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Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae

Nathalie N S E Henriksen Orcid Logo, Laura L Lindqvist Orcid Logo, Mario Wibowo Orcid Logo, Eva C. Sonnenschein Orcid Logo, Mikkel Bentzon-Tilia Orcid Logo, Lone Gram Orcid Logo

FEMS Microbiology Reviews, Volume: 46, Issue: 3

Swansea University Author: Eva C. Sonnenschein Orcid Logo

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DOI (Published version): 10.1093/femsre/fuac007

Abstract

Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. However, several of these metabolites also possess nonantimicrobial functions, both influencing the physiology of the producer and their ecological neighbors. An example of a versa...

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Published in: FEMS Microbiology Reviews
ISSN: 1574-6976
Published: Oxford University Press (OUP) 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61713
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spelling 2022-11-04T18:03:38.7238057 v2 61713 2022-10-31 Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae f6a4027578a15ea3e6453a54b849c686 0000-0001-6959-5100 Eva C. Sonnenschein Eva C. Sonnenschein true false 2022-10-31 SBI Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. However, several of these metabolites also possess nonantimicrobial functions, both influencing the physiology of the producer and their ecological neighbors. An example of a versatile bacterial secondary metabolite with multiple functions is the tropone derivative tropodithietic acid (TDA). TDA is a broad-spectrum antimicrobial compound produced by several members of the Rhodobacteraceae family, a major marine bacterial lineage, within the genera Phaeobacter, Tritonibacter, and Pseudovibrio. The production of TDA is governed by the mode of growth and influenced by the availability of nutrient sources. The antibacterial effect of TDA is caused by disruption of the proton motive force of target microorganisms and, potentially, by its iron-chelating properties. TDA also acts as a signaling molecule, affecting gene expression in other bacteria, and altering phenotypic traits such as motility, biofilm formation, and antibiotic production in the producer. In microbial communities, TDA-producing bacteria cause a reduction of the relative abundance of closely related species and some fast-growing heterotrophic bacteria. Here, we summarize the current understanding of the chemical ecology of TDA, including the environmental niches of TDA-producing bacteria, and the molecular mechanisms governing the function and regulation of TDA. Journal Article FEMS Microbiology Reviews 46 3 Oxford University Press (OUP) 1574-6976 antimicrobials, secondary metabolites, Rhodobacteraceae, tropodithietic acid, marine microbiomes 6 5 2022 2022-05-06 10.1093/femsre/fuac007 COLLEGE NANME Biosciences COLLEGE CODE SBI Swansea University This work was supported by the Danish National Research Foundation to the Center for Microbial Secondary Metabolites (DNRF137) and The Independent Research Fund Denmark (grant number DFF-8048–00035B) to MBT. 2022-11-04T18:03:38.7238057 2022-10-31T12:53:40.9690061 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Nathalie N S E Henriksen 0000-0002-6588-6346 1 Laura L Lindqvist 0000-0001-6591-0767 2 Mario Wibowo 0000-0002-5739-0949 3 Eva C. Sonnenschein 0000-0001-6959-5100 4 Mikkel Bentzon-Tilia 0000-0002-7888-9845 5 Lone Gram 0000-0002-1076-5723 6 61713__25661__48db16dfb8674397b29d329c849fe81f.pdf 61713.pdf 2022-11-04T18:02:14.9300241 Output 1877647 application/pdf Version of Record true Copyright: The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License true eng https://creativecommons.org/licenses/by-nc/4.0/
title Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
spellingShingle Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
Eva C. Sonnenschein
title_short Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
title_full Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
title_fullStr Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
title_full_unstemmed Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
title_sort Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae
author_id_str_mv f6a4027578a15ea3e6453a54b849c686
author_id_fullname_str_mv f6a4027578a15ea3e6453a54b849c686_***_Eva C. Sonnenschein
author Eva C. Sonnenschein
author2 Nathalie N S E Henriksen
Laura L Lindqvist
Mario Wibowo
Eva C. Sonnenschein
Mikkel Bentzon-Tilia
Lone Gram
format Journal article
container_title FEMS Microbiology Reviews
container_volume 46
container_issue 3
publishDate 2022
institution Swansea University
issn 1574-6976
doi_str_mv 10.1093/femsre/fuac007
publisher Oxford University Press (OUP)
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
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description Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. However, several of these metabolites also possess nonantimicrobial functions, both influencing the physiology of the producer and their ecological neighbors. An example of a versatile bacterial secondary metabolite with multiple functions is the tropone derivative tropodithietic acid (TDA). TDA is a broad-spectrum antimicrobial compound produced by several members of the Rhodobacteraceae family, a major marine bacterial lineage, within the genera Phaeobacter, Tritonibacter, and Pseudovibrio. The production of TDA is governed by the mode of growth and influenced by the availability of nutrient sources. The antibacterial effect of TDA is caused by disruption of the proton motive force of target microorganisms and, potentially, by its iron-chelating properties. TDA also acts as a signaling molecule, affecting gene expression in other bacteria, and altering phenotypic traits such as motility, biofilm formation, and antibiotic production in the producer. In microbial communities, TDA-producing bacteria cause a reduction of the relative abundance of closely related species and some fast-growing heterotrophic bacteria. Here, we summarize the current understanding of the chemical ecology of TDA, including the environmental niches of TDA-producing bacteria, and the molecular mechanisms governing the function and regulation of TDA.
published_date 2022-05-06T04:20:44Z
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