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(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino Orcid Logo, Kathrin K. Geyer, Karl F. Hoffmann, Christoph Grunau

Trends in Parasitology, Volume: 33, Issue: 4, Pages: 285 - 294

Swansea University Author: Gilda Padalino Orcid Logo

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DOI (Published version): 10.1016/j.pt.2016.12.002

Abstract

The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, colle...

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Published in: Trends in Parasitology
ISSN: 1471-4922
Published: Elsevier BV 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa64439
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spelling v2 64439 2023-09-05 (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach 7e5526209f02734f57ba19b0d17604ec 0000-0001-8580-1293 Gilda Padalino Gilda Padalino true false 2023-09-05 PHAR The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success. Journal Article Trends in Parasitology 33 4 285 294 Elsevier BV 1471-4922 Schistosoma mansoni, intestinal bilharzia, inheritance system, epigenetic inheritance, genetic inheritance 1 4 2017 2017-04-01 10.1016/j.pt.2016.12.002 http://dx.doi.org/10.1016/j.pt.2016.12.002 COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University G.P., K.K.G., and K.F.H. acknowledge the UK BBSRC (BB/K005448/1), the Life Sciences Research Network Wales (LSRNW), and the Wellcome Trust (107475/Z/15/Z) for supporting the research activities underlying some of the ideas discussed in this review. 2023-10-09T17:47:21.5400855 2023-09-05T16:11:53.6061266 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Céline Cosseau 1 Olaf Wolkenhauer 2 Gilda Padalino 0000-0001-8580-1293 3 Kathrin K. Geyer 4 Karl F. Hoffmann 5 Christoph Grunau 6 64439__28743__180ac81790ea45c0babb6efa85ff9bcd.pdf 64439.VOR.pdf 2023-10-09T17:43:49.2022124 Output 1532385 application/pdf Version of Record true © 2017 The Authors. Published by Elsevier Ltd. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
spellingShingle (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
Gilda Padalino
title_short (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
title_full (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
title_fullStr (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
title_full_unstemmed (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
title_sort (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
author_id_str_mv 7e5526209f02734f57ba19b0d17604ec
author_id_fullname_str_mv 7e5526209f02734f57ba19b0d17604ec_***_Gilda Padalino
author Gilda Padalino
author2 Céline Cosseau
Olaf Wolkenhauer
Gilda Padalino
Kathrin K. Geyer
Karl F. Hoffmann
Christoph Grunau
format Journal article
container_title Trends in Parasitology
container_volume 33
container_issue 4
container_start_page 285
publishDate 2017
institution Swansea University
issn 1471-4922
doi_str_mv 10.1016/j.pt.2016.12.002
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
url http://dx.doi.org/10.1016/j.pt.2016.12.002
document_store_str 1
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description The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
published_date 2017-04-01T17:47:23Z
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score 11.037253

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