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Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches

Georgeta Vulpe, Guoyi Liu, Sam Oakley, Guanghao Yang, Arjun Ajith Mohan Orcid Logo, Mark Waldron Orcid Logo, Sanjiv Sharma Orcid Logo

Lab on a Chip, Volume: 24, Issue: 7, Pages: 2039 - 2048

Swansea University Authors: Georgeta Vulpe, Guoyi Liu, Sam Oakley, Guanghao Yang, Arjun Ajith Mohan Orcid Logo, Mark Waldron Orcid Logo, Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1039/d4lc00073k

Abstract

The advent of digital technologies has spurred the development of wearable sensing devices marking a significant shift in obtaining real-time physiological information. The principal objective is to transition from blood-centric monitoring to minimally invasive modalities, which will enable movement...

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Published in: Lab on a Chip
ISSN: 1473-0197 1473-0189
Published: Royal Society of Chemistry (RSC) 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa65673
first_indexed 2024-02-22T17:41:33Z
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The principal objective is to transition from blood-centric monitoring to minimally invasive modalities, which will enable movement from specialised settings to more accessible environments such as the practices of general practitioners or even home settings. While subcutaneously implanted continuous monitoring devices have demonstrated this transition, detection of analytes from sample matrices like skin interstitial fluid (ISF), is a frontier that offers attractive minimally invasive routes for detection of biomarkers. This manuscript presents a comprehensive overview of our work in subdermal wearable biosensing patches for the simultaneous monitoring of glucose and lactate from ISF in ambulatory conditions. The performance of the subdermal wearable glucose monitoring patch was evaluated over a duration of three days, which is the longest reported duration reported till date. The subdermal wearable lactate sensing patch was worn for the duration of the exercise. Our findings highlight a critical observation that biofouling effects become apparent after a 24-h period. The data presented in this manuscript extends on the knowledge in the areas of continuous metabolite monitoring by introducing multifunctional polyphenol polymer films that can be used for both glucose and lactate monitoring with appropriate modifications. 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spelling 2024-04-03T12:24:29.9298719 v2 65673 2024-02-22 Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches d1d5815c60d63534a10a81489255c681 Georgeta Vulpe Georgeta Vulpe true false 636ea7257659c87975f82f4d9f91e700 Guoyi Liu Guoyi Liu true false c175f66fe127843ca6c711c949c6c157 Sam Oakley Sam Oakley true false 096aa92c5654ee2a7d8d5106e910c7d7 Guanghao Yang Guanghao Yang true false 852f42c2a4dd3f47711475ca17030bf9 0000-0001-6781-2108 Arjun Ajith Mohan Arjun Ajith Mohan true false 70db7c6c54d46f5e70b39e5ae0a056fa 0000-0002-2720-4615 Mark Waldron Mark Waldron true false b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2024-02-22 The advent of digital technologies has spurred the development of wearable sensing devices marking a significant shift in obtaining real-time physiological information. The principal objective is to transition from blood-centric monitoring to minimally invasive modalities, which will enable movement from specialised settings to more accessible environments such as the practices of general practitioners or even home settings. While subcutaneously implanted continuous monitoring devices have demonstrated this transition, detection of analytes from sample matrices like skin interstitial fluid (ISF), is a frontier that offers attractive minimally invasive routes for detection of biomarkers. This manuscript presents a comprehensive overview of our work in subdermal wearable biosensing patches for the simultaneous monitoring of glucose and lactate from ISF in ambulatory conditions. The performance of the subdermal wearable glucose monitoring patch was evaluated over a duration of three days, which is the longest reported duration reported till date. The subdermal wearable lactate sensing patch was worn for the duration of the exercise. Our findings highlight a critical observation that biofouling effects become apparent after a 24-h period. The data presented in this manuscript extends on the knowledge in the areas of continuous metabolite monitoring by introducing multifunctional polyphenol polymer films that can be used for both glucose and lactate monitoring with appropriate modifications. This study underscores the potential of subdermal wearable patches as versatile tools for real-time metabolite monitoring, positioning them as valuable assets in the evolution of personalised healthcare in diverse settings. Journal Article Lab on a Chip 24 7 2039 2048 Royal Society of Chemistry (RSC) 1473-0197 1473-0189 22 2 2024 2024-02-22 10.1039/d4lc00073k COLLEGE NANME COLLEGE CODE Swansea University SU Library paid the OA fee (TA Institutional Deal) G.V, G.L, and S.O. contributed equally to this work. This is a summary of independent research partly funded by DASA/DSTL grant on “Simultaneous monitoring of glucose and lactate using wearable sensors in ambulatory conditions (DSTL 0000010329)”. 2024-04-03T12:24:29.9298719 2024-02-22T17:37:48.6448844 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Georgeta Vulpe 1 Guoyi Liu 2 Sam Oakley 3 Guanghao Yang 4 Arjun Ajith Mohan 0000-0001-6781-2108 5 Mark Waldron 0000-0002-2720-4615 6 Sanjiv Sharma 0000-0003-3828-737X 7 65673__29601__7d756616c3744a2da1bdd4cf17b6a146.pdf 65673_VoR.pdf 2024-02-29T14:07:39.7383284 Output 2315053 application/pdf Version of Record true Released under the terms of a CC-BY-NC license. true eng http://creativecommons.org/licenses/by-nc/3.0/
title Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
spellingShingle Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
Georgeta Vulpe
Guoyi Liu
Sam Oakley
Guanghao Yang
Arjun Ajith Mohan
Mark Waldron
Sanjiv Sharma
title_short Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
title_full Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
title_fullStr Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
title_full_unstemmed Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
title_sort Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches
author_id_str_mv d1d5815c60d63534a10a81489255c681
636ea7257659c87975f82f4d9f91e700
c175f66fe127843ca6c711c949c6c157
096aa92c5654ee2a7d8d5106e910c7d7
852f42c2a4dd3f47711475ca17030bf9
70db7c6c54d46f5e70b39e5ae0a056fa
b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv d1d5815c60d63534a10a81489255c681_***_Georgeta Vulpe
636ea7257659c87975f82f4d9f91e700_***_Guoyi Liu
c175f66fe127843ca6c711c949c6c157_***_Sam Oakley
096aa92c5654ee2a7d8d5106e910c7d7_***_Guanghao Yang
852f42c2a4dd3f47711475ca17030bf9_***_Arjun Ajith Mohan
70db7c6c54d46f5e70b39e5ae0a056fa_***_Mark Waldron
b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Georgeta Vulpe
Guoyi Liu
Sam Oakley
Guanghao Yang
Arjun Ajith Mohan
Mark Waldron
Sanjiv Sharma
author2 Georgeta Vulpe
Guoyi Liu
Sam Oakley
Guanghao Yang
Arjun Ajith Mohan
Mark Waldron
Sanjiv Sharma
format Journal article
container_title Lab on a Chip
container_volume 24
container_issue 7
container_start_page 2039
publishDate 2024
institution Swansea University
issn 1473-0197
1473-0189
doi_str_mv 10.1039/d4lc00073k
publisher Royal Society of Chemistry (RSC)
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
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description The advent of digital technologies has spurred the development of wearable sensing devices marking a significant shift in obtaining real-time physiological information. The principal objective is to transition from blood-centric monitoring to minimally invasive modalities, which will enable movement from specialised settings to more accessible environments such as the practices of general practitioners or even home settings. While subcutaneously implanted continuous monitoring devices have demonstrated this transition, detection of analytes from sample matrices like skin interstitial fluid (ISF), is a frontier that offers attractive minimally invasive routes for detection of biomarkers. This manuscript presents a comprehensive overview of our work in subdermal wearable biosensing patches for the simultaneous monitoring of glucose and lactate from ISF in ambulatory conditions. The performance of the subdermal wearable glucose monitoring patch was evaluated over a duration of three days, which is the longest reported duration reported till date. The subdermal wearable lactate sensing patch was worn for the duration of the exercise. Our findings highlight a critical observation that biofouling effects become apparent after a 24-h period. The data presented in this manuscript extends on the knowledge in the areas of continuous metabolite monitoring by introducing multifunctional polyphenol polymer films that can be used for both glucose and lactate monitoring with appropriate modifications. This study underscores the potential of subdermal wearable patches as versatile tools for real-time metabolite monitoring, positioning them as valuable assets in the evolution of personalised healthcare in diverse settings.
published_date 2024-02-22T08:28:17Z
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