Journal article 261 views 58 downloads
Prostate cancer exosomes as modulators of the tumor microenvironment
Journal of Cancer Metastasis and Treatment, Volume: 3, Issue: 12, Start page: 288
Swansea University Author:
Jason Webber
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DOI (Published version): 10.20517/2394-4722.2017.32
Abstract
Researchers are currently trying to understand why some men with prostate cancer go on to develop aggressive disease whilst others maintain slow growing tumors. Although endogenous genetic anomalies within the tumor cell are important, the prevailing view is that the tissue microenvironment as a who...
| Published in: | Journal of Cancer Metastasis and Treatment |
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| ISSN: | 2394-4722 2454-2857 |
| Published: |
OAE Publishing Inc.
2017
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa64723 |
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| Abstract: |
Researchers are currently trying to understand why some men with prostate cancer go on to develop aggressive disease whilst others maintain slow growing tumors. Although endogenous genetic anomalies within the tumor cell are important, the prevailing view is that the tissue microenvironment as a whole is the determinant factor. Many studies have focussed on the role of soluble factors in modulating the nature of the tumor microenvironment. There is however a growing interest in the role of extracellular vesicles, including exosomes, as regulators of disease progression. A variety of resident cells, as well as infiltrating cells, all contribute to a heterogeneous population of exosomes within the tumor microenvironment. Studies focussing on the role of exosomes in prostate cancer are however relatively rare. In this review, evidence from various cancers, including prostate, is used to present numerous potential roles of exosomes in prostate cancer. Whilst further validation of some functions may remain necessary it is clear that exosomes play a major role in intercellular communication between various cell types within the tumor microenvironment and are necessary for driving disease progression. |
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| Keywords: |
Exosomes, prostate cancer, microenvironment, angiogenesis, stroma, myeloid, matrix metalloproteinases, metabolism |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
The authors are supported by funding from Prostate Cancer UK (awarded to JPW and AS), Cancer Research Wales (awarded to JPW and AC), Life Science Research Network Wales (an initiative funded through the Welsh Government’s Ser Cymru programme; awarded to AC, JPW, and VY), Tenovus Cancer Care (awarded to AC), Cardiff University (awarded to AC) and Welsh Crucible (awarded to JPW). |
| Issue: |
12 |
| Start Page: |
288 |