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Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study

Mads Damkjær Orcid Logo, Ester Garne Orcid Logo, Maria Loane Orcid Logo, Stine K. Urhoj Orcid Logo, Elisa Ballardini Orcid Logo, Clara Cavero‐Carbonell Orcid Logo, Alessio Coi Orcid Logo, Laura García‐Villodre Orcid Logo, Joanne Given Orcid Logo, Mika Gissler Orcid Logo, Anna Heino, Sue Jordan Orcid Logo, Elizabeth Limb Orcid Logo, Amanda J Neville, Anna Pierini Orcid Logo, Anke Rissmann Orcid Logo, Joachim Tan, Ieuan Scanlon, Joan K Morris Orcid Logo

Journal of the American Heart Association, Volume: 12, Issue: 24

Swansea University Authors: Sue Jordan Orcid Logo, Ieuan Scanlon

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DOI (Published version): 10.1161/jaha.122.029871

Abstract

BackgroundThe purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30‐day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their first 5 years of life.Methods and ResultsThis was a popul...

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Published in: Journal of the American Heart Association
ISSN: 2047-9980
Published: Ovid Technologies (Wolters Kluwer Health) 2023
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>65966</id><entry>2024-04-04</entry><title>Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study</title><swanseaauthors><author><sid>24ce9db29b4bde1af4e83b388aae0ea1</sid><ORCID>0000-0002-5691-2987</ORCID><firstname>Sue</firstname><surname>Jordan</surname><name>Sue Jordan</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>9fcb224c6bd804a4d41a2a8570a71185</sid><firstname>Ieuan</firstname><surname>Scanlon</surname><name>Ieuan Scanlon</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-04-04</date><deptcode>HSOC</deptcode><abstract>BackgroundThe purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30‐day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their first 5 years of life.Methods and ResultsThis was a population‐based data linkage cohort study linking information from 9 European congenital anomaly registries to vital statistics and hospital databases. Data were extracted for 5693 children with sCHDs born from 1995 to 2004. Subgroup analyses were performed for specific types of sCHD. Children with sCHDs underwent their first surgical intervention at a median age of 3.6 (95% CI, 2.6–4.5) weeks. The timing of the first surgery for most subtypes of sCHD was consistent across Europe. In the first 5 years of life, children with hypoplastic left heart underwent the most cardiac surgeries, with a median of 4.4 (95% CI, 3.1–5.6). The 30‐day postoperative mortality rate in children aged &lt;1 year ranged from 1.1% (95% CI, 0.5%–2.1%) for tetralogy of Fallot to 23% (95% CI, 12%–37%) for Ebstein anomaly. The 30‐day postoperative mortality rate was highest for children undergoing surgery in the first month of life. Overall 5‐year survival for sCHD was &lt;90% for all sCHDs, except transposition of the great arteries, tetralogy of Fallot, and coarctation of the aorta.ConclusionsThere were no major differences among the 9 regions in the timing, 30‐day postoperative mortality rate, and number of operations performed for sCHD. Despite an overall good prognosis for most congenital heart defects, some lesions were still associated with substantial postoperative death.</abstract><type>Journal Article</type><journal>Journal of the American Heart Association</journal><volume>12</volume><journalNumber>24</journalNumber><paginationStart/><paginationEnd/><publisher>Ovid Technologies (Wolters Kluwer Health)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2047-9980</issnElectronic><keywords>cardiac surgery; congenital heart defects; pediatric cardiology</keywords><publishedDay>19</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-12-19</publishedDate><doi>10.1161/jaha.122.029871</doi><url/><notes/><college>COLLEGE NANME</college><department>Health and Social Care School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HSOC</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>horizon 733001</funders><projectreference/><lastEdited>2024-05-29T13:57:00.7121964</lastEdited><Created>2024-04-04T16:34:28.3652989</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Nursing</level></path><authors><author><firstname>Mads</firstname><surname>Damkjær</surname><orcid>0000-0001-7410-8573</orcid><order>1</order></author><author><firstname>Ester</firstname><surname>Garne</surname><orcid>0000-0003-0430-2594</orcid><order>2</order></author><author><firstname>Maria</firstname><surname>Loane</surname><orcid>0000-0002-1206-3637</orcid><order>3</order></author><author><firstname>Stine K.</firstname><surname>Urhoj</surname><orcid>0000-0002-2069-9723</orcid><order>4</order></author><author><firstname>Elisa</firstname><surname>Ballardini</surname><orcid>0000-0002-8813-1835</orcid><order>5</order></author><author><firstname>Clara</firstname><surname>Cavero‐Carbonell</surname><orcid>0000-0002-4858-6456</orcid><order>6</order></author><author><firstname>Alessio</firstname><surname>Coi</surname><orcid>0000-0002-9816-3144</orcid><order>7</order></author><author><firstname>Laura</firstname><surname>García‐Villodre</surname><orcid>0000-0001-9094-7107</orcid><order>8</order></author><author><firstname>Joanne</firstname><surname>Given</surname><orcid>0000-0003-4921-1944</orcid><order>9</order></author><author><firstname>Mika</firstname><surname>Gissler</surname><orcid>0000-0001-8254-7525</orcid><order>10</order></author><author><firstname>Anna</firstname><surname>Heino</surname><order>11</order></author><author><firstname>Sue</firstname><surname>Jordan</surname><orcid>0000-0002-5691-2987</orcid><order>12</order></author><author><firstname>Elizabeth</firstname><surname>Limb</surname><orcid>0000-0003-0830-7376</orcid><order>13</order></author><author><firstname>Amanda J</firstname><surname>Neville</surname><order>14</order></author><author><firstname>Anna</firstname><surname>Pierini</surname><orcid>0000-0003-3321-9343</orcid><order>15</order></author><author><firstname>Anke</firstname><surname>Rissmann</surname><orcid>0000-0002-9437-2790</orcid><order>16</order></author><author><firstname>Joachim</firstname><surname>Tan</surname><order>17</order></author><author><firstname>Ieuan</firstname><surname>Scanlon</surname><order>18</order></author><author><firstname>Joan K</firstname><surname>Morris</surname><orcid>0000-0002-7164-612x</orcid><order>19</order></author></authors><documents><document><filename>65966__30476__607f9755a33b4d5395acd404f9d4d8c5.pdf</filename><originalFilename>65966.VoR.pdf</originalFilename><uploaded>2024-05-29T13:45:26.1823394</uploaded><type>Output</type><contentLength>332762</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2023 The Authors. 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spelling v2 65966 2024-04-04 Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study 24ce9db29b4bde1af4e83b388aae0ea1 0000-0002-5691-2987 Sue Jordan Sue Jordan true false 9fcb224c6bd804a4d41a2a8570a71185 Ieuan Scanlon Ieuan Scanlon true false 2024-04-04 HSOC BackgroundThe purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30‐day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their first 5 years of life.Methods and ResultsThis was a population‐based data linkage cohort study linking information from 9 European congenital anomaly registries to vital statistics and hospital databases. Data were extracted for 5693 children with sCHDs born from 1995 to 2004. Subgroup analyses were performed for specific types of sCHD. Children with sCHDs underwent their first surgical intervention at a median age of 3.6 (95% CI, 2.6–4.5) weeks. The timing of the first surgery for most subtypes of sCHD was consistent across Europe. In the first 5 years of life, children with hypoplastic left heart underwent the most cardiac surgeries, with a median of 4.4 (95% CI, 3.1–5.6). The 30‐day postoperative mortality rate in children aged <1 year ranged from 1.1% (95% CI, 0.5%–2.1%) for tetralogy of Fallot to 23% (95% CI, 12%–37%) for Ebstein anomaly. The 30‐day postoperative mortality rate was highest for children undergoing surgery in the first month of life. Overall 5‐year survival for sCHD was <90% for all sCHDs, except transposition of the great arteries, tetralogy of Fallot, and coarctation of the aorta.ConclusionsThere were no major differences among the 9 regions in the timing, 30‐day postoperative mortality rate, and number of operations performed for sCHD. Despite an overall good prognosis for most congenital heart defects, some lesions were still associated with substantial postoperative death. Journal Article Journal of the American Heart Association 12 24 Ovid Technologies (Wolters Kluwer Health) 2047-9980 cardiac surgery; congenital heart defects; pediatric cardiology 19 12 2023 2023-12-19 10.1161/jaha.122.029871 COLLEGE NANME Health and Social Care School COLLEGE CODE HSOC Swansea University Another institution paid the OA fee horizon 733001 2024-05-29T13:57:00.7121964 2024-04-04T16:34:28.3652989 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Mads Damkjær 0000-0001-7410-8573 1 Ester Garne 0000-0003-0430-2594 2 Maria Loane 0000-0002-1206-3637 3 Stine K. Urhoj 0000-0002-2069-9723 4 Elisa Ballardini 0000-0002-8813-1835 5 Clara Cavero‐Carbonell 0000-0002-4858-6456 6 Alessio Coi 0000-0002-9816-3144 7 Laura García‐Villodre 0000-0001-9094-7107 8 Joanne Given 0000-0003-4921-1944 9 Mika Gissler 0000-0001-8254-7525 10 Anna Heino 11 Sue Jordan 0000-0002-5691-2987 12 Elizabeth Limb 0000-0003-0830-7376 13 Amanda J Neville 14 Anna Pierini 0000-0003-3321-9343 15 Anke Rissmann 0000-0002-9437-2790 16 Joachim Tan 17 Ieuan Scanlon 18 Joan K Morris 0000-0002-7164-612x 19 65966__30476__607f9755a33b4d5395acd404f9d4d8c5.pdf 65966.VoR.pdf 2024-05-29T13:45:26.1823394 Output 332762 application/pdf Version of Record true © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
spellingShingle Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
Sue Jordan
Ieuan Scanlon
title_short Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
title_full Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
title_fullStr Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
title_full_unstemmed Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
title_sort Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study
author_id_str_mv 24ce9db29b4bde1af4e83b388aae0ea1
9fcb224c6bd804a4d41a2a8570a71185
author_id_fullname_str_mv 24ce9db29b4bde1af4e83b388aae0ea1_***_Sue Jordan
9fcb224c6bd804a4d41a2a8570a71185_***_Ieuan Scanlon
author Sue Jordan
Ieuan Scanlon
author2 Mads Damkjær
Ester Garne
Maria Loane
Stine K. Urhoj
Elisa Ballardini
Clara Cavero‐Carbonell
Alessio Coi
Laura García‐Villodre
Joanne Given
Mika Gissler
Anna Heino
Sue Jordan
Elizabeth Limb
Amanda J Neville
Anna Pierini
Anke Rissmann
Joachim Tan
Ieuan Scanlon
Joan K Morris
format Journal article
container_title Journal of the American Heart Association
container_volume 12
container_issue 24
publishDate 2023
institution Swansea University
issn 2047-9980
doi_str_mv 10.1161/jaha.122.029871
publisher Ovid Technologies (Wolters Kluwer Health)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
document_store_str 1
active_str 0
description BackgroundThe purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30‐day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their first 5 years of life.Methods and ResultsThis was a population‐based data linkage cohort study linking information from 9 European congenital anomaly registries to vital statistics and hospital databases. Data were extracted for 5693 children with sCHDs born from 1995 to 2004. Subgroup analyses were performed for specific types of sCHD. Children with sCHDs underwent their first surgical intervention at a median age of 3.6 (95% CI, 2.6–4.5) weeks. The timing of the first surgery for most subtypes of sCHD was consistent across Europe. In the first 5 years of life, children with hypoplastic left heart underwent the most cardiac surgeries, with a median of 4.4 (95% CI, 3.1–5.6). The 30‐day postoperative mortality rate in children aged <1 year ranged from 1.1% (95% CI, 0.5%–2.1%) for tetralogy of Fallot to 23% (95% CI, 12%–37%) for Ebstein anomaly. The 30‐day postoperative mortality rate was highest for children undergoing surgery in the first month of life. Overall 5‐year survival for sCHD was <90% for all sCHDs, except transposition of the great arteries, tetralogy of Fallot, and coarctation of the aorta.ConclusionsThere were no major differences among the 9 regions in the timing, 30‐day postoperative mortality rate, and number of operations performed for sCHD. Despite an overall good prognosis for most congenital heart defects, some lesions were still associated with substantial postoperative death.
published_date 2023-12-19T13:57:00Z
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score 11.017731

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