Methadone maintenance treatment and impulsivity: premature responding

Weidacker, Kathrin; Zhao, Yijie; Zhang, Yingying; Whiteford, Sebastian; Ren, Qihuan; Zhang, Chencheng; Voon, Valerie

doi:10.1080/13803395.2023.2276483

Journal article 107 views 19 downloads

Methadone maintenance treatment and impulsivity: premature responding

Kathrin Weidacker

, Yijie Zhao, Yingying Zhang, Sebastian Whiteford

, Qihuan Ren, Chencheng Zhang, Valerie Voon

Journal of Clinical and Experimental Neuropsychology, Pages: 1 - 12

Swansea University Authors: Kathrin Weidacker , Sebastian Whiteford

PDF | Version of Record

© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Download (2.08MB)

Check full text

DOI (Published version): 10.1080/13803395.2023.2276483

Abstract

Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure...

Full description

Published in:	Journal of Clinical and Experimental Neuropsychology
ISSN:	1380-3395 1744-411X
Published:	Informa UK Limited 2023
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa64902
Tags:	Add Tag No Tags, Be the first to tag this record!

first_indexed	2023-12-04T14:05:18Z
last_indexed	2023-12-04T14:05:18Z
id	cronfa64902
recordtype	SURis
fullrecord	<?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>64902</id><entry>2023-11-02</entry><title>Methadone maintenance treatment and impulsivity: premature responding</title><swanseaauthors><author><sid>4fed7fdf5381ec1a577001d6bd3d74d8</sid><ORCID>0000-0002-5742-6016</ORCID><firstname>Kathrin</firstname><surname>Weidacker</surname><name>Kathrin Weidacker</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>5bcf7b504f5cb2b2ad68192efc3983f5</sid><ORCID>0000-0003-3859-7220</ORCID><firstname>Sebastian</firstname><surname>Whiteford</surname><name>Sebastian Whiteford</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-11-02</date><deptcode>HPS</deptcode><abstract>Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure to wait for a starting signal. Premature responding is of high translational significance since it predicts the development of addiction-like behaviors in rodents. Methods: We assessed 45 MMT patients and 46 demographically matched (age, sex, education, and handedness) healthy volunteers (HVs) on premature responding alongside action and inhibition of instructed and intentional trials using the Intentional Hand Task (IHT). Results: The results showed markedly enhanced premature responses in the MMT vs. the HV group, which correlated positively with methadone dosage in the MMT patients. Throughout the task, MMT patients were faster across all trial parts and less accurate in response to instructed trials compared to HVs. Conclusions: The increase in premature motor reactions during variable waiting periods alongside increased motion speed and lower accuracy might reflect a specific motor inhibition deficit in MMT, a subcomponent of impulsivity not previously assessed in MMT. Incorporating an experimentally defined measure of impulsivity, such as premature responding, into existing test batteries used by clinicians might enable more tailored treatments addressing the increased impulsivity levels and associated dysfunctional behaviors in MMT.</abstract><type>Journal Article</type><journal>Journal of Clinical and Experimental Neuropsychology</journal><volume/><journalNumber/><paginationStart>1</paginationStart><paginationEnd>12</paginationEnd><publisher>Informa UK Limited</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1380-3395</issnPrint><issnElectronic>1744-411X</issnElectronic><keywords>Premature responses, methadone, addiction, heroin, impulsivity</keywords><publishedDay>2</publishedDay><publishedMonth>11</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-11-02</publishedDate><doi>10.1080/13803395.2023.2276483</doi><url>http://dx.doi.org/10.1080/13803395.2023.2276483</url><notes/><college>COLLEGE NANME</college><department>Psychology</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HPS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders/><projectreference/><lastEdited>2023-12-04T14:06:29.8684658</lastEdited><Created>2023-11-02T10:46:50.4534754</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Psychology</level></path><authors><author><firstname>Kathrin</firstname><surname>Weidacker</surname><orcid>0000-0002-5742-6016</orcid><order>1</order></author><author><firstname>Yijie</firstname><surname>Zhao</surname><order>2</order></author><author><firstname>Yingying</firstname><surname>Zhang</surname><order>3</order></author><author><firstname>Sebastian</firstname><surname>Whiteford</surname><orcid>0000-0003-3859-7220</orcid><order>4</order></author><author><firstname>Qihuan</firstname><surname>Ren</surname><order>5</order></author><author><firstname>Chencheng</firstname><surname>Zhang</surname><order>6</order></author><author><firstname>Valerie</firstname><surname>Voon</surname><order>7</order></author></authors><documents><document><filename>64902__29194__354102ffab374888b532958791ab30c3.pdf</filename><originalFilename>64902.VOR.pdf</originalFilename><uploaded>2023-12-04T13:57:07.7021017</uploaded><type>Output</type><contentLength>2179859</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling	v2 64902 2023-11-02 Methadone maintenance treatment and impulsivity: premature responding 4fed7fdf5381ec1a577001d6bd3d74d8 0000-0002-5742-6016 Kathrin Weidacker Kathrin Weidacker true false 5bcf7b504f5cb2b2ad68192efc3983f5 0000-0003-3859-7220 Sebastian Whiteford Sebastian Whiteford true false 2023-11-02 HPS Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure to wait for a starting signal. Premature responding is of high translational significance since it predicts the development of addiction-like behaviors in rodents. Methods: We assessed 45 MMT patients and 46 demographically matched (age, sex, education, and handedness) healthy volunteers (HVs) on premature responding alongside action and inhibition of instructed and intentional trials using the Intentional Hand Task (IHT). Results: The results showed markedly enhanced premature responses in the MMT vs. the HV group, which correlated positively with methadone dosage in the MMT patients. Throughout the task, MMT patients were faster across all trial parts and less accurate in response to instructed trials compared to HVs. Conclusions: The increase in premature motor reactions during variable waiting periods alongside increased motion speed and lower accuracy might reflect a specific motor inhibition deficit in MMT, a subcomponent of impulsivity not previously assessed in MMT. Incorporating an experimentally defined measure of impulsivity, such as premature responding, into existing test batteries used by clinicians might enable more tailored treatments addressing the increased impulsivity levels and associated dysfunctional behaviors in MMT. Journal Article Journal of Clinical and Experimental Neuropsychology 1 12 Informa UK Limited 1380-3395 1744-411X Premature responses, methadone, addiction, heroin, impulsivity 2 11 2023 2023-11-02 10.1080/13803395.2023.2276483 http://dx.doi.org/10.1080/13803395.2023.2276483 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University Another institution paid the OA fee 2023-12-04T14:06:29.8684658 2023-11-02T10:46:50.4534754 Faculty of Medicine, Health and Life Sciences School of Psychology Kathrin Weidacker 0000-0002-5742-6016 1 Yijie Zhao 2 Yingying Zhang 3 Sebastian Whiteford 0000-0003-3859-7220 4 Qihuan Ren 5 Chencheng Zhang 6 Valerie Voon 7 64902__29194__354102ffab374888b532958791ab30c3.pdf 64902.VOR.pdf 2023-12-04T13:57:07.7021017 Output 2179859 application/pdf Version of Record true © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title	Methadone maintenance treatment and impulsivity: premature responding
spellingShingle	Methadone maintenance treatment and impulsivity: premature responding Kathrin Weidacker Sebastian Whiteford
title_short	Methadone maintenance treatment and impulsivity: premature responding
title_full	Methadone maintenance treatment and impulsivity: premature responding
title_fullStr	Methadone maintenance treatment and impulsivity: premature responding
title_full_unstemmed	Methadone maintenance treatment and impulsivity: premature responding
title_sort	Methadone maintenance treatment and impulsivity: premature responding
author_id_str_mv	4fed7fdf5381ec1a577001d6bd3d74d8 5bcf7b504f5cb2b2ad68192efc3983f5
author_id_fullname_str_mv	4fed7fdf5381ec1a577001d6bd3d74d8_*_Kathrin Weidacker 5bcf7b504f5cb2b2ad68192efc3983f5_*_Sebastian Whiteford
author	Kathrin Weidacker Sebastian Whiteford
author2	Kathrin Weidacker Yijie Zhao Yingying Zhang Sebastian Whiteford Qihuan Ren Chencheng Zhang Valerie Voon
format	Journal article
container_title	Journal of Clinical and Experimental Neuropsychology
container_start_page	1
publishDate	2023
institution	Swansea University
issn	1380-3395 1744-411X
doi_str_mv	10.1080/13803395.2023.2276483
publisher	Informa UK Limited
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
url	http://dx.doi.org/10.1080/13803395.2023.2276483
document_store_str	1
active_str	0
description	Introduction: Previous research showed that methadone maintenance treatment (MMT) is linked to impulsivity, with higher impulsivity levels being associated with for example, increased drug use. One aspect of impulsivity, most commonly studied in rodent research, is premature responding, the failure to wait for a starting signal. Premature responding is of high translational significance since it predicts the development of addiction-like behaviors in rodents. Methods: We assessed 45 MMT patients and 46 demographically matched (age, sex, education, and handedness) healthy volunteers (HVs) on premature responding alongside action and inhibition of instructed and intentional trials using the Intentional Hand Task (IHT). Results: The results showed markedly enhanced premature responses in the MMT vs. the HV group, which correlated positively with methadone dosage in the MMT patients. Throughout the task, MMT patients were faster across all trial parts and less accurate in response to instructed trials compared to HVs. Conclusions: The increase in premature motor reactions during variable waiting periods alongside increased motion speed and lower accuracy might reflect a specific motor inhibition deficit in MMT, a subcomponent of impulsivity not previously assessed in MMT. Incorporating an experimentally defined measure of impulsivity, such as premature responding, into existing test batteries used by clinicians might enable more tailored treatments addressing the increased impulsivity levels and associated dysfunctional behaviors in MMT.
published_date	2023-11-02T14:06:30Z
_version_	1784360511431770112
score	11.013731

Methadone maintenance treatment and impulsivity: premature responding

Similar Items