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The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer

Mari Jones Orcid Logo, Julia Lowin, Berni Sewell Orcid Logo, Rachel Gemine, Sarah Rees Orcid Logo, Kirsty Lanyon Orcid Logo, Keir Lewis Orcid Logo

Value in Health, Volume: 26, Issue: 8, Pages: 1192 - 1200

Swansea University Authors: Mari Jones Orcid Logo, Julia Lowin, Berni Sewell Orcid Logo, Rachel Gemine, Sarah Rees Orcid Logo, Kirsty Lanyon Orcid Logo, Keir Lewis Orcid Logo

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DOI (Published version): 10.1016/j.jval.2023.03.2429

Abstract

Stopping smoking has proven benefits in nearly all illnesses but the impact and health economic benefits of stopping smoking following a diagnosis of lung cancer are less well defined. We assessed the cost-effectiveness of smoking cessation (SC) services for newly diagnosed lung cancer patients agai...

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Published in: Value in Health
ISSN: 1098-3015
Published: Elsevier BV 2023
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We assessed the cost-effectiveness of smoking cessation (SC) services for newly diagnosed lung cancer patients against current usual care, where patients are unlikely to receive SC service referral. A health economic model was constructed in Excel. The modelled population comprised patients with a new diagnosis of non-small-cell lung cancer (NSCLC). Data from the LungCast dataset (Clinical Trials Identifier NCT01192256) were used to estimate model inputs. A structured search of published literature identified inputs not represented in LungCast, including healthcare resource use and costs. Costs were estimated from a 2020/21 UK NHS and Personal Social Services (PSS) perspective. The model estimated the incremental quality-adjusted adjusted life year (QALY) gained in newly diagnosed NSCLC patients receiving targeted SC intervention compared to those receiving no intervention. Extensive one-way sensitivity analyses (SA) explored input and dataset uncertainty.Results: In the five-year base-case, the model estimated an incremental cost of £14,904 per QALY gained through SC intervention. Sensitivity analysis estimated an outcome range of between £9,935 and £32,246 per QALY gained. 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spelling v2 63282 2023-04-28 The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer 8e326860810f5f960b088db10ef58906 0000-0001-9661-4899 Mari Jones Mari Jones true false a9897f4e67e285093fefafcb1c954364 Julia Lowin Julia Lowin true false f6a4af2cfa4275d2a8ebba292fa14421 0000-0001-5471-922X Berni Sewell Berni Sewell true false f6d0b85d0d231588029524ee2e442e56 Rachel Gemine Rachel Gemine true false 86073be88970f36d7ffa0a1f0768be2b 0000-0002-1939-0120 Sarah Rees Sarah Rees true false a3f45c952158fb8d56dc7dbff5a4cf2d 0000-0002-4227-6852 Kirsty Lanyon Kirsty Lanyon true false bc53c343c975d6e0ad88c1d8b9ddd70c 0000-0002-8248-6774 Keir Lewis Keir Lewis true false 2023-04-28 PHAC Stopping smoking has proven benefits in nearly all illnesses but the impact and health economic benefits of stopping smoking following a diagnosis of lung cancer are less well defined. We assessed the cost-effectiveness of smoking cessation (SC) services for newly diagnosed lung cancer patients against current usual care, where patients are unlikely to receive SC service referral. A health economic model was constructed in Excel. The modelled population comprised patients with a new diagnosis of non-small-cell lung cancer (NSCLC). Data from the LungCast dataset (Clinical Trials Identifier NCT01192256) were used to estimate model inputs. A structured search of published literature identified inputs not represented in LungCast, including healthcare resource use and costs. Costs were estimated from a 2020/21 UK NHS and Personal Social Services (PSS) perspective. The model estimated the incremental quality-adjusted adjusted life year (QALY) gained in newly diagnosed NSCLC patients receiving targeted SC intervention compared to those receiving no intervention. Extensive one-way sensitivity analyses (SA) explored input and dataset uncertainty.Results: In the five-year base-case, the model estimated an incremental cost of £14,904 per QALY gained through SC intervention. Sensitivity analysis estimated an outcome range of between £9,935 and £32,246 per QALY gained. The model was most sensitive to the estimates of relative quit rates and expected healthcare resource use. Journal Article Value in Health 26 8 1192 1200 Elsevier BV 1098-3015 cost, economic model, non–small cell lung cancer, quality-adjusted life-year, smoking cessation 1 8 2023 2023-08-01 10.1016/j.jval.2023.03.2429 http://dx.doi.org/10.1016/j.jval.2023.03.2429 COLLEGE NANME Public Health COLLEGE CODE PHAC Swansea University SU Library paid the OA fee (TA Institutional Deal) 2024-03-05T09:30:36.4371313 2023-04-28T15:56:33.8863952 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Mari Jones 0000-0001-9661-4899 1 Julia Lowin 2 Berni Sewell 0000-0001-5471-922X 3 Rachel Gemine 4 Sarah Rees 0000-0002-1939-0120 5 Kirsty Lanyon 0000-0002-4227-6852 6 Keir Lewis 0000-0002-8248-6774 7 63282__27560__0188e07a58fe4b43a9b71ab6a6b0fb24.pdf 63282.pdf 2023-05-22T14:12:43.0838966 Output 806317 application/pdf Version of Record true c. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) true eng http://creativecommons.org/licenses/by/4.0/
title The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
spellingShingle The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
Mari Jones
Julia Lowin
Berni Sewell
Rachel Gemine
Sarah Rees
Kirsty Lanyon
Keir Lewis
title_short The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
title_full The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
title_fullStr The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
title_full_unstemmed The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
title_sort The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
author_id_str_mv 8e326860810f5f960b088db10ef58906
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author_id_fullname_str_mv 8e326860810f5f960b088db10ef58906_***_Mari Jones
a9897f4e67e285093fefafcb1c954364_***_Julia Lowin
f6a4af2cfa4275d2a8ebba292fa14421_***_Berni Sewell
f6d0b85d0d231588029524ee2e442e56_***_Rachel Gemine
86073be88970f36d7ffa0a1f0768be2b_***_Sarah Rees
a3f45c952158fb8d56dc7dbff5a4cf2d_***_Kirsty Lanyon
bc53c343c975d6e0ad88c1d8b9ddd70c_***_Keir Lewis
author Mari Jones
Julia Lowin
Berni Sewell
Rachel Gemine
Sarah Rees
Kirsty Lanyon
Keir Lewis
author2 Mari Jones
Julia Lowin
Berni Sewell
Rachel Gemine
Sarah Rees
Kirsty Lanyon
Keir Lewis
format Journal article
container_title Value in Health
container_volume 26
container_issue 8
container_start_page 1192
publishDate 2023
institution Swansea University
issn 1098-3015
doi_str_mv 10.1016/j.jval.2023.03.2429
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
url http://dx.doi.org/10.1016/j.jval.2023.03.2429
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description Stopping smoking has proven benefits in nearly all illnesses but the impact and health economic benefits of stopping smoking following a diagnosis of lung cancer are less well defined. We assessed the cost-effectiveness of smoking cessation (SC) services for newly diagnosed lung cancer patients against current usual care, where patients are unlikely to receive SC service referral. A health economic model was constructed in Excel. The modelled population comprised patients with a new diagnosis of non-small-cell lung cancer (NSCLC). Data from the LungCast dataset (Clinical Trials Identifier NCT01192256) were used to estimate model inputs. A structured search of published literature identified inputs not represented in LungCast, including healthcare resource use and costs. Costs were estimated from a 2020/21 UK NHS and Personal Social Services (PSS) perspective. The model estimated the incremental quality-adjusted adjusted life year (QALY) gained in newly diagnosed NSCLC patients receiving targeted SC intervention compared to those receiving no intervention. Extensive one-way sensitivity analyses (SA) explored input and dataset uncertainty.Results: In the five-year base-case, the model estimated an incremental cost of £14,904 per QALY gained through SC intervention. Sensitivity analysis estimated an outcome range of between £9,935 and £32,246 per QALY gained. The model was most sensitive to the estimates of relative quit rates and expected healthcare resource use.
published_date 2023-08-01T09:30:34Z
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