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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone
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Jose A. Carnicero,
Karl Hawkins ,
Janet Whitley,
Rangaswamy Mothukuri,
Adrian Evans ,
Keith Morris,
Suresh Pillai,
Jorge D. Erusalimsky
Respiratory Research, Volume: 23, Issue: 1
Swansea University Authors:
Jun-Cezar Zaldua , Karl Hawkins , Adrian Evans
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DOI (Published version): 10.1186/s12931-022-02220-5
Abstract
Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognostic performance of this biomarker in the context of treatments to reduce inflammation is unc...
| Published in: | Respiratory Research |
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| ISSN: | 1465-993X |
| Published: |
Springer Science and Business Media LLC
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa62071 |
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| Abstract: |
Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognostic performance of this biomarker in the context of treatments to reduce inflammation is unclear. In this study we investigated the association between sRAGE and mortality in dexamethasone-treated COVID-19 patients. We studied 89 SARS-CoV-2 positive subjects and 22 controls attending the emergency department of a University Teaching Hospital during the second wave of COVID-19 and measured sRAGE at admission. In positive individuals sRAGE increased with disease severity and correlated with the National Early Warning Score 2 (Pearson’s r = 0.56, p < 0.001). Fourteen out of 72 patients treated with dexamethasone died during 28 days of follow-up. Survival rates were significantly lower in patients with high sRAGE (> 3532 pg/mL) than in those with low sRAGE (p = 0.01). Higher sRAGE levels were associated with an increased risk of death after adjustment for relevant covariates. In contrast, IL-6 did not predict mortality in these patients. These results demonstrate that sRAGE remains an independent predictor of mortality among COVID-19 patients treated with dexamethasone. Determination of sRAGE could be useful for the clinical management of this patient population. |
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| Keywords: |
Mortality, Prognostic, Biomarkers, sRAGE, IL-6, NEWS2, Dexamethasone, COVID-19, SARS-CoV-2 |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This study was supported by Sêr Cymru GOV.WALES |
| Issue: |
1 |