Reaching the Final Endgame for Constant Waves of COVID-19

Ratcliffe, Norman; Castro, Helena Carla; Gonzalez, Marcelo Salabert; Mello, Cicero Brasileiro; Dyson, Paul

doi:10.3390/v14122637

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Reaching the Final Endgame for Constant Waves of COVID-19

Norman Ratcliffe, Helena Carla Castro, Marcelo Salabert Gonzalez, Cicero Brasileiro Mello, Paul Dyson

Viruses, Volume: 14, Issue: 12, Start page: 2637

Swansea University Authors: Norman Ratcliffe, Paul Dyson

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DOI (Published version): 10.3390/v14122637

Abstract

Despite intramuscular vaccines saving millions of lives, constant devastating waves of SARS-CoV-2 infections continue. The elimination of COVID-19 is challenging, but necessary in order to avoid millions more people who would suffer from long COVID if we fail. Our paper describes rapidly advancing a...

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Published in:	Viruses
ISSN:	1999-4915
Published:	MDPI AG 2022
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa62082
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first_indexed	2022-11-29T10:39:34Z
last_indexed	2023-01-13T19:23:18Z
id	cronfa62082
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spelling	2022-12-07T15:50:35.9888671 v2 62082 2022-11-29 Reaching the Final Endgame for Constant Waves of COVID-19 aebb70dc95237305e0a8f4bb80b5ef22 Norman Ratcliffe Norman Ratcliffe true false 300e3f46b70ae83f563b24f41d00cd17 0000-0002-0558-2666 Paul Dyson Paul Dyson true false 2022-11-29 FGSEN Despite intramuscular vaccines saving millions of lives, constant devastating waves of SARS-CoV-2 infections continue. The elimination of COVID-19 is challenging, but necessary in order to avoid millions more people who would suffer from long COVID if we fail. Our paper describes rapidly advancing and innovative therapeutic strategies for the early stage of infection with COVID-19 so that tolerating continuing cycles of infection should be unnecessary in the future. These therapies include new vaccines with broader specificities, nasal therapies and antiviral drugs some targeting COVID-19 at the first stage of infection and preventing the virus entering the body in the first place. Our article describes the advantages and disadvantages of each of these therapeutic options which in various combinations could eventually prevent renewed waves of infection. Finally, important consideration is given to political, social and economic barriers that since 2020 hindered vaccine application and are likely to interfere again with any COVID-19 endgame. Journal Article Viruses 14 12 2637 MDPI AG 1999-4915 SARS-CoV-2; Omicron; COVID-19 elimination; vaccines; nasal therapies; antiviral drugs; new therapeutic options; political and social hindrances 25 11 2022 2022-11-25 10.3390/v14122637 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University Not Required The authors received no specific funding for this work. 2022-12-07T15:50:35.9888671 2022-11-29T10:35:32.1273828 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Norman Ratcliffe 1 Helena Carla Castro 2 Marcelo Salabert Gonzalez 3 Cicero Brasileiro Mello 4 Paul Dyson 0000-0002-0558-2666 5 62082__25947__4a6a4789cab0421c97ed14ceffb7922b.pdf viruses-14-02637-v3.pdf 2022-11-29T10:38:50.2327190 Output 302798 application/pdf Version of Record true © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license true eng https://creativecommons.org/licenses/by/4.0/
title	Reaching the Final Endgame for Constant Waves of COVID-19
spellingShingle	Reaching the Final Endgame for Constant Waves of COVID-19 Norman Ratcliffe Paul Dyson
title_short	Reaching the Final Endgame for Constant Waves of COVID-19
title_full	Reaching the Final Endgame for Constant Waves of COVID-19
title_fullStr	Reaching the Final Endgame for Constant Waves of COVID-19
title_full_unstemmed	Reaching the Final Endgame for Constant Waves of COVID-19
title_sort	Reaching the Final Endgame for Constant Waves of COVID-19
author_id_str_mv	aebb70dc95237305e0a8f4bb80b5ef22 300e3f46b70ae83f563b24f41d00cd17
author_id_fullname_str_mv	aebb70dc95237305e0a8f4bb80b5ef22_*_Norman Ratcliffe 300e3f46b70ae83f563b24f41d00cd17_*_Paul Dyson
author	Norman Ratcliffe Paul Dyson
author2	Norman Ratcliffe Helena Carla Castro Marcelo Salabert Gonzalez Cicero Brasileiro Mello Paul Dyson
format	Journal article
container_title	Viruses
container_volume	14
container_issue	12
container_start_page	2637
publishDate	2022
institution	Swansea University
issn	1999-4915
doi_str_mv	10.3390/v14122637
publisher	MDPI AG
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	Despite intramuscular vaccines saving millions of lives, constant devastating waves of SARS-CoV-2 infections continue. The elimination of COVID-19 is challenging, but necessary in order to avoid millions more people who would suffer from long COVID if we fail. Our paper describes rapidly advancing and innovative therapeutic strategies for the early stage of infection with COVID-19 so that tolerating continuing cycles of infection should be unnecessary in the future. These therapies include new vaccines with broader specificities, nasal therapies and antiviral drugs some targeting COVID-19 at the first stage of infection and preventing the virus entering the body in the first place. Our article describes the advantages and disadvantages of each of these therapeutic options which in various combinations could eventually prevent renewed waves of infection. Finally, important consideration is given to political, social and economic barriers that since 2020 hindered vaccine application and are likely to interfere again with any COVID-19 endgame.
published_date	2022-11-25T04:21:25Z
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Reaching the Final Endgame for Constant Waves of COVID-19

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