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Higher risk of cerebral palsy, seizures/epilepsy, visual‐ and hearing impairments, cancer, injury and child abuse in children with congenital anomalies: Data from the EUROlinkCAT study
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Joan Morris,
Maria Loane,
Elisa Ballardini,
Laia Barrachina‐Bonet,
Clara Cavero‐Carbonell,
Alessio Coi,
Mika Gissler,
Joanne Given,
Anna Heino,
Sue Jordan ,
Amanda Neville,
Michele Santoro,
Joachim Tan,
David Tucker,
Diana Wellesley,
Ester Garne ,
Mads Damkjaer
Acta Paediatrica, Volume: 113, Issue: 5, Pages: 1024 - 1031
Swansea University Author:
Sue Jordan
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DOI (Published version): 10.1111/apa.17136
Abstract
AimThe aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.MethodsThis is a population-based data linkage cohort study linking information...
| Published in: | Acta Paediatrica |
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| ISSN: | 0803-5253 1651-2227 |
| Published: |
Wiley
2024
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa65968 |
| Abstract: |
AimThe aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.MethodsThis is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan–Meier survival estimates.ResultsChildren with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5–15.1) for cerebral palsy, 2.5 (95% CI 2.4–2.6) for seizures/epilepsy, 40.8 (95% CI 33.2–50.2) for visual impairments, 10.0 (95% CI 9.2–10.9) for hearing loss, 3.6 (95% CI 3.2–4.2) for cancer, 1.5 (95% CI 1.4–1.5) for injuries/poisoning and 2.4 (95% CI 1.7–3.4) for child abuse.ConclusionChildren with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children. |
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| Keywords: |
cerebral palsy; congenital anomalies; epilepsy; injuries and poisoning |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
European Union. Grant Number: 733001 |
| Issue: |
5 |
| Start Page: |
1024 |
| End Page: |
1031 |