Journal article 147 views 33 downloads
Mechanical experimentation of the gastrointestinal tract: a systematic review
,
Grégory Chagnon,
Djordje Peric ,
Edouard Girard
Biomechanics and Modeling in Mechanobiology, Volume: 23, Issue: 1, Pages: 23 - 59
Swansea University Authors:
Mokarram Hossain , Djordje Peric
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DOI (Published version): 10.1007/s10237-023-01773-8
Abstract
The gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as...
| Published in: | Biomechanics and Modeling in Mechanobiology |
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| ISSN: | 1617-7959 1617-7940 |
| Published: |
Springer Science and Business Media LLC
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa64587 |
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| Abstract: |
The gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medicine and engineering. This systematic review summarises the experimental studies that are currently in the literature (n = 247) and outlines the areas in which experimentation is lacking, highlighting what is still required in order to more fully understand the mechanical behaviour of the GI organs. These include (i) more human data, allowing for more accurate modelling for applications within medicine, (ii) an increase in time-dependent studies, and (iii) more sophisticated in vivo testing methods which allow for both the layer- and direction-dependent characterisation of the GI organs. The findings of this review can also be used to identify experimental data for the readers’ own constitutive or FE modelling as the experimental studies have been grouped in terms of organ (oesophagus, stomach, small intestine, large intestine or rectum), test condition (ex vivo or in vivo), number of directions studied (isotropic or anisotropic), species family (human, porcine, feline etc.), tissue condition (intact wall or layer-dependent) and the type of test performed (biaxial tension, inflation–extension, distension (pressure-diameter), etc.). Furthermore, the studies that investigated the time-dependent (viscoelastic) behaviour of the tissues have been presented. |
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| Keywords: |
Biomechanics, Mechanical characterisation, Mechanical properties, Digestive system, Soft tissues, Constitutive modelling, Finite element analysis |
| College: |
Faculty of Science and Engineering |
| Funders: |
C. Durcan and M. Hossain are indebted to the Swansea University Strategic Partnerships Research Scholarships (SUSPRS) for funding of the project. |
| Issue: |
1 |
| Start Page: |
23 |
| End Page: |
59 |