E-Thesis 146 views
Challenges in optical micro-rheometry for blood clot detection / LAURA O'DEA
Swansea University Author: LAURA O'DEA
DOI (Published version): 10.23889/SUthesis.64089
Abstract
The need for rapid, cheap and accessible method to accurately quantify the rheological state of a clotting sample of blood has been highlighted by the recent COVID-19 pandemic. Such a device would be significant for use for theranostic application in trauma care and warfarin clinics. Extensive resea...
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Swansea, Wales, UK
2023
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Institution: | Swansea University |
Degree level: | Doctoral |
Degree name: | Ph.D |
Supervisor: | Curtis, Daniel. |
URI: | https://cronfa.swan.ac.uk/Record/cronfa64089 |
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v2 64089 2023-08-21 Challenges in optical micro-rheometry for blood clot detection bd85065cb9bb2acc5c87e28805009a81 LAURA O'DEA LAURA O'DEA true false 2023-08-21 The need for rapid, cheap and accessible method to accurately quantify the rheological state of a clotting sample of blood has been highlighted by the recent COVID-19 pandemic. Such a device would be significant for use for theranostic application in trauma care and warfarin clinics. Extensive research based on conventional rheometric approaches have established the Gel Point (GP) as a biometric for healthy coagulation. Translation of these conventional techniques to the clinical environment however, is challenging and an alternative rheometrical assay that is more amenable to deployment in a clinical setting is required. Presented here, for the first time, is a desktop, point-of-care light scattering technique capable of identifying the GP in a sample undergoing gelation. This is done using standard Diffusing Wave Spectroscopy techniques, with the method extended to gelatin samples with decreased scatterer concentration to mimic scattering properties of biological samples such as blood, using modified Laser Speckle Rheology methods. E-Thesis Swansea, Wales, UK Gel point, clot detection, laser speckle rheometry, diffusing wave spectroscopy 3 3 2023 2023-03-03 10.23889/SUthesis.64089 COLLEGE NANME COLLEGE CODE Swansea University Curtis, Daniel. Doctoral Ph.D EPSRC 2023-10-05T15:19:00.0511625 2023-08-21T10:48:02.8064423 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering LAURA O'DEA 1 Under embargo Under embargo 2023-08-21T10:52:43.1973665 Output 10012742 application/pdf E-Thesis true 2028-05-15T00:00:00.0000000 Copyright: The Author, Laura J. O'Dea, 2023. true eng |
title |
Challenges in optical micro-rheometry for blood clot detection |
spellingShingle |
Challenges in optical micro-rheometry for blood clot detection LAURA O'DEA |
title_short |
Challenges in optical micro-rheometry for blood clot detection |
title_full |
Challenges in optical micro-rheometry for blood clot detection |
title_fullStr |
Challenges in optical micro-rheometry for blood clot detection |
title_full_unstemmed |
Challenges in optical micro-rheometry for blood clot detection |
title_sort |
Challenges in optical micro-rheometry for blood clot detection |
author_id_str_mv |
bd85065cb9bb2acc5c87e28805009a81 |
author_id_fullname_str_mv |
bd85065cb9bb2acc5c87e28805009a81_***_LAURA O'DEA |
author |
LAURA O'DEA |
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LAURA O'DEA |
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E-Thesis |
publishDate |
2023 |
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Swansea University |
doi_str_mv |
10.23889/SUthesis.64089 |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering |
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description |
The need for rapid, cheap and accessible method to accurately quantify the rheological state of a clotting sample of blood has been highlighted by the recent COVID-19 pandemic. Such a device would be significant for use for theranostic application in trauma care and warfarin clinics. Extensive research based on conventional rheometric approaches have established the Gel Point (GP) as a biometric for healthy coagulation. Translation of these conventional techniques to the clinical environment however, is challenging and an alternative rheometrical assay that is more amenable to deployment in a clinical setting is required. Presented here, for the first time, is a desktop, point-of-care light scattering technique capable of identifying the GP in a sample undergoing gelation. This is done using standard Diffusing Wave Spectroscopy techniques, with the method extended to gelatin samples with decreased scatterer concentration to mimic scattering properties of biological samples such as blood, using modified Laser Speckle Rheology methods. |
published_date |
2023-03-03T15:19:01Z |
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1778925480614821888 |
score |
11.02167 |