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Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development

George Zacharopoulos Orcid Logo, Francesco Sella, Uzay Emir Orcid Logo, Roi Cohen Kadosh

eLife, Volume: 12

Swansea University Author: George Zacharopoulos Orcid Logo

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DOI (Published version): 10.7554/elife.84086

Abstract

Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in perceptual, cognitive, and motor tasks. However, the exact involvement of these neurochemical mechanisms in the chain of information processing, and across human development, is unclear. In a cross-sectiona...

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Published in: eLife
ISSN: 2050-084X
Published: eLife Sciences Publications, Ltd 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa64574
first_indexed 2023-09-20T07:12:33Z
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spelling 2023-10-17T17:15:08.0079434 v2 64574 2023-09-20 Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development 7abcfe5e6fd29d20e2c53eff9a4098d1 0000-0003-0574-866X George Zacharopoulos George Zacharopoulos true false 2023-09-20 PSYS Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in perceptual, cognitive, and motor tasks. However, the exact involvement of these neurochemical mechanisms in the chain of information processing, and across human development, is unclear. In a cross-sectional longitudinal design, we used a computational approach to dissociate cognitive, decision, and visuomotor processing in 293 individuals spanning early childhood to adulthood. We found that glutamate and GABA within the intraparietal sulcus (IPS) explained unique variance in visuomotor processing, with higher glutamate predicting poorer visuomotor processing in younger participants but better visuomotor processing in mature participants, while GABA showed the opposite pattern. These findings, which were neurochemically, neuroanatomically and functionally specific, were replicated ~21 mo later and were generalized in two further different behavioral tasks. Using resting functional MRI, we revealed that the relationship between IPS neurochemicals and visuomotor processing is mediated by functional connectivity in the visuomotor network. We then extended our findings to high-level cognitive behavior by predicting fluid intelligence performance. We present evidence that fluid intelligence performance is explained by IPS GABA and glutamate and is mediated by visuomotor processing. However, this evidence was obtained using an uncorrected alpha and needs to be replicated in future studies. These results provide an integrative biological and psychological mechanistic explanation that links cognitive processes and neurotransmitters across human development and establishes their potential involvement in intelligent behavior. Journal Article eLife 12 eLife Sciences Publications, Ltd 2050-084X GABA; computational biology; development; fluid intelligence; frontoparietal network; glutamate; human; neuroscience; systems biology; visuomotor processing. 29 9 2023 2023-09-29 10.7554/elife.84086 http://dx.doi.org/10.7554/elife.84086 COLLEGE NANME Psychology School COLLEGE CODE PSYS Swansea University European Research Council, Wellcome Trust 2023-10-17T17:15:08.0079434 2023-09-20T08:09:22.7850506 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 0000-0003-0574-866X 1 Francesco Sella 2 Uzay Emir 0000-0001-5376-0431 3 Roi Cohen Kadosh 4 64574__28670__dcfd8ba82050410daf673bffb595d785.pdf elife-84086.pdf 2023-10-02T09:15:30.8430835 Output 2642513 application/pdf Version of Record true This article is distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use and redistribution provided that the original author and source are credited. true eng http://creativecommons.org/licenses/by/4.0/
title Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
spellingShingle Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
George Zacharopoulos
title_short Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
title_full Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
title_fullStr Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
title_full_unstemmed Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
title_sort Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development
author_id_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1
author_id_fullname_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos
author George Zacharopoulos
author2 George Zacharopoulos
Francesco Sella
Uzay Emir
Roi Cohen Kadosh
format Journal article
container_title eLife
container_volume 12
publishDate 2023
institution Swansea University
issn 2050-084X
doi_str_mv 10.7554/elife.84086
publisher eLife Sciences Publications, Ltd
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
url http://dx.doi.org/10.7554/elife.84086
document_store_str 1
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description Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in perceptual, cognitive, and motor tasks. However, the exact involvement of these neurochemical mechanisms in the chain of information processing, and across human development, is unclear. In a cross-sectional longitudinal design, we used a computational approach to dissociate cognitive, decision, and visuomotor processing in 293 individuals spanning early childhood to adulthood. We found that glutamate and GABA within the intraparietal sulcus (IPS) explained unique variance in visuomotor processing, with higher glutamate predicting poorer visuomotor processing in younger participants but better visuomotor processing in mature participants, while GABA showed the opposite pattern. These findings, which were neurochemically, neuroanatomically and functionally specific, were replicated ~21 mo later and were generalized in two further different behavioral tasks. Using resting functional MRI, we revealed that the relationship between IPS neurochemicals and visuomotor processing is mediated by functional connectivity in the visuomotor network. We then extended our findings to high-level cognitive behavior by predicting fluid intelligence performance. We present evidence that fluid intelligence performance is explained by IPS GABA and glutamate and is mediated by visuomotor processing. However, this evidence was obtained using an uncorrected alpha and needs to be replicated in future studies. These results provide an integrative biological and psychological mechanistic explanation that links cognitive processes and neurotransmitters across human development and establishes their potential involvement in intelligent behavior.
published_date 2023-09-29T08:24:48Z
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