Journal article 272 views 36 downloads
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease
Zien Zhou 
,
Meg J. Jardine,
Qiang Li,
Brendon L. Neuen ,
Christopher P. Cannon,
Dick de Zeeuw,
Robert Edwards,
Adeera Levin,
Kenneth W. Mahaffey,
Vlado Perkovic,
Bruce Neal ,
Richard I. Lindley ,
Rodolfo Andres Ahuad Guerrero,
Diego Aizenberg,
Juan Pablo Albisu,
Andres Alvarisqueta,
Ines Bartolacci,
Mario Alberto Berli,
Anselmo Bordonava,
Pedro Calella,
Maria Cecilia Cantero,
Luis Rodolfo Cartasegna,
Esteban Cercos,
Gabriela Cecilia Coloma,
Hugo Colombo,
Victor Commendatore,
Jesus Cuadrado,
Carlos Alberto Cuneo,
Ana Maria Cusumano,
Walter Guillermo Douthat,
Ricardo Dario Dran,
Eduardo Farias,
Maria Florencia Fernandez,
Hernan Finkelstein,
Guillermo Fragale,
Jose Osvaldo Fretes,
Nestor Horacio Garcia,
Anibal Gastaldi,
Elizabeth Gelersztein,
Jorge Archibaldo Glenny,
Joaquin Pablo Gonzalez,
Patricia del Carmen Gonzalez Colaso,
Claudia Goycoa,
Gustavo Cristian Greloni,
Adrian Guinsburg,
Sonia Hermida,
Luis Isaias Juncos,
Maria Isabel Klyver,
Florencia Kraft,
Fernando Krynski,
Paulina Virginia Lanchiotti,
Ricardo Alfonso Leon de la Fuente,
Nora Marchetta,
Pablo Mele,
Silvia Nicolai,
Pablo Antonio Novoa,
Silvia Ines Orio,
Fabian Otreras,
Alejandra Oviedo,
Pablo Raffaele,
Jorge Hector Resk,
Lucas Rista,
Nelson Rodriguez Papini,
Jorgelina Sala,
Juan Carlos Santos,
Lilia Beatriz Schiavi,
Horacio Sessa,
Tomas Smith Casabella,
Maria Rosa Ulla,
Maria Valdez,
Augusto Vallejos,
Adriana Villarino,
Virginia Esther Visco,
Alfredo Wassermann,
Cesar Javier Zaidman,
Ngai Wah Cheung,
Carolyn Droste,
Ian Fraser,
David Johnson,
Peak Mann Mah,
Kathy Nicholls,
David Packham,
Joseph Proietto,
Anthony Roberts,
Simon Roger,
Venessa Tsang,
Roberto Abrão Raduan,
Fernando Augusto Alves da Costa,
Celso Amodeo,
Luiz Alberto Andreotti Turatti,
Rachel Bregman,
Fernanda Cristina Camelo Sanches,
Luis Henrique Canani,
Antônio Roberto Chacra,
João Lindolfo Cunha Borges,
Sérgio Alberto Cunha Vêncio,
Roberto Jorge da Silva Franco,
Domingos d’Avila,
Evandro de Souza Portes,
Pedro de Souza,
Luciane Mônica Deboni,
Fadlo Fraige Filho,
Bruno Geloneze Neto,
Marcus Gomes,
Suely Keiko Kohara,
Elizete Keitel,
Jose Francisco Kerr Saraiva,
Hugo Roberto Kurtz Lisboa,
Fabiana Loss de Carvalho Contieri,
Rosângela Milagres,
Renan Montenegro Junior,
Claudia Moreira de Brito,
Miguel Nasser Hissa,
Ângela Regina Nazario Sabbag,
Irene Noronha,
Daniel Panarotto,
Roberto Pecoits Filho,
Márcio Antônio Pereira,
Wladmir Saporito,
Antonio Scafuto Scotton,
Tiago Schuch,
Roberto Simões de Almeida,
Cássio Slompo Ramos,
João Soares Felício,
Fernando Thomé,
Jean Carlo Tibes Hachmann,
Sérgio Yamada,
Cesar Yoiti Hayashida,
Tarissa Beatrice Zanata Petry,
Maria Teresa Zanella,
Viktoria Andreeva,
Angelina Angelova,
Stefan Dimitrov,
Veselka Genadieva,
Gabriela Genova-Hristova,
Kiril Hristozov,
Zdravko Kamenov,
Atanas Koundurdjiev,
Lachezar Lozanov,
Viktor Margaritov,
Boyan Nonchev,
Rangel Rangelov,
Alexander Shinkov,
Margarita Temelkova,
Ekaterina Velichkova,
Andrian Yakov,
Naresh Aggarwal,
Ronnie Aronson,
Harpreet Bajaj,
David Cherney,
Guy Chouinard,
James Conway,
Serge Cournoyer,
Gerald DaRoza,
Sacha De Serres,
François Dubé,
Ronald Goldenberg,
Anil Gupta,
Milan Gupta,
Sam Henein,
Hasnain Khandwala,
Lawrence Leiter,
François Madore,
Alan McMahon,
Norman Muirhead,
Vincent Pichette,
Remi Rabasa-Lhoret,
Andrew Steele,
Navdeep Tangri,
Ali Torshizi,
Vincent Woo,
Nadia Zalunardo,
María Alicia Fernández Montenegro,
Juan Gonzalo Godoy Jorquera,
Marcelo Medina Fariña,
Victor Saavedra Gajardo,
Margarita Vejar,
Nan Chen,
Qinkai Chen,
Shenglian Gan,
Yaozhong Kong,
Detian Li,
Wenge Li,
Xuemei Li,
Hongli Lin,
Jian Liu,
Weiping Lu,
Hong Mao,
Yan Ren,
Weihong Song,
Jiao Sun,
Lin Sun,
Ping Tu,
Guixia Wang,
Jinkui Yang,
Aiping Yin,
Xueqing Yu,
Minghui Zhao,
Hongguang Zheng,
Jose Luis Accini Mendoza,
Edgar Arcos,
Jorge Avendano,
Jorge Ernesto Andres Diaz Ruiz,
Luis Hernando Garcia Ortiz,
Alexander Gonzalez,
Eric Hernandez Triana,
Juan Diego Higuera,
Natalia Malaver,
Dora Inés Molina de Salazar,
Ricardo Rosero,
Monica Alexandra Terront Lozano,
Luis Valderrama Cometa,
Alex Valenzuela,
Ruben Dario Vargas Alonso,
Ivan Villegas,
Hernan Yupanqui,
Dagmar Bartaskova,
Petr Barton,
Jana Belobradkova,
Lenka Dohnalova,
Tomas Drasnar,
Richard Ferkl,
Katarina Halciakova,
Vera Klokocnikova,
Richard Kovar,
Jiri Lastuvka,
Martin Lukac,
Satu Pesickova,
Karel Peterka,
Jiri Pumprla,
Ivan Rychlik,
Frantisek Saudek,
Vladimir Tesar,
Martin Valis,
Pavel Weiner,
Stanislav Zemek,
Eric Alamartine,
Sophie Borot,
Bertrand Cariou,
Bertrand Dussol,
Jean-Pierre Fauvel,
Pierre Gourdy,
Alexandre Klein,
Yannick Le Meur,
Alfred Penfornis,
Ronan Roussel,
Pierre-Jean Saulnier,
Eric Thervet,
Philippe Zaoui,
Volker Burst,
Markus Faghih,
Grit Faulmann,
Hermann Haller,
Reinhold Jerwan-Keim,
Stephan Maxeiner,
Björn Paschen,
Georg Plassmann,
Ludger Rose,
Ronaldo Arturo Gonzalez Orellana,
Franklin Paul Haase,
Juan Pablo Moreira Diaz,
Luis Alberto Ramirez Roca,
Jose Antonio Sánchez Arenales,
José Vicente Sanchez Polo,
Erick Turcios Juarez,
Gyongyi Csecsei,
Botond Csiky,
Peter Danos,
Laszlo Deak,
Mihaly Dudas,
Eleonora Harcsa,
Katalin Keltai,
Sandor Keresztesi,
Krisztian Kiss,
Laszlo Konyves,
Lajos Major,
Margit Mileder,
Marta Molnar,
Janos Mucsi,
Tamas Oroszlan,
Ivan Ory,
Gyorgy Paragh,
Eva Peterfai,
Gizella Petro,
Katalin Revesz,
Robert Takacs,
Sandor Vangel,
Szilard Vasas,
Marianna Zsom,
Abraham Oomman,
Sree Bhushan Raju,
Deepak Dewan,
M. Edwin Fernando,
Natarajan Gopalakrishnan,
Noble Gracious,
Hansraj Alva,
Dinesh Jain,
C. B. Keshavamurthy,
Dinesh Khullar,
Manisha Sahay,
Jayameena Peringat,
Narayan Prasad,
K. Satyanarayana Rao,
Sreedhar Reddy,
Sreelatha Melemadathil,
Bhimavarapu Sudhakar,
Ramesh Chandra Vyasam,
Riccardo Bonadonna,
Pietro Castellino,
Antonio Ceriello,
Luca Chiovato,
Salvatore De Cosmo,
Luca De Nicola,
Giuseppe Derosa,
Alberto Di Carlo,
Graziano Di Cianni,
Giovanni Frascà,
Giorgio Fuiano,
Giovanni Gambaro,
Giacomo Garibotto,
Carlo Giorda,
Fabio Malberti,
Marcora Mandreoli,
Edoardo Mannucci,
Emanuela Orsi,
Piermarco Piatti,
Domenico Santoro,
Ferdinando Carlo Sasso,
Gaetano Serviddio,
Andrea Stella,
Roberto Trevisan,
Anna Maria Veronelli,
Luca Zanoli,
Hitoshi Akiyama,
Hiromi Aoki,
Akimichi Asano,
Tadashi Iitsuka,
Shizuo Kajiyama,
Susumu Kashine,
Toshio Kawada,
Takamoto Kodera,
Hiroshi Kono,
Kazunori Koyama,
Yasuro Kumeda,
Shozo Miyauchi,
Kazuyuki Mizuyama,
Tetsuji Niiya,
Hiroko Oishi,
Satoshi Ota,
Terue Sakakibara,
Masahiko Takai,
Osamu Tomonaga,
Mitsuru Tsujimoto,
Takashi Wada,
Masakiyo Wakasugi,
Yasushi Wakida,
Takayuki Watanabe,
Masayo Yamada,
Kazuhiro Yanagida,
Toshihiko Yanase,
Wataru Yumita,
Egle Gaupsiene,
Dalia Kozloviene,
Antanas Navickas,
Egle Urbanaviciene,
Rohana Abdul Ghani,
Khalid Abdul Kadir,
Norsiah Ali,
Mohd Daud Che Yusof,
Chye Lee Gan,
Mastura Ismail,
Wei Yen Kong,
Swee Win Lam,
Li Yuan Lee,
Soo Kun Lim,
Chek Loong Loh,
Anita Bhajan Manocha,
Kee Sing Ng,
Nik Nur Fatnoon Nik Ahmad,
Vanassa Ratnasingam,
Saiful Shahrizal Bin Shudim,
Paranthaman Vengadasalam,
Luis David Abraira Munoz,
Melchor Alpizar Salazar,
Juan Baas Cruz,
Mario Burgos Soto,
Jose Chevaile Ramos,
Alfredo Chew Wong,
Jose Ricardo Correa Rotter,
Tonatiu Diaz Escalante,
Favio Edmundo Enriquez Sosa,
Fernando Flores Lozano,
Luis Fernando Flota Cervera,
Paul Frenk Baron,
Cecilia Garcia Ballesteros,
Jose David Gomez Rangel,
Luis Enrique Herrera Jimenez,
Sergio Saul Irizar Santana,
Fernando Jimenez Flores,
Hugo Laviada Molina,
Rosa Isela Luna Ceballos,
Belia Martin del Campo Blanco,
Guadalupe Morales Franco,
Oscar Tarsicio Moreno Loza,
Cynthia Mustieles Rocha,
Gregorio Obrador Vera,
Ricardo Orozco Castellanos,
Juan Peralta Calcaneo,
Miguel Angel Reyes Rosano,
Hiromi Rodriguez Pattzi,
Juan Rosas Guzman,
Isabel Erika Rucker Joerg,
Sandra Berenice Saavedra Sanchez,
Jose Hector Sanchez Mijangos,
Pablo Serrano Sanson,
Juan Alfredo Tamayo y Orozco,
Eloisa Tellez Chavez,
Alejandro Valdes Cepeda,
Luis Venegas Carrillo,
Juan Villagordoa Mesa,
Rolando Zamarripa Escobedo,
John Baker,
Paul Noonan,
Russell Scott,
Robert Walker,
Edward Watson,
Michael Williams,
Simon Young,
Zaynab Abejuela,
Jeimeen Agra,
Grace Aquitania,
Clodoaido Caringal,
Rhea Severina Comia,
Lalaine Delos Santos,
Olivert Gomez,
Cecilia Jimeno,
Florence Santos,
Gerry Tan,
Marsha Tolentino,
Christy Yao,
Yvette Ethel Yap,
Ma. Dovie Lallaine Ygpuara,
Renata Bijata-Bronisz,
Lucyna Hotlos,
Andrzej Januszewicz,
Barbara Kaczmarek,
Anna Kaminska,
Lech Lazuka,
Andrzej Madej,
Stanislaw Mazur,
Dorota Mlodawska-Choluj,
Michal Nowicki,
Grazyna Orlowska-Kowalik,
Grazyna Popenda,
Barbara Rewerska,
Dariusz Sowinski,
Liliana Monica Angelescu,
Veronica Anghel,
Rodica-Ioana Avram,
Mihaela-Magdalena Busegeanu,
Adriana Cif,
Dana Cosma,
Carmen Crisan,
Luiza Despina Demian,
Ioana Emilia Ferariu,
Ildiko Halmagyi,
Nicolae Hancu,
Mircea Munteanu,
Doru Negru,
Adriana Gabriela Onaca,
Ligia Petrica,
Amorin Remus Popa,
Aurelian-Emil Ranetti,
Cristian Serafinceanu,
Cristina Toarba,
Alina Agafyina,
Olga Barbarash,
Olga Barysheva,
Daniil Chizhov,
Vladimir Dobronravov,
Alexander Dreval,
Irina Glinkina,
Elena Grineva,
Vladimir Khirmanov,
Elena Kolmakova,
Tatiana Koroleva,
Liudmila Kvitkova,
Viacheslav Marasaev,
Ashot Mkrtumyan,
Tatiana Morugova,
Galina Nagibovich,
Oleg Nagibovich,
Sergei Nedogoda,
Irina Osipova,
Tatiana Raskina,
Yulia Samoylova,
Olga Sazonova,
Minara Shamkhalova,
Elena Shutemova,
Yuriy Shwartz,
Oleg Uriasyev,
Sergey Vorobyev,
Anna Zateyshchikova,
Dmitry Zateyshshikov,
Tatyana Zykova,
Slobodan Antic,
Miodrag Djordjevic,
Aleksandra Kendereski,
Katarina Lalic,
Nebojsa Lalic,
Vesna Popovic-Radinovic,
Jana Babikova,
Olga Benusova,
Ingrid Buganova,
Jan Culak,
Andrej Dzupina,
Jana Dzuponova,
Peter Fulop,
Adriana Ilavska,
Emil Martinka,
Zuzana Ochodnicka,
Daniel Pella,
Iveta Smatanova,
Fayzal Ahmed,
Aysha Badat,
Johannes Breedt,
Lawrence Distiller,
Vimladhevi Govender,
Ravendran Govender,
Mukesh Joshi,
Jaco Jurgens,
Gulam Latiff,
Landman Lombard,
Mohamed Mookadam,
Nomangesi Ngcakani,
Hendrik Nortje,
Helena Oosthuizen,
Larisha Pillay-Ramaya,
Hans Prozesky,
Jeevren Reddy,
Paul Rheeder,
Mary Seeber,
Dong-Wan Chae,
Young Min Cho,
In-Kyung Jeong,
Sin Gon Kim,
Yeong Hoon Kim,
Hyuk-Sang Kwon,
Min Jeong Kwon,
Byung-Wan Lee,
JungEun Lee,
Moon-Kyu Lee,
Moon-Suk Nam,
Kook-Hwan Oh,
Cheol-Young Park,
Sun-Hee Park,
Kun Ho Yoon,
Pere Alvarez Garcia,
Luis Asmarats Mercadal,
Clara Barrios,
Fernando Cereto Castro,
Secundino Cigarran Guldris,
Marta Dominguez Lopez,
Jesus Egido de los Rios,
Gema Fernandez Fresnedo,
Antonio Galan Serrano,
Isabel Garcia,
Francisco Javier Gonzalez Martinez,
Jose Esteban Jodar Gimeno,
Manuel Lopez Mendoza,
Tamara Malek Marin,
Cristobal Morales Portillo,
Maria Antonia Munar Vila,
Manuel Muñoz Torres,
Javier Nieto Iglesias,
Jonay Pantoja Perez,
Merce Perez Vera,
Jose Mª Portoles Perez,
María Angustias Quesada Simón,
Rafael Simo Canonge,
Alfonso Soto Gonzalez,
Manel Terns Riera,
Francisco Jose Tinahones Madueno,
Mercedes Velo Plaza,
Chwen-Tzuei Chang,
Lee-Ming Chuang,
Te-Lin Hsia,
Chang-Hsun Hsieh,
Shang-Jyh Hwang,
Chih-Ching Lin,
Yung-Chuan Lu,
Wayne H-H Sheu,
Olga Barna,
Svitlana D. Bilyk,
Volodymyr Botsyurko,
Iryna Dudar,
Ivan Fushtey,
Olga Godlevska,
Oleksandr Golovchenko,
Olga Gyrina,
Anatoliy Kazmirchuk,
Mykola Kolesnyk,
Iuliia Komisarenko,
Oleksii Korzh,
Nonna Kravchun,
Oleg Legun,
Borys Mankovskyy,
Liliya Martynyuk,
Yuriy Mostovoy,
Nataliia Pashkovska,
Larysa Pererva,
Tetyana Pertseva,
Oleksandr Samoylov,
Ivan Smirnov,
Yevgeniya Svyshchenko,
Halyna Tomashkevych,
Ivan Topchii,
Nadiya Tryshchuk,
Vira Tseluyko,
Vadym Vizir,
Maryna Vlasenko,
Tetiana Zlova,
Liliia Zub,
Salah Abusnana,
Mohamed Railey,
Kamal Abouglila,
Paul Ainsworth,
Zishan Ali,
Vijayaraman Arutchelvam,
Maria Barnard,
Srikanth Bellary,
Emyr Davies,
Mark Davies,
Simon Davies,
Alison Dawson,
Mohsen El Kossi,
Patrick English,
Donald Fraser,
Luigi Gnudi,
Anthony Gunstone,
Timothy Hall,
Wasim Hanif,
Alan Jackson,
Andrew Johnson,
Franklin Joseph,
Singhan Krishnan,
Mick Kumwenda,
Iain MacDougall,
Paul Nixon,
Joseph O’Hare,
Sam Philip,
Shenaz Ramtoola,
Manish Saxena,
Davesh Sennik,
Godwin Simon,
Baldev Singh,
Jeffrey Stephens,
Anna Strzelecka,
Rehan Symonds,
Wayne Turner,
Mona Wahba,
John Wakeling,
David Wheeler,
Peter Winocour,
Joseph Abdallah,
Raied Abdullah,
Matthew Abramowitz,
Idalia Acosta,
Joseph Aiello,
Laura Akright,
Ayim Akyea-Djamson,
Rajendran Alappan,
Radica Alicic,
Amer Al-Karadsheh,
Dale Crawford Allison,
Carlos Arauz-Pacheco,
Shahabul Arfeen,
Ahmed Arif,
Moogali Arvind,
Naveen Atray,
Ahmed Awad,
George Bakris,
Peggy Barnhill,
Elizabeth Barranco,
Carlos Barrera,
Matthew Beacom,
Venkata Behara,
Diogo Belo,
Rhonda Bentley-Lewis,
Ramon Berenguer,
Lidia Bermudez,
Marializa Bernardo,
Mihaela Biscoveanu,
Cynthia Bowman-Stroud,
Donald Brandon,
Osvaldo Brusco,
Robert Busch,
Yamil Canaan,
Alicia Chilito,
Tom Christensen,
Cynthia Christiano,
Elena Christofides,
Caroucel Chuateco,
Kenneth Cohen,
Robert Cohen,
Debbie Cohen-Stein,
Charles Cook,
Daniel Coyne,
Nizar Daboul,
Riad Darwish,
Adarsh Daswani,
Kenneth Deck,
Cyrus Desouza,
Devasmita Dev,
Monika Dhillon,
Sohan Dua,
Frank Eder,
Ana Maria Elosegui,
Mohamed El-Shahawy,
John Ervin,
Alberto Esquenazi,
John Evans,
Steven Fishbane,
Juan Frias,
Eugenia Galindo-Ramos,
Claude Galphin,
Adline Ghazi,
Enrique Gonzalez,
David Gorson,
Anupama Gowda,
Barbara Greco,
Stephen Grubb,
Rakesh Gulati,
Jamal Hammoud,
Stuart Handelsman,
Israel Hartman,
Kenneth Hershon,
Daniel Hiser,
George Hon,
Radu Jacob,
Maria Jaime,
Aamir Jamal,
Charles Kaupke,
Gerald Keightley,
Elizabeth Kern,
Rakhi Khanna,
Zeid Khitan,
Sun Kim,
Nelson Kopyt,
Csaba Kovesdy,
Gopal Krishna,
Jeffrey (Jay) Kropp,
Amrendra Kumar,
Jayant Kumar,
Neil Kumar,
Jorge Kusnir,
Wendy Lane,
Mary Lawrence,
Lawrence Lehrner,
John Lentz,
Dennis Levinson,
Derek Lewis,
Kenneth Liss,
Andreas Maddux,
Hiralal Maheshwari,
Sreedhar Mandayam,
Isam Marar,
Bhasker Mehta,
John Middleton,
Jorge Mordujovich,
Ramon Moreda,
Moustafa Moustafa,
Samuel Mujica Trenche,
Mohanram Narayanan,
Javier Narvarte,
Tareq Nassar,
George Newman,
Brian Nichol,
Philip Nicol,
Josier Nisnisan,
A. Kaldun Nossuli,
Chamberlain Obialo,
Sarah Olelewe,
Michael Oliver,
Andrew O’Shaughnessy,
John Padron,
Rohit Pankhaniya,
Reginald Parker,
Devesh Patel,
Gnyandev Patel,
Nina Patel,
Humberto Pavon,
Armando Perez,
Carlos Perez,
Alan Perlman,
Karlton Pettis,
Walter Pharr,
Andrea Phillips,
Raman Purighalla,
Luis Quesada-Suarez,
Rajiv Ranjan,
Sanjeev Rastogi,
Jakkidi Reddy,
Marc Rendell,
Lisa Rich,
Michael Robinson,
Hector Rodriguez,
Sylvia Rosas,
Fadi Saba,
Rallabhandi Sankaram,
Ravi Sarin,
Robert Schreiman,
David Scott,
Mohamed Sekkarie,
John Sensenbrenner,
Muhammad Shakeel,
Michael Shanik,
Sylvia Shaw,
Stephen Smith,
Richard Solomon,
Amy Sprague,
Leslie Spry,
Pusadee Suchinda,
Senan Sultan,
Prasanth Surampudi,
Sherry Sussman,
Anjanette Tan,
Antonio Terrelonge,
Michael Thompson,
Fernando Trespalacios,
Bruce Trippe,
Pilar Trueba,
Marcel Twahirwa,
John Updegrove,
Peter Van Buren,
Mark Vannorsdall,
Freemu Varghese,
Pedro Velasquez-Mieyer,
Sailaja Ventrapragada,
Goga Vukotic,
Khurram Wadud,
Mark Warren,
Henry Watson,
Ronald Watts,
Daniel Weiner,
James Welker,
Jean Welsh,
Shelley Williams,
Michelle Zaniewski-Singh,
Jeffrey Stephens
,
Meg J. Jardine,
Qiang Li,
Brendon L. Neuen ,
Christopher P. Cannon,
Dick de Zeeuw,
Robert Edwards,
Adeera Levin,
Kenneth W. Mahaffey,
Vlado Perkovic,
Bruce Neal ,
Richard I. Lindley ,
Rodolfo Andres Ahuad Guerrero,
Diego Aizenberg,
Juan Pablo Albisu,
Andres Alvarisqueta,
Ines Bartolacci,
Mario Alberto Berli,
Anselmo Bordonava,
Pedro Calella,
Maria Cecilia Cantero,
Luis Rodolfo Cartasegna,
Esteban Cercos,
Gabriela Cecilia Coloma,
Hugo Colombo,
Victor Commendatore,
Jesus Cuadrado,
Carlos Alberto Cuneo,
Ana Maria Cusumano,
Walter Guillermo Douthat,
Ricardo Dario Dran,
Eduardo Farias,
Maria Florencia Fernandez,
Hernan Finkelstein,
Guillermo Fragale,
Jose Osvaldo Fretes,
Nestor Horacio Garcia,
Anibal Gastaldi,
Elizabeth Gelersztein,
Jorge Archibaldo Glenny,
Joaquin Pablo Gonzalez,
Patricia del Carmen Gonzalez Colaso,
Claudia Goycoa,
Gustavo Cristian Greloni,
Adrian Guinsburg,
Sonia Hermida,
Luis Isaias Juncos,
Maria Isabel Klyver,
Florencia Kraft,
Fernando Krynski,
Paulina Virginia Lanchiotti,
Ricardo Alfonso Leon de la Fuente,
Nora Marchetta,
Pablo Mele,
Silvia Nicolai,
Pablo Antonio Novoa,
Silvia Ines Orio,
Fabian Otreras,
Alejandra Oviedo,
Pablo Raffaele,
Jorge Hector Resk,
Lucas Rista,
Nelson Rodriguez Papini,
Jorgelina Sala,
Juan Carlos Santos,
Lilia Beatriz Schiavi,
Horacio Sessa,
Tomas Smith Casabella,
Maria Rosa Ulla,
Maria Valdez,
Augusto Vallejos,
Adriana Villarino,
Virginia Esther Visco,
Alfredo Wassermann,
Cesar Javier Zaidman,
Ngai Wah Cheung,
Carolyn Droste,
Ian Fraser,
David Johnson,
Peak Mann Mah,
Kathy Nicholls,
David Packham,
Joseph Proietto,
Anthony Roberts,
Simon Roger,
Venessa Tsang,
Roberto Abrão Raduan,
Fernando Augusto Alves da Costa,
Celso Amodeo,
Luiz Alberto Andreotti Turatti,
Rachel Bregman,
Fernanda Cristina Camelo Sanches,
Luis Henrique Canani,
Antônio Roberto Chacra,
João Lindolfo Cunha Borges,
Sérgio Alberto Cunha Vêncio,
Roberto Jorge da Silva Franco,
Domingos d’Avila,
Evandro de Souza Portes,
Pedro de Souza,
Luciane Mônica Deboni,
Fadlo Fraige Filho,
Bruno Geloneze Neto,
Marcus Gomes,
Suely Keiko Kohara,
Elizete Keitel,
Jose Francisco Kerr Saraiva,
Hugo Roberto Kurtz Lisboa,
Fabiana Loss de Carvalho Contieri,
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Jean Carlo Tibes Hachmann,
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Alexander Shinkov,
Margarita Temelkova,
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Naresh Aggarwal,
Ronnie Aronson,
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Sacha De Serres,
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Susumu Kashine,
Toshio Kawada,
Takamoto Kodera,
Hiroshi Kono,
Kazunori Koyama,
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Shozo Miyauchi,
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Bruce Trippe,
Pilar Trueba,
Marcel Twahirwa,
John Updegrove,
Peter Van Buren,
Mark Vannorsdall,
Freemu Varghese,
Pedro Velasquez-Mieyer,
Sailaja Ventrapragada,
Goga Vukotic,
Khurram Wadud,
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Jeffrey Stephens
Stroke, Volume: 52, Issue: 5, Pages: 1545 - 1556
Swansea University Author:
Jeffrey Stephens
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DOI (Published version): 10.1161/strokeaha.120.031623
Abstract
Background and Purpose:Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter...
| Published in: | Stroke |
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| ISSN: | 0039-2499 1524-4628 |
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Ovid Technologies (Wolters Kluwer Health)
2021
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<?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>66406</id><entry>2024-05-14</entry><title>Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease</title><swanseaauthors><author><sid>5219d126f97f8f884bdb622099bd41de</sid><ORCID>0000-0003-2228-086X</ORCID><firstname>Jeffrey</firstname><surname>Stephens</surname><name>Jeffrey Stephens</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-05-14</date><deptcode>MEDS</deptcode><abstract>Background and Purpose:Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.Methods:CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.Results:In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55–1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61–1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19–1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20–1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53–1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82–1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89–1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30–0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49–1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71–0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31–0.79]).Conclusions:Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms.</abstract><type>Journal Article</type><journal>Stroke</journal><volume>52</volume><journalNumber>5</journalNumber><paginationStart>1545</paginationStart><paginationEnd>1556</paginationEnd><publisher>Ovid Technologies (Wolters Kluwer Health)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0039-2499</issnPrint><issnElectronic>1524-4628</issnElectronic><keywords>atrial fibrillation; canagliflozin; glomerular filtration rate; hemorrhagic stroke; ischemic stroke</keywords><publishedDay>1</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-05-01</publishedDate><doi>10.1161/strokeaha.120.031623</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>Supported by Janssen Research & Development, LLC.</funders><projectreference/><lastEdited>2024-06-24T14:20:46.2875930</lastEdited><Created>2024-05-14T09:56:32.2886407</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Zien</firstname><surname>Zhou</surname><orcid>0000-0001-6543-7113</orcid><order>1</order></author><author><firstname>Meg J.</firstname><surname>Jardine</surname><order>2</order></author><author><firstname>Qiang</firstname><surname>Li</surname><order>3</order></author><author><firstname>Brendon L.</firstname><surname>Neuen</surname><orcid>0000-0001-9276-8380</orcid><order>4</order></author><author><firstname>Christopher P.</firstname><surname>Cannon</surname><order>5</order></author><author><firstname>Dick de</firstname><surname>Zeeuw</surname><order>6</order></author><author><firstname>Robert</firstname><surname>Edwards</surname><order>7</order></author><author><firstname>Adeera</firstname><surname>Levin</surname><order>8</order></author><author><firstname>Kenneth W.</firstname><surname>Mahaffey</surname><order>9</order></author><author><firstname>Vlado</firstname><surname>Perkovic</surname><order>10</order></author><author><firstname>Bruce</firstname><surname>Neal</surname><orcid>0000-0002-0490-7465</orcid><order>11</order></author><author><firstname>Richard I.</firstname><surname>Lindley</surname><orcid>0000-0002-0104-5679</orcid><order>12</order></author><author><firstname>Rodolfo Andres Ahuad</firstname><surname>Guerrero</surname><order>13</order></author><author><firstname>Diego</firstname><surname>Aizenberg</surname><order>14</order></author><author><firstname>Juan Pablo</firstname><surname>Albisu</surname><order>15</order></author><author><firstname>Andres</firstname><surname>Alvarisqueta</surname><order>16</order></author><author><firstname>Ines</firstname><surname>Bartolacci</surname><order>17</order></author><author><firstname>Mario Alberto</firstname><surname>Berli</surname><order>18</order></author><author><firstname>Anselmo</firstname><surname>Bordonava</surname><order>19</order></author><author><firstname>Pedro</firstname><surname>Calella</surname><order>20</order></author><author><firstname>Maria Cecilia</firstname><surname>Cantero</surname><order>21</order></author><author><firstname>Luis Rodolfo</firstname><surname>Cartasegna</surname><order>22</order></author><author><firstname>Esteban</firstname><surname>Cercos</surname><order>23</order></author><author><firstname>Gabriela Cecilia</firstname><surname>Coloma</surname><order>24</order></author><author><firstname>Hugo</firstname><surname>Colombo</surname><order>25</order></author><author><firstname>Victor</firstname><surname>Commendatore</surname><order>26</order></author><author><firstname>Jesus</firstname><surname>Cuadrado</surname><order>27</order></author><author><firstname>Carlos Alberto</firstname><surname>Cuneo</surname><order>28</order></author><author><firstname>Ana Maria</firstname><surname>Cusumano</surname><order>29</order></author><author><firstname>Walter Guillermo</firstname><surname>Douthat</surname><order>30</order></author><author><firstname>Ricardo Dario</firstname><surname>Dran</surname><order>31</order></author><author><firstname>Eduardo</firstname><surname>Farias</surname><order>32</order></author><author><firstname>Maria 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De</firstname><surname>Serres</surname><order>155</order></author><author><firstname>François</firstname><surname>Dubé</surname><order>156</order></author><author><firstname>Ronald</firstname><surname>Goldenberg</surname><order>157</order></author><author><firstname>Anil</firstname><surname>Gupta</surname><order>158</order></author><author><firstname>Milan</firstname><surname>Gupta</surname><order>159</order></author><author><firstname>Sam</firstname><surname>Henein</surname><order>160</order></author><author><firstname>Hasnain</firstname><surname>Khandwala</surname><order>161</order></author><author><firstname>Lawrence</firstname><surname>Leiter</surname><order>162</order></author><author><firstname>François</firstname><surname>Madore</surname><order>163</order></author><author><firstname>Alan</firstname><surname>McMahon</surname><order>164</order></author><author><firstname>Norman</firstname><surname>Muirhead</surname><order>165</order></author><author><firstname>Vincent</firstname><surname>Pichette</surname><order>166</order></author><author><firstname>Remi</firstname><surname>Rabasa-Lhoret</surname><order>167</order></author><author><firstname>Andrew</firstname><surname>Steele</surname><order>168</order></author><author><firstname>Navdeep</firstname><surname>Tangri</surname><order>169</order></author><author><firstname>Ali</firstname><surname>Torshizi</surname><order>170</order></author><author><firstname>Vincent</firstname><surname>Woo</surname><order>171</order></author><author><firstname>Nadia</firstname><surname>Zalunardo</surname><order>172</order></author><author><firstname>María Alicia Fernández</firstname><surname>Montenegro</surname><order>173</order></author><author><firstname>Juan Gonzalo Godoy</firstname><surname>Jorquera</surname><order>174</order></author><author><firstname>Marcelo Medina</firstname><surname>Fariña</surname><order>175</order></author><author><firstname>Victor Saavedra</firstname><surname>Gajardo</surname><order>176</order></author><author><firstname>Margarita</firstname><surname>Vejar</surname><order>177</order></author><author><firstname>Nan</firstname><surname>Chen</surname><order>178</order></author><author><firstname>Qinkai</firstname><surname>Chen</surname><order>179</order></author><author><firstname>Shenglian</firstname><surname>Gan</surname><order>180</order></author><author><firstname>Yaozhong</firstname><surname>Kong</surname><order>181</order></author><author><firstname>Detian</firstname><surname>Li</surname><order>182</order></author><author><firstname>Wenge</firstname><surname>Li</surname><order>183</order></author><author><firstname>Xuemei</firstname><surname>Li</surname><order>184</order></author><author><firstname>Hongli</firstname><surname>Lin</surname><order>185</order></author><author><firstname>Jian</firstname><surname>Liu</surname><order>186</order></author><author><firstname>Weiping</firstname><surname>Lu</surname><order>187</order></author><author><firstname>Hong</firstname><surname>Mao</surname><order>188</order></author><author><firstname>Yan</firstname><surname>Ren</surname><order>189</order></author><author><firstname>Weihong</firstname><surname>Song</surname><order>190</order></author><author><firstname>Jiao</firstname><surname>Sun</surname><order>191</order></author><author><firstname>Lin</firstname><surname>Sun</surname><order>192</order></author><author><firstname>Ping</firstname><surname>Tu</surname><order>193</order></author><author><firstname>Guixia</firstname><surname>Wang</surname><order>194</order></author><author><firstname>Jinkui</firstname><surname>Yang</surname><order>195</order></author><author><firstname>Aiping</firstname><surname>Yin</surname><order>196</order></author><author><firstname>Xueqing</firstname><surname>Yu</surname><order>197</order></author><author><firstname>Minghui</firstname><surname>Zhao</surname><order>198</order></author><author><firstname>Hongguang</firstname><surname>Zheng</surname><order>199</order></author><author><firstname>Jose Luis Accini</firstname><surname>Mendoza</surname><order>200</order></author><author><firstname>Edgar</firstname><surname>Arcos</surname><order>201</order></author><author><firstname>Jorge</firstname><surname>Avendano</surname><order>202</order></author><author><firstname>Jorge Ernesto Andres Diaz</firstname><surname>Ruiz</surname><order>203</order></author><author><firstname>Luis Hernando Garcia</firstname><surname>Ortiz</surname><order>204</order></author><author><firstname>Alexander</firstname><surname>Gonzalez</surname><order>205</order></author><author><firstname>Eric Hernandez</firstname><surname>Triana</surname><order>206</order></author><author><firstname>Juan Diego</firstname><surname>Higuera</surname><order>207</order></author><author><firstname>Natalia</firstname><surname>Malaver</surname><order>208</order></author><author><firstname>Dora Inés Molina 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Vargas</firstname><surname>Alonso</surname><order>214</order></author><author><firstname>Ivan</firstname><surname>Villegas</surname><order>215</order></author><author><firstname>Hernan</firstname><surname>Yupanqui</surname><order>216</order></author><author><firstname>Dagmar</firstname><surname>Bartaskova</surname><order>217</order></author><author><firstname>Petr</firstname><surname>Barton</surname><order>218</order></author><author><firstname>Jana</firstname><surname>Belobradkova</surname><order>219</order></author><author><firstname>Lenka</firstname><surname>Dohnalova</surname><order>220</order></author><author><firstname>Tomas</firstname><surname>Drasnar</surname><order>221</order></author><author><firstname>Richard</firstname><surname>Ferkl</surname><order>222</order></author><author><firstname>Katarina</firstname><surname>Halciakova</surname><order>223</order></author><author><firstname>Vera</firstname><surname>Klokocnikova</surname><order>224</order></author><author><firstname>Richard</firstname><surname>Kovar</surname><order>225</order></author><author><firstname>Jiri</firstname><surname>Lastuvka</surname><order>226</order></author><author><firstname>Martin</firstname><surname>Lukac</surname><order>227</order></author><author><firstname>Satu</firstname><surname>Pesickova</surname><order>228</order></author><author><firstname>Karel</firstname><surname>Peterka</surname><order>229</order></author><author><firstname>Jiri</firstname><surname>Pumprla</surname><order>230</order></author><author><firstname>Ivan</firstname><surname>Rychlik</surname><order>231</order></author><author><firstname>Frantisek</firstname><surname>Saudek</surname><order>232</order></author><author><firstname>Vladimir</firstname><surname>Tesar</surname><order>233</order></author><author><firstname>Martin</firstname><surname>Valis</surname><order>234</order></author><author><firstname>Pavel</firstname><surname>Weiner</surname><order>235</order></author><author><firstname>Stanislav</firstname><surname>Zemek</surname><order>236</order></author><author><firstname>Eric</firstname><surname>Alamartine</surname><order>237</order></author><author><firstname>Sophie</firstname><surname>Borot</surname><order>238</order></author><author><firstname>Bertrand</firstname><surname>Cariou</surname><order>239</order></author><author><firstname>Bertrand</firstname><surname>Dussol</surname><order>240</order></author><author><firstname>Jean-Pierre</firstname><surname>Fauvel</surname><order>241</order></author><author><firstname>Pierre</firstname><surname>Gourdy</surname><order>242</order></author><author><firstname>Alexandre</firstname><surname>Klein</surname><order>243</order></author><author><firstname>Yannick Le</firstname><surname>Meur</surname><order>244</order></author><author><firstname>Alfred</firstname><surname>Penfornis</surname><order>245</order></author><author><firstname>Ronan</firstname><surname>Roussel</surname><order>246</order></author><author><firstname>Pierre-Jean</firstname><surname>Saulnier</surname><order>247</order></author><author><firstname>Eric</firstname><surname>Thervet</surname><order>248</order></author><author><firstname>Philippe</firstname><surname>Zaoui</surname><order>249</order></author><author><firstname>Volker</firstname><surname>Burst</surname><order>250</order></author><author><firstname>Markus</firstname><surname>Faghih</surname><order>251</order></author><author><firstname>Grit</firstname><surname>Faulmann</surname><order>252</order></author><author><firstname>Hermann</firstname><surname>Haller</surname><order>253</order></author><author><firstname>Reinhold</firstname><surname>Jerwan-Keim</surname><order>254</order></author><author><firstname>Stephan</firstname><surname>Maxeiner</surname><order>255</order></author><author><firstname>Björn</firstname><surname>Paschen</surname><order>256</order></author><author><firstname>Georg</firstname><surname>Plassmann</surname><order>257</order></author><author><firstname>Ludger</firstname><surname>Rose</surname><order>258</order></author><author><firstname>Ronaldo Arturo Gonzalez</firstname><surname>Orellana</surname><order>259</order></author><author><firstname>Franklin Paul</firstname><surname>Haase</surname><order>260</order></author><author><firstname>Juan Pablo Moreira</firstname><surname>Diaz</surname><order>261</order></author><author><firstname>Luis Alberto Ramirez</firstname><surname>Roca</surname><order>262</order></author><author><firstname>Jose Antonio Sánchez</firstname><surname>Arenales</surname><order>263</order></author><author><firstname>José Vicente Sanchez</firstname><surname>Polo</surname><order>264</order></author><author><firstname>Erick Turcios</firstname><surname>Juarez</surname><order>265</order></author><author><firstname>Gyongyi</firstname><surname>Csecsei</surname><order>266</order></author><author><firstname>Botond</firstname><surname>Csiky</surname><order>267</order></author><author><firstname>Peter</firstname><surname>Danos</surname><order>268</order></author><author><firstname>Laszlo</firstname><surname>Deak</surname><order>269</order></author><author><firstname>Mihaly</firstname><surname>Dudas</surname><order>270</order></author><author><firstname>Eleonora</firstname><surname>Harcsa</surname><order>271</order></author><author><firstname>Katalin</firstname><surname>Keltai</surname><order>272</order></author><author><firstname>Sandor</firstname><surname>Keresztesi</surname><order>273</order></author><author><firstname>Krisztian</firstname><surname>Kiss</surname><order>274</order></author><author><firstname>Laszlo</firstname><surname>Konyves</surname><order>275</order></author><author><firstname>Lajos</firstname><surname>Major</surname><order>276</order></author><author><firstname>Margit</firstname><surname>Mileder</surname><order>277</order></author><author><firstname>Marta</firstname><surname>Molnar</surname><order>278</order></author><author><firstname>Janos</firstname><surname>Mucsi</surname><order>279</order></author><author><firstname>Tamas</firstname><surname>Oroszlan</surname><order>280</order></author><author><firstname>Ivan</firstname><surname>Ory</surname><order>281</order></author><author><firstname>Gyorgy</firstname><surname>Paragh</surname><order>282</order></author><author><firstname>Eva</firstname><surname>Peterfai</surname><order>283</order></author><author><firstname>Gizella</firstname><surname>Petro</surname><order>284</order></author><author><firstname>Katalin</firstname><surname>Revesz</surname><order>285</order></author><author><firstname>Robert</firstname><surname>Takacs</surname><order>286</order></author><author><firstname>Sandor</firstname><surname>Vangel</surname><order>287</order></author><author><firstname>Szilard</firstname><surname>Vasas</surname><order>288</order></author><author><firstname>Marianna</firstname><surname>Zsom</surname><order>289</order></author><author><firstname>Abraham</firstname><surname>Oomman</surname><order>290</order></author><author><firstname>Sree Bhushan</firstname><surname>Raju</surname><order>291</order></author><author><firstname>Deepak</firstname><surname>Dewan</surname><order>292</order></author><author><firstname>M. Edwin</firstname><surname>Fernando</surname><order>293</order></author><author><firstname>Natarajan</firstname><surname>Gopalakrishnan</surname><order>294</order></author><author><firstname>Noble</firstname><surname>Gracious</surname><order>295</order></author><author><firstname>Hansraj</firstname><surname>Alva</surname><order>296</order></author><author><firstname>Dinesh</firstname><surname>Jain</surname><order>297</order></author><author><firstname>C. B.</firstname><surname>Keshavamurthy</surname><order>298</order></author><author><firstname>Dinesh</firstname><surname>Khullar</surname><order>299</order></author><author><firstname>Manisha</firstname><surname>Sahay</surname><order>300</order></author><author><firstname>Jayameena</firstname><surname>Peringat</surname><order>301</order></author><author><firstname>Narayan</firstname><surname>Prasad</surname><order>302</order></author><author><firstname>K. Satyanarayana</firstname><surname>Rao</surname><order>303</order></author><author><firstname>Sreedhar</firstname><surname>Reddy</surname><order>304</order></author><author><firstname>Sreelatha</firstname><surname>Melemadathil</surname><order>305</order></author><author><firstname>Bhimavarapu</firstname><surname>Sudhakar</surname><order>306</order></author><author><firstname>Ramesh Chandra</firstname><surname>Vyasam</surname><order>307</order></author><author><firstname>Riccardo</firstname><surname>Bonadonna</surname><order>308</order></author><author><firstname>Pietro</firstname><surname>Castellino</surname><order>309</order></author><author><firstname>Antonio</firstname><surname>Ceriello</surname><order>310</order></author><author><firstname>Luca</firstname><surname>Chiovato</surname><order>311</order></author><author><firstname>Salvatore De</firstname><surname>Cosmo</surname><order>312</order></author><author><firstname>Luca De</firstname><surname>Nicola</surname><order>313</order></author><author><firstname>Giuseppe</firstname><surname>Derosa</surname><order>314</order></author><author><firstname>Alberto Di</firstname><surname>Carlo</surname><order>315</order></author><author><firstname>Graziano Di</firstname><surname>Cianni</surname><order>316</order></author><author><firstname>Giovanni</firstname><surname>Frascà</surname><order>317</order></author><author><firstname>Giorgio</firstname><surname>Fuiano</surname><order>318</order></author><author><firstname>Giovanni</firstname><surname>Gambaro</surname><order>319</order></author><author><firstname>Giacomo</firstname><surname>Garibotto</surname><order>320</order></author><author><firstname>Carlo</firstname><surname>Giorda</surname><order>321</order></author><author><firstname>Fabio</firstname><surname>Malberti</surname><order>322</order></author><author><firstname>Marcora</firstname><surname>Mandreoli</surname><order>323</order></author><author><firstname>Edoardo</firstname><surname>Mannucci</surname><order>324</order></author><author><firstname>Emanuela</firstname><surname>Orsi</surname><order>325</order></author><author><firstname>Piermarco</firstname><surname>Piatti</surname><order>326</order></author><author><firstname>Domenico</firstname><surname>Santoro</surname><order>327</order></author><author><firstname>Ferdinando Carlo</firstname><surname>Sasso</surname><order>328</order></author><author><firstname>Gaetano</firstname><surname>Serviddio</surname><order>329</order></author><author><firstname>Andrea</firstname><surname>Stella</surname><order>330</order></author><author><firstname>Roberto</firstname><surname>Trevisan</surname><order>331</order></author><author><firstname>Anna Maria</firstname><surname>Veronelli</surname><order>332</order></author><author><firstname>Luca</firstname><surname>Zanoli</surname><order>333</order></author><author><firstname>Hitoshi</firstname><surname>Akiyama</surname><order>334</order></author><author><firstname>Hiromi</firstname><surname>Aoki</surname><order>335</order></author><author><firstname>Akimichi</firstname><surname>Asano</surname><order>336</order></author><author><firstname>Tadashi</firstname><surname>Iitsuka</surname><order>337</order></author><author><firstname>Shizuo</firstname><surname>Kajiyama</surname><order>338</order></author><author><firstname>Susumu</firstname><surname>Kashine</surname><order>339</order></author><author><firstname>Toshio</firstname><surname>Kawada</surname><order>340</order></author><author><firstname>Takamoto</firstname><surname>Kodera</surname><order>341</order></author><author><firstname>Hiroshi</firstname><surname>Kono</surname><order>342</order></author><author><firstname>Kazunori</firstname><surname>Koyama</surname><order>343</order></author><author><firstname>Yasuro</firstname><surname>Kumeda</surname><order>344</order></author><author><firstname>Shozo</firstname><surname>Miyauchi</surname><order>345</order></author><author><firstname>Kazuyuki</firstname><surname>Mizuyama</surname><order>346</order></author><author><firstname>Tetsuji</firstname><surname>Niiya</surname><order>347</order></author><author><firstname>Hiroko</firstname><surname>Oishi</surname><order>348</order></author><author><firstname>Satoshi</firstname><surname>Ota</surname><order>349</order></author><author><firstname>Terue</firstname><surname>Sakakibara</surname><order>350</order></author><author><firstname>Masahiko</firstname><surname>Takai</surname><order>351</order></author><author><firstname>Osamu</firstname><surname>Tomonaga</surname><order>352</order></author><author><firstname>Mitsuru</firstname><surname>Tsujimoto</surname><order>353</order></author><author><firstname>Takashi</firstname><surname>Wada</surname><order>354</order></author><author><firstname>Masakiyo</firstname><surname>Wakasugi</surname><order>355</order></author><author><firstname>Yasushi</firstname><surname>Wakida</surname><order>356</order></author><author><firstname>Takayuki</firstname><surname>Watanabe</surname><order>357</order></author><author><firstname>Masayo</firstname><surname>Yamada</surname><order>358</order></author><author><firstname>Kazuhiro</firstname><surname>Yanagida</surname><order>359</order></author><author><firstname>Toshihiko</firstname><surname>Yanase</surname><order>360</order></author><author><firstname>Wataru</firstname><surname>Yumita</surname><order>361</order></author><author><firstname>Egle</firstname><surname>Gaupsiene</surname><order>362</order></author><author><firstname>Dalia</firstname><surname>Kozloviene</surname><order>363</order></author><author><firstname>Antanas</firstname><surname>Navickas</surname><order>364</order></author><author><firstname>Egle</firstname><surname>Urbanaviciene</surname><order>365</order></author><author><firstname>Rohana Abdul</firstname><surname>Ghani</surname><order>366</order></author><author><firstname>Khalid Abdul</firstname><surname>Kadir</surname><order>367</order></author><author><firstname>Norsiah</firstname><surname>Ali</surname><order>368</order></author><author><firstname>Mohd Daud Che</firstname><surname>Yusof</surname><order>369</order></author><author><firstname>Chye Lee</firstname><surname>Gan</surname><order>370</order></author><author><firstname>Mastura</firstname><surname>Ismail</surname><order>371</order></author><author><firstname>Wei Yen</firstname><surname>Kong</surname><order>372</order></author><author><firstname>Swee Win</firstname><surname>Lam</surname><order>373</order></author><author><firstname>Li Yuan</firstname><surname>Lee</surname><order>374</order></author><author><firstname>Soo Kun</firstname><surname>Lim</surname><order>375</order></author><author><firstname>Chek Loong</firstname><surname>Loh</surname><order>376</order></author><author><firstname>Anita Bhajan</firstname><surname>Manocha</surname><order>377</order></author><author><firstname>Kee Sing</firstname><surname>Ng</surname><order>378</order></author><author><firstname>Nik Nur Fatnoon Nik</firstname><surname>Ahmad</surname><order>379</order></author><author><firstname>Vanassa</firstname><surname>Ratnasingam</surname><order>380</order></author><author><firstname>Saiful Shahrizal Bin</firstname><surname>Shudim</surname><order>381</order></author><author><firstname>Paranthaman</firstname><surname>Vengadasalam</surname><order>382</order></author><author><firstname>Luis David Abraira</firstname><surname>Munoz</surname><order>383</order></author><author><firstname>Melchor Alpizar</firstname><surname>Salazar</surname><order>384</order></author><author><firstname>Juan Baas</firstname><surname>Cruz</surname><order>385</order></author><author><firstname>Mario Burgos</firstname><surname>Soto</surname><order>386</order></author><author><firstname>Jose Chevaile</firstname><surname>Ramos</surname><order>387</order></author><author><firstname>Alfredo Chew</firstname><surname>Wong</surname><order>388</order></author><author><firstname>Jose Ricardo Correa</firstname><surname>Rotter</surname><order>389</order></author><author><firstname>Tonatiu Diaz</firstname><surname>Escalante</surname><order>390</order></author><author><firstname>Favio Edmundo Enriquez</firstname><surname>Sosa</surname><order>391</order></author><author><firstname>Fernando Flores</firstname><surname>Lozano</surname><order>392</order></author><author><firstname>Luis Fernando Flota</firstname><surname>Cervera</surname><order>393</order></author><author><firstname>Paul Frenk</firstname><surname>Baron</surname><order>394</order></author><author><firstname>Cecilia Garcia</firstname><surname>Ballesteros</surname><order>395</order></author><author><firstname>Jose David Gomez</firstname><surname>Rangel</surname><order>396</order></author><author><firstname>Luis Enrique Herrera</firstname><surname>Jimenez</surname><order>397</order></author><author><firstname>Sergio Saul Irizar</firstname><surname>Santana</surname><order>398</order></author><author><firstname>Fernando Jimenez</firstname><surname>Flores</surname><order>399</order></author><author><firstname>Hugo Laviada</firstname><surname>Molina</surname><order>400</order></author><author><firstname>Rosa Isela Luna</firstname><surname>Ceballos</surname><order>401</order></author><author><firstname>Belia Martin del Campo</firstname><surname>Blanco</surname><order>402</order></author><author><firstname>Guadalupe Morales</firstname><surname>Franco</surname><order>403</order></author><author><firstname>Oscar Tarsicio Moreno</firstname><surname>Loza</surname><order>404</order></author><author><firstname>Cynthia Mustieles</firstname><surname>Rocha</surname><order>405</order></author><author><firstname>Gregorio Obrador</firstname><surname>Vera</surname><order>406</order></author><author><firstname>Ricardo Orozco</firstname><surname>Castellanos</surname><order>407</order></author><author><firstname>Juan Peralta</firstname><surname>Calcaneo</surname><order>408</order></author><author><firstname>Miguel Angel Reyes</firstname><surname>Rosano</surname><order>409</order></author><author><firstname>Hiromi Rodriguez</firstname><surname>Pattzi</surname><order>410</order></author><author><firstname>Juan Rosas</firstname><surname>Guzman</surname><order>411</order></author><author><firstname>Isabel Erika Rucker</firstname><surname>Joerg</surname><order>412</order></author><author><firstname>Sandra Berenice Saavedra</firstname><surname>Sanchez</surname><order>413</order></author><author><firstname>Jose Hector Sanchez</firstname><surname>Mijangos</surname><order>414</order></author><author><firstname>Pablo Serrano</firstname><surname>Sanson</surname><order>415</order></author><author><firstname>Juan Alfredo Tamayo y</firstname><surname>Orozco</surname><order>416</order></author><author><firstname>Eloisa Tellez</firstname><surname>Chavez</surname><order>417</order></author><author><firstname>Alejandro Valdes</firstname><surname>Cepeda</surname><order>418</order></author><author><firstname>Luis Venegas</firstname><surname>Carrillo</surname><order>419</order></author><author><firstname>Juan Villagordoa</firstname><surname>Mesa</surname><order>420</order></author><author><firstname>Rolando Zamarripa</firstname><surname>Escobedo</surname><order>421</order></author><author><firstname>John</firstname><surname>Baker</surname><order>422</order></author><author><firstname>Paul</firstname><surname>Noonan</surname><order>423</order></author><author><firstname>Russell</firstname><surname>Scott</surname><order>424</order></author><author><firstname>Robert</firstname><surname>Walker</surname><order>425</order></author><author><firstname>Edward</firstname><surname>Watson</surname><order>426</order></author><author><firstname>Michael</firstname><surname>Williams</surname><order>427</order></author><author><firstname>Simon</firstname><surname>Young</surname><order>428</order></author><author><firstname>Zaynab</firstname><surname>Abejuela</surname><order>429</order></author><author><firstname>Jeimeen</firstname><surname>Agra</surname><order>430</order></author><author><firstname>Grace</firstname><surname>Aquitania</surname><order>431</order></author><author><firstname>Clodoaido</firstname><surname>Caringal</surname><order>432</order></author><author><firstname>Rhea Severina</firstname><surname>Comia</surname><order>433</order></author><author><firstname>Lalaine Delos</firstname><surname>Santos</surname><order>434</order></author><author><firstname>Olivert</firstname><surname>Gomez</surname><order>435</order></author><author><firstname>Cecilia</firstname><surname>Jimeno</surname><order>436</order></author><author><firstname>Florence</firstname><surname>Santos</surname><order>437</order></author><author><firstname>Gerry</firstname><surname>Tan</surname><order>438</order></author><author><firstname>Marsha</firstname><surname>Tolentino</surname><order>439</order></author><author><firstname>Christy</firstname><surname>Yao</surname><order>440</order></author><author><firstname>Yvette Ethel</firstname><surname>Yap</surname><order>441</order></author><author><firstname>Ma. Dovie Lallaine</firstname><surname>Ygpuara</surname><order>442</order></author><author><firstname>Renata</firstname><surname>Bijata-Bronisz</surname><order>443</order></author><author><firstname>Lucyna</firstname><surname>Hotlos</surname><order>444</order></author><author><firstname>Andrzej</firstname><surname>Januszewicz</surname><order>445</order></author><author><firstname>Barbara</firstname><surname>Kaczmarek</surname><order>446</order></author><author><firstname>Anna</firstname><surname>Kaminska</surname><order>447</order></author><author><firstname>Lech</firstname><surname>Lazuka</surname><order>448</order></author><author><firstname>Andrzej</firstname><surname>Madej</surname><order>449</order></author><author><firstname>Stanislaw</firstname><surname>Mazur</surname><order>450</order></author><author><firstname>Dorota</firstname><surname>Mlodawska-Choluj</surname><order>451</order></author><author><firstname>Michal</firstname><surname>Nowicki</surname><order>452</order></author><author><firstname>Grazyna</firstname><surname>Orlowska-Kowalik</surname><order>453</order></author><author><firstname>Grazyna</firstname><surname>Popenda</surname><order>454</order></author><author><firstname>Barbara</firstname><surname>Rewerska</surname><order>455</order></author><author><firstname>Dariusz</firstname><surname>Sowinski</surname><order>456</order></author><author><firstname>Liliana Monica</firstname><surname>Angelescu</surname><order>457</order></author><author><firstname>Veronica</firstname><surname>Anghel</surname><order>458</order></author><author><firstname>Rodica-Ioana</firstname><surname>Avram</surname><order>459</order></author><author><firstname>Mihaela-Magdalena</firstname><surname>Busegeanu</surname><order>460</order></author><author><firstname>Adriana</firstname><surname>Cif</surname><order>461</order></author><author><firstname>Dana</firstname><surname>Cosma</surname><order>462</order></author><author><firstname>Carmen</firstname><surname>Crisan</surname><order>463</order></author><author><firstname>Luiza Despina</firstname><surname>Demian</surname><order>464</order></author><author><firstname>Ioana Emilia</firstname><surname>Ferariu</surname><order>465</order></author><author><firstname>Ildiko</firstname><surname>Halmagyi</surname><order>466</order></author><author><firstname>Nicolae</firstname><surname>Hancu</surname><order>467</order></author><author><firstname>Mircea</firstname><surname>Munteanu</surname><order>468</order></author><author><firstname>Doru</firstname><surname>Negru</surname><order>469</order></author><author><firstname>Adriana Gabriela</firstname><surname>Onaca</surname><order>470</order></author><author><firstname>Ligia</firstname><surname>Petrica</surname><order>471</order></author><author><firstname>Amorin Remus</firstname><surname>Popa</surname><order>472</order></author><author><firstname>Aurelian-Emil</firstname><surname>Ranetti</surname><order>473</order></author><author><firstname>Cristian</firstname><surname>Serafinceanu</surname><order>474</order></author><author><firstname>Cristina</firstname><surname>Toarba</surname><order>475</order></author><author><firstname>Alina</firstname><surname>Agafyina</surname><order>476</order></author><author><firstname>Olga</firstname><surname>Barbarash</surname><order>477</order></author><author><firstname>Olga</firstname><surname>Barysheva</surname><order>478</order></author><author><firstname>Daniil</firstname><surname>Chizhov</surname><order>479</order></author><author><firstname>Vladimir</firstname><surname>Dobronravov</surname><order>480</order></author><author><firstname>Alexander</firstname><surname>Dreval</surname><order>481</order></author><author><firstname>Irina</firstname><surname>Glinkina</surname><order>482</order></author><author><firstname>Elena</firstname><surname>Grineva</surname><order>483</order></author><author><firstname>Vladimir</firstname><surname>Khirmanov</surname><order>484</order></author><author><firstname>Elena</firstname><surname>Kolmakova</surname><order>485</order></author><author><firstname>Tatiana</firstname><surname>Koroleva</surname><order>486</order></author><author><firstname>Liudmila</firstname><surname>Kvitkova</surname><order>487</order></author><author><firstname>Viacheslav</firstname><surname>Marasaev</surname><order>488</order></author><author><firstname>Ashot</firstname><surname>Mkrtumyan</surname><order>489</order></author><author><firstname>Tatiana</firstname><surname>Morugova</surname><order>490</order></author><author><firstname>Galina</firstname><surname>Nagibovich</surname><order>491</order></author><author><firstname>Oleg</firstname><surname>Nagibovich</surname><order>492</order></author><author><firstname>Sergei</firstname><surname>Nedogoda</surname><order>493</order></author><author><firstname>Irina</firstname><surname>Osipova</surname><order>494</order></author><author><firstname>Tatiana</firstname><surname>Raskina</surname><order>495</order></author><author><firstname>Yulia</firstname><surname>Samoylova</surname><order>496</order></author><author><firstname>Olga</firstname><surname>Sazonova</surname><order>497</order></author><author><firstname>Minara</firstname><surname>Shamkhalova</surname><order>498</order></author><author><firstname>Elena</firstname><surname>Shutemova</surname><order>499</order></author><author><firstname>Yuriy</firstname><surname>Shwartz</surname><order>500</order></author><author><firstname>Oleg</firstname><surname>Uriasyev</surname><order>501</order></author><author><firstname>Sergey</firstname><surname>Vorobyev</surname><order>502</order></author><author><firstname>Anna</firstname><surname>Zateyshchikova</surname><order>503</order></author><author><firstname>Dmitry</firstname><surname>Zateyshshikov</surname><order>504</order></author><author><firstname>Tatyana</firstname><surname>Zykova</surname><order>505</order></author><author><firstname>Slobodan</firstname><surname>Antic</surname><order>506</order></author><author><firstname>Miodrag</firstname><surname>Djordjevic</surname><order>507</order></author><author><firstname>Aleksandra</firstname><surname>Kendereski</surname><order>508</order></author><author><firstname>Katarina</firstname><surname>Lalic</surname><order>509</order></author><author><firstname>Nebojsa</firstname><surname>Lalic</surname><order>510</order></author><author><firstname>Vesna</firstname><surname>Popovic-Radinovic</surname><order>511</order></author><author><firstname>Jana</firstname><surname>Babikova</surname><order>512</order></author><author><firstname>Olga</firstname><surname>Benusova</surname><order>513</order></author><author><firstname>Ingrid</firstname><surname>Buganova</surname><order>514</order></author><author><firstname>Jan</firstname><surname>Culak</surname><order>515</order></author><author><firstname>Andrej</firstname><surname>Dzupina</surname><order>516</order></author><author><firstname>Jana</firstname><surname>Dzuponova</surname><order>517</order></author><author><firstname>Peter</firstname><surname>Fulop</surname><order>518</order></author><author><firstname>Adriana</firstname><surname>Ilavska</surname><order>519</order></author><author><firstname>Emil</firstname><surname>Martinka</surname><order>520</order></author><author><firstname>Zuzana</firstname><surname>Ochodnicka</surname><order>521</order></author><author><firstname>Daniel</firstname><surname>Pella</surname><order>522</order></author><author><firstname>Iveta</firstname><surname>Smatanova</surname><order>523</order></author><author><firstname>Fayzal</firstname><surname>Ahmed</surname><order>524</order></author><author><firstname>Aysha</firstname><surname>Badat</surname><order>525</order></author><author><firstname>Johannes</firstname><surname>Breedt</surname><order>526</order></author><author><firstname>Lawrence</firstname><surname>Distiller</surname><order>527</order></author><author><firstname>Vimladhevi</firstname><surname>Govender</surname><order>528</order></author><author><firstname>Ravendran</firstname><surname>Govender</surname><order>529</order></author><author><firstname>Mukesh</firstname><surname>Joshi</surname><order>530</order></author><author><firstname>Jaco</firstname><surname>Jurgens</surname><order>531</order></author><author><firstname>Gulam</firstname><surname>Latiff</surname><order>532</order></author><author><firstname>Landman</firstname><surname>Lombard</surname><order>533</order></author><author><firstname>Mohamed</firstname><surname>Mookadam</surname><order>534</order></author><author><firstname>Nomangesi</firstname><surname>Ngcakani</surname><order>535</order></author><author><firstname>Hendrik</firstname><surname>Nortje</surname><order>536</order></author><author><firstname>Helena</firstname><surname>Oosthuizen</surname><order>537</order></author><author><firstname>Larisha</firstname><surname>Pillay-Ramaya</surname><order>538</order></author><author><firstname>Hans</firstname><surname>Prozesky</surname><order>539</order></author><author><firstname>Jeevren</firstname><surname>Reddy</surname><order>540</order></author><author><firstname>Paul</firstname><surname>Rheeder</surname><order>541</order></author><author><firstname>Mary</firstname><surname>Seeber</surname><order>542</order></author><author><firstname>Dong-Wan</firstname><surname>Chae</surname><order>543</order></author><author><firstname>Young Min</firstname><surname>Cho</surname><order>544</order></author><author><firstname>In-Kyung</firstname><surname>Jeong</surname><order>545</order></author><author><firstname>Sin Gon</firstname><surname>Kim</surname><order>546</order></author><author><firstname>Yeong Hoon</firstname><surname>Kim</surname><order>547</order></author><author><firstname>Hyuk-Sang</firstname><surname>Kwon</surname><order>548</order></author><author><firstname>Min Jeong</firstname><surname>Kwon</surname><order>549</order></author><author><firstname>Byung-Wan</firstname><surname>Lee</surname><order>550</order></author><author><firstname>JungEun</firstname><surname>Lee</surname><order>551</order></author><author><firstname>Moon-Kyu</firstname><surname>Lee</surname><order>552</order></author><author><firstname>Moon-Suk</firstname><surname>Nam</surname><order>553</order></author><author><firstname>Kook-Hwan</firstname><surname>Oh</surname><order>554</order></author><author><firstname>Cheol-Young</firstname><surname>Park</surname><order>555</order></author><author><firstname>Sun-Hee</firstname><surname>Park</surname><order>556</order></author><author><firstname>Kun Ho</firstname><surname>Yoon</surname><order>557</order></author><author><firstname>Pere Alvarez</firstname><surname>Garcia</surname><order>558</order></author><author><firstname>Luis Asmarats</firstname><surname>Mercadal</surname><order>559</order></author><author><firstname>Clara</firstname><surname>Barrios</surname><order>560</order></author><author><firstname>Fernando Cereto</firstname><surname>Castro</surname><order>561</order></author><author><firstname>Secundino Cigarran</firstname><surname>Guldris</surname><order>562</order></author><author><firstname>Marta Dominguez</firstname><surname>Lopez</surname><order>563</order></author><author><firstname>Jesus Egido de los</firstname><surname>Rios</surname><order>564</order></author><author><firstname>Gema Fernandez</firstname><surname>Fresnedo</surname><order>565</order></author><author><firstname>Antonio Galan</firstname><surname>Serrano</surname><order>566</order></author><author><firstname>Isabel</firstname><surname>Garcia</surname><order>567</order></author><author><firstname>Francisco Javier Gonzalez</firstname><surname>Martinez</surname><order>568</order></author><author><firstname>Jose Esteban Jodar</firstname><surname>Gimeno</surname><order>569</order></author><author><firstname>Manuel Lopez</firstname><surname>Mendoza</surname><order>570</order></author><author><firstname>Tamara Malek</firstname><surname>Marin</surname><order>571</order></author><author><firstname>Cristobal Morales</firstname><surname>Portillo</surname><order>572</order></author><author><firstname>Maria Antonia Munar</firstname><surname>Vila</surname><order>573</order></author><author><firstname>Manuel Muñoz</firstname><surname>Torres</surname><order>574</order></author><author><firstname>Javier Nieto</firstname><surname>Iglesias</surname><order>575</order></author><author><firstname>Jonay Pantoja</firstname><surname>Perez</surname><order>576</order></author><author><firstname>Merce Perez</firstname><surname>Vera</surname><order>577</order></author><author><firstname>Jose Mª Portoles</firstname><surname>Perez</surname><order>578</order></author><author><firstname>María Angustias Quesada</firstname><surname>Simón</surname><order>579</order></author><author><firstname>Rafael Simo</firstname><surname>Canonge</surname><order>580</order></author><author><firstname>Alfonso Soto</firstname><surname>Gonzalez</surname><order>581</order></author><author><firstname>Manel Terns</firstname><surname>Riera</surname><order>582</order></author><author><firstname>Francisco Jose Tinahones</firstname><surname>Madueno</surname><order>583</order></author><author><firstname>Mercedes Velo</firstname><surname>Plaza</surname><order>584</order></author><author><firstname>Chwen-Tzuei</firstname><surname>Chang</surname><order>585</order></author><author><firstname>Lee-Ming</firstname><surname>Chuang</surname><order>586</order></author><author><firstname>Te-Lin</firstname><surname>Hsia</surname><order>587</order></author><author><firstname>Chang-Hsun</firstname><surname>Hsieh</surname><order>588</order></author><author><firstname>Shang-Jyh</firstname><surname>Hwang</surname><order>589</order></author><author><firstname>Chih-Ching</firstname><surname>Lin</surname><order>590</order></author><author><firstname>Yung-Chuan</firstname><surname>Lu</surname><order>591</order></author><author><firstname>Wayne H-H</firstname><surname>Sheu</surname><order>592</order></author><author><firstname>Olga</firstname><surname>Barna</surname><order>593</order></author><author><firstname>Svitlana D.</firstname><surname>Bilyk</surname><order>594</order></author><author><firstname>Volodymyr</firstname><surname>Botsyurko</surname><order>595</order></author><author><firstname>Iryna</firstname><surname>Dudar</surname><order>596</order></author><author><firstname>Ivan</firstname><surname>Fushtey</surname><order>597</order></author><author><firstname>Olga</firstname><surname>Godlevska</surname><order>598</order></author><author><firstname>Oleksandr</firstname><surname>Golovchenko</surname><order>599</order></author><author><firstname>Olga</firstname><surname>Gyrina</surname><order>600</order></author><author><firstname>Anatoliy</firstname><surname>Kazmirchuk</surname><order>601</order></author><author><firstname>Mykola</firstname><surname>Kolesnyk</surname><order>602</order></author><author><firstname>Iuliia</firstname><surname>Komisarenko</surname><order>603</order></author><author><firstname>Oleksii</firstname><surname>Korzh</surname><order>604</order></author><author><firstname>Nonna</firstname><surname>Kravchun</surname><order>605</order></author><author><firstname>Oleg</firstname><surname>Legun</surname><order>606</order></author><author><firstname>Borys</firstname><surname>Mankovskyy</surname><order>607</order></author><author><firstname>Liliya</firstname><surname>Martynyuk</surname><order>608</order></author><author><firstname>Yuriy</firstname><surname>Mostovoy</surname><order>609</order></author><author><firstname>Nataliia</firstname><surname>Pashkovska</surname><order>610</order></author><author><firstname>Larysa</firstname><surname>Pererva</surname><order>611</order></author><author><firstname>Tetyana</firstname><surname>Pertseva</surname><order>612</order></author><author><firstname>Oleksandr</firstname><surname>Samoylov</surname><order>613</order></author><author><firstname>Ivan</firstname><surname>Smirnov</surname><order>614</order></author><author><firstname>Yevgeniya</firstname><surname>Svyshchenko</surname><order>615</order></author><author><firstname>Halyna</firstname><surname>Tomashkevych</surname><order>616</order></author><author><firstname>Ivan</firstname><surname>Topchii</surname><order>617</order></author><author><firstname>Nadiya</firstname><surname>Tryshchuk</surname><order>618</order></author><author><firstname>Vira</firstname><surname>Tseluyko</surname><order>619</order></author><author><firstname>Vadym</firstname><surname>Vizir</surname><order>620</order></author><author><firstname>Maryna</firstname><surname>Vlasenko</surname><order>621</order></author><author><firstname>Tetiana</firstname><surname>Zlova</surname><order>622</order></author><author><firstname>Liliia</firstname><surname>Zub</surname><order>623</order></author><author><firstname>Salah</firstname><surname>Abusnana</surname><order>624</order></author><author><firstname>Mohamed</firstname><surname>Railey</surname><order>625</order></author><author><firstname>Kamal</firstname><surname>Abouglila</surname><order>626</order></author><author><firstname>Paul</firstname><surname>Ainsworth</surname><order>627</order></author><author><firstname>Zishan</firstname><surname>Ali</surname><order>628</order></author><author><firstname>Vijayaraman</firstname><surname>Arutchelvam</surname><order>629</order></author><author><firstname>Maria</firstname><surname>Barnard</surname><order>630</order></author><author><firstname>Srikanth</firstname><surname>Bellary</surname><order>631</order></author><author><firstname>Emyr</firstname><surname>Davies</surname><order>632</order></author><author><firstname>Mark</firstname><surname>Davies</surname><order>633</order></author><author><firstname>Simon</firstname><surname>Davies</surname><order>634</order></author><author><firstname>Alison</firstname><surname>Dawson</surname><order>635</order></author><author><firstname>Mohsen El</firstname><surname>Kossi</surname><order>636</order></author><author><firstname>Patrick</firstname><surname>English</surname><order>637</order></author><author><firstname>Donald</firstname><surname>Fraser</surname><order>638</order></author><author><firstname>Luigi</firstname><surname>Gnudi</surname><order>639</order></author><author><firstname>Anthony</firstname><surname>Gunstone</surname><order>640</order></author><author><firstname>Timothy</firstname><surname>Hall</surname><order>641</order></author><author><firstname>Wasim</firstname><surname>Hanif</surname><order>642</order></author><author><firstname>Alan</firstname><surname>Jackson</surname><order>643</order></author><author><firstname>Andrew</firstname><surname>Johnson</surname><order>644</order></author><author><firstname>Franklin</firstname><surname>Joseph</surname><order>645</order></author><author><firstname>Singhan</firstname><surname>Krishnan</surname><order>646</order></author><author><firstname>Mick</firstname><surname>Kumwenda</surname><order>647</order></author><author><firstname>Iain</firstname><surname>MacDougall</surname><order>648</order></author><author><firstname>Paul</firstname><surname>Nixon</surname><order>649</order></author><author><firstname>Joseph</firstname><surname>O’Hare</surname><order>650</order></author><author><firstname>Sam</firstname><surname>Philip</surname><order>651</order></author><author><firstname>Shenaz</firstname><surname>Ramtoola</surname><order>652</order></author><author><firstname>Manish</firstname><surname>Saxena</surname><order>653</order></author><author><firstname>Davesh</firstname><surname>Sennik</surname><order>654</order></author><author><firstname>Godwin</firstname><surname>Simon</surname><order>655</order></author><author><firstname>Baldev</firstname><surname>Singh</surname><order>656</order></author><author><firstname>Jeffrey</firstname><surname>Stephens</surname><order>657</order></author><author><firstname>Anna</firstname><surname>Strzelecka</surname><order>658</order></author><author><firstname>Rehan</firstname><surname>Symonds</surname><order>659</order></author><author><firstname>Wayne</firstname><surname>Turner</surname><order>660</order></author><author><firstname>Mona</firstname><surname>Wahba</surname><order>661</order></author><author><firstname>John</firstname><surname>Wakeling</surname><order>662</order></author><author><firstname>David</firstname><surname>Wheeler</surname><order>663</order></author><author><firstname>Peter</firstname><surname>Winocour</surname><order>664</order></author><author><firstname>Joseph</firstname><surname>Abdallah</surname><order>665</order></author><author><firstname>Raied</firstname><surname>Abdullah</surname><order>666</order></author><author><firstname>Matthew</firstname><surname>Abramowitz</surname><order>667</order></author><author><firstname>Idalia</firstname><surname>Acosta</surname><order>668</order></author><author><firstname>Joseph</firstname><surname>Aiello</surname><order>669</order></author><author><firstname>Laura</firstname><surname>Akright</surname><order>670</order></author><author><firstname>Ayim</firstname><surname>Akyea-Djamson</surname><order>671</order></author><author><firstname>Rajendran</firstname><surname>Alappan</surname><order>672</order></author><author><firstname>Radica</firstname><surname>Alicic</surname><order>673</order></author><author><firstname>Amer</firstname><surname>Al-Karadsheh</surname><order>674</order></author><author><firstname>Dale 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v2 66406 2024-05-14 Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease 5219d126f97f8f884bdb622099bd41de 0000-0003-2228-086X Jeffrey Stephens Jeffrey Stephens true false 2024-05-14 MEDS Background and Purpose:Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.Methods:CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.Results:In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55–1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61–1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19–1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20–1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53–1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82–1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89–1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30–0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49–1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71–0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31–0.79]).Conclusions:Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Journal Article Stroke 52 5 1545 1556 Ovid Technologies (Wolters Kluwer Health) 0039-2499 1524-4628 atrial fibrillation; canagliflozin; glomerular filtration rate; hemorrhagic stroke; ischemic stroke 1 5 2021 2021-05-01 10.1161/strokeaha.120.031623 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Supported by Janssen Research & Development, LLC. 2024-06-24T14:20:46.2875930 2024-05-14T09:56:32.2886407 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Zien Zhou 0000-0001-6543-7113 1 Meg J. Jardine 2 Qiang Li 3 Brendon L. Neuen 0000-0001-9276-8380 4 Christopher P. Cannon 5 Dick de Zeeuw 6 Robert Edwards 7 Adeera Levin 8 Kenneth W. Mahaffey 9 Vlado Perkovic 10 Bruce Neal 0000-0002-0490-7465 11 Richard I. Lindley 0000-0002-0104-5679 12 Rodolfo Andres Ahuad Guerrero 13 Diego Aizenberg 14 Juan Pablo Albisu 15 Andres Alvarisqueta 16 Ines Bartolacci 17 Mario Alberto Berli 18 Anselmo Bordonava 19 Pedro Calella 20 Maria Cecilia Cantero 21 Luis Rodolfo Cartasegna 22 Esteban Cercos 23 Gabriela Cecilia Coloma 24 Hugo Colombo 25 Victor Commendatore 26 Jesus Cuadrado 27 Carlos Alberto Cuneo 28 Ana Maria Cusumano 29 Walter Guillermo Douthat 30 Ricardo Dario Dran 31 Eduardo Farias 32 Maria Florencia Fernandez 33 Hernan Finkelstein 34 Guillermo Fragale 35 Jose Osvaldo Fretes 36 Nestor Horacio Garcia 37 Anibal Gastaldi 38 Elizabeth Gelersztein 39 Jorge Archibaldo Glenny 40 Joaquin Pablo Gonzalez 41 Patricia del Carmen Gonzalez Colaso 42 Claudia Goycoa 43 Gustavo Cristian Greloni 44 Adrian Guinsburg 45 Sonia Hermida 46 Luis Isaias Juncos 47 Maria Isabel Klyver 48 Florencia Kraft 49 Fernando Krynski 50 Paulina Virginia Lanchiotti 51 Ricardo Alfonso Leon de la Fuente 52 Nora Marchetta 53 Pablo Mele 54 Silvia Nicolai 55 Pablo Antonio Novoa 56 Silvia Ines Orio 57 Fabian Otreras 58 Alejandra Oviedo 59 Pablo Raffaele 60 Jorge Hector Resk 61 Lucas Rista 62 Nelson Rodriguez Papini 63 Jorgelina Sala 64 Juan Carlos Santos 65 Lilia Beatriz Schiavi 66 Horacio Sessa 67 Tomas Smith Casabella 68 Maria Rosa Ulla 69 Maria Valdez 70 Augusto Vallejos 71 Adriana Villarino 72 Virginia Esther Visco 73 Alfredo Wassermann 74 Cesar Javier Zaidman 75 Ngai Wah Cheung 76 Carolyn Droste 77 Ian Fraser 78 David Johnson 79 Peak Mann Mah 80 Kathy Nicholls 81 David Packham 82 Joseph Proietto 83 Anthony Roberts 84 Simon Roger 85 Venessa Tsang 86 Roberto Abrão Raduan 87 Fernando Augusto Alves da Costa 88 Celso Amodeo 89 Luiz Alberto Andreotti Turatti 90 Rachel Bregman 91 Fernanda Cristina Camelo Sanches 92 Luis Henrique Canani 93 Antônio Roberto Chacra 94 João Lindolfo Cunha Borges 95 Sérgio Alberto Cunha Vêncio 96 Roberto Jorge da Silva Franco 97 Domingos d’Avila 98 Evandro de Souza Portes 99 Pedro de Souza 100 Luciane Mônica Deboni 101 Fadlo Fraige Filho 102 Bruno Geloneze Neto 103 Marcus Gomes 104 Suely Keiko Kohara 105 Elizete Keitel 106 Jose Francisco Kerr Saraiva 107 Hugo Roberto Kurtz Lisboa 108 Fabiana Loss de Carvalho Contieri 109 Rosângela Milagres 110 Renan Montenegro Junior 111 Claudia Moreira de Brito 112 Miguel Nasser Hissa 113 Ângela Regina Nazario Sabbag 114 Irene Noronha 115 Daniel Panarotto 116 Roberto Pecoits Filho 117 Márcio Antônio Pereira 118 Wladmir Saporito 119 Antonio Scafuto Scotton 120 Tiago Schuch 121 Roberto Simões de Almeida 122 Cássio Slompo Ramos 123 João Soares Felício 124 Fernando Thomé 125 Jean Carlo Tibes Hachmann 126 Sérgio Yamada 127 Cesar Yoiti Hayashida 128 Tarissa Beatrice Zanata Petry 129 Maria Teresa Zanella 130 Viktoria Andreeva 131 Angelina Angelova 132 Stefan Dimitrov 133 Veselka Genadieva 134 Gabriela Genova-Hristova 135 Kiril Hristozov 136 Zdravko Kamenov 137 Atanas Koundurdjiev 138 Lachezar Lozanov 139 Viktor Margaritov 140 Boyan Nonchev 141 Rangel Rangelov 142 Alexander Shinkov 143 Margarita Temelkova 144 Ekaterina Velichkova 145 Andrian Yakov 146 Naresh Aggarwal 147 Ronnie Aronson 148 Harpreet Bajaj 149 David Cherney 150 Guy Chouinard 151 James Conway 152 Serge Cournoyer 153 Gerald DaRoza 154 Sacha De Serres 155 François Dubé 156 Ronald Goldenberg 157 Anil Gupta 158 Milan Gupta 159 Sam Henein 160 Hasnain Khandwala 161 Lawrence Leiter 162 François Madore 163 Alan McMahon 164 Norman Muirhead 165 Vincent Pichette 166 Remi Rabasa-Lhoret 167 Andrew Steele 168 Navdeep Tangri 169 Ali Torshizi 170 Vincent Woo 171 Nadia Zalunardo 172 María Alicia Fernández Montenegro 173 Juan Gonzalo Godoy Jorquera 174 Marcelo Medina Fariña 175 Victor Saavedra Gajardo 176 Margarita Vejar 177 Nan Chen 178 Qinkai Chen 179 Shenglian Gan 180 Yaozhong Kong 181 Detian Li 182 Wenge Li 183 Xuemei Li 184 Hongli Lin 185 Jian Liu 186 Weiping Lu 187 Hong Mao 188 Yan Ren 189 Weihong Song 190 Jiao Sun 191 Lin Sun 192 Ping Tu 193 Guixia Wang 194 Jinkui Yang 195 Aiping Yin 196 Xueqing Yu 197 Minghui Zhao 198 Hongguang Zheng 199 Jose Luis Accini Mendoza 200 Edgar Arcos 201 Jorge Avendano 202 Jorge Ernesto Andres Diaz Ruiz 203 Luis Hernando Garcia Ortiz 204 Alexander Gonzalez 205 Eric Hernandez Triana 206 Juan Diego Higuera 207 Natalia Malaver 208 Dora Inés Molina de Salazar 209 Ricardo Rosero 210 Monica Alexandra Terront Lozano 211 Luis Valderrama Cometa 212 Alex Valenzuela 213 Ruben Dario Vargas Alonso 214 Ivan Villegas 215 Hernan Yupanqui 216 Dagmar Bartaskova 217 Petr Barton 218 Jana Belobradkova 219 Lenka Dohnalova 220 Tomas Drasnar 221 Richard Ferkl 222 Katarina Halciakova 223 Vera Klokocnikova 224 Richard Kovar 225 Jiri Lastuvka 226 Martin Lukac 227 Satu Pesickova 228 Karel Peterka 229 Jiri Pumprla 230 Ivan Rychlik 231 Frantisek Saudek 232 Vladimir Tesar 233 Martin Valis 234 Pavel Weiner 235 Stanislav Zemek 236 Eric Alamartine 237 Sophie Borot 238 Bertrand Cariou 239 Bertrand Dussol 240 Jean-Pierre Fauvel 241 Pierre Gourdy 242 Alexandre Klein 243 Yannick Le Meur 244 Alfred Penfornis 245 Ronan Roussel 246 Pierre-Jean Saulnier 247 Eric Thervet 248 Philippe Zaoui 249 Volker Burst 250 Markus Faghih 251 Grit Faulmann 252 Hermann Haller 253 Reinhold Jerwan-Keim 254 Stephan Maxeiner 255 Björn Paschen 256 Georg Plassmann 257 Ludger Rose 258 Ronaldo Arturo Gonzalez Orellana 259 Franklin Paul Haase 260 Juan Pablo Moreira Diaz 261 Luis Alberto Ramirez Roca 262 Jose Antonio Sánchez Arenales 263 José Vicente Sanchez Polo 264 Erick Turcios Juarez 265 Gyongyi Csecsei 266 Botond Csiky 267 Peter Danos 268 Laszlo Deak 269 Mihaly Dudas 270 Eleonora Harcsa 271 Katalin Keltai 272 Sandor Keresztesi 273 Krisztian Kiss 274 Laszlo Konyves 275 Lajos Major 276 Margit Mileder 277 Marta Molnar 278 Janos Mucsi 279 Tamas Oroszlan 280 Ivan Ory 281 Gyorgy Paragh 282 Eva Peterfai 283 Gizella Petro 284 Katalin Revesz 285 Robert Takacs 286 Sandor Vangel 287 Szilard Vasas 288 Marianna Zsom 289 Abraham Oomman 290 Sree Bhushan Raju 291 Deepak Dewan 292 M. Edwin Fernando 293 Natarajan Gopalakrishnan 294 Noble Gracious 295 Hansraj Alva 296 Dinesh Jain 297 C. B. Keshavamurthy 298 Dinesh Khullar 299 Manisha Sahay 300 Jayameena Peringat 301 Narayan Prasad 302 K. Satyanarayana Rao 303 Sreedhar Reddy 304 Sreelatha Melemadathil 305 Bhimavarapu Sudhakar 306 Ramesh Chandra Vyasam 307 Riccardo Bonadonna 308 Pietro Castellino 309 Antonio Ceriello 310 Luca Chiovato 311 Salvatore De Cosmo 312 Luca De Nicola 313 Giuseppe Derosa 314 Alberto Di Carlo 315 Graziano Di Cianni 316 Giovanni Frascà 317 Giorgio Fuiano 318 Giovanni Gambaro 319 Giacomo Garibotto 320 Carlo Giorda 321 Fabio Malberti 322 Marcora Mandreoli 323 Edoardo Mannucci 324 Emanuela Orsi 325 Piermarco Piatti 326 Domenico Santoro 327 Ferdinando Carlo Sasso 328 Gaetano Serviddio 329 Andrea Stella 330 Roberto Trevisan 331 Anna Maria Veronelli 332 Luca Zanoli 333 Hitoshi Akiyama 334 Hiromi Aoki 335 Akimichi Asano 336 Tadashi Iitsuka 337 Shizuo Kajiyama 338 Susumu Kashine 339 Toshio Kawada 340 Takamoto Kodera 341 Hiroshi Kono 342 Kazunori Koyama 343 Yasuro Kumeda 344 Shozo Miyauchi 345 Kazuyuki Mizuyama 346 Tetsuji Niiya 347 Hiroko Oishi 348 Satoshi Ota 349 Terue Sakakibara 350 Masahiko Takai 351 Osamu Tomonaga 352 Mitsuru Tsujimoto 353 Takashi Wada 354 Masakiyo Wakasugi 355 Yasushi Wakida 356 Takayuki Watanabe 357 Masayo Yamada 358 Kazuhiro Yanagida 359 Toshihiko Yanase 360 Wataru Yumita 361 Egle Gaupsiene 362 Dalia Kozloviene 363 Antanas Navickas 364 Egle Urbanaviciene 365 Rohana Abdul Ghani 366 Khalid Abdul Kadir 367 Norsiah Ali 368 Mohd Daud Che Yusof 369 Chye Lee Gan 370 Mastura Ismail 371 Wei Yen Kong 372 Swee Win Lam 373 Li Yuan Lee 374 Soo Kun Lim 375 Chek Loong Loh 376 Anita Bhajan Manocha 377 Kee Sing Ng 378 Nik Nur Fatnoon Nik Ahmad 379 Vanassa Ratnasingam 380 Saiful Shahrizal Bin Shudim 381 Paranthaman Vengadasalam 382 Luis David Abraira Munoz 383 Melchor Alpizar Salazar 384 Juan Baas Cruz 385 Mario Burgos Soto 386 Jose Chevaile Ramos 387 Alfredo Chew Wong 388 Jose Ricardo Correa Rotter 389 Tonatiu Diaz Escalante 390 Favio Edmundo Enriquez Sosa 391 Fernando Flores Lozano 392 Luis Fernando Flota Cervera 393 Paul Frenk Baron 394 Cecilia Garcia Ballesteros 395 Jose David Gomez Rangel 396 Luis Enrique Herrera Jimenez 397 Sergio Saul Irizar Santana 398 Fernando Jimenez Flores 399 Hugo Laviada Molina 400 Rosa Isela Luna Ceballos 401 Belia Martin del Campo Blanco 402 Guadalupe Morales Franco 403 Oscar Tarsicio Moreno Loza 404 Cynthia Mustieles Rocha 405 Gregorio Obrador Vera 406 Ricardo Orozco Castellanos 407 Juan Peralta Calcaneo 408 Miguel Angel Reyes Rosano 409 Hiromi Rodriguez Pattzi 410 Juan Rosas Guzman 411 Isabel Erika Rucker Joerg 412 Sandra Berenice Saavedra Sanchez 413 Jose Hector Sanchez Mijangos 414 Pablo Serrano Sanson 415 Juan Alfredo Tamayo y Orozco 416 Eloisa Tellez Chavez 417 Alejandro Valdes Cepeda 418 Luis Venegas Carrillo 419 Juan Villagordoa Mesa 420 Rolando Zamarripa Escobedo 421 John Baker 422 Paul Noonan 423 Russell Scott 424 Robert Walker 425 Edward Watson 426 Michael Williams 427 Simon Young 428 Zaynab Abejuela 429 Jeimeen Agra 430 Grace Aquitania 431 Clodoaido Caringal 432 Rhea Severina Comia 433 Lalaine Delos Santos 434 Olivert Gomez 435 Cecilia Jimeno 436 Florence Santos 437 Gerry Tan 438 Marsha Tolentino 439 Christy Yao 440 Yvette Ethel Yap 441 Ma. Dovie Lallaine Ygpuara 442 Renata Bijata-Bronisz 443 Lucyna Hotlos 444 Andrzej Januszewicz 445 Barbara Kaczmarek 446 Anna Kaminska 447 Lech Lazuka 448 Andrzej Madej 449 Stanislaw Mazur 450 Dorota Mlodawska-Choluj 451 Michal Nowicki 452 Grazyna Orlowska-Kowalik 453 Grazyna Popenda 454 Barbara Rewerska 455 Dariusz Sowinski 456 Liliana Monica Angelescu 457 Veronica Anghel 458 Rodica-Ioana Avram 459 Mihaela-Magdalena Busegeanu 460 Adriana Cif 461 Dana Cosma 462 Carmen Crisan 463 Luiza Despina Demian 464 Ioana Emilia Ferariu 465 Ildiko Halmagyi 466 Nicolae Hancu 467 Mircea Munteanu 468 Doru Negru 469 Adriana Gabriela Onaca 470 Ligia Petrica 471 Amorin Remus Popa 472 Aurelian-Emil Ranetti 473 Cristian Serafinceanu 474 Cristina Toarba 475 Alina Agafyina 476 Olga Barbarash 477 Olga Barysheva 478 Daniil Chizhov 479 Vladimir Dobronravov 480 Alexander Dreval 481 Irina Glinkina 482 Elena Grineva 483 Vladimir Khirmanov 484 Elena Kolmakova 485 Tatiana Koroleva 486 Liudmila Kvitkova 487 Viacheslav Marasaev 488 Ashot Mkrtumyan 489 Tatiana Morugova 490 Galina Nagibovich 491 Oleg Nagibovich 492 Sergei Nedogoda 493 Irina Osipova 494 Tatiana Raskina 495 Yulia Samoylova 496 Olga Sazonova 497 Minara Shamkhalova 498 Elena Shutemova 499 Yuriy Shwartz 500 Oleg Uriasyev 501 Sergey Vorobyev 502 Anna Zateyshchikova 503 Dmitry Zateyshshikov 504 Tatyana Zykova 505 Slobodan Antic 506 Miodrag Djordjevic 507 Aleksandra Kendereski 508 Katarina Lalic 509 Nebojsa Lalic 510 Vesna Popovic-Radinovic 511 Jana Babikova 512 Olga Benusova 513 Ingrid Buganova 514 Jan Culak 515 Andrej Dzupina 516 Jana Dzuponova 517 Peter Fulop 518 Adriana Ilavska 519 Emil Martinka 520 Zuzana Ochodnicka 521 Daniel Pella 522 Iveta Smatanova 523 Fayzal Ahmed 524 Aysha Badat 525 Johannes Breedt 526 Lawrence Distiller 527 Vimladhevi Govender 528 Ravendran Govender 529 Mukesh Joshi 530 Jaco Jurgens 531 Gulam Latiff 532 Landman Lombard 533 Mohamed Mookadam 534 Nomangesi Ngcakani 535 Hendrik Nortje 536 Helena Oosthuizen 537 Larisha Pillay-Ramaya 538 Hans Prozesky 539 Jeevren Reddy 540 Paul Rheeder 541 Mary Seeber 542 Dong-Wan Chae 543 Young Min Cho 544 In-Kyung Jeong 545 Sin Gon Kim 546 Yeong Hoon Kim 547 Hyuk-Sang Kwon 548 Min Jeong Kwon 549 Byung-Wan Lee 550 JungEun Lee 551 Moon-Kyu Lee 552 Moon-Suk Nam 553 Kook-Hwan Oh 554 Cheol-Young Park 555 Sun-Hee Park 556 Kun Ho Yoon 557 Pere Alvarez Garcia 558 Luis Asmarats Mercadal 559 Clara Barrios 560 Fernando Cereto Castro 561 Secundino Cigarran Guldris 562 Marta Dominguez Lopez 563 Jesus Egido de los Rios 564 Gema Fernandez Fresnedo 565 Antonio Galan Serrano 566 Isabel Garcia 567 Francisco Javier Gonzalez Martinez 568 Jose Esteban Jodar Gimeno 569 Manuel Lopez Mendoza 570 Tamara Malek Marin 571 Cristobal Morales Portillo 572 Maria Antonia Munar Vila 573 Manuel Muñoz Torres 574 Javier Nieto Iglesias 575 Jonay Pantoja Perez 576 Merce Perez Vera 577 Jose Mª Portoles Perez 578 María Angustias Quesada Simón 579 Rafael Simo Canonge 580 Alfonso Soto Gonzalez 581 Manel Terns Riera 582 Francisco Jose Tinahones Madueno 583 Mercedes Velo Plaza 584 Chwen-Tzuei Chang 585 Lee-Ming Chuang 586 Te-Lin Hsia 587 Chang-Hsun Hsieh 588 Shang-Jyh Hwang 589 Chih-Ching Lin 590 Yung-Chuan Lu 591 Wayne H-H Sheu 592 Olga Barna 593 Svitlana D. Bilyk 594 Volodymyr Botsyurko 595 Iryna Dudar 596 Ivan Fushtey 597 Olga Godlevska 598 Oleksandr Golovchenko 599 Olga Gyrina 600 Anatoliy Kazmirchuk 601 Mykola Kolesnyk 602 Iuliia Komisarenko 603 Oleksii Korzh 604 Nonna Kravchun 605 Oleg Legun 606 Borys Mankovskyy 607 Liliya Martynyuk 608 Yuriy Mostovoy 609 Nataliia Pashkovska 610 Larysa Pererva 611 Tetyana Pertseva 612 Oleksandr Samoylov 613 Ivan Smirnov 614 Yevgeniya Svyshchenko 615 Halyna Tomashkevych 616 Ivan Topchii 617 Nadiya Tryshchuk 618 Vira Tseluyko 619 Vadym Vizir 620 Maryna Vlasenko 621 Tetiana Zlova 622 Liliia Zub 623 Salah Abusnana 624 Mohamed Railey 625 Kamal Abouglila 626 Paul Ainsworth 627 Zishan Ali 628 Vijayaraman Arutchelvam 629 Maria Barnard 630 Srikanth Bellary 631 Emyr Davies 632 Mark Davies 633 Simon Davies 634 Alison Dawson 635 Mohsen El Kossi 636 Patrick English 637 Donald Fraser 638 Luigi Gnudi 639 Anthony Gunstone 640 Timothy Hall 641 Wasim Hanif 642 Alan Jackson 643 Andrew Johnson 644 Franklin Joseph 645 Singhan Krishnan 646 Mick Kumwenda 647 Iain MacDougall 648 Paul Nixon 649 Joseph O’Hare 650 Sam Philip 651 Shenaz Ramtoola 652 Manish Saxena 653 Davesh Sennik 654 Godwin Simon 655 Baldev Singh 656 Jeffrey Stephens 657 Anna Strzelecka 658 Rehan Symonds 659 Wayne Turner 660 Mona Wahba 661 John Wakeling 662 David Wheeler 663 Peter Winocour 664 Joseph Abdallah 665 Raied Abdullah 666 Matthew Abramowitz 667 Idalia Acosta 668 Joseph Aiello 669 Laura Akright 670 Ayim Akyea-Djamson 671 Rajendran Alappan 672 Radica Alicic 673 Amer Al-Karadsheh 674 Dale Crawford Allison 675 Carlos Arauz-Pacheco 676 Shahabul Arfeen 677 Ahmed Arif 678 Moogali Arvind 679 Naveen Atray 680 Ahmed Awad 681 George Bakris 682 Peggy Barnhill 683 Elizabeth Barranco 684 Carlos Barrera 685 Matthew Beacom 686 Venkata Behara 687 Diogo Belo 688 Rhonda Bentley-Lewis 689 Ramon Berenguer 690 Lidia Bermudez 691 Marializa Bernardo 692 Mihaela Biscoveanu 693 Cynthia Bowman-Stroud 694 Donald Brandon 695 Osvaldo Brusco 696 Robert Busch 697 Yamil Canaan 698 Alicia Chilito 699 Tom Christensen 700 Cynthia Christiano 701 Elena Christofides 702 Caroucel Chuateco 703 Kenneth Cohen 704 Robert Cohen 705 Debbie Cohen-Stein 706 Charles Cook 707 Daniel Coyne 708 Nizar Daboul 709 Riad Darwish 710 Adarsh Daswani 711 Kenneth Deck 712 Cyrus Desouza 713 Devasmita Dev 714 Monika Dhillon 715 Sohan Dua 716 Frank Eder 717 Ana Maria Elosegui 718 Mohamed El-Shahawy 719 John Ervin 720 Alberto Esquenazi 721 John Evans 722 Steven Fishbane 723 Juan Frias 724 Eugenia Galindo-Ramos 725 Claude Galphin 726 Adline Ghazi 727 Enrique Gonzalez 728 David Gorson 729 Anupama Gowda 730 Barbara Greco 731 Stephen Grubb 732 Rakesh Gulati 733 Jamal Hammoud 734 Stuart Handelsman 735 Israel Hartman 736 Kenneth Hershon 737 Daniel Hiser 738 George Hon 739 Radu Jacob 740 Maria Jaime 741 Aamir Jamal 742 Charles Kaupke 743 Gerald Keightley 744 Elizabeth Kern 745 Rakhi Khanna 746 Zeid Khitan 747 Sun Kim 748 Nelson Kopyt 749 Csaba Kovesdy 750 Gopal Krishna 751 Jeffrey (Jay) Kropp 752 Amrendra Kumar 753 Jayant Kumar 754 Neil Kumar 755 Jorge Kusnir 756 Wendy Lane 757 Mary Lawrence 758 Lawrence Lehrner 759 John Lentz 760 Dennis Levinson 761 Derek Lewis 762 Kenneth Liss 763 Andreas Maddux 764 Hiralal Maheshwari 765 Sreedhar Mandayam 766 Isam Marar 767 Bhasker Mehta 768 John Middleton 769 Jorge Mordujovich 770 Ramon Moreda 771 Moustafa Moustafa 772 Samuel Mujica Trenche 773 Mohanram Narayanan 774 Javier Narvarte 775 Tareq Nassar 776 George Newman 777 Brian Nichol 778 Philip Nicol 779 Josier Nisnisan 780 A. Kaldun Nossuli 781 Chamberlain Obialo 782 Sarah Olelewe 783 Michael Oliver 784 Andrew O’Shaughnessy 785 John Padron 786 Rohit Pankhaniya 787 Reginald Parker 788 Devesh Patel 789 Gnyandev Patel 790 Nina Patel 791 Humberto Pavon 792 Armando Perez 793 Carlos Perez 794 Alan Perlman 795 Karlton Pettis 796 Walter Pharr 797 Andrea Phillips 798 Raman Purighalla 799 Luis Quesada-Suarez 800 Rajiv Ranjan 801 Sanjeev Rastogi 802 Jakkidi Reddy 803 Marc Rendell 804 Lisa Rich 805 Michael Robinson 806 Hector Rodriguez 807 Sylvia Rosas 808 Fadi Saba 809 Rallabhandi Sankaram 810 Ravi Sarin 811 Robert Schreiman 812 David Scott 813 Mohamed Sekkarie 814 John Sensenbrenner 815 Muhammad Shakeel 816 Michael Shanik 817 Sylvia Shaw 818 Stephen Smith 819 Richard Solomon 820 Amy Sprague 821 Leslie Spry 822 Pusadee Suchinda 823 Senan Sultan 824 Prasanth Surampudi 825 Sherry Sussman 826 Anjanette Tan 827 Antonio Terrelonge 828 Michael Thompson 829 Fernando Trespalacios 830 Bruce Trippe 831 Pilar Trueba 832 Marcel Twahirwa 833 John Updegrove 834 Peter Van Buren 835 Mark Vannorsdall 836 Freemu Varghese 837 Pedro Velasquez-Mieyer 838 Sailaja Ventrapragada 839 Goga Vukotic 840 Khurram Wadud 841 Mark Warren 842 Henry Watson 843 Ronald Watts 844 Daniel Weiner 845 James Welker 846 Jean Welsh 847 Shelley Williams 848 Michelle Zaniewski-Singh 849 Jeffrey Stephens 0000-0003-2228-086X 850 66406__30346__2d9e10aaa9ca47428cc221beebc2319b.pdf 66406.pdf 2024-05-14T09:59:42.2556927 Output 690491 application/pdf Version of Record true This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License. true eng http://creativecommons.org/licenses/by-nc- nd/4.0/ |
| title |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease |
| spellingShingle |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease Jeffrey Stephens |
| title_short |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease |
| title_full |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease |
| title_fullStr |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease |
| title_full_unstemmed |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease |
| title_sort |
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease |
| author_id_str_mv |
5219d126f97f8f884bdb622099bd41de |
| author_id_fullname_str_mv |
5219d126f97f8f884bdb622099bd41de_***_Jeffrey Stephens |
| author |
Jeffrey Stephens |
| author2 |
Zien Zhou Meg J. Jardine Qiang Li Brendon L. Neuen Christopher P. Cannon Dick de Zeeuw Robert Edwards Adeera Levin Kenneth W. Mahaffey Vlado Perkovic Bruce Neal Richard I. Lindley Rodolfo Andres Ahuad Guerrero Diego Aizenberg Juan Pablo Albisu Andres Alvarisqueta Ines Bartolacci Mario Alberto Berli Anselmo Bordonava Pedro Calella Maria Cecilia Cantero Luis Rodolfo Cartasegna Esteban Cercos Gabriela Cecilia Coloma Hugo Colombo Victor Commendatore Jesus Cuadrado Carlos Alberto Cuneo Ana Maria Cusumano Walter Guillermo Douthat Ricardo Dario Dran Eduardo Farias Maria Florencia Fernandez Hernan Finkelstein Guillermo Fragale Jose Osvaldo Fretes Nestor Horacio Garcia Anibal Gastaldi Elizabeth Gelersztein Jorge Archibaldo Glenny Joaquin Pablo Gonzalez Patricia del Carmen Gonzalez Colaso Claudia Goycoa Gustavo Cristian Greloni Adrian Guinsburg Sonia Hermida Luis Isaias Juncos Maria Isabel Klyver Florencia Kraft Fernando Krynski Paulina Virginia Lanchiotti Ricardo Alfonso Leon de la Fuente Nora Marchetta Pablo Mele Silvia Nicolai Pablo Antonio Novoa Silvia Ines Orio Fabian Otreras Alejandra Oviedo Pablo Raffaele Jorge Hector Resk Lucas Rista Nelson Rodriguez Papini Jorgelina Sala Juan Carlos Santos Lilia Beatriz Schiavi Horacio Sessa Tomas Smith Casabella Maria Rosa Ulla Maria Valdez Augusto Vallejos Adriana Villarino Virginia Esther Visco Alfredo Wassermann Cesar Javier Zaidman Ngai Wah Cheung Carolyn Droste Ian Fraser David Johnson Peak Mann Mah Kathy Nicholls David Packham Joseph Proietto Anthony Roberts Simon Roger Venessa Tsang Roberto Abrão Raduan Fernando Augusto Alves da Costa Celso Amodeo Luiz Alberto Andreotti Turatti Rachel Bregman Fernanda Cristina Camelo Sanches Luis Henrique Canani Antônio Roberto Chacra João Lindolfo Cunha Borges Sérgio Alberto Cunha Vêncio Roberto Jorge da Silva Franco Domingos d’Avila Evandro de Souza Portes Pedro de Souza Luciane Mônica Deboni Fadlo Fraige Filho Bruno Geloneze Neto Marcus Gomes Suely Keiko Kohara Elizete Keitel Jose Francisco Kerr Saraiva Hugo Roberto Kurtz Lisboa Fabiana Loss de Carvalho Contieri Rosângela Milagres Renan Montenegro Junior Claudia Moreira de Brito Miguel Nasser Hissa Ângela Regina Nazario Sabbag Irene Noronha Daniel Panarotto Roberto Pecoits Filho Márcio Antônio Pereira Wladmir Saporito Antonio Scafuto Scotton Tiago Schuch Roberto Simões de Almeida Cássio Slompo Ramos João Soares Felício Fernando Thomé Jean Carlo Tibes Hachmann Sérgio Yamada Cesar Yoiti Hayashida Tarissa Beatrice Zanata Petry Maria Teresa Zanella Viktoria Andreeva Angelina Angelova Stefan Dimitrov Veselka Genadieva Gabriela Genova-Hristova Kiril Hristozov Zdravko Kamenov Atanas Koundurdjiev Lachezar Lozanov Viktor Margaritov Boyan Nonchev Rangel Rangelov Alexander Shinkov Margarita Temelkova Ekaterina Velichkova Andrian Yakov Naresh Aggarwal Ronnie Aronson Harpreet Bajaj David Cherney Guy Chouinard James Conway Serge Cournoyer Gerald DaRoza Sacha De Serres François Dubé Ronald Goldenberg Anil Gupta Milan Gupta Sam Henein Hasnain Khandwala Lawrence Leiter François Madore Alan McMahon Norman Muirhead Vincent Pichette Remi Rabasa-Lhoret Andrew Steele Navdeep Tangri Ali Torshizi Vincent Woo Nadia Zalunardo María Alicia Fernández Montenegro Juan Gonzalo Godoy Jorquera Marcelo Medina Fariña Victor Saavedra Gajardo Margarita Vejar Nan Chen Qinkai Chen Shenglian Gan Yaozhong Kong Detian Li Wenge Li Xuemei Li Hongli Lin Jian Liu Weiping Lu Hong Mao Yan Ren Weihong Song Jiao Sun Lin Sun Ping Tu Guixia Wang Jinkui Yang Aiping Yin Xueqing Yu Minghui Zhao Hongguang Zheng Jose Luis Accini Mendoza Edgar Arcos Jorge Avendano Jorge Ernesto Andres Diaz Ruiz Luis Hernando Garcia Ortiz Alexander Gonzalez Eric Hernandez Triana Juan Diego Higuera Natalia Malaver Dora Inés Molina de Salazar Ricardo Rosero Monica Alexandra Terront Lozano Luis Valderrama Cometa Alex Valenzuela Ruben Dario Vargas Alonso Ivan Villegas Hernan Yupanqui Dagmar Bartaskova Petr Barton Jana Belobradkova Lenka Dohnalova Tomas Drasnar Richard Ferkl Katarina Halciakova Vera Klokocnikova Richard Kovar Jiri Lastuvka Martin Lukac Satu Pesickova Karel Peterka Jiri Pumprla Ivan Rychlik Frantisek Saudek Vladimir Tesar Martin Valis Pavel Weiner Stanislav Zemek Eric Alamartine Sophie Borot Bertrand Cariou Bertrand Dussol Jean-Pierre Fauvel Pierre Gourdy Alexandre Klein Yannick Le Meur Alfred Penfornis Ronan Roussel Pierre-Jean Saulnier Eric Thervet Philippe Zaoui Volker Burst Markus Faghih Grit Faulmann Hermann Haller Reinhold Jerwan-Keim Stephan Maxeiner Björn Paschen Georg Plassmann Ludger Rose Ronaldo Arturo Gonzalez Orellana Franklin Paul Haase Juan Pablo Moreira Diaz Luis Alberto Ramirez Roca Jose Antonio Sánchez Arenales José Vicente Sanchez Polo Erick Turcios Juarez Gyongyi Csecsei Botond Csiky Peter Danos Laszlo Deak Mihaly Dudas Eleonora Harcsa Katalin Keltai Sandor Keresztesi Krisztian Kiss Laszlo Konyves Lajos Major Margit Mileder Marta Molnar Janos Mucsi Tamas Oroszlan Ivan Ory Gyorgy Paragh Eva Peterfai Gizella Petro Katalin Revesz Robert Takacs Sandor Vangel Szilard Vasas Marianna Zsom Abraham Oomman Sree Bhushan Raju Deepak Dewan M. Edwin Fernando Natarajan Gopalakrishnan Noble Gracious Hansraj Alva Dinesh Jain C. B. Keshavamurthy Dinesh Khullar Manisha Sahay Jayameena Peringat Narayan Prasad K. Satyanarayana Rao Sreedhar Reddy Sreelatha Melemadathil Bhimavarapu Sudhakar Ramesh Chandra Vyasam Riccardo Bonadonna Pietro Castellino Antonio Ceriello Luca Chiovato Salvatore De Cosmo Luca De Nicola Giuseppe Derosa Alberto Di Carlo Graziano Di Cianni Giovanni Frascà Giorgio Fuiano Giovanni Gambaro Giacomo Garibotto Carlo Giorda Fabio Malberti Marcora Mandreoli Edoardo Mannucci Emanuela Orsi Piermarco Piatti Domenico Santoro Ferdinando Carlo Sasso Gaetano Serviddio Andrea Stella Roberto Trevisan Anna Maria Veronelli Luca Zanoli Hitoshi Akiyama Hiromi Aoki Akimichi Asano Tadashi Iitsuka Shizuo Kajiyama Susumu Kashine Toshio Kawada Takamoto Kodera Hiroshi Kono Kazunori Koyama Yasuro Kumeda Shozo Miyauchi Kazuyuki Mizuyama Tetsuji Niiya Hiroko Oishi Satoshi Ota Terue Sakakibara Masahiko Takai Osamu Tomonaga Mitsuru Tsujimoto Takashi Wada Masakiyo Wakasugi Yasushi Wakida Takayuki Watanabe Masayo Yamada Kazuhiro Yanagida Toshihiko Yanase Wataru Yumita Egle Gaupsiene Dalia Kozloviene Antanas Navickas Egle Urbanaviciene Rohana Abdul Ghani Khalid Abdul Kadir Norsiah Ali Mohd Daud Che Yusof Chye Lee Gan Mastura Ismail Wei Yen Kong Swee Win Lam Li Yuan Lee Soo Kun Lim Chek Loong Loh Anita Bhajan Manocha Kee Sing Ng Nik Nur Fatnoon Nik Ahmad Vanassa Ratnasingam Saiful Shahrizal Bin Shudim Paranthaman Vengadasalam Luis David Abraira Munoz Melchor Alpizar Salazar Juan Baas Cruz Mario Burgos Soto Jose Chevaile Ramos Alfredo Chew Wong Jose Ricardo Correa Rotter Tonatiu Diaz Escalante Favio Edmundo Enriquez Sosa Fernando Flores Lozano Luis Fernando Flota Cervera Paul Frenk Baron Cecilia Garcia Ballesteros Jose David Gomez Rangel Luis Enrique Herrera Jimenez Sergio Saul Irizar Santana Fernando Jimenez Flores Hugo Laviada Molina Rosa Isela Luna Ceballos Belia Martin del Campo Blanco Guadalupe Morales Franco Oscar Tarsicio Moreno Loza Cynthia Mustieles Rocha Gregorio Obrador Vera Ricardo Orozco Castellanos Juan Peralta Calcaneo Miguel Angel Reyes Rosano Hiromi Rodriguez Pattzi Juan Rosas Guzman Isabel Erika Rucker Joerg Sandra Berenice Saavedra Sanchez Jose Hector Sanchez Mijangos Pablo Serrano Sanson Juan Alfredo Tamayo y Orozco Eloisa Tellez Chavez Alejandro Valdes Cepeda Luis Venegas Carrillo Juan Villagordoa Mesa Rolando Zamarripa Escobedo John Baker Paul Noonan Russell Scott Robert Walker Edward Watson Michael Williams Simon Young Zaynab Abejuela Jeimeen Agra Grace Aquitania Clodoaido Caringal Rhea Severina Comia Lalaine Delos Santos Olivert Gomez Cecilia Jimeno Florence Santos Gerry Tan Marsha Tolentino Christy Yao Yvette Ethel Yap Ma. Dovie Lallaine Ygpuara Renata Bijata-Bronisz Lucyna Hotlos Andrzej Januszewicz Barbara Kaczmarek Anna Kaminska Lech Lazuka Andrzej Madej Stanislaw Mazur Dorota Mlodawska-Choluj Michal Nowicki Grazyna Orlowska-Kowalik Grazyna Popenda Barbara Rewerska Dariusz Sowinski Liliana Monica Angelescu Veronica Anghel Rodica-Ioana Avram Mihaela-Magdalena Busegeanu Adriana Cif Dana Cosma Carmen Crisan Luiza Despina Demian Ioana Emilia Ferariu Ildiko Halmagyi Nicolae Hancu Mircea Munteanu Doru Negru Adriana Gabriela Onaca Ligia Petrica Amorin Remus Popa Aurelian-Emil Ranetti Cristian Serafinceanu Cristina Toarba Alina Agafyina Olga Barbarash Olga Barysheva Daniil Chizhov Vladimir Dobronravov Alexander Dreval Irina Glinkina Elena Grineva Vladimir Khirmanov Elena Kolmakova Tatiana Koroleva Liudmila Kvitkova Viacheslav Marasaev Ashot Mkrtumyan Tatiana Morugova Galina Nagibovich Oleg Nagibovich Sergei Nedogoda Irina Osipova Tatiana Raskina Yulia Samoylova Olga Sazonova Minara Shamkhalova Elena Shutemova Yuriy Shwartz Oleg Uriasyev Sergey Vorobyev Anna Zateyshchikova Dmitry Zateyshshikov Tatyana Zykova Slobodan Antic Miodrag Djordjevic Aleksandra Kendereski Katarina Lalic Nebojsa Lalic Vesna Popovic-Radinovic Jana Babikova Olga Benusova Ingrid Buganova Jan Culak Andrej Dzupina Jana Dzuponova Peter Fulop Adriana Ilavska Emil Martinka Zuzana Ochodnicka Daniel Pella Iveta Smatanova Fayzal Ahmed Aysha Badat Johannes Breedt Lawrence Distiller Vimladhevi Govender Ravendran Govender Mukesh Joshi Jaco Jurgens Gulam Latiff Landman Lombard Mohamed Mookadam Nomangesi Ngcakani Hendrik Nortje Helena Oosthuizen Larisha Pillay-Ramaya Hans Prozesky Jeevren Reddy Paul Rheeder Mary Seeber Dong-Wan Chae Young Min Cho In-Kyung Jeong Sin Gon Kim Yeong Hoon Kim Hyuk-Sang Kwon Min Jeong Kwon Byung-Wan Lee JungEun Lee Moon-Kyu Lee Moon-Suk Nam Kook-Hwan Oh Cheol-Young Park Sun-Hee Park Kun Ho Yoon Pere Alvarez Garcia Luis Asmarats Mercadal Clara Barrios Fernando Cereto Castro Secundino Cigarran Guldris Marta Dominguez Lopez Jesus Egido de los Rios Gema Fernandez Fresnedo Antonio Galan Serrano Isabel Garcia Francisco Javier Gonzalez Martinez Jose Esteban Jodar Gimeno Manuel Lopez Mendoza Tamara Malek Marin Cristobal Morales Portillo Maria Antonia Munar Vila Manuel Muñoz Torres Javier Nieto Iglesias Jonay Pantoja Perez Merce Perez Vera Jose Mª Portoles Perez María Angustias Quesada Simón Rafael Simo Canonge Alfonso Soto Gonzalez Manel Terns Riera Francisco Jose Tinahones Madueno Mercedes Velo Plaza Chwen-Tzuei Chang Lee-Ming Chuang Te-Lin Hsia Chang-Hsun Hsieh Shang-Jyh Hwang Chih-Ching Lin Yung-Chuan Lu Wayne H-H Sheu Olga Barna Svitlana D. Bilyk Volodymyr Botsyurko Iryna Dudar Ivan Fushtey Olga Godlevska Oleksandr Golovchenko Olga Gyrina Anatoliy Kazmirchuk Mykola Kolesnyk Iuliia Komisarenko Oleksii Korzh Nonna Kravchun Oleg Legun Borys Mankovskyy Liliya Martynyuk Yuriy Mostovoy Nataliia Pashkovska Larysa Pererva Tetyana Pertseva Oleksandr Samoylov Ivan Smirnov Yevgeniya Svyshchenko Halyna Tomashkevych Ivan Topchii Nadiya Tryshchuk Vira Tseluyko Vadym Vizir Maryna Vlasenko Tetiana Zlova Liliia Zub Salah Abusnana Mohamed Railey Kamal Abouglila Paul Ainsworth Zishan Ali Vijayaraman Arutchelvam Maria Barnard Srikanth Bellary Emyr Davies Mark Davies Simon Davies Alison Dawson Mohsen El Kossi Patrick English Donald Fraser Luigi Gnudi Anthony Gunstone Timothy Hall Wasim Hanif Alan Jackson Andrew Johnson Franklin Joseph Singhan Krishnan Mick Kumwenda Iain MacDougall Paul Nixon Joseph O’Hare Sam Philip Shenaz Ramtoola Manish Saxena Davesh Sennik Godwin Simon Baldev Singh Jeffrey Stephens Anna Strzelecka Rehan Symonds Wayne Turner Mona Wahba John Wakeling David Wheeler Peter Winocour Joseph Abdallah Raied Abdullah Matthew Abramowitz Idalia Acosta Joseph Aiello Laura Akright Ayim Akyea-Djamson Rajendran Alappan Radica Alicic Amer Al-Karadsheh Dale Crawford Allison Carlos Arauz-Pacheco Shahabul Arfeen Ahmed Arif Moogali Arvind Naveen Atray Ahmed Awad George Bakris Peggy Barnhill Elizabeth Barranco Carlos Barrera Matthew Beacom Venkata Behara Diogo Belo Rhonda Bentley-Lewis Ramon Berenguer Lidia Bermudez Marializa Bernardo Mihaela Biscoveanu Cynthia Bowman-Stroud Donald Brandon Osvaldo Brusco Robert Busch Yamil Canaan Alicia Chilito Tom Christensen Cynthia Christiano Elena Christofides Caroucel Chuateco Kenneth Cohen Robert Cohen Debbie Cohen-Stein Charles Cook Daniel Coyne Nizar Daboul Riad Darwish Adarsh Daswani Kenneth Deck Cyrus Desouza Devasmita Dev Monika Dhillon Sohan Dua Frank Eder Ana Maria Elosegui Mohamed El-Shahawy John Ervin Alberto Esquenazi John Evans Steven Fishbane Juan Frias Eugenia Galindo-Ramos Claude Galphin Adline Ghazi Enrique Gonzalez David Gorson Anupama Gowda Barbara Greco Stephen Grubb Rakesh Gulati Jamal Hammoud Stuart Handelsman Israel Hartman Kenneth Hershon Daniel Hiser George Hon Radu Jacob Maria Jaime Aamir Jamal Charles Kaupke Gerald Keightley Elizabeth Kern Rakhi Khanna Zeid Khitan Sun Kim Nelson Kopyt Csaba Kovesdy Gopal Krishna Jeffrey (Jay) Kropp Amrendra Kumar Jayant Kumar Neil Kumar Jorge Kusnir Wendy Lane Mary Lawrence Lawrence Lehrner John Lentz Dennis Levinson Derek Lewis Kenneth Liss Andreas Maddux Hiralal Maheshwari Sreedhar Mandayam Isam Marar Bhasker Mehta John Middleton Jorge Mordujovich Ramon Moreda Moustafa Moustafa Samuel Mujica Trenche Mohanram Narayanan Javier Narvarte Tareq Nassar George Newman Brian Nichol Philip Nicol Josier Nisnisan A. Kaldun Nossuli Chamberlain Obialo Sarah Olelewe Michael Oliver Andrew O’Shaughnessy John Padron Rohit Pankhaniya Reginald Parker Devesh Patel Gnyandev Patel Nina Patel Humberto Pavon Armando Perez Carlos Perez Alan Perlman Karlton Pettis Walter Pharr Andrea Phillips Raman Purighalla Luis Quesada-Suarez Rajiv Ranjan Sanjeev Rastogi Jakkidi Reddy Marc Rendell Lisa Rich Michael Robinson Hector Rodriguez Sylvia Rosas Fadi Saba Rallabhandi Sankaram Ravi Sarin Robert Schreiman David Scott Mohamed Sekkarie John Sensenbrenner Muhammad Shakeel Michael Shanik Sylvia Shaw Stephen Smith Richard Solomon Amy Sprague Leslie Spry Pusadee Suchinda Senan Sultan Prasanth Surampudi Sherry Sussman Anjanette Tan Antonio Terrelonge Michael Thompson Fernando Trespalacios Bruce Trippe Pilar Trueba Marcel Twahirwa John Updegrove Peter Van Buren Mark Vannorsdall Freemu Varghese Pedro Velasquez-Mieyer Sailaja Ventrapragada Goga Vukotic Khurram Wadud Mark Warren Henry Watson Ronald Watts Daniel Weiner James Welker Jean Welsh Shelley Williams Michelle Zaniewski-Singh Jeffrey Stephens |
| format |
Journal article |
| container_title |
Stroke |
| container_volume |
52 |
| container_issue |
5 |
| container_start_page |
1545 |
| publishDate |
2021 |
| institution |
Swansea University |
| issn |
0039-2499 1524-4628 |
| doi_str_mv |
10.1161/strokeaha.120.031623 |
| publisher |
Ovid Technologies (Wolters Kluwer Health) |
| college_str |
Faculty of Medicine, Health and Life Sciences |
| hierarchytype |
|
| hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
| hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
| hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
| hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
| department_str |
Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science |
| document_store_str |
1 |
| active_str |
0 |
| description |
Background and Purpose:Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.Methods:CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.Results:In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55–1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61–1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19–1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20–1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53–1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82–1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89–1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30–0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49–1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71–0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31–0.79]).Conclusions:Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. |
| published_date |
2021-05-01T14:20:49Z |
| _version_ |
1802748820609564672 |
| score |
11.037603 |