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Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook

Joana Amaral Duarte De Moura, Kirsty Meldrum, Shareen Doak Orcid Logo, Martin Clift Orcid Logo

Seminars in Cell & Developmental Biology, Volume: 147, Pages: 70 - 82

Swansea University Authors: Joana Amaral Duarte De Moura, Kirsty Meldrum, Shareen Doak Orcid Logo, Martin Clift Orcid Logo

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DOI (Published version): 10.1016/j.semcdb.2022.12.006

Abstract

Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the inhalation of hazardous materials), it is important to further develop and implement physiologically relevant models of the entire respiratory tract. Lung model development has the aim to create human relevan...

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Published in: Seminars in Cell & Developmental Biology
ISSN: 1084-9521
Published: Elsevier BV 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa62217
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spelling v2 62217 2022-12-28 Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook 8aaab6d4bf74b728fdd77352fc8a4a28 Joana Amaral Duarte De Moura Joana Amaral Duarte De Moura true false bbb7bd27bfa3c6ffc73da8facfebc793 Kirsty Meldrum Kirsty Meldrum true false 8f70286908f67238a527a98cbf66d387 0000-0002-6753-1987 Shareen Doak Shareen Doak true false 71bf49b157691e541950f5c3f49c9169 0000-0001-6133-3368 Martin Clift Martin Clift true false 2022-12-28 BMS Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the inhalation of hazardous materials), it is important to further develop and implement physiologically relevant models of the entire respiratory tract. Lung model development has the aim to create human relevant systems that may replace animal use whilst balancing cost, laborious nature and regulatory ambition. There is an imperative need to move away from rodent models and implement models that mimic the holistic characteristics important in lung function. The purpose of this review is therefore, to describe and identify the various alternative models that are being applied towards assessing the pulmonary toxicology of inhaled substances, as well as the current and potential developments of various advanced models and how they may be applied towards toxicology testing strategies. These models aim to mimic various regions of the lung, as well as implementing different exposure methods with the addition of various physiologically relevent conditions (such as fluid-flow and dynamic movement). There is further progress in the type of models used with focus on the development of lung-on-a-chip technologies and bioprinting, as well as and the optimization of such models to fill current knowledge gaps within toxicology. Journal Article Seminars in Cell &amp; Developmental Biology 147 70 82 Elsevier BV 1084-9521 Lung; In vitro systems; Toxicology; Alternative models; Bio-engineering 1 9 2023 2023-09-01 10.1016/j.semcdb.2022.12.006 http://dx.doi.org/10.1016/j.semcdb.2022.12.006 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University SU Library paid the OA fee (TA Institutional Deal) Horizon 2020 Framework Programme - 760813; Natural Environment Research Council- NE/V015192/1; 2023-05-24T16:03:51.3819382 2022-12-28T12:03:44.2947890 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Joana Amaral Duarte De Moura 1 Kirsty Meldrum 2 Shareen Doak 0000-0002-6753-1987 3 Martin Clift 0000-0001-6133-3368 4 62217__27461__5bc2e248a3e7495dabba7907ce86ec75.pdf 62217.VOR.pdf 2023-05-12T15:36:38.8434784 Output 2234649 application/pdf Version of Record true © 2022 The Authors. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
spellingShingle Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
Joana Amaral Duarte De Moura
Kirsty Meldrum
Shareen Doak
Martin Clift
title_short Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
title_full Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
title_fullStr Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
title_full_unstemmed Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
title_sort Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook
author_id_str_mv 8aaab6d4bf74b728fdd77352fc8a4a28
bbb7bd27bfa3c6ffc73da8facfebc793
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author_id_fullname_str_mv 8aaab6d4bf74b728fdd77352fc8a4a28_***_Joana Amaral Duarte De Moura
bbb7bd27bfa3c6ffc73da8facfebc793_***_Kirsty Meldrum
8f70286908f67238a527a98cbf66d387_***_Shareen Doak
71bf49b157691e541950f5c3f49c9169_***_Martin Clift
author Joana Amaral Duarte De Moura
Kirsty Meldrum
Shareen Doak
Martin Clift
author2 Joana Amaral Duarte De Moura
Kirsty Meldrum
Shareen Doak
Martin Clift
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container_title Seminars in Cell &amp; Developmental Biology
container_volume 147
container_start_page 70
publishDate 2023
institution Swansea University
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doi_str_mv 10.1016/j.semcdb.2022.12.006
publisher Elsevier BV
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department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://dx.doi.org/10.1016/j.semcdb.2022.12.006
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description Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the inhalation of hazardous materials), it is important to further develop and implement physiologically relevant models of the entire respiratory tract. Lung model development has the aim to create human relevant systems that may replace animal use whilst balancing cost, laborious nature and regulatory ambition. There is an imperative need to move away from rodent models and implement models that mimic the holistic characteristics important in lung function. The purpose of this review is therefore, to describe and identify the various alternative models that are being applied towards assessing the pulmonary toxicology of inhaled substances, as well as the current and potential developments of various advanced models and how they may be applied towards toxicology testing strategies. These models aim to mimic various regions of the lung, as well as implementing different exposure methods with the addition of various physiologically relevent conditions (such as fluid-flow and dynamic movement). There is further progress in the type of models used with focus on the development of lung-on-a-chip technologies and bioprinting, as well as and the optimization of such models to fill current knowledge gaps within toxicology.
published_date 2023-09-01T16:03:52Z
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