A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers

Correia, Bárbara; Oliveira, Daniela; Vulpe, Georgeta; M., Ana P.; F., M. Goreti; Duarte, Abel J.; Sharma, Sanjiv; C., Felismina T.

doi:10.1039/d3sd00022b

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A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers

Bárbara Correia, Daniela Oliveira, Georgeta Vulpe, Ana P. M. Tavares, M. Goreti F. Sales

, Abel J. Duarte

, Sanjiv Sharma

, Felismina T. C. Moreira

Sensors & Diagnostics

Swansea University Authors: Georgeta Vulpe, Sanjiv Sharma

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DOI (Published version): 10.1039/d3sd00022b

Abstract

Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based Po...

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Published in:	Sensors & Diagnostics
ISSN:	2635-0998
Published:	Royal Society of Chemistry (RSC)
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URI:	https://cronfa.swan.ac.uk/Record/cronfa63391
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first_indexed	2023-05-10T13:23:11Z
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Daniela O. acknowledge funding from Fundação para a Ciência e Tecnologia, I.P., through the PhD grant reference SFRH/BD/137832/2018. This work was also supported by Multi-year funding of European Union (FEDER funds through Compete) and National Funds (FCT/MCTES) through Project UID/QUI/50006/2019 and UIDB/04730/2020.</funders><projectreference/><lastEdited>2023-06-21T10:08:00.0245015</lastEdited><Created>2023-05-10T14:18:35.3894177</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Bárbara</firstname><surname>Correia</surname><order>1</order></author><author><firstname>Daniela</firstname><surname>Oliveira</surname><order>2</order></author><author><firstname>Georgeta</firstname><surname>Vulpe</surname><order>3</order></author><author><firstname>Ana P. M.</firstname><surname>Tavares</surname><order>4</order></author><author><firstname>M. 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spelling	v2 63391 2023-05-10 A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers d1d5815c60d63534a10a81489255c681 Georgeta Vulpe Georgeta Vulpe true false b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2023-05-10 FGSEN Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based PoCT device. Cork is known to be fully biodegradable and easily recycled without producing toxic residues. We report on how cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an "artificial antibody" can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg/mL, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. In addition, it has a huge environmental impact as it can reduce the waste generated by other polymeric/ceramic carriers used for the same purpose. Journal Article Sensors & Diagnostics Royal Society of Chemistry (RSC) 2635-0998 0 0 0 0001-01-01 10.1039/d3sd00022b http://dx.doi.org/10.1039/d3sd00022b COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University The authors acknowledge funding through project 2IQBioneuro with the reference (0624_2IQBIONEURO_6_E), entitled, Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases, EP-INTERREG V Spain Portugal (POCTEP). Daniela O. acknowledge funding from Fundação para a Ciência e Tecnologia, I.P., through the PhD grant reference SFRH/BD/137832/2018. This work was also supported by Multi-year funding of European Union (FEDER funds through Compete) and National Funds (FCT/MCTES) through Project UID/QUI/50006/2019 and UIDB/04730/2020. 2023-06-21T10:08:00.0245015 2023-05-10T14:18:35.3894177 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Bárbara Correia 1 Daniela Oliveira 2 Georgeta Vulpe 3 Ana P. M. Tavares 4 M. Goreti F. Sales 0000-0001-9936-7336 5 Abel J. Duarte 0000-0003-0218-1952 6 Sanjiv Sharma 0000-0003-3828-737X 7 Felismina T. C. Moreira 8 63391__27407__189bf69c78fd416493436613282a98aa.pdf 63391.pdf 2023-05-10T14:24:12.9829948 Output 1652369 application/pdf Accepted Manuscript true false 63391__27769__4cb3100d79ff4981ab0b2c6455ea225c.pdf 63391.pdf 2023-06-08T15:21:01.4263592 Output 1499130 application/pdf Version of Record true Open Access Article. . This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence true eng http://creativecommons.org/licenses/by-nc/3.0/
title	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
spellingShingle	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers Georgeta Vulpe Sanjiv Sharma
title_short	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_full	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_fullStr	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_full_unstemmed	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_sort	A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
author_id_str_mv	d1d5815c60d63534a10a81489255c681 b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv	d1d5815c60d63534a10a81489255c681_*_Georgeta Vulpe b6b7506358522f607b171ec9c94757b7_*_Sanjiv Sharma
author	Georgeta Vulpe Sanjiv Sharma
author2	Bárbara Correia Daniela Oliveira Georgeta Vulpe Ana P. M. Tavares M. Goreti F. Sales Abel J. Duarte Sanjiv Sharma Felismina T. C. Moreira
format	Journal article
container_title	Sensors & Diagnostics
institution	Swansea University
issn	2635-0998
doi_str_mv	10.1039/d3sd00022b
publisher	Royal Society of Chemistry (RSC)
college_str	Faculty of Science and Engineering
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hierarchy_top_title	Faculty of Science and Engineering
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department_str	School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url	http://dx.doi.org/10.1039/d3sd00022b
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description	Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based PoCT device. Cork is known to be fully biodegradable and easily recycled without producing toxic residues. We report on how cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an "artificial antibody" can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg/mL, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. In addition, it has a huge environmental impact as it can reduce the waste generated by other polymeric/ceramic carriers used for the same purpose.
published_date	0001-01-01T10:07:58Z
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A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers

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