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Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus

Julanta Carriere, Nia Davies, Margaret R. Cunningham Orcid Logo, Lisa Wallace Orcid Logo, Aidan Seeley Orcid Logo

Pharmacology Research and Perspectives, Volume: 11, Issue: 6

Swansea University Authors: Julanta Carriere, Nia Davies, Lisa Wallace Orcid Logo, Aidan Seeley Orcid Logo

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DOI (Published version): 10.1002/prp2.1158

Abstract

Co-creation within higher education emphasizes learner empowerment to promote collaboration between the students and staff, enabling students to become active participants in their learning process and the construction of resources with academic staff. Concurrently, a diminishing number of higher ed...

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Published in: Pharmacology Research and Perspectives
ISSN: 2052-1707 2052-1707
Published: Wiley 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63445
first_indexed 2023-05-12T11:03:46Z
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Concurrently, a diminishing number of higher education institutions offer in vivo practical classes, resulting in an in vivo skills shortage. To address this, and to actively engage students in their own learning, we describe the co-creation of a student-led drug trial using Lumbriculus variegatus. Under blinded conditions, final-year undergraduate biomedical science students, under the tutelage of academic staff and fellow students, were involved in the co-creation of an in vivo practical class to determine the effects of histamine and histamine receptor inverse agonists mepyramine and loratadine. Throughout this process, undergraduate- and masters-level students played key roles in every aspect of practical delivery and data analysis. Herein, students demonstrated the test compounds, both in isolation and in combination, resulted in reduced stereotypical movements of L. variegatus (p&#x2009;&lt;&#x2009;.05, n&#x2009;&#x2265;&#x2009;6). 15% of students in the class responded to a feedback survey (n&#x2009;=&#x2009;8) after the class. Students reported the class provided &#x201C;real life&#x201D; insights into in vivo research and enabled the development of hands-on skills which would be useful in applying in their future careers. All students reported that they enjoyed the class with 25% (n&#x2009;=&#x2009;2) reporting concerns about animal use in research, enabling useful discussions about animals in research. 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spelling 2024-06-07T11:45:39.7421555 v2 63445 2023-05-12 Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus 4d91151193de7925ea048bf39f32198b Julanta Carriere Julanta Carriere true false 977abe5c673627024e4913d034dcbc95 Nia Davies Nia Davies true false 5cebf16bdbc8022118a35da9d13f5087 0000-0001-7471-9833 Lisa Wallace Lisa Wallace true false c69dba86b3ccf9a140b67b7e97d68bba 0000-0001-7085-4296 Aidan Seeley Aidan Seeley true false 2023-05-12 Co-creation within higher education emphasizes learner empowerment to promote collaboration between the students and staff, enabling students to become active participants in their learning process and the construction of resources with academic staff. Concurrently, a diminishing number of higher education institutions offer in vivo practical classes, resulting in an in vivo skills shortage. To address this, and to actively engage students in their own learning, we describe the co-creation of a student-led drug trial using Lumbriculus variegatus. Under blinded conditions, final-year undergraduate biomedical science students, under the tutelage of academic staff and fellow students, were involved in the co-creation of an in vivo practical class to determine the effects of histamine and histamine receptor inverse agonists mepyramine and loratadine. Throughout this process, undergraduate- and masters-level students played key roles in every aspect of practical delivery and data analysis. Herein, students demonstrated the test compounds, both in isolation and in combination, resulted in reduced stereotypical movements of L. variegatus (p < .05, n ≥ 6). 15% of students in the class responded to a feedback survey (n = 8) after the class. Students reported the class provided “real life” insights into in vivo research and enabled the development of hands-on skills which would be useful in applying in their future careers. All students reported that they enjoyed the class with 25% (n = 2) reporting concerns about animal use in research, enabling useful discussions about animals in research. Moreover, these student-led in vivo trials add to the pharmacological knowledge of L. variegatus promoting education-led research. Journal Article Pharmacology Research and Perspectives 11 6 Wiley 2052-1707 2052-1707 animal models, co-creation, histamine, invertebrates, student-led, teaching 8 12 2023 2023-12-08 10.1002/prp2.1158 COLLEGE NANME COLLEGE CODE Swansea University SU Library paid the OA fee (TA Institutional Deal) British Pharmacological Society - Education Grant 2024-06-07T11:45:39.7421555 2023-05-12T12:01:03.0641523 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Julanta Carriere 1 Nia Davies 2 Margaret R. Cunningham 0000-0001-6454-8671 3 Lisa Wallace 0000-0001-7471-9833 4 Aidan Seeley 0000-0001-7085-4296 5 63445__29395__a5d8ebbf04684a10846de2bb9603165e.pdf 63445.pdf 2024-01-05T14:35:34.3803702 Output 2565807 application/pdf Version of Record true This is an open access article under the terms of the Creative Commons Attribution License. true eng https://creativecommons.org/licenses/by/4.0/
title Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
spellingShingle Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
Julanta Carriere
Nia Davies
Lisa Wallace
Aidan Seeley
title_short Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
title_full Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
title_fullStr Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
title_full_unstemmed Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
title_sort Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
author_id_str_mv 4d91151193de7925ea048bf39f32198b
977abe5c673627024e4913d034dcbc95
5cebf16bdbc8022118a35da9d13f5087
c69dba86b3ccf9a140b67b7e97d68bba
author_id_fullname_str_mv 4d91151193de7925ea048bf39f32198b_***_Julanta Carriere
977abe5c673627024e4913d034dcbc95_***_Nia Davies
5cebf16bdbc8022118a35da9d13f5087_***_Lisa Wallace
c69dba86b3ccf9a140b67b7e97d68bba_***_Aidan Seeley
author Julanta Carriere
Nia Davies
Lisa Wallace
Aidan Seeley
author2 Julanta Carriere
Nia Davies
Margaret R. Cunningham
Lisa Wallace
Aidan Seeley
format Journal article
container_title Pharmacology Research and Perspectives
container_volume 11
container_issue 6
publishDate 2023
institution Swansea University
issn 2052-1707
2052-1707
doi_str_mv 10.1002/prp2.1158
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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description Co-creation within higher education emphasizes learner empowerment to promote collaboration between the students and staff, enabling students to become active participants in their learning process and the construction of resources with academic staff. Concurrently, a diminishing number of higher education institutions offer in vivo practical classes, resulting in an in vivo skills shortage. To address this, and to actively engage students in their own learning, we describe the co-creation of a student-led drug trial using Lumbriculus variegatus. Under blinded conditions, final-year undergraduate biomedical science students, under the tutelage of academic staff and fellow students, were involved in the co-creation of an in vivo practical class to determine the effects of histamine and histamine receptor inverse agonists mepyramine and loratadine. Throughout this process, undergraduate- and masters-level students played key roles in every aspect of practical delivery and data analysis. Herein, students demonstrated the test compounds, both in isolation and in combination, resulted in reduced stereotypical movements of L. variegatus (p < .05, n ≥ 6). 15% of students in the class responded to a feedback survey (n = 8) after the class. Students reported the class provided “real life” insights into in vivo research and enabled the development of hands-on skills which would be useful in applying in their future careers. All students reported that they enjoyed the class with 25% (n = 2) reporting concerns about animal use in research, enabling useful discussions about animals in research. Moreover, these student-led in vivo trials add to the pharmacological knowledge of L. variegatus promoting education-led research.
published_date 2023-12-08T14:24:55Z
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