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Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy

Judy Haworth, Michelle Phillips, Margaret Newson, Peter J. Rogers, Anna Torrens-Burton, Andrea Tales Orcid Logo

Journal of Alzheimer's Disease, Volume: 51, Issue: 1, Pages: 263 - 275

Swansea University Author: Andrea Tales Orcid Logo

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DOI (Published version): 10.3233/jad-150791

Abstract

A substantial body of research evidence is indicative of disproportionately slowed information processing speed in a wide range of multi-trial, computer-based, neuroimaging- and electroencephalography-based reaction time (RT) tests in Alzheimer’s disease and mild cognitive impairment (MCI). However,...

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Published in: Journal of Alzheimer's Disease
ISSN: 1387-2877 1875-8908
Published: IOS Press 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa65528
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first_indexed 2024-01-29T14:21:35Z
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spelling v2 65528 2024-01-29 Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy 9b53a866ddacb566c38ee336706aef5f 0000-0003-4825-4555 Andrea Tales Andrea Tales true false 2024-01-29 PHAC A substantial body of research evidence is indicative of disproportionately slowed information processing speed in a wide range of multi-trial, computer-based, neuroimaging- and electroencephalography-based reaction time (RT) tests in Alzheimer’s disease and mild cognitive impairment (MCI). However, in what is arguably a dichotomy between research evidence and clinical practice, RT associated with different brain functions is rarely assessed as part of their diagnosis. Indeed, often only the time taken to perform a single, specific task, commonly the Trail making test (TMT), is measured. In clinical practice therefore, there can be a failure to assess adequately the integrity of the rapid, serial information processing and response, necessary for efficient, appropriate, and safe interaction with the environment. We examined whether a typical research-based RT task could at least match the TMT in differentiating amnestic MCI (aMCI) from cognitively healthy aging at group level. As aMCI is a heterogeneous group, typically containing only a proportion of individuals for whom aMCI represents the early stages of dementia, we examined the ability of each test to provide intra-group performance variation. The results indicate that as well as significant slowing in performance of the operations involved in TMT part B (but not part A), individuals with aMCI also experience significant slowing in RT compared to controls. The results also suggest that research-typical RT tests may be superior to the TMT in differentiating between cognitively healthy aging and aMCI at group level and in revealing the performance variability one would expect from an etiologically heterogeneous disorder such as aMCI. Journal Article Journal of Alzheimer's Disease 51 1 263 275 IOS Press 1387-2877 1875-8908 Dementia, information processing speed, mild cognitive impairment, reaction time 27 2 2016 2016-02-27 10.3233/jad-150791 COLLEGE NANME Public Health COLLEGE CODE PHAC Swansea University 2024-03-23T11:50:15.7366497 2024-01-29T14:20:57.8305504 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Judy Haworth 1 Michelle Phillips 2 Margaret Newson 3 Peter J. Rogers 4 Anna Torrens-Burton 5 Andrea Tales 0000-0003-4825-4555 6
title Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
spellingShingle Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
Andrea Tales
title_short Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
title_full Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
title_fullStr Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
title_full_unstemmed Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
title_sort Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy
author_id_str_mv 9b53a866ddacb566c38ee336706aef5f
author_id_fullname_str_mv 9b53a866ddacb566c38ee336706aef5f_***_Andrea Tales
author Andrea Tales
author2 Judy Haworth
Michelle Phillips
Margaret Newson
Peter J. Rogers
Anna Torrens-Burton
Andrea Tales
format Journal article
container_title Journal of Alzheimer's Disease
container_volume 51
container_issue 1
container_start_page 263
publishDate 2016
institution Swansea University
issn 1387-2877
1875-8908
doi_str_mv 10.3233/jad-150791
publisher IOS Press
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
document_store_str 0
active_str 0
description A substantial body of research evidence is indicative of disproportionately slowed information processing speed in a wide range of multi-trial, computer-based, neuroimaging- and electroencephalography-based reaction time (RT) tests in Alzheimer’s disease and mild cognitive impairment (MCI). However, in what is arguably a dichotomy between research evidence and clinical practice, RT associated with different brain functions is rarely assessed as part of their diagnosis. Indeed, often only the time taken to perform a single, specific task, commonly the Trail making test (TMT), is measured. In clinical practice therefore, there can be a failure to assess adequately the integrity of the rapid, serial information processing and response, necessary for efficient, appropriate, and safe interaction with the environment. We examined whether a typical research-based RT task could at least match the TMT in differentiating amnestic MCI (aMCI) from cognitively healthy aging at group level. As aMCI is a heterogeneous group, typically containing only a proportion of individuals for whom aMCI represents the early stages of dementia, we examined the ability of each test to provide intra-group performance variation. The results indicate that as well as significant slowing in performance of the operations involved in TMT part B (but not part A), individuals with aMCI also experience significant slowing in RT compared to controls. The results also suggest that research-typical RT tests may be superior to the TMT in differentiating between cognitively healthy aging and aMCI at group level and in revealing the performance variability one would expect from an etiologically heterogeneous disorder such as aMCI.
published_date 2016-02-27T11:50:12Z
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