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Diet and the evolution of ADH7 across seven orders of mammals

Swellan L. Pinto, Mareike C. Janiak, Gwen Dutyschaever, Marília A. S. Barros, Adrian Guadamuz Chavarria, Maria Pia Martin, Fred Y. Y. Tuh, Carmen Soto Valverde, Lisa M. Sims, Robert M. R. Barclay, Konstans Wells Orcid Logo, Nathaniel J. Dominy, Daniel M. A. Pessoa, Matthew A. Carrigan, Amanda D. Melin

Royal Society Open Science, Volume: 10, Issue: 7

Swansea University Author: Konstans Wells Orcid Logo

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DOI (Published version): 10.1098/rsos.230451

Abstract

Dietary variation within and across species drives the eco-evolutionary responsiveness of genes necessary to metabolize nutrients and other components. Recent evidence from humans and other mammals suggests that sugar-rich diets of floral nectar and ripe fruit have favoured mutations in, and functio...

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Published in: Royal Society Open Science
ISSN: 2054-5703
Published: The Royal Society 2023
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spelling v2 63870 2023-07-12 Diet and the evolution of ADH7 across seven orders of mammals d18166c31e89833c55ef0f2cbb551243 0000-0003-0377-2463 Konstans Wells Konstans Wells true false 2023-07-12 SBI Dietary variation within and across species drives the eco-evolutionary responsiveness of genes necessary to metabolize nutrients and other components. Recent evidence from humans and other mammals suggests that sugar-rich diets of floral nectar and ripe fruit have favoured mutations in, and functional preservation of, the ADH7 gene, which encodes the ADH class 4 enzyme responsible for metabolizing ethanol. Here we interrogate a large, comparative dataset of ADH7 gene sequence variation, including that underlying the amino acid residue located at the key site (294) that regulates the affinity of ADH7 for ethanol. Our analyses span 171 mammal species, including 59 newly sequenced. We report extensive variation, especially among frugivorous and nectarivorous bats, with potential for functional impact. We also report widespread variation in the retention and probable pseudogenization of ADH7. However, we find little statistical evidence of an overarching impact of dietary behaviour on putative ADH7 function or presence of derived alleles at site 294 across mammals, which suggests that the evolution of ADH7 is shaped by complex factors. Our study reports extensive new diversity in a gene of longstanding ecological interest, offers new sources of variation to be explored in functional assays in future study, and advances our understanding of the processes of molecular evolution. Journal Article Royal Society Open Science 10 7 The Royal Society 2054-5703 Ethanol metabolism, alcohol dehydrogenase, dietary adaptation, comparative genetics, mammals 31 7 2023 2023-07-31 10.1098/rsos.230451 http://dx.doi.org/10.1098/rsos.230451 COLLEGE NANME Biosciences COLLEGE CODE SBI Swansea University Another institution paid the OA fee Canada Research Chairs Program (950-231257), David and Lucile Packard Foundation (2007-31754), Leakey Foundation, Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-03782), Sigma Xi, the Scientific Research Honour Society (S.L.P.) 2023-08-24T10:08:18.5804337 2023-07-12T11:33:03.3536743 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Swellan L. Pinto 1 Mareike C. Janiak 2 Gwen Dutyschaever 3 Marília A. S. Barros 4 Adrian Guadamuz Chavarria 5 Maria Pia Martin 6 Fred Y. Y. Tuh 7 Carmen Soto Valverde 8 Lisa M. Sims 9 Robert M. R. Barclay 10 Konstans Wells 0000-0003-0377-2463 11 Nathaniel J. Dominy 12 Daniel M. A. Pessoa 13 Matthew A. Carrigan 14 Amanda D. Melin 15 63870__28111__fb36ad811ba5489d98ed34da70ccb43c.pdf Pinto_etal_2023_RSocOpenSci.pdf 2023-07-13T07:54:26.1824652 Output 1778031 application/pdf Version of Record true © 2023 The Authors. Published by the Royal Society. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/ 198 true https://datadryad.org/stash/dataset/doi:10.5061/dryad.t4b8gtj6r
title Diet and the evolution of ADH7 across seven orders of mammals
spellingShingle Diet and the evolution of ADH7 across seven orders of mammals
Konstans Wells
title_short Diet and the evolution of ADH7 across seven orders of mammals
title_full Diet and the evolution of ADH7 across seven orders of mammals
title_fullStr Diet and the evolution of ADH7 across seven orders of mammals
title_full_unstemmed Diet and the evolution of ADH7 across seven orders of mammals
title_sort Diet and the evolution of ADH7 across seven orders of mammals
author_id_str_mv d18166c31e89833c55ef0f2cbb551243
author_id_fullname_str_mv d18166c31e89833c55ef0f2cbb551243_***_Konstans Wells
author Konstans Wells
author2 Swellan L. Pinto
Mareike C. Janiak
Gwen Dutyschaever
Marília A. S. Barros
Adrian Guadamuz Chavarria
Maria Pia Martin
Fred Y. Y. Tuh
Carmen Soto Valverde
Lisa M. Sims
Robert M. R. Barclay
Konstans Wells
Nathaniel J. Dominy
Daniel M. A. Pessoa
Matthew A. Carrigan
Amanda D. Melin
format Journal article
container_title Royal Society Open Science
container_volume 10
container_issue 7
publishDate 2023
institution Swansea University
issn 2054-5703
doi_str_mv 10.1098/rsos.230451
publisher The Royal Society
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
url http://dx.doi.org/10.1098/rsos.230451
document_store_str 1
active_str 0
description Dietary variation within and across species drives the eco-evolutionary responsiveness of genes necessary to metabolize nutrients and other components. Recent evidence from humans and other mammals suggests that sugar-rich diets of floral nectar and ripe fruit have favoured mutations in, and functional preservation of, the ADH7 gene, which encodes the ADH class 4 enzyme responsible for metabolizing ethanol. Here we interrogate a large, comparative dataset of ADH7 gene sequence variation, including that underlying the amino acid residue located at the key site (294) that regulates the affinity of ADH7 for ethanol. Our analyses span 171 mammal species, including 59 newly sequenced. We report extensive variation, especially among frugivorous and nectarivorous bats, with potential for functional impact. We also report widespread variation in the retention and probable pseudogenization of ADH7. However, we find little statistical evidence of an overarching impact of dietary behaviour on putative ADH7 function or presence of derived alleles at site 294 across mammals, which suggests that the evolution of ADH7 is shaped by complex factors. Our study reports extensive new diversity in a gene of longstanding ecological interest, offers new sources of variation to be explored in functional assays in future study, and advances our understanding of the processes of molecular evolution.
published_date 2023-07-31T10:08:19Z
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