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Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease
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Spyridon Zisimopoulos
Biomolecules, Volume: 12, Issue: 8, Start page: 1030
Swansea University Author:
Spyridon Zisimopoulos
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DOI (Published version): 10.3390/biom12081030
Abstract
AbstractThe ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are required to form the quaternary structure th...
| Published in: | Biomolecules |
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| ISSN: | 2218-273X |
| Published: |
MDPI AG
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa62164 |
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| Abstract: |
AbstractThe ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are required to form the quaternary structure that comprises the functional channel. Numerous mutations in the gene encoding RyR2 protein have been identified and many are linked to a wide spectrum of arrhythmic heart disease. Gain of function mutations (GoF) result in a hyperactive channel that causes excessive spontaneous SR Ca2+ release. This is the predominant cause of the inherited syndrome catecholaminergic polymorphic ventricular tachycardia (CPVT). Recently, rare hypoactive loss of function (LoF) mutations have been identified that produce atypical effects on cardiac Ca2+ handling that has been termed calcium release deficiency syndrome (CRDS). Aberrant Ca2+ release resulting from both GoF and LoF mutations can result in arrhythmias through the Na+/Ca2+ exchange mechanism. This mini-review discusses recent findings regarding the role of RyR2 domains and endogenous regulators that influence RyR2 gating normally and with GoF/LoF mutations. The arrhythmogenic consequences of GoF/LoF mutations will then be discussed at the macromolecular and cellular level. |
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| Keywords: |
ryanodine receptor; catecholaminergic polymorphic ventricular tachycardia; calcium release deficiency syndrome; delayed afterdepolarizations; early afterdepolarizations; calcium sparks; long QT syndrome; arrhythmias |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
E.D.F. was supported by funding from the British Heart Foundation, grant number FS/IBSRF/21/25071. S.Z. was supported by funding from the British Heart Foundation, grant number PG/21/10657. |
| Issue: |
8 |
| Start Page: |
1030 |