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Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization

Viruja Ummat, Saravana Periaswamy Sivagnanam, Dilip K. Rai, Colm O’Donnell, Gill Conway Orcid Logo, Shane Heffernan Orcid Logo, Stephen Fitzpatrick, Henry Lyons, James Curtin, Brijesh Kumar Tiwari

Scientific Reports, Volume: 14, Issue: 1

Swansea University Authors: Gill Conway Orcid Logo, Shane Heffernan Orcid Logo

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DOI (Published version): 10.1038/s41598-024-55225-z

Abstract

Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternativ...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: Springer Science and Business Media LLC 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa65672
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However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternative solvents. Also, the high viscosity and low cell permeability of the high molecular mass fucoidan, leads to low functionality in drug action, while the low molecular weight (Mw) fractions demonstrate enhanced biological activity and are also used as food supplements. The objectives of the study were 1) to extract fucoidan from seaweed Fucus vesiculosus (FV) using a green solvent and compare with the most commonly used extraction solvent i.e. hydrochloric acid 2) Determine the effect of ultrasound assisted depolymerization of the fucoidan extracts in reducing the Mw and investigating the cytotoxic effect of the different Mw fractions. The results showed that the green depolymerization solvent along with ultrasound with a short treatment time, was efficient in reducing the Mw of the sample. Furthermore, a significant reduction of cell viability was observed in a selection of samples demonstrating anticancer potential. 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spelling v2 65672 2024-02-22 Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization e33e0ee5a076ad91fe6615117caa1800 0000-0002-5991-0960 Gill Conway Gill Conway true false 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 2024-02-22 BMS Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternative solvents. Also, the high viscosity and low cell permeability of the high molecular mass fucoidan, leads to low functionality in drug action, while the low molecular weight (Mw) fractions demonstrate enhanced biological activity and are also used as food supplements. The objectives of the study were 1) to extract fucoidan from seaweed Fucus vesiculosus (FV) using a green solvent and compare with the most commonly used extraction solvent i.e. hydrochloric acid 2) Determine the effect of ultrasound assisted depolymerization of the fucoidan extracts in reducing the Mw and investigating the cytotoxic effect of the different Mw fractions. The results showed that the green depolymerization solvent along with ultrasound with a short treatment time, was efficient in reducing the Mw of the sample. Furthermore, a significant reduction of cell viability was observed in a selection of samples demonstrating anticancer potential. Ultrasound was therefore, found to be an efficient depolymerization method and can be used for carrying out depolymerization of crude fucoidan from seaweed Fucus Vesiculosus. Journal Article Scientific Reports 14 1 Springer Science and Business Media LLC 2045-2322 Seaweed, Fucoidan, Extraction, Ultrasound, Depolymerization 14 3 2024 2024-03-14 10.1038/s41598-024-55225-z COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University This research was supported by the BiOrbic SFI Bioeconomy Research Centre, funded by Ireland’s European Structural and Investment Programmes, Science Foundation Ireland (16/RC/3889) and the European Regional Development Fund. 2024-03-26T12:28:19.1567574 2024-02-22T17:29:09.8216094 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Viruja Ummat 1 Saravana Periaswamy Sivagnanam 2 Dilip K. Rai 3 Colm O’Donnell 4 Gill Conway 0000-0002-5991-0960 5 Shane Heffernan 0000-0002-3297-9335 6 Stephen Fitzpatrick 7 Henry Lyons 8 James Curtin 9 Brijesh Kumar Tiwari 10 65672__29852__38468d993e9240ab8a808ead5628c48a.pdf 65672.VOR.pdf 2024-03-26T12:26:28.1667682 Output 3512633 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
spellingShingle Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
Gill Conway
Shane Heffernan
title_short Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
title_full Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
title_fullStr Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
title_full_unstemmed Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
title_sort Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization
author_id_str_mv e33e0ee5a076ad91fe6615117caa1800
72c0b36891dfbec0378c0d0f7916e807
author_id_fullname_str_mv e33e0ee5a076ad91fe6615117caa1800_***_Gill Conway
72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan
author Gill Conway
Shane Heffernan
author2 Viruja Ummat
Saravana Periaswamy Sivagnanam
Dilip K. Rai
Colm O’Donnell
Gill Conway
Shane Heffernan
Stephen Fitzpatrick
Henry Lyons
James Curtin
Brijesh Kumar Tiwari
format Journal article
container_title Scientific Reports
container_volume 14
container_issue 1
publishDate 2024
institution Swansea University
issn 2045-2322
doi_str_mv 10.1038/s41598-024-55225-z
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 1
active_str 0
description Fucoidan, has gained a lot of interest from researchers and pharmaceuticals owing to its anti-oxidant, anti-coagulant, anti-inflammatory, anti-tumor and health promoting properties. However, extraction of fucoidan from seaweeds, involves use of harsh chemicals, thereby creating a need for alternative solvents. Also, the high viscosity and low cell permeability of the high molecular mass fucoidan, leads to low functionality in drug action, while the low molecular weight (Mw) fractions demonstrate enhanced biological activity and are also used as food supplements. The objectives of the study were 1) to extract fucoidan from seaweed Fucus vesiculosus (FV) using a green solvent and compare with the most commonly used extraction solvent i.e. hydrochloric acid 2) Determine the effect of ultrasound assisted depolymerization of the fucoidan extracts in reducing the Mw and investigating the cytotoxic effect of the different Mw fractions. The results showed that the green depolymerization solvent along with ultrasound with a short treatment time, was efficient in reducing the Mw of the sample. Furthermore, a significant reduction of cell viability was observed in a selection of samples demonstrating anticancer potential. Ultrasound was therefore, found to be an efficient depolymerization method and can be used for carrying out depolymerization of crude fucoidan from seaweed Fucus Vesiculosus.
published_date 2024-03-14T12:28:16Z
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score 11.013148

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