The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell

McCarthy, Olivia; Schmidt, Signe; Christensen, Merete Bechmann; Bain, Steve; Nørgaard, Kirsten; Bracken, Richard

doi:10.3389/fendo.2022.981723

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The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell

Olivia McCarthy, Signe Schmidt, Merete Bechmann Christensen, Steve Bain

, Kirsten Nørgaard, Richard Bracken

Frontiers in Endocrinology, Volume: 13

Swansea University Authors: Olivia McCarthy, Steve Bain , Richard Bracken

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DOI (Published version): 10.3389/fendo.2022.981723

Abstract

Although important for digestion and metabolism in repose, the healthy endocrine pancreas also plays a key role in facilitating energy transduction around physical exercise. During exercise, decrements in pancreatic β-cell mediated insulin release opposed by increments in α-cell glucagon secretion s...

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Published in:	Frontiers in Endocrinology
ISSN:	1664-2392
Published:	Frontiers Media SA 2022
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URI:	https://cronfa.swan.ac.uk/Record/cronfa61554
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first_indexed	2022-10-18T08:14:01Z
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During exercise, decrements in pancreatic β-cell mediated insulin release opposed by increments in α-cell glucagon secretion stand chief among the hierarchy of glucose-counterregulatory responses to decreasing plasma glucose levels. As a control hub for several major glucose regulatory hormones, the endogenous pancreas is therefore essential in ensuring glucose homeostasis. Type 1 diabetes (T1D) is pathophysiological condition characterised by a destruction of pancreatic β-cells resulting in pronounced aberrations in glucose control. Yet beyond the beta-cell perhaps less considered is the impact of T1D on all other pancreatic endocrine cell responses during exercise and whether they differ to those observed in healthy man. For physicians, understanding how the endocrine pancreas responds to exercise in people with and without T1D may serve as a useful model from which to identify whether there are clinically relevant adaptations that need consideration for glycaemic management. From a physiological perspective, delineating differences or indeed similarities in such responses may help inform appropriate exercise test interpretation and subsequent program prescription. With more complex advances in automated insulin delivery (AID) systems and emerging data on exercise algorithms, a timely update is warranted in our understanding of the endogenous endocrine pancreatic responses to physical exercise in people with and without T1D. 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spelling	2022-10-20T11:03:51.2317125 v2 61554 2022-10-14 The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell 4fea3e19b39712dea1d051d317614572 Olivia McCarthy Olivia McCarthy true false 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2022-10-14 STSC Although important for digestion and metabolism in repose, the healthy endocrine pancreas also plays a key role in facilitating energy transduction around physical exercise. During exercise, decrements in pancreatic β-cell mediated insulin release opposed by increments in α-cell glucagon secretion stand chief among the hierarchy of glucose-counterregulatory responses to decreasing plasma glucose levels. As a control hub for several major glucose regulatory hormones, the endogenous pancreas is therefore essential in ensuring glucose homeostasis. Type 1 diabetes (T1D) is pathophysiological condition characterised by a destruction of pancreatic β-cells resulting in pronounced aberrations in glucose control. Yet beyond the beta-cell perhaps less considered is the impact of T1D on all other pancreatic endocrine cell responses during exercise and whether they differ to those observed in healthy man. For physicians, understanding how the endocrine pancreas responds to exercise in people with and without T1D may serve as a useful model from which to identify whether there are clinically relevant adaptations that need consideration for glycaemic management. From a physiological perspective, delineating differences or indeed similarities in such responses may help inform appropriate exercise test interpretation and subsequent program prescription. With more complex advances in automated insulin delivery (AID) systems and emerging data on exercise algorithms, a timely update is warranted in our understanding of the endogenous endocrine pancreatic responses to physical exercise in people with and without T1D. By placing our focus here, we may be able to offer a nexus of better understanding between the clinical and engineering importance of AIDs requirements during physical exercise. Journal Article Frontiers in Endocrinology 13 Frontiers Media SA 1664-2392 type 1 diabetes, exercise, pancreatic hormones, endocrine pancreas, physical activity 6 9 2022 2022-09-06 10.3389/fendo.2022.981723 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2022-10-20T11:03:51.2317125 2022-10-14T10:18:32.1800549 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Olivia McCarthy 1 Signe Schmidt 2 Merete Bechmann Christensen 3 Steve Bain 0000-0001-8519-4964 4 Kirsten Nørgaard 5 Richard Bracken 0000-0002-6986-6449 6 61554__25514__7a30770fcdc74e2ab4aed515a578a94c.pdf 61554_VoR.pdf 2022-10-20T11:02:10.6701850 Output 869051 application/pdf Version of Record true © 2022 McCarthy, Schmidt, Christensen, Bain, Nørgaard and Bracken. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng http://creativecommons.org/licenses/by/4.0/
title	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell
spellingShingle	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell Olivia McCarthy Steve Bain Richard Bracken
title_short	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell
title_full	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell
title_fullStr	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell
title_full_unstemmed	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell
title_sort	The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell
author_id_str_mv	4fea3e19b39712dea1d051d317614572 5399f4c6e6a70f3608a084ddb938511a f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv	4fea3e19b39712dea1d051d317614572_*_Olivia McCarthy 5399f4c6e6a70f3608a084ddb938511a__Steve Bain f5da81cd18adfdedb2ccb845bddc12f7_**_Richard Bracken
author	Olivia McCarthy Steve Bain Richard Bracken
author2	Olivia McCarthy Signe Schmidt Merete Bechmann Christensen Steve Bain Kirsten Nørgaard Richard Bracken
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publisher	Frontiers Media SA
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description	Although important for digestion and metabolism in repose, the healthy endocrine pancreas also plays a key role in facilitating energy transduction around physical exercise. During exercise, decrements in pancreatic β-cell mediated insulin release opposed by increments in α-cell glucagon secretion stand chief among the hierarchy of glucose-counterregulatory responses to decreasing plasma glucose levels. As a control hub for several major glucose regulatory hormones, the endogenous pancreas is therefore essential in ensuring glucose homeostasis. Type 1 diabetes (T1D) is pathophysiological condition characterised by a destruction of pancreatic β-cells resulting in pronounced aberrations in glucose control. Yet beyond the beta-cell perhaps less considered is the impact of T1D on all other pancreatic endocrine cell responses during exercise and whether they differ to those observed in healthy man. For physicians, understanding how the endocrine pancreas responds to exercise in people with and without T1D may serve as a useful model from which to identify whether there are clinically relevant adaptations that need consideration for glycaemic management. From a physiological perspective, delineating differences or indeed similarities in such responses may help inform appropriate exercise test interpretation and subsequent program prescription. With more complex advances in automated insulin delivery (AID) systems and emerging data on exercise algorithms, a timely update is warranted in our understanding of the endogenous endocrine pancreatic responses to physical exercise in people with and without T1D. By placing our focus here, we may be able to offer a nexus of better understanding between the clinical and engineering importance of AIDs requirements during physical exercise.
published_date	2022-09-06T04:20:27Z
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The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell

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