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Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis

Stephen Roberts Orcid Logo, Sian Morrison-Rees, Nikhil Thapar Orcid Logo, John Williams

United European Gastroenterology Journal, Volume: 12, Issue: 1, Pages: 89 - 102

Swansea University Authors: Stephen Roberts Orcid Logo, Sian Morrison-Rees, John Williams

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DOI (Published version): 10.1002/ueg2.12465

Abstract

BackgroundSeveral studies have reported large increases in the incidence of eosinophilic oesophagitis (EoE) in the last 20 years. We aimed to systematically review the incidence and prevalence of EoE, focused on all European countries.MethodsSystematic review and meta-analysis up to 31 December 2022...

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Published in: United European Gastroenterology Journal
ISSN: 2050-6406 2050-6414
Published: Wiley 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa63509
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We aimed to systematically review the incidence and prevalence of EoE, focused on all European countries.MethodsSystematic review and meta-analysis up to 31 December 2022, based on PubMed, CINAHL and extensive hand searching of reference lists. Twenty-five eligible studies were identified and included.ResultsFor both adults and children, the highest EoE incidence and prevalence have been reported from regional studies in Spain. EoE incidence for both adults and children was significantly lower (p &lt; 0.001) in nationwide studies (meta-analysis = 3.64 per 100,000 person-years overall) compared with regional or centre-based studies (7.16). EoE incidence and prevalence were significantly higher (p &lt; 0.001) in adults than children. All studies that reported on longitudinal trends in EoE incidence showed increases over time, more markedly during more recent years. Larger increases in incidence tend to refer to regional rather than nationwide studies; from Spain, Switzerland and Denmark, both for paediatric and adult age groups. Increases in EoE incidence 100,000 person-years were larger than for incidence per number of diagnostic endoscopies. The most frequently reported co-morbidities in adults were rhinitis, followed by asthma, food allergy and gastroesophageal reflux disease, and in children, erosive oesophagitis, asthma, food allergy and rhinitis.ConclusionsThe incidence of EoE has increased in Europe over the last 30 years, exceeding increases in the volume of oesophago-gastro-duodenoscopies performed. The patchy and low incidence and prevalence of EoE generally in Europe and compared with North America, may reflect a lack of clinical awareness and research focus rather than a genuinely low incidence of EoE. 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spelling v2 63509 2023-05-19 Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis cb60dd928f72fe7ea03595dab995f070 0000-0001-7981-520X Stephen Roberts Stephen Roberts true false bad1f56ff19d41eb07cfaa13a50bff6e Sian Morrison-Rees Sian Morrison-Rees true false 911a5c03419acf47eab0844e2cd5ab7f John Williams John Williams true false 2023-05-19 MEDS BackgroundSeveral studies have reported large increases in the incidence of eosinophilic oesophagitis (EoE) in the last 20 years. We aimed to systematically review the incidence and prevalence of EoE, focused on all European countries.MethodsSystematic review and meta-analysis up to 31 December 2022, based on PubMed, CINAHL and extensive hand searching of reference lists. Twenty-five eligible studies were identified and included.ResultsFor both adults and children, the highest EoE incidence and prevalence have been reported from regional studies in Spain. EoE incidence for both adults and children was significantly lower (p < 0.001) in nationwide studies (meta-analysis = 3.64 per 100,000 person-years overall) compared with regional or centre-based studies (7.16). EoE incidence and prevalence were significantly higher (p < 0.001) in adults than children. All studies that reported on longitudinal trends in EoE incidence showed increases over time, more markedly during more recent years. Larger increases in incidence tend to refer to regional rather than nationwide studies; from Spain, Switzerland and Denmark, both for paediatric and adult age groups. Increases in EoE incidence 100,000 person-years were larger than for incidence per number of diagnostic endoscopies. The most frequently reported co-morbidities in adults were rhinitis, followed by asthma, food allergy and gastroesophageal reflux disease, and in children, erosive oesophagitis, asthma, food allergy and rhinitis.ConclusionsThe incidence of EoE has increased in Europe over the last 30 years, exceeding increases in the volume of oesophago-gastro-duodenoscopies performed. The patchy and low incidence and prevalence of EoE generally in Europe and compared with North America, may reflect a lack of clinical awareness and research focus rather than a genuinely low incidence of EoE. A co-ordinated Europe-wide study that uses standardised methodology is urgently needed to provide a comprehensive picture of EoE incidence and prevalence across Europe. Journal Article United European Gastroenterology Journal 12 1 89 102 Wiley 2050-6406 2050-6414 eosinophilic oesophagitis; Europe; incidence; prevalence; trends 1 2 2024 2024-02-01 10.1002/ueg2.12465 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) United European Gastroenterology 2024-07-15T12:19:42.9832225 2023-05-19T12:57:31.3333899 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Stephen Roberts 0000-0001-7981-520X 1 Sian Morrison-Rees 2 Nikhil Thapar 0000-0002-0276-9951 3 John Williams 4 63509__29990__a740191511734260a474cfe3362feff3.pdf 63509.VOR.pdf 2024-04-11T12:33:50.4984132 Output 1279434 application/pdf Version of Record true This is an open access article under the terms of the Creative Commons Attribution NonCommercial‐NoDerivs License. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
spellingShingle Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
Stephen Roberts
Sian Morrison-Rees
John Williams
title_short Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
title_full Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
title_fullStr Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
title_full_unstemmed Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
title_sort Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta‐analysis
author_id_str_mv cb60dd928f72fe7ea03595dab995f070
bad1f56ff19d41eb07cfaa13a50bff6e
911a5c03419acf47eab0844e2cd5ab7f
author_id_fullname_str_mv cb60dd928f72fe7ea03595dab995f070_***_Stephen Roberts
bad1f56ff19d41eb07cfaa13a50bff6e_***_Sian Morrison-Rees
911a5c03419acf47eab0844e2cd5ab7f_***_John Williams
author Stephen Roberts
Sian Morrison-Rees
John Williams
author2 Stephen Roberts
Sian Morrison-Rees
Nikhil Thapar
John Williams
format Journal article
container_title United European Gastroenterology Journal
container_volume 12
container_issue 1
container_start_page 89
publishDate 2024
institution Swansea University
issn 2050-6406
2050-6414
doi_str_mv 10.1002/ueg2.12465
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
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description BackgroundSeveral studies have reported large increases in the incidence of eosinophilic oesophagitis (EoE) in the last 20 years. We aimed to systematically review the incidence and prevalence of EoE, focused on all European countries.MethodsSystematic review and meta-analysis up to 31 December 2022, based on PubMed, CINAHL and extensive hand searching of reference lists. Twenty-five eligible studies were identified and included.ResultsFor both adults and children, the highest EoE incidence and prevalence have been reported from regional studies in Spain. EoE incidence for both adults and children was significantly lower (p < 0.001) in nationwide studies (meta-analysis = 3.64 per 100,000 person-years overall) compared with regional or centre-based studies (7.16). EoE incidence and prevalence were significantly higher (p < 0.001) in adults than children. All studies that reported on longitudinal trends in EoE incidence showed increases over time, more markedly during more recent years. Larger increases in incidence tend to refer to regional rather than nationwide studies; from Spain, Switzerland and Denmark, both for paediatric and adult age groups. Increases in EoE incidence 100,000 person-years were larger than for incidence per number of diagnostic endoscopies. The most frequently reported co-morbidities in adults were rhinitis, followed by asthma, food allergy and gastroesophageal reflux disease, and in children, erosive oesophagitis, asthma, food allergy and rhinitis.ConclusionsThe incidence of EoE has increased in Europe over the last 30 years, exceeding increases in the volume of oesophago-gastro-duodenoscopies performed. The patchy and low incidence and prevalence of EoE generally in Europe and compared with North America, may reflect a lack of clinical awareness and research focus rather than a genuinely low incidence of EoE. A co-ordinated Europe-wide study that uses standardised methodology is urgently needed to provide a comprehensive picture of EoE incidence and prevalence across Europe.
published_date 2024-02-01T12:19:42Z
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