Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Curry, Bryony A.; Drane, Aimee; Atencia, Rebeca; Feltrer, Yedra; Calvi, Thalita; Milnes, Ellie L.; Moittié, Sophie; Weigold, Annika; Knauf-Witzens, Tobias; Kusuma, Arga Sawung; Howatson, Glyn; Palmer, Christopher; Stembridge, Mike R.; Gorzynski, John E.; Eves, Neil D.; Dawkins, Tony G.; Shave, Rob E.

doi:10.1038/s42003-024-06280-9

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Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Bryony A. Curry, Aimee Drane

, Rebeca Atencia, Yedra Feltrer, Thalita Calvi, Ellie L. Milnes

, Sophie Moittié, Annika Weigold, Tobias Knauf-Witzens, Arga Sawung Kusuma, Glyn Howatson, Christopher Palmer, Mike R. Stembridge, John E. Gorzynski

, Neil D. Eves, Tony G. Dawkins

, Rob E. Shave

Communications Biology, Volume: 7, Issue: 1

Swansea University Author: Aimee Drane

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DOI (Published version): 10.1038/s42003-024-06280-9

Abstract

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon,...

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Published in:	Communications Biology
ISSN:	2399-3642
Published:	Springer Science and Business Media LLC 2024
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa66968

first_indexed	2024-07-05T15:00:24Z
last_indexed	2024-11-25T14:19:16Z
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spelling	2024-09-12T14:32:26.1451814 v2 66968 2024-07-05 Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype 32adcb7b814aa529984f3a80d902215f 0000-0002-5208-917X Aimee Drane Aimee Drane true false 2024-07-05 HSOC Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche. Journal Article Communications Biology 7 1 Springer Science and Business Media LLC 2399-3642 Biological anthropology, Cardiovascular biology 14 6 2024 2024-06-14 10.1038/s42003-024-06280-9 COLLEGE NANME Health and Social Care School COLLEGE CODE HSOC Swansea University Another institution paid the OA fee We thank all the staff and volunteers that care for the animals included in this study, particularly the teams at Tchimpounga Wildlife Sanctuary (Congo), Chimfunshi Wildlife Sanctuary (Zambia), Tacugama Chimpanzee Sanctuary (Sierra Leone), Nyaru Menteng Orangutan Rescue and Rehabilitation Center (Borneo), the Zoological Society of London (UK), Paignton Zoo (UK), Bristol Zoo Gardens (UK), Burgers’ Zoo (Netherlands) and Wilhelma Zoo (Germany). This work was supported by the Natural Sciences and Engineering Research Council, grant no. GR017741 (R.E.S.), and the Canadian Foundation for Innovation grant no. GR014935 (R.E.S.). 2024-09-12T14:32:26.1451814 2024-07-05T14:54:16.3289219 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Healthcare Science Bryony A. Curry 1 Aimee Drane 0000-0002-5208-917X 2 Rebeca Atencia 3 Yedra Feltrer 4 Thalita Calvi 5 Ellie L. Milnes 0000-0002-7797-2217 6 Sophie Moittié 7 Annika Weigold 8 Tobias Knauf-Witzens 9 Arga Sawung Kusuma 10 Glyn Howatson 11 Christopher Palmer 12 Mike R. Stembridge 13 John E. Gorzynski 0000-0002-9034-9016 14 Neil D. Eves 15 Tony G. Dawkins 0000-0001-5203-135x 16 Rob E. Shave 0000-0002-0283-037x 17 66968__31278__255b22fa07a34ec4a77e54f7faf156b7.pdf 66968.VOR.pdf 2024-09-06T15:07:56.3857884 Output 1704621 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. true eng http://creativecommons.org/licenses/by/4.0/ 259
title	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
spellingShingle	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype Aimee Drane
title_short	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
title_full	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
title_fullStr	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
title_full_unstemmed	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
title_sort	Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
author_id_str_mv	32adcb7b814aa529984f3a80d902215f
author_id_fullname_str_mv	32adcb7b814aa529984f3a80d902215f_***_Aimee Drane
author	Aimee Drane
author2	Bryony A. Curry Aimee Drane Rebeca Atencia Yedra Feltrer Thalita Calvi Ellie L. Milnes Sophie Moittié Annika Weigold Tobias Knauf-Witzens Arga Sawung Kusuma Glyn Howatson Christopher Palmer Mike R. Stembridge John E. Gorzynski Neil D. Eves Tony G. Dawkins Rob E. Shave
format	Journal article
container_title	Communications Biology
container_volume	7
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publishDate	2024
institution	Swansea University
issn	2399-3642
doi_str_mv	10.1038/s42003-024-06280-9
publisher	Springer Science and Business Media LLC
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department_str	School of Health and Social Care - Healthcare Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Healthcare Science
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description	Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.
published_date	2024-06-14T14:41:39Z
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Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

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