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The effect of particle size on drug bioavailability in various parts of the body

Zi Hong Mok Orcid Logo

Pharmaceutical Science Advances, Volume: 2, Start page: 100031

Swansea University Author: Zi Hong Mok Orcid Logo

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DOI (Published version): 10.1016/j.pscia.2023.100031

Abstract

Multiple mechanisms are involved in driving the efficacy of drug delivery. Drug particle size is one of the challenges as particles need to be delivered from the external environment, into the circulation or interstitial fluid and transiting the cell membranes for cellular internalisation. Small par...

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Published in: Pharmaceutical Science Advances
ISSN: 2773-2169
Published: Elsevier BV 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa65724
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first_indexed 2024-03-01T14:57:10Z
last_indexed 2024-03-01T14:57:10Z
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spelling v2 65724 2024-03-01 The effect of particle size on drug bioavailability in various parts of the body 4a0b8a58c748d6a2c87a54f263f4d397 0000-0002-1231-5048 Zi Hong Mok Zi Hong Mok true false 2024-03-01 PHAR Multiple mechanisms are involved in driving the efficacy of drug delivery. Drug particle size is one of the challenges as particles need to be delivered from the external environment, into the circulation or interstitial fluid and transiting the cell membranes for cellular internalisation. Small particles are presumably easier to be internalised, yet they are not easy to retain as they are subject to fast clearance. Big particles do not cross biological barriers as easily, but their size distribution is easier to be controlled. Because of the various routes of administration, the size range of these particles will also need to be catered for the anatomical, biological, and dynamic barriers involved. This review hopes to provide an insight into the range of particle size that has been engineered for drug delivery via various routes of administration of the body, such as to cross the epithelium of gastrointestinal tract, lungs, skin, blood-brain barrier, kidney and liver, the eye, nose, and ear, the cancer tumour matrix and into the muscles. While successful drug delivery also depends on the material properties of the delivery systems and the bio/nano interface related properties, this review focuses on the importance of particle size for enhancing bioavailability at the various organs of the body. Journal Article Pharmaceutical Science Advances 2 100031 Elsevier BV 2773-2169 Particle size; Nanoparticles; Microparticles; Absorption; Internalisation 1 12 2024 2024-12-01 10.1016/j.pscia.2023.100031 COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University Another institution paid the OA fee Shandong University 2024-04-25T22:12:23.9974529 2024-03-01T14:55:25.6990894 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Zi Hong Mok 0000-0002-1231-5048 1 65724__29623__c973540bebd340d5b56db2cc895425a7.pdf 65724.pdf 2024-03-05T08:51:28.9563719 Output 2566740 application/pdf Version of Record true © 2023 The Author. This is an open access article under the CC BY license. true eng https://creativecommons.org/licenses/by/4.0/
title The effect of particle size on drug bioavailability in various parts of the body
spellingShingle The effect of particle size on drug bioavailability in various parts of the body
Zi Hong Mok
title_short The effect of particle size on drug bioavailability in various parts of the body
title_full The effect of particle size on drug bioavailability in various parts of the body
title_fullStr The effect of particle size on drug bioavailability in various parts of the body
title_full_unstemmed The effect of particle size on drug bioavailability in various parts of the body
title_sort The effect of particle size on drug bioavailability in various parts of the body
author_id_str_mv 4a0b8a58c748d6a2c87a54f263f4d397
author_id_fullname_str_mv 4a0b8a58c748d6a2c87a54f263f4d397_***_Zi Hong Mok
author Zi Hong Mok
author2 Zi Hong Mok
format Journal article
container_title Pharmaceutical Science Advances
container_volume 2
container_start_page 100031
publishDate 2024
institution Swansea University
issn 2773-2169
doi_str_mv 10.1016/j.pscia.2023.100031
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
document_store_str 1
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description Multiple mechanisms are involved in driving the efficacy of drug delivery. Drug particle size is one of the challenges as particles need to be delivered from the external environment, into the circulation or interstitial fluid and transiting the cell membranes for cellular internalisation. Small particles are presumably easier to be internalised, yet they are not easy to retain as they are subject to fast clearance. Big particles do not cross biological barriers as easily, but their size distribution is easier to be controlled. Because of the various routes of administration, the size range of these particles will also need to be catered for the anatomical, biological, and dynamic barriers involved. This review hopes to provide an insight into the range of particle size that has been engineered for drug delivery via various routes of administration of the body, such as to cross the epithelium of gastrointestinal tract, lungs, skin, blood-brain barrier, kidney and liver, the eye, nose, and ear, the cancer tumour matrix and into the muscles. While successful drug delivery also depends on the material properties of the delivery systems and the bio/nano interface related properties, this review focuses on the importance of particle size for enhancing bioavailability at the various organs of the body.
published_date 2024-12-01T22:12:24Z
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score 11.013148

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