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Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size

Shaohui Xu Orcid Logo, Sumati Bhatia Orcid Logo, Xin Fan, Philip Nickl, Rainer Haag Orcid Logo

Advanced Materials Interfaces, Volume: 9, Issue: 9

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/admi.202102315

Abstract

Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship betwe...

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Published in: Advanced Materials Interfaces
ISSN: 2196-7350 2196-7350
Published: Wiley 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa64857
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spelling v2 64857 2023-11-01 Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2023-11-01 CHEM Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship between its physiochemical properties and antibacterial activities has yet to be explored. This work is the first to investigate the combination effects of different sized and functionalized MoS2 sheets on their antibacterial activities. The bacterial capture abilities of 3 µm mannosylated, galactosylated, and glucosylated sheets, as well as 300 nm mannosylated sheets, all with similar sugar densities, are compared. Only mannosylated MoS2 sheets are found to agglutinate normal Escherichia coli (E. coli) and large mannosylated MoS2 sheets show the strongest E. coli agglutination. Despite slightly weaker photothermal performance under near-infrared (NIR) laser irradiation, large mannosylated MoS2 sheets exhibit higher antibacterial activity than the smaller sheets. By much stronger specific multivalent binding, large sheets capture E. coli more efficiently and compensate for their reduced photothermal activity. Besides providing a facile approach to eliminate E. coli bacteria, these findings offer valuable guidance for future development of 2D nanomaterial-based antibacterial agents and filter holder materials, where large-functionalized sheets can capture and eliminate bacteria powerfully. Journal Article Advanced Materials Interfaces 9 9 Wiley 2196-7350 2196-7350 1 3 2022 2022-03-01 10.1002/admi.202102315 http://dx.doi.org/10.1002/admi.202102315 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University Another institution paid the OA fee 2023-12-21T15:05:48.7400933 2023-11-01T10:34:10.3542407 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Shaohui Xu 0000-0001-6470-2755 1 Sumati Bhatia 0000-0002-5123-4937 2 Xin Fan 3 Philip Nickl 4 Rainer Haag 0000-0003-3840-162x 5
title Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
spellingShingle Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
Sumati Bhatia
title_short Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_full Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_fullStr Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_full_unstemmed Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_sort Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
author_id_str_mv a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author Sumati Bhatia
author2 Shaohui Xu
Sumati Bhatia
Xin Fan
Philip Nickl
Rainer Haag
format Journal article
container_title Advanced Materials Interfaces
container_volume 9
container_issue 9
publishDate 2022
institution Swansea University
issn 2196-7350
2196-7350
doi_str_mv 10.1002/admi.202102315
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url http://dx.doi.org/10.1002/admi.202102315
document_store_str 0
active_str 0
description Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship between its physiochemical properties and antibacterial activities has yet to be explored. This work is the first to investigate the combination effects of different sized and functionalized MoS2 sheets on their antibacterial activities. The bacterial capture abilities of 3 µm mannosylated, galactosylated, and glucosylated sheets, as well as 300 nm mannosylated sheets, all with similar sugar densities, are compared. Only mannosylated MoS2 sheets are found to agglutinate normal Escherichia coli (E. coli) and large mannosylated MoS2 sheets show the strongest E. coli agglutination. Despite slightly weaker photothermal performance under near-infrared (NIR) laser irradiation, large mannosylated MoS2 sheets exhibit higher antibacterial activity than the smaller sheets. By much stronger specific multivalent binding, large sheets capture E. coli more efficiently and compensate for their reduced photothermal activity. Besides providing a facile approach to eliminate E. coli bacteria, these findings offer valuable guidance for future development of 2D nanomaterial-based antibacterial agents and filter holder materials, where large-functionalized sheets can capture and eliminate bacteria powerfully.
published_date 2022-03-01T15:05:49Z
_version_ 1785904390806175744
score 11.013731

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