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A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen

Chaoya Xiong, Hai Chen, Jie Zhang, Hui Deng, Zhihui Feng, Pan Xiang, Yupeng Tian, Lei Chen, Martin Gill Orcid Logo, Xiaohe Tian

Sensors and Actuators B: Chemical, Volume: 388, Start page: 133868

Swansea University Author: Martin Gill Orcid Logo

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DOI (Published version): 10.1016/j.snb.2023.133868

Abstract

Visualization of 1O2 in cells is of great significance for revealing the laws of life activities. Although many 1O2 fluorescent probes have been reported, their mechanism of capturing 1O2 has not been innovated. Herein, we report a ruthenium(Ⅱ) bipyridyl complex [Ru(bpy)2L3]PF6 with the ability to s...

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Published in: Sensors and Actuators B: Chemical
ISSN: 0925-4005
Published: Elsevier BV 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63243
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first_indexed 2023-04-25T14:48:16Z
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spelling v2 63243 2023-04-25 A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen 485d85b532851e8863cd19c6af7e00f7 0000-0002-1371-5676 Martin Gill Martin Gill true false 2023-04-25 CHEM Visualization of 1O2 in cells is of great significance for revealing the laws of life activities. Although many 1O2 fluorescent probes have been reported, their mechanism of capturing 1O2 has not been innovated. Herein, we report a ruthenium(Ⅱ) bipyridyl complex [Ru(bpy)2L3]PF6 with the ability to specifically identify 1O2 based on a novel mechanism of action. The non-fluorescent [Ru(bpy)2L3]PF6 can be accurately oxidized by 1O2 to generate a fluorescent substance with a large Stokes shift (184 nm). [Ru(bpy)2L3]PF6 was successfully applied for visualizing the generation process of 1O2 in living cells and monitoring the morphological changes of mitochondria during photodamage. Therefore, [Ru(bpy)2L3]PF6 has potential to be a useful molecular probe for analyzing physiological processes related to 1O2 in organisms. Journal Article Sensors and Actuators B: Chemical 388 133868 Elsevier BV 0925-4005 1 8 2023 2023-08-01 10.1016/j.snb.2023.133868 http://dx.doi.org/10.1016/j.snb.2023.133868 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University Other This work was supported by the National Natural Science Foundation of China (32171001) and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Y2021YY002). 2023-05-24T15:00:02.7660451 2023-04-25T15:36:27.5828252 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Chaoya Xiong 1 Hai Chen 2 Jie Zhang 3 Hui Deng 4 Zhihui Feng 5 Pan Xiang 6 Yupeng Tian 7 Lei Chen 8 Martin Gill 0000-0002-1371-5676 9 Xiaohe Tian 10
title A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
spellingShingle A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
Martin Gill
title_short A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
title_full A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
title_fullStr A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
title_full_unstemmed A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
title_sort A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen
author_id_str_mv 485d85b532851e8863cd19c6af7e00f7
author_id_fullname_str_mv 485d85b532851e8863cd19c6af7e00f7_***_Martin Gill
author Martin Gill
author2 Chaoya Xiong
Hai Chen
Jie Zhang
Hui Deng
Zhihui Feng
Pan Xiang
Yupeng Tian
Lei Chen
Martin Gill
Xiaohe Tian
format Journal article
container_title Sensors and Actuators B: Chemical
container_volume 388
container_start_page 133868
publishDate 2023
institution Swansea University
issn 0925-4005
doi_str_mv 10.1016/j.snb.2023.133868
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url http://dx.doi.org/10.1016/j.snb.2023.133868
document_store_str 0
active_str 0
description Visualization of 1O2 in cells is of great significance for revealing the laws of life activities. Although many 1O2 fluorescent probes have been reported, their mechanism of capturing 1O2 has not been innovated. Herein, we report a ruthenium(Ⅱ) bipyridyl complex [Ru(bpy)2L3]PF6 with the ability to specifically identify 1O2 based on a novel mechanism of action. The non-fluorescent [Ru(bpy)2L3]PF6 can be accurately oxidized by 1O2 to generate a fluorescent substance with a large Stokes shift (184 nm). [Ru(bpy)2L3]PF6 was successfully applied for visualizing the generation process of 1O2 in living cells and monitoring the morphological changes of mitochondria during photodamage. Therefore, [Ru(bpy)2L3]PF6 has potential to be a useful molecular probe for analyzing physiological processes related to 1O2 in organisms.
published_date 2023-08-01T15:00:01Z
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