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A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms

Alberto Coccarelli Orcid Logo, Raoul van Loon Orcid Logo, Aichi Chien

Annals of Biomedical Engineering, Volume: 52, Pages: 2000 - 2012

Swansea University Authors: Alberto Coccarelli Orcid Logo, Raoul van Loon Orcid Logo

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DOI (Published version): 10.1007/s10439-024-03493-1

Abstract

Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related...

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Published in: Annals of Biomedical Engineering
ISSN: 0090-6964 1573-9686
Published: Springer Nature 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa65905
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spelling v2 65905 2024-03-26 A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 880b30f90841a022f1e5bac32fb12193 0000-0003-3581-5827 Raoul van Loon Raoul van Loon true false 2024-03-26 ACEM Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related with intracranial aneurysm (IA) growth. In this work, we introduced a novel reduced-order modelling strategy for the systematic quantification of longitudinal blood flow changes across the whole CoW in patients with stable and unstable/growing aneurysm. Magnetic Resonance Angiography (MRA) images were converted into one-dimensional (1-D) vessel networks through a semi-automated procedure, with a level of geometric reconstruction accuracy controlled by user-dependent parameters. The proposed pipeline was used to systematically analyse longitudinal haemodynamic changes in seven different clinical cases. Our preliminary simulation results indicate that growing aneurysms are not necessarily associated with significant changes in mean flow over time. A concise sensitivity analysis also shed light on which modelling aspects need to be further characterized in order to have reliable patient-specific predictions. This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms. Journal Article Annals of Biomedical Engineering 52 2000 2012 Springer Nature 0090-6964 1573-9686 Circle of Willis; Aneurysm development; Cerebral vasculature; One-dimensional blood flow dynamics; Longitudinal study 1 8 2024 2024-08-01 10.1007/s10439-024-03493-1 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University SU Library paid the OA fee (TA Institutional Deal) Aichi Chien acknowledges the funding provided by Foundation for the National Institutes of Health (R01HL152270). 2024-10-04T14:33:56.7784797 2024-03-26T09:16:25.1960296 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Raoul van Loon 0000-0003-3581-5827 2 Aichi Chien 3 65905__30024__acc5c8f8308d49c5b2e9ed7bc7bc5d71.pdf 65905.VOR.pdf 2024-04-15T17:19:02.7408474 Output 2791833 application/pdf Version of Record true © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
spellingShingle A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
Alberto Coccarelli
Raoul van Loon
title_short A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
title_full A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
title_fullStr A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
title_full_unstemmed A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
title_sort A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
880b30f90841a022f1e5bac32fb12193
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
880b30f90841a022f1e5bac32fb12193_***_Raoul van Loon
author Alberto Coccarelli
Raoul van Loon
author2 Alberto Coccarelli
Raoul van Loon
Aichi Chien
format Journal article
container_title Annals of Biomedical Engineering
container_volume 52
container_start_page 2000
publishDate 2024
institution Swansea University
issn 0090-6964
1573-9686
doi_str_mv 10.1007/s10439-024-03493-1
publisher Springer Nature
college_str Faculty of Science and Engineering
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hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
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description Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related with intracranial aneurysm (IA) growth. In this work, we introduced a novel reduced-order modelling strategy for the systematic quantification of longitudinal blood flow changes across the whole CoW in patients with stable and unstable/growing aneurysm. Magnetic Resonance Angiography (MRA) images were converted into one-dimensional (1-D) vessel networks through a semi-automated procedure, with a level of geometric reconstruction accuracy controlled by user-dependent parameters. The proposed pipeline was used to systematically analyse longitudinal haemodynamic changes in seven different clinical cases. Our preliminary simulation results indicate that growing aneurysms are not necessarily associated with significant changes in mean flow over time. A concise sensitivity analysis also shed light on which modelling aspects need to be further characterized in order to have reliable patient-specific predictions. This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms.
published_date 2024-08-01T14:33:56Z
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