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The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance

Elliott C.R. Hall, Sarah J. Lockey, Shane Heffernan Orcid Logo, Adam J. Herbert, Georgina K. Stebbings, Stephen H. Day, Malcolm Collins, Yannis P. Pitsiladis, Robert M. Erskine, Alun Williams

Journal of Sports Sciences, Volume: 41, Issue: 1, Pages: 56 - 62

Swansea University Authors: Shane Heffernan Orcid Logo, Alun Williams

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DOI (Published version): 10.1080/02640414.2023.2195737

Abstract

Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism h...

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Published in: Journal of Sports Sciences
ISSN: 0264-0414 1466-447X
Published: Informa UK Limited 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63006
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The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study’s definition of ‘elite’). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p=0.030). 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spelling v2 63006 2023-03-22 The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 050a482b2c9699d25870b9c591541998 Alun Williams Alun Williams true false 2023-03-22 STSC Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study’s definition of ‘elite’). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p=0.030). This study demonstrates that performance differences between elite long-distance runners are associated with rs8192678 genotype, with the Ser allele appearing to enhance performance. Journal Article Journal of Sports Sciences 41 1 56 62 Informa UK Limited 0264-0414 1466-447X Endurance running, road running, genetics, personal best 2 1 2023 2023-01-02 10.1080/02640414.2023.2195737 http://dx.doi.org/10.1080/02640414.2023.2195737 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2023-04-26T12:09:13.2568856 2023-03-22T11:13:10.3471467 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Elliott C.R. Hall 1 Sarah J. Lockey 2 Shane Heffernan 0000-0002-3297-9335 3 Adam J. Herbert 4 Georgina K. Stebbings 5 Stephen H. Day 6 Malcolm Collins 7 Yannis P. Pitsiladis 8 Robert M. Erskine 9 Alun Williams 10 63006__26987__df5d0b5cf7df487b89d9aa0c19db6f93.pdf 63006.pdf 2023-04-05T11:38:24.0136730 Output 779728 application/pdf Version of Record true © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
spellingShingle The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
Shane Heffernan
Alun Williams
title_short The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
title_full The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
title_fullStr The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
title_full_unstemmed The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
title_sort The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance
author_id_str_mv 72c0b36891dfbec0378c0d0f7916e807
050a482b2c9699d25870b9c591541998
author_id_fullname_str_mv 72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan
050a482b2c9699d25870b9c591541998_***_Alun Williams
author Shane Heffernan
Alun Williams
author2 Elliott C.R. Hall
Sarah J. Lockey
Shane Heffernan
Adam J. Herbert
Georgina K. Stebbings
Stephen H. Day
Malcolm Collins
Yannis P. Pitsiladis
Robert M. Erskine
Alun Williams
format Journal article
container_title Journal of Sports Sciences
container_volume 41
container_issue 1
container_start_page 56
publishDate 2023
institution Swansea University
issn 0264-0414
1466-447X
doi_str_mv 10.1080/02640414.2023.2195737
publisher Informa UK Limited
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
url http://dx.doi.org/10.1080/02640414.2023.2195737
document_store_str 1
active_str 0
description Success in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study’s definition of ‘elite’). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p=0.030). This study demonstrates that performance differences between elite long-distance runners are associated with rs8192678 genotype, with the Ser allele appearing to enhance performance.
published_date 2023-01-02T12:09:12Z
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