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The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study

Rachel Churm Orcid Logo, Liam M. Williams, Gareth Dunseath, Sarah L. Prior, Richard M. Bracken, Gareth Dunseath Orcid Logo, Sarah Prior Orcid Logo, Richard Bracken Orcid Logo

European Journal of Nutrition, Volume: 62, Issue: 3, Pages: 1517 - 1526

Swansea University Authors: Rachel Churm Orcid Logo, Gareth Dunseath Orcid Logo, Sarah Prior Orcid Logo, Richard Bracken Orcid Logo

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DOI (Published version): 10.1007/s00394-023-03092-1

Abstract

Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigal...

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Published in: European Journal of Nutrition
ISSN: 1436-6207 1436-6215
Published: Springer Science and Business Media LLC 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa62385
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>62385</id><entry>2023-01-20</entry><title>The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study</title><swanseaauthors><author><sid>c6cd8267ff0b13f2ea333bbfefdae144</sid><ORCID>0000-0001-9855-6282</ORCID><firstname>Rachel</firstname><surname>Churm</surname><name>Rachel Churm</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>fccbba9edcaee08a839a3c5cff8cbe19</sid><ORCID>0000-0001-6022-862X</ORCID><firstname>Gareth</firstname><surname>Dunseath</surname><name>Gareth Dunseath</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cdda101035997acfaa6fdf17097f52b2</sid><ORCID>0000-0001-8703-8092</ORCID><firstname>Sarah</firstname><surname>Prior</surname><name>Sarah Prior</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>f5da81cd18adfdedb2ccb845bddc12f7</sid><ORCID>0000-0002-6986-6449</ORCID><firstname>Richard</firstname><surname>Bracken</surname><name>Richard Bracken</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-01-20</date><deptcode>STSC</deptcode><abstract>Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods: Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26). Results: Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P &lt; 0.05), LT (P &lt; 0.001) and VO2peak (P &lt; 0.01). Noradrenaline (NA) was lower under EGCG at POST (P &lt; 0.05), FATpeak (P &lt; 0.05), LT (P &lt; 0.01) and VO2peak (P &lt; 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P &lt; 0.05). Cycle time to exhaustion was similar (NS). Conclusion: Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate.</abstract><type>Journal Article</type><journal>European Journal of Nutrition</journal><volume>62</volume><journalNumber>3</journalNumber><paginationStart>1517</paginationStart><paginationEnd>1526</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1436-6207</issnPrint><issnElectronic>1436-6215</issnElectronic><keywords>Epigallocatechin gallate, Catecholamines, Substrate metabolism, Graded exercise</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-04-01</publishedDate><doi>10.1007/s00394-023-03092-1</doi><url>http://dx.doi.org/10.1007/s00394-023-03092-1</url><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</funders><projectreference/><lastEdited>2023-06-20T16:22:16.8718593</lastEdited><Created>2023-01-20T11:57:33.4121990</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Sport and Exercise Sciences</level></path><authors><author><firstname>Rachel</firstname><surname>Churm</surname><orcid>0000-0001-9855-6282</orcid><order>1</order></author><author><firstname>Liam M.</firstname><surname>Williams</surname><order>2</order></author><author><firstname>Gareth</firstname><surname>Dunseath</surname><order>3</order></author><author><firstname>Sarah L.</firstname><surname>Prior</surname><order>4</order></author><author><firstname>Richard M.</firstname><surname>Bracken</surname><order>5</order></author><author><firstname>Gareth</firstname><surname>Dunseath</surname><orcid>0000-0001-6022-862X</orcid><order>6</order></author><author><firstname>Sarah</firstname><surname>Prior</surname><orcid>0000-0001-8703-8092</orcid><order>7</order></author><author><firstname>Richard</firstname><surname>Bracken</surname><orcid>0000-0002-6986-6449</orcid><order>8</order></author></authors><documents><document><filename>62385__27898__3dc279e334ba4129bbcaef519c231d83.pdf</filename><originalFilename>62385.VOR.pdf</originalFilename><uploaded>2023-06-20T16:18:56.3313011</uploaded><type>Output</type><contentLength>698775</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© The Author(s) 2023. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling v2 62385 2023-01-20 The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false fccbba9edcaee08a839a3c5cff8cbe19 0000-0001-6022-862X Gareth Dunseath Gareth Dunseath true false cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2023-01-20 STSC Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods: Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26). Results: Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P < 0.05), LT (P < 0.001) and VO2peak (P < 0.01). Noradrenaline (NA) was lower under EGCG at POST (P < 0.05), FATpeak (P < 0.05), LT (P < 0.01) and VO2peak (P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P < 0.05). Cycle time to exhaustion was similar (NS). Conclusion: Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate. Journal Article European Journal of Nutrition 62 3 1517 1526 Springer Science and Business Media LLC 1436-6207 1436-6215 Epigallocatechin gallate, Catecholamines, Substrate metabolism, Graded exercise 1 4 2023 2023-04-01 10.1007/s00394-023-03092-1 http://dx.doi.org/10.1007/s00394-023-03092-1 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University SU Library paid the OA fee (TA Institutional Deal) This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. 2023-06-20T16:22:16.8718593 2023-01-20T11:57:33.4121990 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Rachel Churm 0000-0001-9855-6282 1 Liam M. Williams 2 Gareth Dunseath 3 Sarah L. Prior 4 Richard M. Bracken 5 Gareth Dunseath 0000-0001-6022-862X 6 Sarah Prior 0000-0001-8703-8092 7 Richard Bracken 0000-0002-6986-6449 8 62385__27898__3dc279e334ba4129bbcaef519c231d83.pdf 62385.VOR.pdf 2023-06-20T16:18:56.3313011 Output 698775 application/pdf Version of Record true © The Author(s) 2023. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
spellingShingle The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
Rachel Churm
Gareth Dunseath
Sarah Prior
Richard Bracken
title_short The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
title_full The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
title_fullStr The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
title_full_unstemmed The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
title_sort The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
author_id_str_mv c6cd8267ff0b13f2ea333bbfefdae144
fccbba9edcaee08a839a3c5cff8cbe19
cdda101035997acfaa6fdf17097f52b2
f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel Churm
fccbba9edcaee08a839a3c5cff8cbe19_***_Gareth Dunseath
cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior
f5da81cd18adfdedb2ccb845bddc12f7_***_Richard Bracken
author Rachel Churm
Gareth Dunseath
Sarah Prior
Richard Bracken
author2 Rachel Churm
Liam M. Williams
Gareth Dunseath
Sarah L. Prior
Richard M. Bracken
Gareth Dunseath
Sarah Prior
Richard Bracken
format Journal article
container_title European Journal of Nutrition
container_volume 62
container_issue 3
container_start_page 1517
publishDate 2023
institution Swansea University
issn 1436-6207
1436-6215
doi_str_mv 10.1007/s00394-023-03092-1
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
url http://dx.doi.org/10.1007/s00394-023-03092-1
document_store_str 1
active_str 0
description Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods: Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26). Results: Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P < 0.05), LT (P < 0.001) and VO2peak (P < 0.01). Noradrenaline (NA) was lower under EGCG at POST (P < 0.05), FATpeak (P < 0.05), LT (P < 0.01) and VO2peak (P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P < 0.05). Cycle time to exhaustion was similar (NS). Conclusion: Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate.
published_date 2023-04-01T16:22:14Z
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score 11.037056

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