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Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study

Margriet S. Westerterp‐Plantenga Orcid Logo, Mathijs Drummen, Lea Tischmann, Nils Swindell, Gareth Stratton Orcid Logo, Anne Raben, Marit Westerterp, Tanja Adam, Nils Joseph Swindell Orcid Logo

Obesity, Volume: 31, Issue: 3, Pages: 744 - 756

Swansea University Authors: Nils Swindell, Gareth Stratton Orcid Logo, Nils Joseph Swindell Orcid Logo

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DOI (Published version): 10.1002/oby.23670

Abstract

Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), P...

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Published in: Obesity
ISSN: 1930-7381 1930-739X
Published: Wiley 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa61804
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Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), PA, systolic and diastolic blood-pressure (SBP, DBP), heart-rate (HR), plasma HDL-cholesterol-, LDL-cholesterol-, remnant cholesterol (RC)-, triacylglycerol (TAG)-, C-reactive-protein (CRP)-concentrations, were determined in 91 free-living participants (age=56.6±10y;BMI=28.2;HOMA-IR=3.2±3.1) and in 38 participants in sedentary respiration-chamber conditions (age=56.6±10y;BMI=28.5±4.0;HOMA-IR=3.3±1.4). Associations of circadian-rhythm parameters and PA with cardiometabolic-risk factors were determined using factor-analyses followed by Pearson’s correlations. Results: Values of cardiometabolic-risk factors were similar, while circadian-rhythm parameters and PA differed significantly (P&lt;0.05) between conditions. In both conditions, parameters indicating a robust circadian-rhythm associated inversely with CRP and positively with plasma HDL-c-concentrations. In free-living conditions, PA associated inversely with SBP and HR, and positively with HDL-c and robust-circadian-rhythm parameters. In sedentary conditions PA associated positively with HR and inversely with robust-circadian-rhythm parameters. PA mediated the inverse association of parameters indicating a robust circadian rhythm with SBP in free-living conditions.Conclusion: In adults with obesity and prediabetes, parameters indicating a robust circadian-rhythm were, independently of PA, associated with lower cardiometabolic risk and C-reactive-protein. 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spelling v2 61804 2022-11-08 Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study d89a0a3fb118e1cf625fddc68cdf25bb Nils Swindell Nils Swindell true false 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 189d1ae79723a932dc37ae54fff6e4cd 0000-0003-3742-6139 Nils Joseph Swindell Nils Joseph Swindell true true 2022-11-08 ISSS Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), PA, systolic and diastolic blood-pressure (SBP, DBP), heart-rate (HR), plasma HDL-cholesterol-, LDL-cholesterol-, remnant cholesterol (RC)-, triacylglycerol (TAG)-, C-reactive-protein (CRP)-concentrations, were determined in 91 free-living participants (age=56.6±10y;BMI=28.2;HOMA-IR=3.2±3.1) and in 38 participants in sedentary respiration-chamber conditions (age=56.6±10y;BMI=28.5±4.0;HOMA-IR=3.3±1.4). Associations of circadian-rhythm parameters and PA with cardiometabolic-risk factors were determined using factor-analyses followed by Pearson’s correlations. Results: Values of cardiometabolic-risk factors were similar, while circadian-rhythm parameters and PA differed significantly (P<0.05) between conditions. In both conditions, parameters indicating a robust circadian-rhythm associated inversely with CRP and positively with plasma HDL-c-concentrations. In free-living conditions, PA associated inversely with SBP and HR, and positively with HDL-c and robust-circadian-rhythm parameters. In sedentary conditions PA associated positively with HR and inversely with robust-circadian-rhythm parameters. PA mediated the inverse association of parameters indicating a robust circadian rhythm with SBP in free-living conditions.Conclusion: In adults with obesity and prediabetes, parameters indicating a robust circadian-rhythm were, independently of PA, associated with lower cardiometabolic risk and C-reactive-protein. Only in free-living conditions, PA mediated the association of higher circadian-stability with lower SBP. Journal Article Obesity 31 3 744 756 Wiley 1930-7381 1930-739X Obesity, Prediabetes, Blood-pressure, Lipids/lipoproteins, Inflammation 1 3 2023 2023-03-01 10.1002/oby.23670 http://dx.doi.org/10.1002/oby.23670 COLLEGE NANME Inclusive Student Support Services COLLEGE CODE ISSS Swansea University 2023-06-01T14:52:48.4335573 2022-11-08T10:05:31.5508683 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Margriet S. Westerterp‐Plantenga 0000-0002-6326-3102 1 Mathijs Drummen 2 Lea Tischmann 3 Nils Swindell 4 Gareth Stratton 0000-0001-5618-0803 5 Anne Raben 6 Marit Westerterp 7 Tanja Adam 8 Nils Joseph Swindell 0000-0003-3742-6139 9 61804__26587__ded37e653d034570a9a0e8c12923c4ee.pdf 61804.pdf 2023-02-14T15:35:41.7666029 Output 2068092 application/pdf Version of Record true This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
spellingShingle Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
Nils Swindell
Gareth Stratton
Nils Joseph Swindell
title_short Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
title_full Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
title_fullStr Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
title_full_unstemmed Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
title_sort Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
author_id_str_mv d89a0a3fb118e1cf625fddc68cdf25bb
6d62b2ed126961bed81a94a2beba8a01
189d1ae79723a932dc37ae54fff6e4cd
author_id_fullname_str_mv d89a0a3fb118e1cf625fddc68cdf25bb_***_Nils Swindell
6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
189d1ae79723a932dc37ae54fff6e4cd_***_Nils Joseph Swindell
author Nils Swindell
Gareth Stratton
Nils Joseph Swindell
author2 Margriet S. Westerterp‐Plantenga
Mathijs Drummen
Lea Tischmann
Nils Swindell
Gareth Stratton
Anne Raben
Marit Westerterp
Tanja Adam
Nils Joseph Swindell
format Journal article
container_title Obesity
container_volume 31
container_issue 3
container_start_page 744
publishDate 2023
institution Swansea University
issn 1930-7381
1930-739X
doi_str_mv 10.1002/oby.23670
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
url http://dx.doi.org/10.1002/oby.23670
document_store_str 1
active_str 0
description Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), PA, systolic and diastolic blood-pressure (SBP, DBP), heart-rate (HR), plasma HDL-cholesterol-, LDL-cholesterol-, remnant cholesterol (RC)-, triacylglycerol (TAG)-, C-reactive-protein (CRP)-concentrations, were determined in 91 free-living participants (age=56.6±10y;BMI=28.2;HOMA-IR=3.2±3.1) and in 38 participants in sedentary respiration-chamber conditions (age=56.6±10y;BMI=28.5±4.0;HOMA-IR=3.3±1.4). Associations of circadian-rhythm parameters and PA with cardiometabolic-risk factors were determined using factor-analyses followed by Pearson’s correlations. Results: Values of cardiometabolic-risk factors were similar, while circadian-rhythm parameters and PA differed significantly (P<0.05) between conditions. In both conditions, parameters indicating a robust circadian-rhythm associated inversely with CRP and positively with plasma HDL-c-concentrations. In free-living conditions, PA associated inversely with SBP and HR, and positively with HDL-c and robust-circadian-rhythm parameters. In sedentary conditions PA associated positively with HR and inversely with robust-circadian-rhythm parameters. PA mediated the inverse association of parameters indicating a robust circadian rhythm with SBP in free-living conditions.Conclusion: In adults with obesity and prediabetes, parameters indicating a robust circadian-rhythm were, independently of PA, associated with lower cardiometabolic risk and C-reactive-protein. Only in free-living conditions, PA mediated the association of higher circadian-stability with lower SBP.
published_date 2023-03-01T14:52:47Z
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