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Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia

Grace A. Bailey Orcid Logo, Anna Rawlings, Fatemeh Torabi, Owen Pickrell Orcid Logo, Kathryn J. Peall Orcid Logo

European Journal of Neurology, Volume: 29, Issue: 12, Pages: 3513 - 3527

Swansea University Authors: Anna Rawlings, Fatemeh Torabi, Owen Pickrell Orcid Logo

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DOI (Published version): 10.1111/ene.15530

Abstract

Background and purposeAlthough psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescri...

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Published in: European Journal of Neurology
ISSN: 1351-5101 1468-1331
Published: Wiley 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa62203
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2023-01-11T14:50:21.7080222</datestamp><bib-version>v2</bib-version><id>62203</id><entry>2022-12-22</entry><title>Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia</title><swanseaauthors><author><sid>f4f5ea10d85950ed97dc305ee31b2b22</sid><firstname>Anna</firstname><surname>Rawlings</surname><name>Anna Rawlings</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>82d3ece22f59fb20bd77eaf40c36e03b</sid><firstname>Fatemeh</firstname><surname>Torabi</surname><name>Fatemeh Torabi</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>1c3044b5ff7a6552ff5e8c9e3901c807</sid><ORCID>0000-0003-4396-5657</ORCID><firstname>Owen</firstname><surname>Pickrell</surname><name>Owen Pickrell</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-12-22</date><deptcode>HDAT</deptcode><abstract>Background and purposeAlthough psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescription in those diagnosed with idiopathic dystsuponia compared to matched controls.MethodsA longitudinal population-based cohort study using anonymized electronic health care data in Wales (UK) was conducted to identify individuals with idiopathic dystonia and comorbid psychiatric diagnoses/prescriptions between 1 January 1994 and 31 December 2017. Psychiatric diagnoses/prescriptions were identified from primary and secondary health care records.ResultsIndividuals with idiopathic dystonia (n =&#x2009;52,589) had higher rates of psychiatric diagnosis and psychiatric medication prescription when compared to controls (n =&#x2009;216,754, 43% vs. 31%, p &lt;&#x2009;0.001; 45% vs. 37.9%, p &lt;&#x2009;0.001, respectively), with depression and anxiety being most common (cases: 31% and 28%). Psychiatric diagnoses predominantly predated dystonia diagnosis, particularly in the 12 months prior to diagnosis (incidence rate ratio [IRR]&#x2009;=&#x2009;1.98, 95% confidence interval [CI]&#x2009;=&#x2009;1.9&#x2013;2.1), with an IRR of 12.4 (95% CI = 11.8&#x2013;13.1) for anxiety disorders. There was, however, an elevated rate of most psychiatric diagnoses throughout the study period, including the 12 months after dystonia diagnosis (IRR = 1.96, 95% CI = 1.85&#x2013;2.07).ConclusionsThis study suggests a bidirectional relationship between psychiatric disorders and dystonia, particularly with mood disorders. Psychiatric and motor symptoms in dystonia may have common aetiological mechanisms, with psychiatric disorders potentially forming prodromal symptoms of idiopathic dystonia.</abstract><type>Journal Article</type><journal>European Journal of Neurology</journal><volume>29</volume><journalNumber>12</journalNumber><paginationStart>3513</paginationStart><paginationEnd>3527</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1351-5101</issnPrint><issnElectronic>1468-1331</issnElectronic><keywords>dystonia, movement disorders, neurological disorders, psychiatric disorders</keywords><publishedDay>1</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-12-01</publishedDate><doi>10.1111/ene.15530</doi><url/><notes/><college>COLLEGE NANME</college><department>Health Data Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HDAT</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>Brain Repair and Intracranial Neurotherapeutics. Grant Number: UA05 British Heart Foundation Cardiff University Chief Scientist Office of the Scottish Government Health and Social Care Directorates Department of Health and Social Care Economic and Social Research Council Engineering and Physical Sciences Research Council European Social Fund Health and Care Research Wales Health and Social Care Research and Development Division (Welsh Government) Health Data Research UK. Grant Number: HDR-9006 KESS 2. Grant Number: 517008 Llywodraeth Cymru Medical Research Council. 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This is an open access article under the terms of the Creative Commons Attribution License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2023-01-11T14:50:21.7080222 v2 62203 2022-12-22 Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia f4f5ea10d85950ed97dc305ee31b2b22 Anna Rawlings Anna Rawlings true false 82d3ece22f59fb20bd77eaf40c36e03b Fatemeh Torabi Fatemeh Torabi true false 1c3044b5ff7a6552ff5e8c9e3901c807 0000-0003-4396-5657 Owen Pickrell Owen Pickrell true false 2022-12-22 HDAT Background and purposeAlthough psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescription in those diagnosed with idiopathic dystsuponia compared to matched controls.MethodsA longitudinal population-based cohort study using anonymized electronic health care data in Wales (UK) was conducted to identify individuals with idiopathic dystonia and comorbid psychiatric diagnoses/prescriptions between 1 January 1994 and 31 December 2017. Psychiatric diagnoses/prescriptions were identified from primary and secondary health care records.ResultsIndividuals with idiopathic dystonia (n = 52,589) had higher rates of psychiatric diagnosis and psychiatric medication prescription when compared to controls (n = 216,754, 43% vs. 31%, p < 0.001; 45% vs. 37.9%, p < 0.001, respectively), with depression and anxiety being most common (cases: 31% and 28%). Psychiatric diagnoses predominantly predated dystonia diagnosis, particularly in the 12 months prior to diagnosis (incidence rate ratio [IRR] = 1.98, 95% confidence interval [CI] = 1.9–2.1), with an IRR of 12.4 (95% CI = 11.8–13.1) for anxiety disorders. There was, however, an elevated rate of most psychiatric diagnoses throughout the study period, including the 12 months after dystonia diagnosis (IRR = 1.96, 95% CI = 1.85–2.07).ConclusionsThis study suggests a bidirectional relationship between psychiatric disorders and dystonia, particularly with mood disorders. Psychiatric and motor symptoms in dystonia may have common aetiological mechanisms, with psychiatric disorders potentially forming prodromal symptoms of idiopathic dystonia. Journal Article European Journal of Neurology 29 12 3513 3527 Wiley 1351-5101 1468-1331 dystonia, movement disorders, neurological disorders, psychiatric disorders 1 12 2022 2022-12-01 10.1111/ene.15530 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University Another institution paid the OA fee Brain Repair and Intracranial Neurotherapeutics. Grant Number: UA05 British Heart Foundation Cardiff University Chief Scientist Office of the Scottish Government Health and Social Care Directorates Department of Health and Social Care Economic and Social Research Council Engineering and Physical Sciences Research Council European Social Fund Health and Care Research Wales Health and Social Care Research and Development Division (Welsh Government) Health Data Research UK. Grant Number: HDR-9006 KESS 2. Grant Number: 517008 Llywodraeth Cymru Medical Research Council. Grant Number: MR/P008593/1 Public Health Agency Wellcome Trust 2023-01-11T14:50:21.7080222 2022-12-22T11:40:12.2014302 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Grace A. Bailey 0000-0003-4646-3134 1 Anna Rawlings 2 Fatemeh Torabi 3 Owen Pickrell 0000-0003-4396-5657 4 Kathryn J. Peall 0000-0003-4749-4944 5 62203__26254__0c88bfc9ff7e4fe2acaea5e2a2d74058.pdf 62203.pdf 2023-01-11T14:48:46.7127088 Output 8034204 application/pdf Version of Record true © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
spellingShingle Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
Anna Rawlings
Fatemeh Torabi
Owen Pickrell
title_short Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
title_full Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
title_fullStr Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
title_full_unstemmed Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
title_sort Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia
author_id_str_mv f4f5ea10d85950ed97dc305ee31b2b22
82d3ece22f59fb20bd77eaf40c36e03b
1c3044b5ff7a6552ff5e8c9e3901c807
author_id_fullname_str_mv f4f5ea10d85950ed97dc305ee31b2b22_***_Anna Rawlings
82d3ece22f59fb20bd77eaf40c36e03b_***_Fatemeh Torabi
1c3044b5ff7a6552ff5e8c9e3901c807_***_Owen Pickrell
author Anna Rawlings
Fatemeh Torabi
Owen Pickrell
author2 Grace A. Bailey
Anna Rawlings
Fatemeh Torabi
Owen Pickrell
Kathryn J. Peall
format Journal article
container_title European Journal of Neurology
container_volume 29
container_issue 12
container_start_page 3513
publishDate 2022
institution Swansea University
issn 1351-5101
1468-1331
doi_str_mv 10.1111/ene.15530
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Background and purposeAlthough psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescription in those diagnosed with idiopathic dystsuponia compared to matched controls.MethodsA longitudinal population-based cohort study using anonymized electronic health care data in Wales (UK) was conducted to identify individuals with idiopathic dystonia and comorbid psychiatric diagnoses/prescriptions between 1 January 1994 and 31 December 2017. Psychiatric diagnoses/prescriptions were identified from primary and secondary health care records.ResultsIndividuals with idiopathic dystonia (n = 52,589) had higher rates of psychiatric diagnosis and psychiatric medication prescription when compared to controls (n = 216,754, 43% vs. 31%, p < 0.001; 45% vs. 37.9%, p < 0.001, respectively), with depression and anxiety being most common (cases: 31% and 28%). Psychiatric diagnoses predominantly predated dystonia diagnosis, particularly in the 12 months prior to diagnosis (incidence rate ratio [IRR] = 1.98, 95% confidence interval [CI] = 1.9–2.1), with an IRR of 12.4 (95% CI = 11.8–13.1) for anxiety disorders. There was, however, an elevated rate of most psychiatric diagnoses throughout the study period, including the 12 months after dystonia diagnosis (IRR = 1.96, 95% CI = 1.85–2.07).ConclusionsThis study suggests a bidirectional relationship between psychiatric disorders and dystonia, particularly with mood disorders. Psychiatric and motor symptoms in dystonia may have common aetiological mechanisms, with psychiatric disorders potentially forming prodromal symptoms of idiopathic dystonia.
published_date 2022-12-01T04:21:38Z
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