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Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP

S. Footitt, Steve Slocombe Orcid Logo

The EMBO Journal, Volume: 21, Issue: 12, Pages: 2912 - 2922

Swansea University Author: Steve Slocombe Orcid Logo

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DOI (Published version): 10.1093/emboj/cdf300

Abstract

Embryo dormancy in flowering plants is an important dispersal mechanism that promotes survival of the seed through time. The subsequent transition to germination is a critical control point regulating initiation of vegetative growth. Here we show that the Arabidopsis COMATOSE (CTS) locus is required...

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Published in: The EMBO Journal
ISSN: 1460-2075
Published: Springer Science and Business Media LLC 2002
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URI: https://cronfa.swan.ac.uk/Record/cronfa65487
first_indexed 2024-01-22T14:15:41Z
last_indexed 2024-11-25T14:16:11Z
id cronfa65487
recordtype SURis
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spelling 2024-03-21T16:20:46.4571788 v2 65487 2024-01-22 Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP 4a1ea486a78ed357efdfa053a277ae40 0000-0002-3549-7999 Steve Slocombe Steve Slocombe true false 2024-01-22 BGPS Embryo dormancy in flowering plants is an important dispersal mechanism that promotes survival of the seed through time. The subsequent transition to germination is a critical control point regulating initiation of vegetative growth. Here we show that the Arabidopsis COMATOSE (CTS) locus is required for this transition, and acts, at least in part, by profoundly affecting the metabolism of stored lipids. CTS encodes a peroxisomal protein of the ATP binding cassette (ABC) transporter class with significant identity to the human X-linked adrenoleukodystrophy protein (ALDP). Like X-ALD patients, cts mutant embryos and seedlings exhibit pleiotropic phenotypes associated with perturbation in fatty acid metabolism. CTS expression transiently increases shortly after imbibition during germination, but not in imbibed dormant seeds, and genetic analyses show that CTS is negatively regulated by loci that promote embryo dormancy through multiple independent pathways. Our results demonstrate that CTS regulates transport of acyl CoAs into the peroxisome, and indicate that regulation of CTS function is a major control point for the switch between the opposing developmental programmes of dormancy and germination. Journal Article The EMBO Journal 21 12 2912 2922 Springer Science and Business Media LLC 1460-2075 17 6 2002 2002-06-17 10.1093/emboj/cdf300 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University 2024-03-21T16:20:46.4571788 2024-01-22T14:14:46.7166773 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences S. Footitt 1 Steve Slocombe 0000-0002-3549-7999 2
title Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
spellingShingle Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
Steve Slocombe
title_short Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
title_full Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
title_fullStr Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
title_full_unstemmed Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
title_sort Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
author_id_str_mv 4a1ea486a78ed357efdfa053a277ae40
author_id_fullname_str_mv 4a1ea486a78ed357efdfa053a277ae40_***_Steve Slocombe
author Steve Slocombe
author2 S. Footitt
Steve Slocombe
format Journal article
container_title The EMBO Journal
container_volume 21
container_issue 12
container_start_page 2912
publishDate 2002
institution Swansea University
issn 1460-2075
doi_str_mv 10.1093/emboj/cdf300
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 0
active_str 0
description Embryo dormancy in flowering plants is an important dispersal mechanism that promotes survival of the seed through time. The subsequent transition to germination is a critical control point regulating initiation of vegetative growth. Here we show that the Arabidopsis COMATOSE (CTS) locus is required for this transition, and acts, at least in part, by profoundly affecting the metabolism of stored lipids. CTS encodes a peroxisomal protein of the ATP binding cassette (ABC) transporter class with significant identity to the human X-linked adrenoleukodystrophy protein (ALDP). Like X-ALD patients, cts mutant embryos and seedlings exhibit pleiotropic phenotypes associated with perturbation in fatty acid metabolism. CTS expression transiently increases shortly after imbibition during germination, but not in imbibed dormant seeds, and genetic analyses show that CTS is negatively regulated by loci that promote embryo dormancy through multiple independent pathways. Our results demonstrate that CTS regulates transport of acyl CoAs into the peroxisome, and indicate that regulation of CTS function is a major control point for the switch between the opposing developmental programmes of dormancy and germination.
published_date 2002-06-17T08:27:41Z
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score 11.048171

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