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The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol

Olga Roldan Reoyo, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, S. Jones, S. Emery Orcid Logo, O. Uzun, Michael Lewis

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Swansea University Authors: Olga Roldan Reoyo, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Michael Lewis

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DOI (Published version): 10.1101/2022.04.27.22274359

Abstract

Background Exercise can be beneficial to cardiovascular system function, but its influence during pregnancy is less well understood. Heterogeneity in research studies has led to a lack of consensus on whether physical exercise during pregnancy can elicit cardiovascular adaptations during a period in...

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Published: Cold Spring Harbor Laboratory 2022
URI: https://cronfa.swan.ac.uk/Record/cronfa62066
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Heterogeneity in research studies has led to a lack of consensus on whether physical exercise during pregnancy can elicit cardiovascular adaptations during a period in which the cardiovascular system is already being challenged. Furthermore, little research has been conducted regarding the influence of physical exercise on foetal heart rate (FHR). This paper presents the protocol for a randomised controlled trial which will evaluate the influence of supervised antenatal physical exercise on cardiovascular adaptations during and after pregnancy, as well as the FHR response to acute and chronic maternal exercise. Methods: The PE-CAMP Study (Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy) is a randomised controlled trial (RCT) in which pregnant women will be randomised into an intervention group (INT), which attended supervised physical exercise programme up to three days per week, or a comparison group (COMP) which followed standard health care. All participants were assessed at three time-points i) 18-22 weeks pregnant, time-point 1; ii) 33-37 weeks pregnant, time-point 2; and iii) 12-16 weeks postnatal, time-point 3. A standardised experimental protocol was used for data collection, including body composition assessment, upper-body flexibility and strength assessment, physical activity assessment via questionnaires and acceletometry, and haemodynamic and cardiovascular evaluation before, during and after an acute 10-minute exercise bout. Foetal heart rate will be assessed at the time point 2 before, during and after acute exercise. Discussion: Although it is necessary and informative to continue investigating the effects of exercise on maternal cardiac and haemodynamic responses using specific laboratory-based tests, it is also critical to evaluate It is made available under a CC-BY-NC-ND 4.0 International license . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. medRxiv preprint doi: https://doi.org/10.1101/2022.04.27.22274359; this version posted April 28, 2022. The copyright holder for this preprintThe PE-CAMP research project. Protocol paper3these influences during activities that are more achievable and realistic for pregnant women. The PE-CAMP study will provide data on the cardiac and haemodynamic responses to a typical acute bout of exercise, which could help inform future decisions and policies on maternal exercise prescription made by maternity healthcare providers and exercise professionals.Clinical Trials Registration Number: NCT03748888</abstract><type>Journal Article</type><journal>medRxiv</journal><volume/><journalNumber/><paginationStart/><paginationEnd/><publisher>Cold Spring Harbor Laboratory</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic/><keywords/><publishedDay>28</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-04-28</publishedDate><doi>10.1101/2022.04.27.22274359</doi><url/><notes>Preprint article before certification by peer review.</notes><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2022-12-09T11:01:23.3582241</lastEdited><Created>2022-11-28T11:45:10.3887907</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Uncategorised</level></path><authors><author><firstname>Olga</firstname><surname>Roldan Reoyo</surname><order>1</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>2</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>3</order></author><author><firstname>S.</firstname><surname>Jones</surname><order>4</order></author><author><firstname>S.</firstname><surname>Emery</surname><orcid>0000-0003-3807-7735</orcid><order>5</order></author><author><firstname>O.</firstname><surname>Uzun</surname><order>6</order></author><author><firstname>Michael</firstname><surname>Lewis</surname><order>7</order></author></authors><documents><document><filename>62066__25931__cee1db5b75864789b66558b66cd2d4f4.pdf</filename><originalFilename>62066.pdf</originalFilename><uploaded>2022-11-28T13:21:16.0890499</uploaded><type>Output</type><contentLength>495855</contentLength><contentType>application/pdf</contentType><version>Pre-print</version><cronfaStatus>true</cronfaStatus><documentNotes>Released under the terms of a CC-BY-NC-ND 4.0 International license.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-12-09T11:01:23.3582241 v2 62066 2022-11-28 The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol 35f52c995d9f8758aac2ac079605faea Olga Roldan Reoyo Olga Roldan Reoyo true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 2022-11-28 STSC Background Exercise can be beneficial to cardiovascular system function, but its influence during pregnancy is less well understood. Heterogeneity in research studies has led to a lack of consensus on whether physical exercise during pregnancy can elicit cardiovascular adaptations during a period in which the cardiovascular system is already being challenged. Furthermore, little research has been conducted regarding the influence of physical exercise on foetal heart rate (FHR). This paper presents the protocol for a randomised controlled trial which will evaluate the influence of supervised antenatal physical exercise on cardiovascular adaptations during and after pregnancy, as well as the FHR response to acute and chronic maternal exercise. Methods: The PE-CAMP Study (Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy) is a randomised controlled trial (RCT) in which pregnant women will be randomised into an intervention group (INT), which attended supervised physical exercise programme up to three days per week, or a comparison group (COMP) which followed standard health care. All participants were assessed at three time-points i) 18-22 weeks pregnant, time-point 1; ii) 33-37 weeks pregnant, time-point 2; and iii) 12-16 weeks postnatal, time-point 3. A standardised experimental protocol was used for data collection, including body composition assessment, upper-body flexibility and strength assessment, physical activity assessment via questionnaires and acceletometry, and haemodynamic and cardiovascular evaluation before, during and after an acute 10-minute exercise bout. Foetal heart rate will be assessed at the time point 2 before, during and after acute exercise. Discussion: Although it is necessary and informative to continue investigating the effects of exercise on maternal cardiac and haemodynamic responses using specific laboratory-based tests, it is also critical to evaluate It is made available under a CC-BY-NC-ND 4.0 International license . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. medRxiv preprint doi: https://doi.org/10.1101/2022.04.27.22274359; this version posted April 28, 2022. The copyright holder for this preprintThe PE-CAMP research project. Protocol paper3these influences during activities that are more achievable and realistic for pregnant women. The PE-CAMP study will provide data on the cardiac and haemodynamic responses to a typical acute bout of exercise, which could help inform future decisions and policies on maternal exercise prescription made by maternity healthcare providers and exercise professionals.Clinical Trials Registration Number: NCT03748888 Journal Article medRxiv Cold Spring Harbor Laboratory 28 4 2022 2022-04-28 10.1101/2022.04.27.22274359 Preprint article before certification by peer review. COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2022-12-09T11:01:23.3582241 2022-11-28T11:45:10.3887907 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Olga Roldan Reoyo 1 Kelly Mackintosh 0000-0003-0355-6357 2 Melitta McNarry 0000-0003-0813-7477 3 S. Jones 4 S. Emery 0000-0003-3807-7735 5 O. Uzun 6 Michael Lewis 7 62066__25931__cee1db5b75864789b66558b66cd2d4f4.pdf 62066.pdf 2022-11-28T13:21:16.0890499 Output 495855 application/pdf Pre-print true Released under the terms of a CC-BY-NC-ND 4.0 International license. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
spellingShingle The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
Olga Roldan Reoyo
Kelly Mackintosh
Melitta McNarry
Michael Lewis
title_short The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
title_full The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
title_fullStr The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
title_full_unstemmed The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
title_sort The Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP) Randomised Controlled Trial Protocol
author_id_str_mv 35f52c995d9f8758aac2ac079605faea
bdb20e3f31bcccf95c7bc116070c4214
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author_id_fullname_str_mv 35f52c995d9f8758aac2ac079605faea_***_Olga Roldan Reoyo
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
b59c8f5c056bac7e6995385f22ad1639_***_Michael Lewis
author Olga Roldan Reoyo
Kelly Mackintosh
Melitta McNarry
Michael Lewis
author2 Olga Roldan Reoyo
Kelly Mackintosh
Melitta McNarry
S. Jones
S. Emery
O. Uzun
Michael Lewis
format Journal article
container_title medRxiv
publishDate 2022
institution Swansea University
doi_str_mv 10.1101/2022.04.27.22274359
publisher Cold Spring Harbor Laboratory
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
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description Background Exercise can be beneficial to cardiovascular system function, but its influence during pregnancy is less well understood. Heterogeneity in research studies has led to a lack of consensus on whether physical exercise during pregnancy can elicit cardiovascular adaptations during a period in which the cardiovascular system is already being challenged. Furthermore, little research has been conducted regarding the influence of physical exercise on foetal heart rate (FHR). This paper presents the protocol for a randomised controlled trial which will evaluate the influence of supervised antenatal physical exercise on cardiovascular adaptations during and after pregnancy, as well as the FHR response to acute and chronic maternal exercise. Methods: The PE-CAMP Study (Physical Exercise and Cardiovascular Adaptation Monitoring in Pregnancy) is a randomised controlled trial (RCT) in which pregnant women will be randomised into an intervention group (INT), which attended supervised physical exercise programme up to three days per week, or a comparison group (COMP) which followed standard health care. All participants were assessed at three time-points i) 18-22 weeks pregnant, time-point 1; ii) 33-37 weeks pregnant, time-point 2; and iii) 12-16 weeks postnatal, time-point 3. A standardised experimental protocol was used for data collection, including body composition assessment, upper-body flexibility and strength assessment, physical activity assessment via questionnaires and acceletometry, and haemodynamic and cardiovascular evaluation before, during and after an acute 10-minute exercise bout. Foetal heart rate will be assessed at the time point 2 before, during and after acute exercise. Discussion: Although it is necessary and informative to continue investigating the effects of exercise on maternal cardiac and haemodynamic responses using specific laboratory-based tests, it is also critical to evaluate It is made available under a CC-BY-NC-ND 4.0 International license . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. medRxiv preprint doi: https://doi.org/10.1101/2022.04.27.22274359; this version posted April 28, 2022. The copyright holder for this preprintThe PE-CAMP research project. Protocol paper3these influences during activities that are more achievable and realistic for pregnant women. The PE-CAMP study will provide data on the cardiac and haemodynamic responses to a typical acute bout of exercise, which could help inform future decisions and policies on maternal exercise prescription made by maternity healthcare providers and exercise professionals.Clinical Trials Registration Number: NCT03748888
published_date 2022-04-28T04:21:23Z
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