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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
Bo Meng,
Steven A. Kemp,
Guido Papa,
Rawlings Datir,
Isabella A.T.M. Ferreira,
Sara Marelli,
William T. Harvey,
Spyros Lytras,
Ahmed Mohamed,
Giulia Gallo,
Nazia Thakur,
Dami A. Collier,
Petra Mlcochova,
Lidia M. Duncan,
Alessandro M. Carabelli,
Julia C. Kenyon,
Andrew M. Lever,
Anna De Marco,
Christian Saliba,
Katja Culap,
Elisabetta Cameroni,
Nicholas J. Matheson,
Luca Piccoli,
Davide Corti,
Leo C. James,
David L. Robertson,
Dalan Bailey,
Ravindra K. Gupta,
Samuel C. Robson,
Nicholas J. Loman,
Thomas R. Connor,
Tanya Golubchik,
Rocio T. Martinez Nunez,
Catherine Ludden,
Sally Corden,
Ian Johnston,
David Bonsall,
Colin P. Smith,
Ali R. Awan,
Giselda Bucca,
M. Estee Torok,
Kordo Saeed,
Jacqui A. Prieto,
David K. Jackson,
William L. Hamilton,
Luke B. Snell,
Catherine Moore,
Ewan M. Harrison,
Sonia Goncalves,
Derek J. Fairley,
Matthew W. Loose,
Joanne Watkins,
Rich Livett,
Samuel Moses,
Roberto Amato,
Sam Nicholls,
Matthew Bull,
Darren L. Smith,
Jeff Barrett,
David M. Aanensen,
Martin D. Curran,
Surendra Parmar,
Dinesh Aggarwal,
James G. Shepherd,
Matthew D. Parker,
Sharon Glaysher,
Matthew Bashton,
Anthony P. Underwood,
Nicole Pacchiarini,
Katie F. Loveson,
Kate E. Templeton,
Cordelia F. Langford,
John Sillitoe,
Thushan I. de Silva,
Dennis Wang,
Dominic Kwiatkowski,
Andrew Rambaut,
Justin O’Grady,
Simon Cottrell,
Matthew T.G. Holden,
Emma C. Thomson,
Husam Osman,
Monique Andersson,
Anoop J. Chauhan,
Mohammed O. Hassan-Ibrahim,
Mara Lawniczak,
Alex Alderton,
Meera Chand,
Chrystala Constantinidou,
Meera Unnikrishnan,
Alistair C. Darby,
Julian A. Hiscox,
Steve Paterson,
Inigo Martincorena,
Erik M. Volz,
Andrew J. Page,
Oliver G. Pybus,
Andrew R. Bassett,
Cristina V. Ariani,
Michael H. Spencer Chapman,
Kathy K. Li,
Rajiv N. Shah,
Natasha G. Jesudason,
Yusri Taha,
Martin P. McHugh,
Rebecca Dewar,
Aminu S. Jahun,
Claire McMurray,
Sarojini Pandey,
James P. McKenna,
Andrew Nelson,
Gregory R. Young,
Clare M. McCann,
Scott Elliott,
Hannah Lowe,
Ben Temperton,
Sunando Roy,
Anna Price,
Sara Rey,
Matthew Wyles,
Stefan Rooke,
Sharif Shaaban,
Mariateresa de Cesare,
Laura Letchford,
Siona Silveira,
Emanuela Pelosi,
Eleri Wilson-Davies,
Myra Hosmillo,
Áine O’Toole,
Andrew R. Hesketh,
Richard Stark,
Louis du Plessis,
Chris Ruis,
Helen Adams,
Yann Bourgeois,
Stephen L. Michell,
Dimitris Grammatopoulos,
Jonathan Edgeworth,
Judith Breuer,
John A. Todd,
Christophe Fraser,
David Buck,
Michaela John,
Gemma L. Kay,
Steve Palmer,
Sharon J. Peacock,
David Heyburn,
Danni Weldon,
Esther Robinson,
Alan McNally,
Peter Muir,
Ian B. Vipond,
John Boyes,
Venkat Sivaprakasam,
Tranprit Salluja,
Samir Dervisevic,
Emma J. Meader,
Naomi R. Park,
Karen Oliver,
Aaron R. Jeffries,
Sascha Ott,
Ana da Silva Filipe,
David A. Simpson,
Chris Williams,
Jane A.H. Masoli,
Bridget A. Knight,
Christopher R. Jones,
Cherian Koshy,
Amy Ash,
Anna Casey,
Andrew Bosworth,
Liz Ratcliffe,
Li Xu-McCrae,
Hannah M. Pymont,
Stephanie Hutchings,
Lisa Berry,
Katie Jones,
Fenella Halstead,
Thomas Davis,
Christopher Holmes,
Miren Iturriza-Gomara,
Anita O. Lucaci,
Paul Anthony Randell,
Alison Cox,
Pinglawathee Madona,
Kathryn Ann Harris,
Julianne Rose Brown,
Tabitha W. Mahungu,
Dianne Irish-Tavares,
Tanzina Haque,
Jennifer Hart,
Eric Witele,
Melisa Louise Fenton,
Steven Liggett,
Clive Graham,
Emma Swindells,
Jennifer Collins,
Gary Eltringham,
Sharon Campbell,
Patrick C. McClure,
Gemma Clark,
Tim J. Sloan,
Carl Jones,
Jessica Lynch,
Ben Warne,
Steven Leonard,
Jillian Durham,
Thomas Williams,
Sam T. Haldenby,
Nathaniel Storey,
Nabil-Fareed Alikhan,
Nadine Holmes,
Christopher Moore,
Matthew Carlile,
Malorie Perry,
Noel Craine,
Ronan A. Lyons,
Angela H. Beckett,
Salman Goudarzi,
Christopher Fearn,
Kate Cook,
Hannah Dent,
Hannah Paul,
Robert Davies,
Beth Blane,
Sophia T. Girgis,
Mathew A. Beale,
Katherine L. Bellis,
Matthew J. Dorman,
Eleanor Drury,
Leanne Kane,
Sally Kay,
Samantha McGuigan,
Rachel Nelson,
Liam Prestwood,
Shavanthi Rajatileka,
Rahul Batra,
Rachel J. Williams,
Mark Kristiansen,
Angie Green,
Anita Justice,
Adhyana I.K. Mahanama,
Buddhini Samaraweera,
Nazreen F. Hadjirin,
Joshua Quick,
Radoslaw Poplawski,
Leanne M. Kermack,
Nicola Reynolds,
Grant Hall,
Yasmin Chaudhry,
Malte L. Pinckert,
Iliana Georgana,
Robin J. Moll,
Alicia Thornton,
Richard Myers,
Joanne Stockton,
Charlotte A. Williams,
Wen C. Yew,
Alexander J. Trotter,
Amy Trebes,
George MacIntyre-Cockett,
Alec Birchley,
Alexander Adams,
Amy Plimmer,
Bree Gatica-Wilcox,
Caoimhe McKerr,
Ember Hilvers,
Hannah Jones,
Hibo Asad,
Jason Coombes,
Johnathan M. Evans,
Laia Fina,
Lauren Gilbert,
Lee Graham,
Michelle Cronin,
Sara Kumziene-Summerhayes,
Sarah Taylor,
Sophie Jones,
Danielle C. Groves,
Peijun Zhang,
Marta Gallis,
Stavroula F. Louka,
Igor Starinskij,
Chris Jackson,
Marina Gourtovaia,
Gerry Tonkin-Hill,
Kevin Lewis,
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Keith James,
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Fabricia F. Nascimento,
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Jayna Raghwani,
Moritz U.G. Kraemer,
Joel Southgate,
Benjamin B. Lindsey,
Timothy M. Freeman,
Jon-Paul Keatley,
Joshua B. Singer,
Leonardo de Oliveira Martins,
Corin A. Yeats,
Khalil Abudahab,
Ben E.W. Taylor,
Mirko Menegazzo,
John Danesh,
Wendy Hogsden,
Sahar Eldirdiri,
Anita Kenyon,
Jenifer Mason,
Trevor I. Robinson,
Alison Holmes,
James Price,
John A. Hartley,
Tanya Curran,
Alison E. Mather,
Giri Shankar,
Rachel Jones,
Robin Howe,
Sian Morgan,
Elizabeth Wastenge,
Michael R. Chapman,
Siddharth Mookerjee,
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Wendy Smith,
Timothy Peto,
David Eyre,
Derrick Crook,
Gabrielle Vernet,
Christine Kitchen,
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Ronan Lyons 
Cell Reports, Volume: 35, Issue: 13, Start page: 109292
Swansea University Author:
Ronan Lyons
DOI (Published version): 10.1016/j.celrep.2021.109292
Abstract
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape...
| Published in: | Cell Reports |
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| ISSN: | 2211-1247 |
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Elsevier BV
2021
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa66421 |
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<?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>66421</id><entry>2024-05-14</entry><title>Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7</title><swanseaauthors><author><sid>83efcf2a9dfcf8b55586999d3d152ac6</sid><ORCID>0000-0001-5225-000X</ORCID><firstname>Ronan</firstname><surname>Lyons</surname><name>Ronan Lyons</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-05-14</date><deptcode>MEDS</deptcode><abstract>We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape. In vitro, we show that, although ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity associated with enhanced incorporation of cleaved spike into virions. ΔH69/V70 is able to partially rescue infectivity of spike proteins that have acquired N439K and Y453F escape mutations by increased spike incorporation. In addition, replacement of the H69 and V70 residues in the Alpha variant B.1.1.7 spike (where ΔH69/V70 occurs naturally) impairs spike incorporation and entry efficiency of the B.1.1.7 spike pseudotyped virus. Alpha variant B.1.1.7 spike mediates faster kinetics of cell-cell fusion than wild-type Wuhan-1 D614G, dependent on ΔH69/V70. Therefore, as ΔH69/V70 compensates for immune escape mutations that impair infectivity, continued surveillance for deletions with functional effects is warranted.</abstract><type>Journal Article</type><journal>Cell Reports</journal><volume>35</volume><journalNumber>13</journalNumber><paginationStart>109292</paginationStart><paginationEnd/><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>2211-1247</issnPrint><issnElectronic/><keywords>SARS-CoV-2; COVID-19; antibody escape; neutralizing antibodies; infectivity; spike mutation; Alpha variant; resistance; B.1.1.7; deletion</keywords><publishedDay>29</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-06-29</publishedDate><doi>10.1016/j.celrep.2021.109292</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>.K.G. is supported by a Wellcome Trust Senior Fellowship in Clinical Science (WT108082AIA). I.A.T.M.F. is funded by the Sub-Saharan African Network for TB/HIV Research Excellence fellowship (SANTHE, a DELTAS Africa Initiative; DEL-15–006). COG-UK is supported by funding from the Medical Research Council (MRC), part of UK Research & Innovation (UKRI), the National Institute of Health Research (NIHR), and Genome Research Limited, operating as the Wellcome Sanger Institute. This study was supported by the Cambridge NIHRB Biomedical Research Centre. S.A.K. is supported by the Bill and Melinda Gates Foundation via PANGEA grant OPP1175094. D.L.R. is funded by the MRC (MC UU 1201412). W.H. is funded by the MRC (MR/R024758/1). We thank James Voss for the kind gift of HeLa cells stably expressing ACE2, Paul Lehner for Calu-3 cells, and Simon Cook for H1299 cells. N.J.M. is funded by the MRC (CSF ref. MR/P008801/1), NHSBT (grant ref. WPA15-02), and the Addenbrooke's Charitable Trust, Cambridge University Hospitals (grant ref. 900239). We thank Wendy Barclay and Thomas Peacock for helpful discussions and the Geno2pheno UK Consortium. S.L. is funded by Medical Research Council MC_UU_12014/12. This study was also partly funded by the Rosetrees Trust. A.M.L. is funded by the Cambridge NIHRB Biomedical Research Centre.</funders><projectreference/><lastEdited>2024-06-24T12:43:47.7477318</lastEdited><Created>2024-05-14T15:55:32.4763741</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Health Data Science</level></path><authors><author><firstname>Bo</firstname><surname>Meng</surname><order>1</order></author><author><firstname>Steven A.</firstname><surname>Kemp</surname><order>2</order></author><author><firstname>Guido</firstname><surname>Papa</surname><order>3</order></author><author><firstname>Rawlings</firstname><surname>Datir</surname><order>4</order></author><author><firstname>Isabella A.T.M.</firstname><surname>Ferreira</surname><order>5</order></author><author><firstname>Sara</firstname><surname>Marelli</surname><order>6</order></author><author><firstname>William T.</firstname><surname>Harvey</surname><order>7</order></author><author><firstname>Spyros</firstname><surname>Lytras</surname><order>8</order></author><author><firstname>Ahmed</firstname><surname>Mohamed</surname><order>9</order></author><author><firstname>Giulia</firstname><surname>Gallo</surname><order>10</order></author><author><firstname>Nazia</firstname><surname>Thakur</surname><order>11</order></author><author><firstname>Dami A.</firstname><surname>Collier</surname><order>12</order></author><author><firstname>Petra</firstname><surname>Mlcochova</surname><order>13</order></author><author><firstname>Lidia M.</firstname><surname>Duncan</surname><order>14</order></author><author><firstname>Alessandro M.</firstname><surname>Carabelli</surname><order>15</order></author><author><firstname>Julia C.</firstname><surname>Kenyon</surname><order>16</order></author><author><firstname>Andrew M.</firstname><surname>Lever</surname><order>17</order></author><author><firstname>Anna De</firstname><surname>Marco</surname><order>18</order></author><author><firstname>Christian</firstname><surname>Saliba</surname><order>19</order></author><author><firstname>Katja</firstname><surname>Culap</surname><order>20</order></author><author><firstname>Elisabetta</firstname><surname>Cameroni</surname><order>21</order></author><author><firstname>Nicholas J.</firstname><surname>Matheson</surname><order>22</order></author><author><firstname>Luca</firstname><surname>Piccoli</surname><order>23</order></author><author><firstname>Davide</firstname><surname>Corti</surname><order>24</order></author><author><firstname>Leo C.</firstname><surname>James</surname><order>25</order></author><author><firstname>David L.</firstname><surname>Robertson</surname><order>26</order></author><author><firstname>Dalan</firstname><surname>Bailey</surname><order>27</order></author><author><firstname>Ravindra K.</firstname><surname>Gupta</surname><order>28</order></author><author><firstname>Samuel C.</firstname><surname>Robson</surname><order>29</order></author><author><firstname>Nicholas J.</firstname><surname>Loman</surname><order>30</order></author><author><firstname>Thomas R.</firstname><surname>Connor</surname><order>31</order></author><author><firstname>Tanya</firstname><surname>Golubchik</surname><order>32</order></author><author><firstname>Rocio T. 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T.</firstname><surname>Bradley</surname><order>342</order></author><author><firstname>Tim</firstname><surname>Wyatt</surname><order>343</order></author><author><firstname>Charlotte</firstname><surname>Beaver</surname><order>344</order></author><author><firstname>Luke</firstname><surname>Foulser</surname><order>345</order></author><author><firstname>Sophie</firstname><surname>Palmer</surname><order>346</order></author><author><firstname>Carol M.</firstname><surname>Churcher</surname><order>347</order></author><author><firstname>Ellena</firstname><surname>Brooks</surname><order>348</order></author><author><firstname>Kim S.</firstname><surname>Smith</surname><order>349</order></author><author><firstname>Katerina</firstname><surname>Galai</surname><order>350</order></author><author><firstname>Georgina 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P.</firstname><surname>Scarlett</surname><order>360</order></author><author><firstname>Sarah</firstname><surname>Jeremiah</surname><order>361</order></author><author><firstname>Nikki</firstname><surname>Smith</surname><order>362</order></author><author><firstname>Danielle</firstname><surname>Leek</surname><order>363</order></author><author><firstname>Sushmita</firstname><surname>Sridhar</surname><order>364</order></author><author><firstname>Sally</firstname><surname>Forrest</surname><order>365</order></author><author><firstname>Claire</firstname><surname>Cormie</surname><order>366</order></author><author><firstname>Harmeet K.</firstname><surname>Gill</surname><order>367</order></author><author><firstname>Joana</firstname><surname>Dias</surname><order>368</order></author><author><firstname>Ellen 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P.</firstname><surname>George</surname><order>413</order></author><author><firstname>Lance</firstname><surname>Turtle</surname><order>414</order></author><author><firstname>Elaine</firstname><surname>O’Toole</surname><order>415</order></author><author><firstname>Joanne</firstname><surname>Watts</surname><order>416</order></author><author><firstname>Cassie</firstname><surname>Breen</surname><order>417</order></author><author><firstname>Angela</firstname><surname>Cowell</surname><order>418</order></author><author><firstname>Adela</firstname><surname>Alcolea-Medina</surname><order>419</order></author><author><firstname>Themoula</firstname><surname>Charalampous</surname><order>420</order></author><author><firstname>Amita</firstname><surname>Patel</surname><order>421</order></author><author><firstname>Lisa J.</firstname><surname>Levett</surname><order>422</order></author><author><firstname>Judith</firstname><surname>Heaney</surname><order>423</order></author><author><firstname>Aileen</firstname><surname>Rowan</surname><order>424</order></author><author><firstname>Graham P.</firstname><surname>Taylor</surname><order>425</order></author><author><firstname>Divya</firstname><surname>Shah</surname><order>426</order></author><author><firstname>Laura</firstname><surname>Atkinson</surname><order>427</order></author><author><firstname>Jack C.D.</firstname><surname>Lee</surname><order>428</order></author><author><firstname>Adam P.</firstname><surname>Westhorpe</surname><order>429</order></author><author><firstname>Riaz</firstname><surname>Jannoo</surname><order>430</order></author><author><firstname>Helen L.</firstname><surname>Lowe</surname><order>431</order></author><author><firstname>Angeliki</firstname><surname>Karamani</surname><order>432</order></author><author><firstname>Leah</firstname><surname>Ensell</surname><order>433</order></author><author><firstname>Wendy</firstname><surname>Chatterton</surname><order>434</order></author><author><firstname>Monika</firstname><surname>Pusok</surname><order>435</order></author><author><firstname>Ashok</firstname><surname>Dadrah</surname><order>436</order></author><author><firstname>Amanda</firstname><surname>Symmonds</surname><order>437</order></author><author><firstname>Graciela</firstname><surname>Sluga</surname><order>438</order></author><author><firstname>Zoltan</firstname><surname>Molnar</surname><order>439</order></author><author><firstname>Paul</firstname><surname>Baker</surname><order>440</order></author><author><firstname>Stephen</firstname><surname>Bonner</surname><order>441</order></author><author><firstname>Sarah</firstname><surname>Essex</surname><order>442</order></author><author><firstname>Edward</firstname><surname>Barton</surname><order>443</order></author><author><firstname>Debra</firstname><surname>Padgett</surname><order>444</order></author><author><firstname>Garren</firstname><surname>Scott</surname><order>445</order></author><author><firstname>Jane</firstname><surname>Greenaway</surname><order>446</order></author><author><firstname>Brendan A.I.</firstname><surname>Payne</surname><order>447</order></author><author><firstname>Shirelle</firstname><surname>Burton-Fanning</surname><order>448</order></author><author><firstname>Sheila</firstname><surname>Waugh</surname><order>449</order></author><author><firstname>Veena</firstname><surname>Raviprakash</surname><order>450</order></author><author><firstname>Nicola</firstname><surname>Sheriff</surname><order>451</order></author><author><firstname>Victoria</firstname><surname>Blakey</surname><order>452</order></author><author><firstname>Lesley-Anne</firstname><surname>Williams</surname><order>453</order></author><author><firstname>Jonathan</firstname><surname>Moore</surname><order>454</order></author><author><firstname>Susanne</firstname><surname>Stonehouse</surname><order>455</order></author><author><firstname>Louise</firstname><surname>Smith</surname><order>456</order></author><author><firstname>Rose 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S.</firstname><surname>Malone</surname><order>485</order></author><author><firstname>Benjamin J.</firstname><surname>Cogger</surname><order>486</order></author><author><firstname>Nick</firstname><surname>Levene</surname><order>487</order></author><author><firstname>Lynn</firstname><surname>Monaghan</surname><order>488</order></author><author><firstname>Alexander J.</firstname><surname>Keeley</surname><order>489</order></author><author><firstname>David G.</firstname><surname>Partridge</surname><order>490</order></author><author><firstname>Mohammad</firstname><surname>Raza</surname><order>491</order></author><author><firstname>Cariad</firstname><surname>Evans</surname><order>492</order></author><author><firstname>Kate</firstname><surname>Johnson</surname><order>493</order></author><author><firstname>Emma</firstname><surname>Betteridge</surname><order>494</order></author><author><firstname>Ben W.</firstname><surname>Farr</surname><order>495</order></author><author><firstname>Scott</firstname><surname>Goodwin</surname><order>496</order></author><author><firstname>Michael A.</firstname><surname>Quail</surname><order>497</order></author><author><firstname>Carol</firstname><surname>Scott</surname><order>498</order></author><author><firstname>Lesley</firstname><surname>Shirley</surname><order>499</order></author><author><firstname>Scott A.J.</firstname><surname>Thurston</surname><order>500</order></author><author><firstname>Diana</firstname><surname>Rajan</surname><order>501</order></author><author><firstname>Iraad F.</firstname><surname>Bronner</surname><order>502</order></author><author><firstname>Louise</firstname><surname>Aigrain</surname><order>503</order></author><author><firstname>Nicholas M.</firstname><surname>Redshaw</surname><order>504</order></author><author><firstname>Stefanie 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Kay</firstname><surname>Buddenborg</surname><order>642</order></author><author><firstname>Robert</firstname><surname>Bush</surname><order>643</order></author><author><firstname>Catarina</firstname><surname>Caetano</surname><order>644</order></author><author><firstname>Alex</firstname><surname>Cagan</surname><order>645</order></author><author><firstname>Nicola</firstname><surname>Carter</surname><order>646</order></author><author><firstname>Joanna</firstname><surname>Cartwright</surname><order>647</order></author><author><firstname>Tiago Carvalho</firstname><surname>Monteiro</surname><order>648</order></author><author><firstname>Liz</firstname><surname>Chapman</surname><order>649</order></author><author><firstname>Tracey-Jane</firstname><surname>Chillingworth</surname><order>650</order></author><author><firstname>Peter</firstname><surname>Clapham</surname><order>651</order></author><author><firstname>Richard</firstname><surname>Clark</surname><order>652</order></author><author><firstname>Adrian</firstname><surname>Clarke</surname><order>653</order></author><author><firstname>Catriona</firstname><surname>Clarke</surname><order>654</order></author><author><firstname>Daryl</firstname><surname>Cole</surname><order>655</order></author><author><firstname>Elizabeth</firstname><surname>Cook</surname><order>656</order></author><author><firstname>Maria</firstname><surname>Coppola</surname><order>657</order></author><author><firstname>Linda</firstname><surname>Cornell</surname><order>658</order></author><author><firstname>Clare</firstname><surname>Cornwell</surname><order>659</order></author><author><firstname>Craig</firstname><surname>Corton</surname><order>660</order></author><author><firstname>Abby</firstname><surname>Crackett</surname><order>661</order></author><author><firstname>Alison</firstname><surname>Cranage</surname><order>662</order></author><author><firstname>Harriet</firstname><surname>Craven</surname><order>663</order></author><author><firstname>Sarah</firstname><surname>Craw</surname><order>664</order></author><author><firstname>Mark</firstname><surname>Crawford</surname><order>665</order></author><author><firstname>Tim</firstname><surname>Cutts</surname><order>666</order></author><author><firstname>Monika</firstname><surname>Dabrowska</surname><order>667</order></author><author><firstname>Matt</firstname><surname>Davies</surname><order>668</order></author><author><firstname>Joseph</firstname><surname>Dawson</surname><order>669</order></author><author><firstname>Callum</firstname><surname>Day</surname><order>670</order></author><author><firstname>Aiden</firstname><surname>Densem</surname><order>671</order></author><author><firstname>Thomas</firstname><surname>Dibling</surname><order>672</order></author><author><firstname>Cat</firstname><surname>Dockree</surname><order>673</order></author><author><firstname>David</firstname><surname>Dodd</surname><order>674</order></author><author><firstname>Sunil</firstname><surname>Dogga</surname><order>675</order></author><author><firstname>Matthew</firstname><surname>Dorman</surname><order>676</order></author><author><firstname>Gordon</firstname><surname>Dougan</surname><order>677</order></author><author><firstname>Martin</firstname><surname>Dougherty</surname><order>678</order></author><author><firstname>Alexander</firstname><surname>Dove</surname><order>679</order></author><author><firstname>Lucy</firstname><surname>Drummond</surname><order>680</order></author><author><firstname>Monika</firstname><surname>Dudek</surname><order>681</order></author><author><firstname>Laura</firstname><surname>Durrant</surname><order>682</order></author><author><firstname>Elizabeth</firstname><surname>Easthope</surname><order>683</order></author><author><firstname>Sabine</firstname><surname>Eckert</surname><order>684</order></author><author><firstname>Pete</firstname><surname>Ellis</surname><order>685</order></author><author><firstname>Ben</firstname><surname>Farr</surname><order>686</order></author><author><firstname>Michael</firstname><surname>Fenton</surname><order>687</order></author><author><firstname>Marcella</firstname><surname>Ferrero</surname><order>688</order></author><author><firstname>Neil</firstname><surname>Flack</surname><order>689</order></author><author><firstname>Howerd</firstname><surname>Fordham</surname><order>690</order></author><author><firstname>Grace</firstname><surname>Forsythe</surname><order>691</order></author><author><firstname>Matt</firstname><surname>Francis</surname><order>692</order></author><author><firstname>Audrey</firstname><surname>Fraser</surname><order>693</order></author><author><firstname>Adam</firstname><surname>Freeman</surname><order>694</order></author><author><firstname>Anastasia</firstname><surname>Galvin</surname><order>695</order></author><author><firstname>Maria</firstname><surname>Garcia-Casado</surname><order>696</order></author><author><firstname>Alex</firstname><surname>Gedny</surname><order>697</order></author><author><firstname>Sophia</firstname><surname>Girgis</surname><order>698</order></author><author><firstname>James</firstname><surname>Glover</surname><order>699</order></author><author><firstname>Oliver</firstname><surname>Gould</surname><order>700</order></author><author><firstname>Andy</firstname><surname>Gray</surname><order>701</order></author><author><firstname>Emma</firstname><surname>Gray</surname><order>702</order></author><author><firstname>Coline</firstname><surname>Griffiths</surname><order>703</order></author><author><firstname>Yong</firstname><surname>Gu</surname><order>704</order></author><author><firstname>Florence</firstname><surname>Guerin</surname><order>705</order></author><author><firstname>Will</firstname><surname>Hamilton</surname><order>706</order></author><author><firstname>Hannah</firstname><surname>Hanks</surname><order>707</order></author><author><firstname>Ewan</firstname><surname>Harrison</surname><order>708</order></author><author><firstname>Alexandria</firstname><surname>Harrott</surname><order>709</order></author><author><firstname>Edward</firstname><surname>Harry</surname><order>710</order></author><author><firstname>Julia</firstname><surname>Harvison</surname><order>711</order></author><author><firstname>Paul</firstname><surname>Heath</surname><order>712</order></author><author><firstname>Anastasia</firstname><surname>Hernandez-Koutoucheva</surname><order>713</order></author><author><firstname>Rhiannon</firstname><surname>Hobbs</surname><order>714</order></author><author><firstname>Dave</firstname><surname>Holland</surname><order>715</order></author><author><firstname>Sarah</firstname><surname>Holmes</surname><order>716</order></author><author><firstname>Gary</firstname><surname>Hornett</surname><order>717</order></author><author><firstname>Nicholas</firstname><surname>Hough</surname><order>718</order></author><author><firstname>Liz</firstname><surname>Huckle</surname><order>719</order></author><author><firstname>Lena</firstname><surname>Hughes-Hallet</surname><order>720</order></author><author><firstname>Adam</firstname><surname>Hunter</surname><order>721</order></author><author><firstname>Stephen</firstname><surname>Inglis</surname><order>722</order></author><author><firstname>Sameena</firstname><surname>Iqbal</surname><order>723</order></author><author><firstname>Adam</firstname><surname>Jackson</surname><order>724</order></author><author><firstname>David</firstname><surname>Jackson</surname><order>725</order></author><author><firstname>Carlos 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v2 66421 2024-05-14 Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 83efcf2a9dfcf8b55586999d3d152ac6 0000-0001-5225-000X Ronan Lyons Ronan Lyons true false 2024-05-14 MEDS We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape. In vitro, we show that, although ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity associated with enhanced incorporation of cleaved spike into virions. ΔH69/V70 is able to partially rescue infectivity of spike proteins that have acquired N439K and Y453F escape mutations by increased spike incorporation. In addition, replacement of the H69 and V70 residues in the Alpha variant B.1.1.7 spike (where ΔH69/V70 occurs naturally) impairs spike incorporation and entry efficiency of the B.1.1.7 spike pseudotyped virus. Alpha variant B.1.1.7 spike mediates faster kinetics of cell-cell fusion than wild-type Wuhan-1 D614G, dependent on ΔH69/V70. Therefore, as ΔH69/V70 compensates for immune escape mutations that impair infectivity, continued surveillance for deletions with functional effects is warranted. Journal Article Cell Reports 35 13 109292 Elsevier BV 2211-1247 SARS-CoV-2; COVID-19; antibody escape; neutralizing antibodies; infectivity; spike mutation; Alpha variant; resistance; B.1.1.7; deletion 29 6 2021 2021-06-29 10.1016/j.celrep.2021.109292 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University .K.G. is supported by a Wellcome Trust Senior Fellowship in Clinical Science (WT108082AIA). I.A.T.M.F. is funded by the Sub-Saharan African Network for TB/HIV Research Excellence fellowship (SANTHE, a DELTAS Africa Initiative; DEL-15–006). COG-UK is supported by funding from the Medical Research Council (MRC), part of UK Research & Innovation (UKRI), the National Institute of Health Research (NIHR), and Genome Research Limited, operating as the Wellcome Sanger Institute. This study was supported by the Cambridge NIHRB Biomedical Research Centre. S.A.K. is supported by the Bill and Melinda Gates Foundation via PANGEA grant OPP1175094. D.L.R. is funded by the MRC (MC UU 1201412). W.H. is funded by the MRC (MR/R024758/1). We thank James Voss for the kind gift of HeLa cells stably expressing ACE2, Paul Lehner for Calu-3 cells, and Simon Cook for H1299 cells. N.J.M. is funded by the MRC (CSF ref. MR/P008801/1), NHSBT (grant ref. WPA15-02), and the Addenbrooke's Charitable Trust, Cambridge University Hospitals (grant ref. 900239). We thank Wendy Barclay and Thomas Peacock for helpful discussions and the Geno2pheno UK Consortium. S.L. is funded by Medical Research Council MC_UU_12014/12. This study was also partly funded by the Rosetrees Trust. A.M.L. is funded by the Cambridge NIHRB Biomedical Research Centre. 2024-06-24T12:43:47.7477318 2024-05-14T15:55:32.4763741 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Bo Meng 1 Steven A. Kemp 2 Guido Papa 3 Rawlings Datir 4 Isabella A.T.M. Ferreira 5 Sara Marelli 6 William T. Harvey 7 Spyros Lytras 8 Ahmed Mohamed 9 Giulia Gallo 10 Nazia Thakur 11 Dami A. Collier 12 Petra Mlcochova 13 Lidia M. Duncan 14 Alessandro M. Carabelli 15 Julia C. Kenyon 16 Andrew M. Lever 17 Anna De Marco 18 Christian Saliba 19 Katja Culap 20 Elisabetta Cameroni 21 Nicholas J. Matheson 22 Luca Piccoli 23 Davide Corti 24 Leo C. James 25 David L. Robertson 26 Dalan Bailey 27 Ravindra K. Gupta 28 Samuel C. Robson 29 Nicholas J. Loman 30 Thomas R. Connor 31 Tanya Golubchik 32 Rocio T. Martinez Nunez 33 Catherine Ludden 34 Sally Corden 35 Ian Johnston 36 David Bonsall 37 Colin P. Smith 38 Ali R. Awan 39 Giselda Bucca 40 M. Estee Torok 41 Kordo Saeed 42 Jacqui A. Prieto 43 David K. Jackson 44 William L. Hamilton 45 Luke B. Snell 46 Catherine Moore 47 Ewan M. Harrison 48 Sonia Goncalves 49 Derek J. Fairley 50 Matthew W. Loose 51 Joanne Watkins 52 Rich Livett 53 Samuel Moses 54 Roberto Amato 55 Sam Nicholls 56 Matthew Bull 57 Darren L. Smith 58 Jeff Barrett 59 David M. Aanensen 60 Martin D. Curran 61 Surendra Parmar 62 Dinesh Aggarwal 63 James G. Shepherd 64 Matthew D. Parker 65 Sharon Glaysher 66 Matthew Bashton 67 Anthony P. Underwood 68 Nicole Pacchiarini 69 Katie F. Loveson 70 Kate E. Templeton 71 Cordelia F. Langford 72 John Sillitoe 73 Thushan I. de Silva 74 Dennis Wang 75 Dominic Kwiatkowski 76 Andrew Rambaut 77 Justin O’Grady 78 Simon Cottrell 79 Matthew T.G. Holden 80 Emma C. Thomson 81 Husam Osman 82 Monique Andersson 83 Anoop J. Chauhan 84 Mohammed O. Hassan-Ibrahim 85 Mara Lawniczak 86 Alex Alderton 87 Meera Chand 88 Chrystala Constantinidou 89 Meera Unnikrishnan 90 Alistair C. Darby 91 Julian A. Hiscox 92 Steve Paterson 93 Inigo Martincorena 94 Erik M. Volz 95 Andrew J. Page 96 Oliver G. Pybus 97 Andrew R. Bassett 98 Cristina V. Ariani 99 Michael H. Spencer Chapman 100 Kathy K. Li 101 Rajiv N. Shah 102 Natasha G. Jesudason 103 Yusri Taha 104 Martin P. McHugh 105 Rebecca Dewar 106 Aminu S. Jahun 107 Claire McMurray 108 Sarojini Pandey 109 James P. McKenna 110 Andrew Nelson 111 Gregory R. Young 112 Clare M. McCann 113 Scott Elliott 114 Hannah Lowe 115 Ben Temperton 116 Sunando Roy 117 Anna Price 118 Sara Rey 119 Matthew Wyles 120 Stefan Rooke 121 Sharif Shaaban 122 Mariateresa de Cesare 123 Laura Letchford 124 Siona Silveira 125 Emanuela Pelosi 126 Eleri Wilson-Davies 127 Myra Hosmillo 128 Áine O’Toole 129 Andrew R. Hesketh 130 Richard Stark 131 Louis du Plessis 132 Chris Ruis 133 Helen Adams 134 Yann Bourgeois 135 Stephen L. Michell 136 Dimitris Grammatopoulos 137 Jonathan Edgeworth 138 Judith Breuer 139 John A. Todd 140 Christophe Fraser 141 David Buck 142 Michaela John 143 Gemma L. Kay 144 Steve Palmer 145 Sharon J. Peacock 146 David Heyburn 147 Danni Weldon 148 Esther Robinson 149 Alan McNally 150 Peter Muir 151 Ian B. Vipond 152 John Boyes 153 Venkat Sivaprakasam 154 Tranprit Salluja 155 Samir Dervisevic 156 Emma J. Meader 157 Naomi R. Park 158 Karen Oliver 159 Aaron R. Jeffries 160 Sascha Ott 161 Ana da Silva Filipe 162 David A. Simpson 163 Chris Williams 164 Jane A.H. Masoli 165 Bridget A. Knight 166 Christopher R. Jones 167 Cherian Koshy 168 Amy Ash 169 Anna Casey 170 Andrew Bosworth 171 Liz Ratcliffe 172 Li Xu-McCrae 173 Hannah M. Pymont 174 Stephanie Hutchings 175 Lisa Berry 176 Katie Jones 177 Fenella Halstead 178 Thomas Davis 179 Christopher Holmes 180 Miren Iturriza-Gomara 181 Anita O. Lucaci 182 Paul Anthony Randell 183 Alison Cox 184 Pinglawathee Madona 185 Kathryn Ann Harris 186 Julianne Rose Brown 187 Tabitha W. Mahungu 188 Dianne Irish-Tavares 189 Tanzina Haque 190 Jennifer Hart 191 Eric Witele 192 Melisa Louise Fenton 193 Steven Liggett 194 Clive Graham 195 Emma Swindells 196 Jennifer Collins 197 Gary Eltringham 198 Sharon Campbell 199 Patrick C. McClure 200 Gemma Clark 201 Tim J. Sloan 202 Carl Jones 203 Jessica Lynch 204 Ben Warne 205 Steven Leonard 206 Jillian Durham 207 Thomas Williams 208 Sam T. Haldenby 209 Nathaniel Storey 210 Nabil-Fareed Alikhan 211 Nadine Holmes 212 Christopher Moore 213 Matthew Carlile 214 Malorie Perry 215 Noel Craine 216 Ronan A. Lyons 217 Angela H. Beckett 218 Salman Goudarzi 219 Christopher Fearn 220 Kate Cook 221 Hannah Dent 222 Hannah Paul 223 Robert Davies 224 Beth Blane 225 Sophia T. Girgis 226 Mathew A. Beale 227 Katherine L. Bellis 228 Matthew J. Dorman 229 Eleanor Drury 230 Leanne Kane 231 Sally Kay 232 Samantha McGuigan 233 Rachel Nelson 234 Liam Prestwood 235 Shavanthi Rajatileka 236 Rahul Batra 237 Rachel J. Williams 238 Mark Kristiansen 239 Angie Green 240 Anita Justice 241 Adhyana I.K. Mahanama 242 Buddhini Samaraweera 243 Nazreen F. Hadjirin 244 Joshua Quick 245 Radoslaw Poplawski 246 Leanne M. Kermack 247 Nicola Reynolds 248 Grant Hall 249 Yasmin Chaudhry 250 Malte L. Pinckert 251 Iliana Georgana 252 Robin J. Moll 253 Alicia Thornton 254 Richard Myers 255 Joanne Stockton 256 Charlotte A. Williams 257 Wen C. Yew 258 Alexander J. Trotter 259 Amy Trebes 260 George MacIntyre-Cockett 261 Alec Birchley 262 Alexander Adams 263 Amy Plimmer 264 Bree Gatica-Wilcox 265 Caoimhe McKerr 266 Ember Hilvers 267 Hannah Jones 268 Hibo Asad 269 Jason Coombes 270 Johnathan M. Evans 271 Laia Fina 272 Lauren Gilbert 273 Lee Graham 274 Michelle Cronin 275 Sara Kumziene-Summerhayes 276 Sarah Taylor 277 Sophie Jones 278 Danielle C. Groves 279 Peijun Zhang 280 Marta Gallis 281 Stavroula F. Louka 282 Igor Starinskij 283 Chris Jackson 284 Marina Gourtovaia 285 Gerry Tonkin-Hill 286 Kevin Lewis 287 Jaime M. Tovar-Corona 288 Keith James 289 Laura Baxter 290 Mohammad T. Alam 291 Richard J. Orton 292 Joseph Hughes 293 Sreenu Vattipally 294 Manon Ragonnet-Cronin 295 Fabricia F. Nascimento 296 David Jorgensen 297 Olivia Boyd 298 Lily Geidelberg 299 Alex E. Zarebski 300 Jayna Raghwani 301 Moritz U.G. Kraemer 302 Joel Southgate 303 Benjamin B. Lindsey 304 Timothy M. Freeman 305 Jon-Paul Keatley 306 Joshua B. Singer 307 Leonardo de Oliveira Martins 308 Corin A. Yeats 309 Khalil Abudahab 310 Ben E.W. Taylor 311 Mirko Menegazzo 312 John Danesh 313 Wendy Hogsden 314 Sahar Eldirdiri 315 Anita Kenyon 316 Jenifer Mason 317 Trevor I. Robinson 318 Alison Holmes 319 James Price 320 John A. Hartley 321 Tanya Curran 322 Alison E. Mather 323 Giri Shankar 324 Rachel Jones 325 Robin Howe 326 Sian Morgan 327 Elizabeth Wastenge 328 Michael R. Chapman 329 Siddharth Mookerjee 330 Rachael Stanley 331 Wendy Smith 332 Timothy Peto 333 David Eyre 334 Derrick Crook 335 Gabrielle Vernet 336 Christine Kitchen 337 Huw Gulliver 338 Ian Merrick 339 Martyn Guest 340 Robert Munn 341 Declan T. Bradley 342 Tim Wyatt 343 Charlotte Beaver 344 Luke Foulser 345 Sophie Palmer 346 Carol M. Churcher 347 Ellena Brooks 348 Kim S. Smith 349 Katerina Galai 350 Georgina M. McManus 351 Frances Bolt 352 Francesc Coll 353 Lizzie Meadows 354 Stephen W. Attwood 355 Alisha Davies 356 Elen De Lacy 357 Fatima Downing 358 Sue Edwards 359 Garry P. Scarlett 360 Sarah Jeremiah 361 Nikki Smith 362 Danielle Leek 363 Sushmita Sridhar 364 Sally Forrest 365 Claire Cormie 366 Harmeet K. Gill 367 Joana Dias 368 Ellen E. Higginson 369 Mailis Maes 370 Jamie Young 371 Michelle Wantoch 372 Dorota Jamrozy 373 Stephanie Lo 374 Minal Patel 375 Verity Hill 376 Claire M. Bewshea 377 Sian Ellard 378 Cressida Auckland 379 Ian Harrison 380 Chloe Bishop 381 Vicki Chalker 382 Alex Richter 383 Andrew Beggs 384 Angus Best 385 Benita Percival 386 Jeremy Mirza 387 Oliver Megram 388 Megan Mayhew 389 Liam Crawford 390 Fiona Ashcroft 391 Emma Moles-Garcia 392 Nicola Cumley 393 Richard Hopes 394 Patawee Asamaphan 395 Marc O. Niebel 396 Rory N. Gunson 397 Amanda Bradley 398 Alasdair Maclean 399 Guy Mollett 400 Rachel Blacow 401 Paul Bird 402 Thomas Helmer 403 Karlie Fallon 404 Julian Tang 405 Antony D. Hale 406 Louissa R. Macfarlane-Smith 407 Katherine L. Harper 408 Holli Carden 409 Nicholas W. Machin 410 Kathryn A. Jackson 411 Shazaad S.Y. Ahmad 412 Ryan P. George 413 Lance Turtle 414 Elaine O’Toole 415 Joanne Watts 416 Cassie Breen 417 Angela Cowell 418 Adela Alcolea-Medina 419 Themoula Charalampous 420 Amita Patel 421 Lisa J. Levett 422 Judith Heaney 423 Aileen Rowan 424 Graham P. Taylor 425 Divya Shah 426 Laura Atkinson 427 Jack C.D. Lee 428 Adam P. Westhorpe 429 Riaz Jannoo 430 Helen L. Lowe 431 Angeliki Karamani 432 Leah Ensell 433 Wendy Chatterton 434 Monika Pusok 435 Ashok Dadrah 436 Amanda Symmonds 437 Graciela Sluga 438 Zoltan Molnar 439 Paul Baker 440 Stephen Bonner 441 Sarah Essex 442 Edward Barton 443 Debra Padgett 444 Garren Scott 445 Jane Greenaway 446 Brendan A.I. Payne 447 Shirelle Burton-Fanning 448 Sheila Waugh 449 Veena Raviprakash 450 Nicola Sheriff 451 Victoria Blakey 452 Lesley-Anne Williams 453 Jonathan Moore 454 Susanne Stonehouse 455 Louise Smith 456 Rose K. Davidson 457 Luke Bedford 458 Lindsay Coupland 459 Victoria Wright 460 Joseph G. Chappell 461 Theocharis Tsoleridis 462 Jonathan Ball 463 Manjinder Khakh 464 Vicki M. Fleming 465 Michelle M. Lister 466 Hannah C. Howson-Wells 467 Louise Berry 468 Tim Boswell 469 Amelia Joseph 470 Iona Willingham 471 Nichola Duckworth 472 Sarah Walsh 473 Emma Wise 474 Nathan Moore 475 Matilde Mori 476 Nick Cortes 477 Stephen Kidd 478 Rebecca Williams 479 Laura Gifford 480 Kelly Bicknell 481 Sarah Wyllie 482 Allyson Lloyd 483 Robert Impey 484 Cassandra S. Malone 485 Benjamin J. Cogger 486 Nick Levene 487 Lynn Monaghan 488 Alexander J. Keeley 489 David G. Partridge 490 Mohammad Raza 491 Cariad Evans 492 Kate Johnson 493 Emma Betteridge 494 Ben W. Farr 495 Scott Goodwin 496 Michael A. Quail 497 Carol Scott 498 Lesley Shirley 499 Scott A.J. Thurston 500 Diana Rajan 501 Iraad F. Bronner 502 Louise Aigrain 503 Nicholas M. Redshaw 504 Stefanie V. Lensing 505 Shane McCarthy 506 Alex Makunin 507 Carlos E. Balcazar 508 Michael D. Gallagher 509 Kathleen A. Williamson 510 Thomas D. Stanton 511 Michelle L. Michelsen 512 Joanna Warwick-Dugdale 513 Robin Manley 514 Audrey Farbos 515 James W. Harrison 516 Christine M. Sambles 517 David J. Studholme 518 Angie Lackenby 519 Tamyo Mbisa 520 Steven Platt 521 Shahjahan Miah 522 David Bibby 523 Carmen Manso 524 Jonathan Hubb 525 Gavin Dabrera 526 Mary Ramsay 527 Daniel Bradshaw 528 Ulf Schaefer 529 Natalie Groves 530 Eileen Gallagher 531 David Lee 532 David Williams 533 Nicholas Ellaby 534 Hassan Hartman 535 Nikos Manesis 536 Vineet Patel 537 Juan Ledesma 538 Katherine A. Twohig 539 Elias Allara 540 Clare Pearson 541 Jeffrey K.J. Cheng 542 Hannah E. Bridgewater 543 Lucy R. Frost 544 Grace Taylor-Joyce 545 Paul E. Brown 546 Lily Tong 547 Alice Broos 548 Daniel Mair 549 Jenna Nichols 550 Stephen N. Carmichael 551 Katherine L. Smollett 552 Kyriaki Nomikou 553 Elihu Aranday-Cortes 554 Natasha Johnson 555 Seema Nickbakhsh 556 Edith E. Vamos 557 Margaret Hughes 558 Lucille Rainbow 559 Richard Eccles 560 Charlotte Nelson 561 Mark Whitehead 562 Richard Gregory 563 Matthew Gemmell 564 Claudia Wierzbicki 565 Hermione J. Webster 566 Chloe L. Fisher 567 Adrian W. Signell 568 Gilberto Betancor 569 Harry D. Wilson 570 Gaia Nebbia 571 Flavia Flaviani 572 Alberto C. Cerda 573 Tammy V. Merrill 574 Rebekah E. Wilson 575 Marius Cotic 576 Nadua Bayzid 577 Thomas Thompson 578 Erwan Acheson 579 Steven Rushton 580 Sarah O’Brien 581 David J. Baker 582 Steven Rudder 583 Alp Aydin 584 Fei Sang 585 Johnny Debebe 586 Sarah Francois 587 Tetyana I. Vasylyeva 588 Marina Escalera Zamudio 589 Bernardo Gutierrez 590 Angela Marchbank 591 Joshua Maksimovic 592 Karla Spellman 593 Kathryn McCluggage 594 Mari Morgan 595 Robert Beer 596 Safiah Afifi 597 Trudy Workman 598 William Fuller 599 Catherine Bresner 600 Adrienn Angyal 601 Luke R. Green 602 Paul J. Parsons 603 Rachel M. Tucker 604 Rebecca Brown 605 Max Whiteley 606 James Bonfield 607 Christoph Puethe 608 Andrew Whitwham 609 Jennifier Liddle 610 Will Rowe 611 Igor Siveroni 612 Thanh Le-Viet 613 Amy Gaskin 614 Rob Johnson 615 Irina Abnizova 616 Mozam Ali 617 Laura Allen 618 Ralph Anderson 619 Cristina Ariani 620 Siobhan Austin-Guest 621 Sendu Bala 622 Jeffrey Barrett 623 Andrew Bassett 624 Kristina Battleday 625 James Beal 626 Mathew Beale 627 Sam Bellany 628 Tristram Bellerby 629 Katie Bellis 630 Duncan Berger 631 Matt Berriman 632 Paul Bevan 633 Simon Binley 634 Jason Bishop 635 Kirsty Blackburn 636 Nick Boughton 637 Sam Bowker 638 Timothy Brendler-Spaeth 639 Iraad Bronner 640 Tanya Brooklyn 641 Sarah Kay Buddenborg 642 Robert Bush 643 Catarina Caetano 644 Alex Cagan 645 Nicola Carter 646 Joanna Cartwright 647 Tiago Carvalho Monteiro 648 Liz Chapman 649 Tracey-Jane Chillingworth 650 Peter Clapham 651 Richard Clark 652 Adrian Clarke 653 Catriona Clarke 654 Daryl Cole 655 Elizabeth Cook 656 Maria Coppola 657 Linda Cornell 658 Clare Cornwell 659 Craig Corton 660 Abby Crackett 661 Alison Cranage 662 Harriet Craven 663 Sarah Craw 664 Mark Crawford 665 Tim Cutts 666 Monika Dabrowska 667 Matt Davies 668 Joseph Dawson 669 Callum Day 670 Aiden Densem 671 Thomas Dibling 672 Cat Dockree 673 David Dodd 674 Sunil Dogga 675 Matthew Dorman 676 Gordon Dougan 677 Martin Dougherty 678 Alexander Dove 679 Lucy Drummond 680 Monika Dudek 681 Laura Durrant 682 Elizabeth Easthope 683 Sabine Eckert 684 Pete Ellis 685 Ben Farr 686 Michael Fenton 687 Marcella Ferrero 688 Neil Flack 689 Howerd Fordham 690 Grace Forsythe 691 Matt Francis 692 Audrey Fraser 693 Adam Freeman 694 Anastasia Galvin 695 Maria Garcia-Casado 696 Alex Gedny 697 Sophia Girgis 698 James Glover 699 Oliver Gould 700 Andy Gray 701 Emma Gray 702 Coline Griffiths 703 Yong Gu 704 Florence Guerin 705 Will Hamilton 706 Hannah Hanks 707 Ewan Harrison 708 Alexandria Harrott 709 Edward Harry 710 Julia Harvison 711 Paul Heath 712 Anastasia Hernandez-Koutoucheva 713 Rhiannon Hobbs 714 Dave Holland 715 Sarah Holmes 716 Gary Hornett 717 Nicholas Hough 718 Liz Huckle 719 Lena Hughes-Hallet 720 Adam Hunter 721 Stephen Inglis 722 Sameena Iqbal 723 Adam Jackson 724 David Jackson 725 Carlos Jimenez Verdejo 726 Matthew Jones 727 Kalyan Kallepally 728 Keely Kay 729 Jon Keatley 730 Alan Keith 731 Alison King 732 Lucy Kitchin 733 Matt Kleanthous 734 Martina Klimekova 735 Petra Korlevic 736 Ksenia Krasheninnkova 737 Greg Lane 738 Cordelia Langford 739 Adam Laverack 740 Katharine Law 741 Stefanie Lensing 742 Amanah Lewis-Wade 743 Jennifer Liddle 744 Quan Lin 745 Sarah Lindsay 746 Sally Linsdell 747 Rhona Long 748 Jamie Lovell 749 Jon Lovell 750 James Mack 751 Mark Maddison 752 Aleksei Makunin 753 Irfan Mamun 754 Jenny Mansfield 755 Neil Marriott 756 Matt Martin 757 Matthew Mayho 758 Jo McClintock 759 Sandra McHugh 760 Liz MapcMinn 761 Carl Meadows 762 Emily Mobley 763 Robin Moll 764 Maria Morra 765 Leanne Morrow 766 Kathryn Murie 767 Sian Nash 768 Claire Nathwani 769 Plamena Naydenova 770 Alexandra Neaverson 771 Ed Nerou 772 Jon Nicholson 773 Tabea Nimz 774 Guillaume G. Noell 775 Sarah O’Meara 776 Valeriu Ohan 777 Charles Olney 778 Doug Ormond 779 Agnes Oszlanczi 780 Yoke Fei Pang 781 Barbora Pardubska 782 Naomi Park 783 Aaron Parmar 784 Gaurang Patel 785 Maggie Payne 786 Sharon Peacock 787 Arabella Petersen 788 Deborah Plowman 789 Tom Preston 790 Michael Quail 791 Richard Rance 792 Suzannah Rawlings 793 Nicholas Redshaw 794 Joe Reynolds 795 Mark Reynolds 796 Simon Rice 797 Matt Richardson 798 Connor Roberts 799 Katrina Robinson 800 Melanie Robinson 801 David Robinson 802 Hazel Rogers 803 Eduardo Martin Rojo 804 Daljit Roopra 805 Mark Rose 806 Luke Rudd 807 Ramin Sadri 808 Nicholas Salmon 809 David Saul 810 Frank Schwach 811 Phil Seekings 812 Alison Simms 813 Matt Sinnott 814 Shanthi Sivadasan 815 Bart Siwek 816 Dale Sizer 817 Kenneth Skeldon 818 Jason Skelton 819 Joanna Slater-Tunstill 820 Lisa Sloper 821 Nathalie Smerdon 822 Chris Smith 823 Christen Smith 824 James Smith 825 Katie Smith 826 Michelle Smith 827 Sean Smith 828 Tina Smith 829 Leighton Sneade 830 Carmen Diaz Soria 831 Catarina Sousa 832 Emily Souster 833 Andrew Sparkes 834 Michael Spencer-Chapman 835 Janet Squares 836 Robert Stanley 837 Claire Steed 838 Tim Stickland 839 Ian Still 840 Mike Stratton 841 Michelle Strickland 842 Allen Swann 843 Agnieszka Swiatkowska 844 Neil Sycamore 845 Emma Swift 846 Edward Symons 847 Suzanne Szluha 848 Emma Taluy 849 Nunu Tao 850 Katy Taylor 851 Sam Taylor 852 Stacey Thompson 853 Mark Thompson 854 Mark Thomson 855 Nicholas Thomson 856 Scott Thurston 857 Dee Toombs 858 Benjamin Topping 859 Jaime Tovar-Corona 860 Daniel Ungureanu 861 James Uphill 862 Jana Urbanova 863 Philip Jansen Van 864 Valerie Vancollie 865 Paul Voak 866 Danielle Walker 867 Matthew Walker 868 Matt Waller 869 Gary Ward 870 Charlie Weatherhogg 871 Niki Webb 872 Alan Wells 873 Eloise Wells 874 Luke Westwood 875 Theo Whipp 876 Thomas Whiteley 877 Georgia Whitton 878 Sara Widaa 879 Mia Williams 880 Mark Wilson 881 Sean Wright 882 Ronan Lyons 0000-0001-5225-000X 883 66421__30366__ffa92792170a42d09ea880aaeb061ace.pdf 66421.pdf 2024-05-14T15:58:12.3817092 Output 4649672 application/pdf Version of Record true This is an open access article under the CC BY license. true eng https://creativecommons.org/licenses/by/4.0/ |
| title |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 |
| spellingShingle |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 Ronan Lyons |
| title_short |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 |
| title_full |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 |
| title_fullStr |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 |
| title_full_unstemmed |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 |
| title_sort |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 |
| author_id_str_mv |
83efcf2a9dfcf8b55586999d3d152ac6 |
| author_id_fullname_str_mv |
83efcf2a9dfcf8b55586999d3d152ac6_***_Ronan Lyons |
| author |
Ronan Lyons |
| author2 |
Bo Meng Steven A. Kemp Guido Papa Rawlings Datir Isabella A.T.M. Ferreira Sara Marelli William T. Harvey Spyros Lytras Ahmed Mohamed Giulia Gallo Nazia Thakur Dami A. Collier Petra Mlcochova Lidia M. Duncan Alessandro M. Carabelli Julia C. Kenyon Andrew M. Lever Anna De Marco Christian Saliba Katja Culap Elisabetta Cameroni Nicholas J. Matheson Luca Piccoli Davide Corti Leo C. James David L. Robertson Dalan Bailey Ravindra K. Gupta Samuel C. Robson Nicholas J. Loman Thomas R. Connor Tanya Golubchik Rocio T. Martinez Nunez Catherine Ludden Sally Corden Ian Johnston David Bonsall Colin P. Smith Ali R. Awan Giselda Bucca M. Estee Torok Kordo Saeed Jacqui A. Prieto David K. Jackson William L. Hamilton Luke B. Snell Catherine Moore Ewan M. Harrison Sonia Goncalves Derek J. Fairley Matthew W. Loose Joanne Watkins Rich Livett Samuel Moses Roberto Amato Sam Nicholls Matthew Bull Darren L. Smith Jeff Barrett David M. Aanensen Martin D. Curran Surendra Parmar Dinesh Aggarwal James G. Shepherd Matthew D. Parker Sharon Glaysher Matthew Bashton Anthony P. Underwood Nicole Pacchiarini Katie F. Loveson Kate E. Templeton Cordelia F. Langford John Sillitoe Thushan I. de Silva Dennis Wang Dominic Kwiatkowski Andrew Rambaut Justin O’Grady Simon Cottrell Matthew T.G. Holden Emma C. Thomson Husam Osman Monique Andersson Anoop J. Chauhan Mohammed O. Hassan-Ibrahim Mara Lawniczak Alex Alderton Meera Chand Chrystala Constantinidou Meera Unnikrishnan Alistair C. Darby Julian A. Hiscox Steve Paterson Inigo Martincorena Erik M. Volz Andrew J. Page Oliver G. Pybus Andrew R. Bassett Cristina V. Ariani Michael H. Spencer Chapman Kathy K. Li Rajiv N. Shah Natasha G. Jesudason Yusri Taha Martin P. McHugh Rebecca Dewar Aminu S. Jahun Claire McMurray Sarojini Pandey James P. McKenna Andrew Nelson Gregory R. Young Clare M. McCann Scott Elliott Hannah Lowe Ben Temperton Sunando Roy Anna Price Sara Rey Matthew Wyles Stefan Rooke Sharif Shaaban Mariateresa de Cesare Laura Letchford Siona Silveira Emanuela Pelosi Eleri Wilson-Davies Myra Hosmillo Áine O’Toole Andrew R. Hesketh Richard Stark Louis du Plessis Chris Ruis Helen Adams Yann Bourgeois Stephen L. Michell Dimitris Grammatopoulos Jonathan Edgeworth Judith Breuer John A. Todd Christophe Fraser David Buck Michaela John Gemma L. Kay Steve Palmer Sharon J. Peacock David Heyburn Danni Weldon Esther Robinson Alan McNally Peter Muir Ian B. Vipond John Boyes Venkat Sivaprakasam Tranprit Salluja Samir Dervisevic Emma J. Meader Naomi R. Park Karen Oliver Aaron R. Jeffries Sascha Ott Ana da Silva Filipe David A. Simpson Chris Williams Jane A.H. Masoli Bridget A. Knight Christopher R. Jones Cherian Koshy Amy Ash Anna Casey Andrew Bosworth Liz Ratcliffe Li Xu-McCrae Hannah M. Pymont Stephanie Hutchings Lisa Berry Katie Jones Fenella Halstead Thomas Davis Christopher Holmes Miren Iturriza-Gomara Anita O. Lucaci Paul Anthony Randell Alison Cox Pinglawathee Madona Kathryn Ann Harris Julianne Rose Brown Tabitha W. Mahungu Dianne Irish-Tavares Tanzina Haque Jennifer Hart Eric Witele Melisa Louise Fenton Steven Liggett Clive Graham Emma Swindells Jennifer Collins Gary Eltringham Sharon Campbell Patrick C. McClure Gemma Clark Tim J. Sloan Carl Jones Jessica Lynch Ben Warne Steven Leonard Jillian Durham Thomas Williams Sam T. Haldenby Nathaniel Storey Nabil-Fareed Alikhan Nadine Holmes Christopher Moore Matthew Carlile Malorie Perry Noel Craine Ronan A. Lyons Angela H. Beckett Salman Goudarzi Christopher Fearn Kate Cook Hannah Dent Hannah Paul Robert Davies Beth Blane Sophia T. Girgis Mathew A. Beale Katherine L. Bellis Matthew J. Dorman Eleanor Drury Leanne Kane Sally Kay Samantha McGuigan Rachel Nelson Liam Prestwood Shavanthi Rajatileka Rahul Batra Rachel J. Williams Mark Kristiansen Angie Green Anita Justice Adhyana I.K. Mahanama Buddhini Samaraweera Nazreen F. Hadjirin Joshua Quick Radoslaw Poplawski Leanne M. Kermack Nicola Reynolds Grant Hall Yasmin Chaudhry Malte L. Pinckert Iliana Georgana Robin J. Moll Alicia Thornton Richard Myers Joanne Stockton Charlotte A. Williams Wen C. Yew Alexander J. Trotter Amy Trebes George MacIntyre-Cockett Alec Birchley Alexander Adams Amy Plimmer Bree Gatica-Wilcox Caoimhe McKerr Ember Hilvers Hannah Jones Hibo Asad Jason Coombes Johnathan M. Evans Laia Fina Lauren Gilbert Lee Graham Michelle Cronin Sara Kumziene-Summerhayes Sarah Taylor Sophie Jones Danielle C. Groves Peijun Zhang Marta Gallis Stavroula F. Louka Igor Starinskij Chris Jackson Marina Gourtovaia Gerry Tonkin-Hill Kevin Lewis Jaime M. Tovar-Corona Keith James Laura Baxter Mohammad T. Alam Richard J. Orton Joseph Hughes Sreenu Vattipally Manon Ragonnet-Cronin Fabricia F. Nascimento David Jorgensen Olivia Boyd Lily Geidelberg Alex E. Zarebski Jayna Raghwani Moritz U.G. Kraemer Joel Southgate Benjamin B. Lindsey Timothy M. Freeman Jon-Paul Keatley Joshua B. Singer Leonardo de Oliveira Martins Corin A. Yeats Khalil Abudahab Ben E.W. Taylor Mirko Menegazzo John Danesh Wendy Hogsden Sahar Eldirdiri Anita Kenyon Jenifer Mason Trevor I. Robinson Alison Holmes James Price John A. Hartley Tanya Curran Alison E. Mather Giri Shankar Rachel Jones Robin Howe Sian Morgan Elizabeth Wastenge Michael R. Chapman Siddharth Mookerjee Rachael Stanley Wendy Smith Timothy Peto David Eyre Derrick Crook Gabrielle Vernet Christine Kitchen Huw Gulliver Ian Merrick Martyn Guest Robert Munn Declan T. Bradley Tim Wyatt Charlotte Beaver Luke Foulser Sophie Palmer Carol M. Churcher Ellena Brooks Kim S. Smith Katerina Galai Georgina M. McManus Frances Bolt Francesc Coll Lizzie Meadows Stephen W. Attwood Alisha Davies Elen De Lacy Fatima Downing Sue Edwards Garry P. Scarlett Sarah Jeremiah Nikki Smith Danielle Leek Sushmita Sridhar Sally Forrest Claire Cormie Harmeet K. Gill Joana Dias Ellen E. Higginson Mailis Maes Jamie Young Michelle Wantoch Dorota Jamrozy Stephanie Lo Minal Patel Verity Hill Claire M. Bewshea Sian Ellard Cressida Auckland Ian Harrison Chloe Bishop Vicki Chalker Alex Richter Andrew Beggs Angus Best Benita Percival Jeremy Mirza Oliver Megram Megan Mayhew Liam Crawford Fiona Ashcroft Emma Moles-Garcia Nicola Cumley Richard Hopes Patawee Asamaphan Marc O. Niebel Rory N. Gunson Amanda Bradley Alasdair Maclean Guy Mollett Rachel Blacow Paul Bird Thomas Helmer Karlie Fallon Julian Tang Antony D. Hale Louissa R. Macfarlane-Smith Katherine L. Harper Holli Carden Nicholas W. Machin Kathryn A. Jackson Shazaad S.Y. Ahmad Ryan P. George Lance Turtle Elaine O’Toole Joanne Watts Cassie Breen Angela Cowell Adela Alcolea-Medina Themoula Charalampous Amita Patel Lisa J. Levett Judith Heaney Aileen Rowan Graham P. Taylor Divya Shah Laura Atkinson Jack C.D. Lee Adam P. Westhorpe Riaz Jannoo Helen L. Lowe Angeliki Karamani Leah Ensell Wendy Chatterton Monika Pusok Ashok Dadrah Amanda Symmonds Graciela Sluga Zoltan Molnar Paul Baker Stephen Bonner Sarah Essex Edward Barton Debra Padgett Garren Scott Jane Greenaway Brendan A.I. Payne Shirelle Burton-Fanning Sheila Waugh Veena Raviprakash Nicola Sheriff Victoria Blakey Lesley-Anne Williams Jonathan Moore Susanne Stonehouse Louise Smith Rose K. Davidson Luke Bedford Lindsay Coupland Victoria Wright Joseph G. Chappell Theocharis Tsoleridis Jonathan Ball Manjinder Khakh Vicki M. Fleming Michelle M. Lister Hannah C. Howson-Wells Louise Berry Tim Boswell Amelia Joseph Iona Willingham Nichola Duckworth Sarah Walsh Emma Wise Nathan Moore Matilde Mori Nick Cortes Stephen Kidd Rebecca Williams Laura Gifford Kelly Bicknell Sarah Wyllie Allyson Lloyd Robert Impey Cassandra S. Malone Benjamin J. Cogger Nick Levene Lynn Monaghan Alexander J. Keeley David G. Partridge Mohammad Raza Cariad Evans Kate Johnson Emma Betteridge Ben W. Farr Scott Goodwin Michael A. Quail Carol Scott Lesley Shirley Scott A.J. Thurston Diana Rajan Iraad F. Bronner Louise Aigrain Nicholas M. Redshaw Stefanie V. Lensing Shane McCarthy Alex Makunin Carlos E. Balcazar Michael D. Gallagher Kathleen A. Williamson Thomas D. Stanton Michelle L. Michelsen Joanna Warwick-Dugdale Robin Manley Audrey Farbos James W. Harrison Christine M. Sambles David J. Studholme Angie Lackenby Tamyo Mbisa Steven Platt Shahjahan Miah David Bibby Carmen Manso Jonathan Hubb Gavin Dabrera Mary Ramsay Daniel Bradshaw Ulf Schaefer Natalie Groves Eileen Gallagher David Lee David Williams Nicholas Ellaby Hassan Hartman Nikos Manesis Vineet Patel Juan Ledesma Katherine A. Twohig Elias Allara Clare Pearson Jeffrey K.J. Cheng Hannah E. Bridgewater Lucy R. Frost Grace Taylor-Joyce Paul E. Brown Lily Tong Alice Broos Daniel Mair Jenna Nichols Stephen N. Carmichael Katherine L. Smollett Kyriaki Nomikou Elihu Aranday-Cortes Natasha Johnson Seema Nickbakhsh Edith E. Vamos Margaret Hughes Lucille Rainbow Richard Eccles Charlotte Nelson Mark Whitehead Richard Gregory Matthew Gemmell Claudia Wierzbicki Hermione J. Webster Chloe L. Fisher Adrian W. Signell Gilberto Betancor Harry D. Wilson Gaia Nebbia Flavia Flaviani Alberto C. Cerda Tammy V. Merrill Rebekah E. Wilson Marius Cotic Nadua Bayzid Thomas Thompson Erwan Acheson Steven Rushton Sarah O’Brien David J. Baker Steven Rudder Alp Aydin Fei Sang Johnny Debebe Sarah Francois Tetyana I. Vasylyeva Marina Escalera Zamudio Bernardo Gutierrez Angela Marchbank Joshua Maksimovic Karla Spellman Kathryn McCluggage Mari Morgan Robert Beer Safiah Afifi Trudy Workman William Fuller Catherine Bresner Adrienn Angyal Luke R. Green Paul J. Parsons Rachel M. Tucker Rebecca Brown Max Whiteley James Bonfield Christoph Puethe Andrew Whitwham Jennifier Liddle Will Rowe Igor Siveroni Thanh Le-Viet Amy Gaskin Rob Johnson Irina Abnizova Mozam Ali Laura Allen Ralph Anderson Cristina Ariani Siobhan Austin-Guest Sendu Bala Jeffrey Barrett Andrew Bassett Kristina Battleday James Beal Mathew Beale Sam Bellany Tristram Bellerby Katie Bellis Duncan Berger Matt Berriman Paul Bevan Simon Binley Jason Bishop Kirsty Blackburn Nick Boughton Sam Bowker Timothy Brendler-Spaeth Iraad Bronner Tanya Brooklyn Sarah Kay Buddenborg Robert Bush Catarina Caetano Alex Cagan Nicola Carter Joanna Cartwright Tiago Carvalho Monteiro Liz Chapman Tracey-Jane Chillingworth Peter Clapham Richard Clark Adrian Clarke Catriona Clarke Daryl Cole Elizabeth Cook Maria Coppola Linda Cornell Clare Cornwell Craig Corton Abby Crackett Alison Cranage Harriet Craven Sarah Craw Mark Crawford Tim Cutts Monika Dabrowska Matt Davies Joseph Dawson Callum Day Aiden Densem Thomas Dibling Cat Dockree David Dodd Sunil Dogga Matthew Dorman Gordon Dougan Martin Dougherty Alexander Dove Lucy Drummond Monika Dudek Laura Durrant Elizabeth Easthope Sabine Eckert Pete Ellis Ben Farr Michael Fenton Marcella Ferrero Neil Flack Howerd Fordham Grace Forsythe Matt Francis Audrey Fraser Adam Freeman Anastasia Galvin Maria Garcia-Casado Alex Gedny Sophia Girgis James Glover Oliver Gould Andy Gray Emma Gray Coline Griffiths Yong Gu Florence Guerin Will Hamilton Hannah Hanks Ewan Harrison Alexandria Harrott Edward Harry Julia Harvison Paul Heath Anastasia Hernandez-Koutoucheva Rhiannon Hobbs Dave Holland Sarah Holmes Gary Hornett Nicholas Hough Liz Huckle Lena Hughes-Hallet Adam Hunter Stephen Inglis Sameena Iqbal Adam Jackson David Jackson Carlos Jimenez Verdejo Matthew Jones Kalyan Kallepally Keely Kay Jon Keatley Alan Keith Alison King Lucy Kitchin Matt Kleanthous Martina Klimekova Petra Korlevic Ksenia Krasheninnkova Greg Lane Cordelia Langford Adam Laverack Katharine Law Stefanie Lensing Amanah Lewis-Wade Jennifer Liddle Quan Lin Sarah Lindsay Sally Linsdell Rhona Long Jamie Lovell Jon Lovell James Mack Mark Maddison Aleksei Makunin Irfan Mamun Jenny Mansfield Neil Marriott Matt Martin Matthew Mayho Jo McClintock Sandra McHugh Liz MapcMinn Carl Meadows Emily Mobley Robin Moll Maria Morra Leanne Morrow Kathryn Murie Sian Nash Claire Nathwani Plamena Naydenova Alexandra Neaverson Ed Nerou Jon Nicholson Tabea Nimz Guillaume G. Noell Sarah O’Meara Valeriu Ohan Charles Olney Doug Ormond Agnes Oszlanczi Yoke Fei Pang Barbora Pardubska Naomi Park Aaron Parmar Gaurang Patel Maggie Payne Sharon Peacock Arabella Petersen Deborah Plowman Tom Preston Michael Quail Richard Rance Suzannah Rawlings Nicholas Redshaw Joe Reynolds Mark Reynolds Simon Rice Matt Richardson Connor Roberts Katrina Robinson Melanie Robinson David Robinson Hazel Rogers Eduardo Martin Rojo Daljit Roopra Mark Rose Luke Rudd Ramin Sadri Nicholas Salmon David Saul Frank Schwach Phil Seekings Alison Simms Matt Sinnott Shanthi Sivadasan Bart Siwek Dale Sizer Kenneth Skeldon Jason Skelton Joanna Slater-Tunstill Lisa Sloper Nathalie Smerdon Chris Smith Christen Smith James Smith Katie Smith Michelle Smith Sean Smith Tina Smith Leighton Sneade Carmen Diaz Soria Catarina Sousa Emily Souster Andrew Sparkes Michael Spencer-Chapman Janet Squares Robert Stanley Claire Steed Tim Stickland Ian Still Mike Stratton Michelle Strickland Allen Swann Agnieszka Swiatkowska Neil Sycamore Emma Swift Edward Symons Suzanne Szluha Emma Taluy Nunu Tao Katy Taylor Sam Taylor Stacey Thompson Mark Thompson Mark Thomson Nicholas Thomson Scott Thurston Dee Toombs Benjamin Topping Jaime Tovar-Corona Daniel Ungureanu James Uphill Jana Urbanova Philip Jansen Van Valerie Vancollie Paul Voak Danielle Walker Matthew Walker Matt Waller Gary Ward Charlie Weatherhogg Niki Webb Alan Wells Eloise Wells Luke Westwood Theo Whipp Thomas Whiteley Georgia Whitton Sara Widaa Mia Williams Mark Wilson Sean Wright Ronan Lyons |
| format |
Journal article |
| container_title |
Cell Reports |
| container_volume |
35 |
| container_issue |
13 |
| container_start_page |
109292 |
| publishDate |
2021 |
| institution |
Swansea University |
| issn |
2211-1247 |
| doi_str_mv |
10.1016/j.celrep.2021.109292 |
| publisher |
Elsevier BV |
| college_str |
Faculty of Medicine, Health and Life Sciences |
| hierarchytype |
|
| hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
| hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
| hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
| hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
| department_str |
Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science |
| document_store_str |
1 |
| active_str |
0 |
| description |
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape. In vitro, we show that, although ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity associated with enhanced incorporation of cleaved spike into virions. ΔH69/V70 is able to partially rescue infectivity of spike proteins that have acquired N439K and Y453F escape mutations by increased spike incorporation. In addition, replacement of the H69 and V70 residues in the Alpha variant B.1.1.7 spike (where ΔH69/V70 occurs naturally) impairs spike incorporation and entry efficiency of the B.1.1.7 spike pseudotyped virus. Alpha variant B.1.1.7 spike mediates faster kinetics of cell-cell fusion than wild-type Wuhan-1 D614G, dependent on ΔH69/V70. Therefore, as ΔH69/V70 compensates for immune escape mutations that impair infectivity, continued surveillance for deletions with functional effects is warranted. |
| published_date |
2021-06-29T12:43:50Z |
| _version_ |
1802742719873810432 |
| score |
11.013596 |