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Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis

Massimiliano Calabrese Orcid Logo, Paolo Preziosa Orcid Logo, Antonio Scalfari Orcid Logo, Elisa Colato, Damiano Marastoni, Martina Absinta, Marco Battaglini, Nicola De Stefano, Massimiliano Di Filippo Orcid Logo, Simon Hametner, Owain Howell Orcid Logo, Matilde Inglese, Hans Lassmann, Roland Martin, Richard Nicholas Orcid Logo, Richard Reynolds, Maria A. Rocca Orcid Logo, Agnese Tamanti, Marco Vercellino, Luisa Maria Villar Orcid Logo, Massimo Filippi Orcid Logo, Roberta Magliozzi Orcid Logo

Annals of Neurology, Volume: 96, Issue: 1, Pages: 1 - 20

Swansea University Author: Owain Howell Orcid Logo

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DOI (Published version): 10.1002/ana.26913

Abstract

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability, which proceeds relentlessly and independently of clinical and radiological relapses...

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Published in: Annals of Neurology
ISSN: 0364-5134 1531-8249
Published: Wiley 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa66032
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spelling 2024-10-17T14:58:24.7114733 v2 66032 2024-04-11 Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis 58c995486fc93a242b987640b692db8c 0000-0003-2157-9157 Owain Howell Owain Howell true false 2024-04-11 MEDS Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability, which proceeds relentlessly and independently of clinical and radiological relapses (PIRA). The complex system of pathological events driving “chronic” worsening is likely linked with the early accumulation of compartmentalized inflammation within the central nervous system as well as insufficient repair phenomena and mitochondrial failure. These mechanisms are partially lesion-independent and differ from those causing clinical relapses and the formation of new focal demyelinating lesions; they lead to neuroaxonal dysfunction and death, myelin loss, glia alterations, and finally, a neuronal network dysfunction outweighing central nervous system (CNS) compensatory mechanisms. This review aims to provide an overview of the state of the art of neuropathological, immunological, and imaging knowledge about the mechanisms underlying the smoldering disease activity, focusing on possible early biomarkers and their translation into clinical practice. Journal Article Annals of Neurology 96 1 1 20 Wiley 0364-5134 1531-8249 1 7 2024 2024-07-01 10.1002/ana.26913 Review COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee 2024-10-17T14:58:24.7114733 2024-04-11T08:51:49.3141321 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Massimiliano Calabrese 0000-0002-3362-7403 1 Paolo Preziosa 0000-0002-7826-0019 2 Antonio Scalfari 0000-0002-7757-0293 3 Elisa Colato 4 Damiano Marastoni 5 Martina Absinta 6 Marco Battaglini 7 Nicola De Stefano 8 Massimiliano Di Filippo 0000-0002-2645-7477 9 Simon Hametner 10 Owain Howell 0000-0003-2157-9157 11 Matilde Inglese 12 Hans Lassmann 13 Roland Martin 14 Richard Nicholas 0000-0003-0414-1225 15 Richard Reynolds 16 Maria A. Rocca 0000-0003-2358-4320 17 Agnese Tamanti 18 Marco Vercellino 19 Luisa Maria Villar 0000-0002-9067-3668 20 Massimo Filippi 0000-0002-5485-0479 21 Roberta Magliozzi 0000-0001-8284-7763 22 66032__30216__419d7864db5c48218ca3d6cf5518fe7a.pdf 66032.pdf 2024-05-01T14:24:58.5888395 Output 15332175 application/pdf Version of Record true This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivsLicense. true eng http://creativecommons.org/licenses/by-nc- nd/4.0/
title Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
spellingShingle Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
Owain Howell
title_short Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
title_full Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
title_fullStr Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
title_full_unstemmed Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
title_sort Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
author_id_str_mv 58c995486fc93a242b987640b692db8c
author_id_fullname_str_mv 58c995486fc93a242b987640b692db8c_***_Owain Howell
author Owain Howell
author2 Massimiliano Calabrese
Paolo Preziosa
Antonio Scalfari
Elisa Colato
Damiano Marastoni
Martina Absinta
Marco Battaglini
Nicola De Stefano
Massimiliano Di Filippo
Simon Hametner
Owain Howell
Matilde Inglese
Hans Lassmann
Roland Martin
Richard Nicholas
Richard Reynolds
Maria A. Rocca
Agnese Tamanti
Marco Vercellino
Luisa Maria Villar
Massimo Filippi
Roberta Magliozzi
format Journal article
container_title Annals of Neurology
container_volume 96
container_issue 1
container_start_page 1
publishDate 2024
institution Swansea University
issn 0364-5134
1531-8249
doi_str_mv 10.1002/ana.26913
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
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description Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability, which proceeds relentlessly and independently of clinical and radiological relapses (PIRA). The complex system of pathological events driving “chronic” worsening is likely linked with the early accumulation of compartmentalized inflammation within the central nervous system as well as insufficient repair phenomena and mitochondrial failure. These mechanisms are partially lesion-independent and differ from those causing clinical relapses and the formation of new focal demyelinating lesions; they lead to neuroaxonal dysfunction and death, myelin loss, glia alterations, and finally, a neuronal network dysfunction outweighing central nervous system (CNS) compensatory mechanisms. This review aims to provide an overview of the state of the art of neuropathological, immunological, and imaging knowledge about the mechanisms underlying the smoldering disease activity, focusing on possible early biomarkers and their translation into clinical practice.
published_date 2024-07-01T14:38:44Z
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