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A new model for evaluating pressure-induced vascular tone in small cerebral arteries

Alberto Coccarelli Orcid Logo, Sanjay Pant, Ioannis Polydoros, Osama F. Harraz, Sanjay Pant Orcid Logo

Biomechanics and Modeling in Mechanobiology, Volume: 23, Issue: 1, Pages: 271 - 286

Swansea University Authors: Alberto Coccarelli Orcid Logo, Sanjay Pant Orcid Logo

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DOI (Published version): 10.1007/s10237-023-01774-7

Abstract

The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological conditions. Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure a...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: Springer Science and Business Media LLC 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa64583
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Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure and vascular tone generation in SCAs. This is assembled by combining a chemical sub-model, representing pressure-induced smooth muscle cell (SMC) signalling, with a mechanical sub-model for the tone generation and its transduction at tissue level. The devised model can accurately reproduce the impact of luminal pressure on different cytoplasmic components involved in myogenic signalling, both in the control case and when combined with some specific pharmacological interventions. Furthermore, the model is also able to capture and predict experimentally recorded pressure-outer diameter relationships obtained for vessels under control conditions, both in a Ca-free bath and under drug inhibition. 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spelling v2 64583 2023-09-21 A new model for evaluating pressure-induced vascular tone in small cerebral arteries 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 43b388e955511a9d1b86b863c2018a9f 0000-0002-2081-308X Sanjay Pant Sanjay Pant true false 2023-09-21 MECH The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological conditions. Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure and vascular tone generation in SCAs. This is assembled by combining a chemical sub-model, representing pressure-induced smooth muscle cell (SMC) signalling, with a mechanical sub-model for the tone generation and its transduction at tissue level. The devised model can accurately reproduce the impact of luminal pressure on different cytoplasmic components involved in myogenic signalling, both in the control case and when combined with some specific pharmacological interventions. Furthermore, the model is also able to capture and predict experimentally recorded pressure-outer diameter relationships obtained for vessels under control conditions, both in a Ca-free bath and under drug inhibition. The modularity of the proposed framework allows the integration of new components for the study of a broad range of processes involved in the vascular function. Journal Article Biomechanics and Modeling in Mechanobiology 23 1 271 286 Springer Science and Business Media LLC 1617-7959 1617-7940 1 2 2024 2024-02-01 10.1007/s10237-023-01774-7 http://dx.doi.org/10.1007/s10237-023-01774-7 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University SU Library paid the OA fee (TA Institutional Deal) A.C. and I.P. acknowledge the support by Swansea University through the College of Engineering Zienkiewicz/Centenary scholarship. O.F.H. was supported by the National Heart, Lung, and Blood Institute (R01HL169681), the National Institute of Aging (R21AG082193), the National Institute of General Medical Sciences (P20GM135007), the American Heart Association (20CDA35310097), the Totman Medical Research Trust, the Larner College of Medicine, University of Vermont, the Bloomfield Professorship in Cardiovascular Research, and the Cardiovascular Research Institute of Vermont. 2024-04-04T12:27:50.6239463 2023-09-21T11:46:57.5475803 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Sanjay Pant 2 Ioannis Polydoros 3 Osama F. Harraz 4 Sanjay Pant 0000-0002-2081-308X 5 64583__29001__7ff25f712db94e5a87bfd80db9ca7a57.pdf 64583.pdf 2023-11-13T13:22:21.9198509 Output 1474705 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. false eng http://creativecommons.org/licenses/by/4.0/
title A new model for evaluating pressure-induced vascular tone in small cerebral arteries
spellingShingle A new model for evaluating pressure-induced vascular tone in small cerebral arteries
Alberto Coccarelli
Sanjay Pant
title_short A new model for evaluating pressure-induced vascular tone in small cerebral arteries
title_full A new model for evaluating pressure-induced vascular tone in small cerebral arteries
title_fullStr A new model for evaluating pressure-induced vascular tone in small cerebral arteries
title_full_unstemmed A new model for evaluating pressure-induced vascular tone in small cerebral arteries
title_sort A new model for evaluating pressure-induced vascular tone in small cerebral arteries
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
43b388e955511a9d1b86b863c2018a9f
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
43b388e955511a9d1b86b863c2018a9f_***_Sanjay Pant
author Alberto Coccarelli
Sanjay Pant
author2 Alberto Coccarelli
Sanjay Pant
Ioannis Polydoros
Osama F. Harraz
Sanjay Pant
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 23
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institution Swansea University
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publisher Springer Science and Business Media LLC
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department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
url http://dx.doi.org/10.1007/s10237-023-01774-7
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description The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological conditions. Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure and vascular tone generation in SCAs. This is assembled by combining a chemical sub-model, representing pressure-induced smooth muscle cell (SMC) signalling, with a mechanical sub-model for the tone generation and its transduction at tissue level. The devised model can accurately reproduce the impact of luminal pressure on different cytoplasmic components involved in myogenic signalling, both in the control case and when combined with some specific pharmacological interventions. Furthermore, the model is also able to capture and predict experimentally recorded pressure-outer diameter relationships obtained for vessels under control conditions, both in a Ca-free bath and under drug inhibition. The modularity of the proposed framework allows the integration of new components for the study of a broad range of processes involved in the vascular function.
published_date 2024-02-01T12:27:47Z
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