision, yet their contribution is vital to fully understand the rationale for non-adherence.This paper aims to present a case study on the perspectives of one person with PD, a participant in a previously published qualitative study investigating the barriers and facilitators to medication adherence in PD. In this paper, the participant's diagnostic journey is described, and experiences of medical consultations are summarised to explain their reasons for not adhering to any of the standard UK PD treatments prescribed. The participant's preferences for using Vitamin B1 (thiamine) injections to manage the symptoms are reported and the rationale for doing so is discussed. 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spelling 2024-09-18T14:59:02.0695810 v2 67319 2024-08-05 Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research 10f33f117e548cddfa6758ea130c3407 0000-0002-7286-2764 Rhian Thomas Rhian Thomas true false 2024-08-05 MEDS Parkinson's disease (PD) is a progressive neurodegenerative disease which primarily presents with the core symptoms of rigidity, postural instability, tremor, and bradykinesia. Non-adherence to prescribed PD treatments can have significant ramifications, such as poor symptom control and greater disease burden. Reasons for poor adherence are multifaceted, particularly when medication regimens are complex and often based on perceptual and practical barriers. Additionally, engaging fully non-adherent patients in research is challenging since they may have dropped out of service provision, yet their contribution is vital to fully understand the rationale for non-adherence.This paper aims to present a case study on the perspectives of one person with PD, a participant in a previously published qualitative study investigating the barriers and facilitators to medication adherence in PD. In this paper, the participant's diagnostic journey is described, and experiences of medical consultations are summarised to explain their reasons for not adhering to any of the standard UK PD treatments prescribed. The participant's preferences for using Vitamin B1 (thiamine) injections to manage the symptoms are reported and the rationale for doing so is discussed. We consider the case through the lens of a behavioural science approach, drawing on health psychology theory, the Theoretical Domains Framework (TDF), to inform the review and the practical challenges faced when analysing the data for this participant. Implications for pharmacy practice, in particular, are also put forward with view to ensuring that patients such as Mr. Wilkinson are provided with the opportunity to discuss treatment choices and self-management of long-term conditions such as PD. We also discuss the importance of reaching under-represented members of the population in medication adherence research, which embraces the principles of equality, diversity, and inclusion in research. Journal Article Exploratory Research in Clinical and Social Pharmacy 14 Elsevier BV 2667-2766 Parkinson&apos;s disease, medication adherence, patient perspectives, self-management, theoretical domain framework (TDF), case study, representation in research 1 6 2024 2024-06-01 10.1016/j.rcsop.2024.100450 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University This research received no specific grant from any finding agency in the public, commercial, or not for profit sectors. The work was completed as part of a MSc in Health Psychology at Cardiff Metropolitan University which was self-funded by JS. 2024-09-18T14:59:02.0695810 2024-08-05T12:11:58.5592246 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Delyth James 1 Joshua Smith 2 Emma Lane 3 Rhian Thomas 0000-0002-7286-2764 4 Sarah Brown 5 Heidi Seage 6 67319__31364__0c713e853dc94607ad754422725cecde.pdf 67319.VOR.pdf 2024-09-18T14:55:26.4877010 Output 451183 application/pdf Version of Record true © 2024 The Authors. This is an open access article under the CC BY-NC-ND license. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
spellingShingle Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
Rhian Thomas
title_short Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
title_full Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
title_fullStr Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
title_full_unstemmed Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
title_sort Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
author_id_str_mv 10f33f117e548cddfa6758ea130c3407
author_id_fullname_str_mv 10f33f117e548cddfa6758ea130c3407_***_Rhian Thomas
author Rhian Thomas
author2 Delyth James
Joshua Smith
Emma Lane
Rhian Thomas
Sarah Brown
Heidi Seage
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description Parkinson's disease (PD) is a progressive neurodegenerative disease which primarily presents with the core symptoms of rigidity, postural instability, tremor, and bradykinesia. Non-adherence to prescribed PD treatments can have significant ramifications, such as poor symptom control and greater disease burden. Reasons for poor adherence are multifaceted, particularly when medication regimens are complex and often based on perceptual and practical barriers. Additionally, engaging fully non-adherent patients in research is challenging since they may have dropped out of service provision, yet their contribution is vital to fully understand the rationale for non-adherence.This paper aims to present a case study on the perspectives of one person with PD, a participant in a previously published qualitative study investigating the barriers and facilitators to medication adherence in PD. In this paper, the participant's diagnostic journey is described, and experiences of medical consultations are summarised to explain their reasons for not adhering to any of the standard UK PD treatments prescribed. The participant's preferences for using Vitamin B1 (thiamine) injections to manage the symptoms are reported and the rationale for doing so is discussed. We consider the case through the lens of a behavioural science approach, drawing on health psychology theory, the Theoretical Domains Framework (TDF), to inform the review and the practical challenges faced when analysing the data for this participant. Implications for pharmacy practice, in particular, are also put forward with view to ensuring that patients such as Mr. Wilkinson are provided with the opportunity to discuss treatment choices and self-management of long-term conditions such as PD. We also discuss the importance of reaching under-represented members of the population in medication adherence research, which embraces the principles of equality, diversity, and inclusion in research.
published_date 2024-06-01T14:42:08Z
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