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The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice

Luke Roberts, Amanda K. E. Hornsby Orcid Logo, Alanna Thomas, Martina Sassi, Aimee Kinzett, Nathan Hsiao Orcid Logo, Beth David, Mark Good, Timothy Wells Orcid Logo, Jeffrey Davies Orcid Logo

EMBO reports, Volume: 24, Issue: 12

Swansea University Authors: Luke Roberts, Amanda K. E. Hornsby Orcid Logo, Alanna Thomas, Martina Sassi, Beth David, Jeffrey Davies Orcid Logo

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DOI (Published version): 10.15252/embr.202357269

Abstract

New neurones are generated throughout life in the mammalian brain in a process known as adult hippocampal neurogenesis (AHN). Since this phenomenon grants a high degree of neuroplasticity influencing learning and memory, identifying factors that regulate AHN may be important for ameliorating age‐rel...

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Published in: EMBO reports
ISSN: 1469-221X 1469-3178
Published: Springer Science and Business Media LLC 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa61550
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spelling 2024-09-20T11:19:12.1457091 v2 61550 2022-10-13 The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice 22576ee8492628137b76a5b8cb68a384 Luke Roberts Luke Roberts true false 75e331827c3379f6057bbea3d378a149 0000-0002-4386-316X Amanda K. E. Hornsby Amanda K. E. Hornsby true true 47b7dbda1a3bd6e687b52b0dcbad2eae Alanna Thomas Alanna Thomas true false 73844ea9bb96bff6f83ffeffa8f64a49 Martina Sassi Martina Sassi true false a8ca972ac6cb6e3786557a13b6b5b059 Beth David Beth David true false 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false 2022-10-13 MEDS New neurones are generated throughout life in the mammalian brain in a process known as adult hippocampal neurogenesis (AHN). Since this phenomenon grants a high degree of neuroplasticity influencing learning and memory, identifying factors that regulate AHN may be important for ameliorating age‐related cognitive decline. Calorie restriction (CR) has been shown to enhance AHN and improve memory, mediated by the stomach hormone, ghrelin. Intermittent fasting (IF), a dietary strategy offering more flexibility than conventional CR, has also been shown to promote aspects of AHN. The 5:2 diet is a popular form of IF; however, its effects on AHN are not well characterised. To address this, we quantified AHN in adolescent and adult wild‐type and ghrelin‐receptor‐deficient mice following 6 weeks on a 5:2 diet. We report an age‐related decline in neurogenic processes. However, the 5:2 diet does not increase AHN nor enhance memory performance, suggesting that this specific form of IF is ineffective in promoting brain plasticity to support learning. Journal Article EMBO reports 24 12 Springer Science and Business Media LLC 1469-221X 1469-3178 5:2 diet; dietary restriction; ghrelin receptor; intermittent fasting; neurogenesis 6 12 2023 2023-12-06 10.15252/embr.202357269 http://dx.doi.org/10.15252/embr.202357269 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) This project was supported by a grant from the British Society of Neuroendocrinology to LDR, TW and JSD, grants from The Waterloo Foundation (1403/3689, 1403/3758, 1403/4120) and The Rosetrees Trust (A2248) to AKEH, JSD and TW. AKEH and TW wish to acknowledge the generous financial support of the Cardiff University Research Contingency Fund. 2024-09-20T11:19:12.1457091 2022-10-13T16:03:44.6520242 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Luke Roberts 1 Amanda K. E. Hornsby 0000-0002-4386-316X 2 Alanna Thomas 3 Martina Sassi 4 Aimee Kinzett 5 Nathan Hsiao 0000-0002-5276-1456 6 Beth David 7 Mark Good 8 Timothy Wells 0000-0003-3618-0595 9 Jeffrey Davies 0000-0002-4234-0033 10 61550__29350__dfa4b2fefaf945768058690835b44470.pdf 61550.VOR.pdf 2024-01-03T11:38:13.9477241 Output 3650507 application/pdf Version of Record true © 2023 The Authors. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
spellingShingle The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
Luke Roberts
Amanda K. E. Hornsby
Alanna Thomas
Martina Sassi
Beth David
Jeffrey Davies
title_short The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
title_full The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
title_fullStr The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
title_full_unstemmed The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
title_sort The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
author_id_str_mv 22576ee8492628137b76a5b8cb68a384
75e331827c3379f6057bbea3d378a149
47b7dbda1a3bd6e687b52b0dcbad2eae
73844ea9bb96bff6f83ffeffa8f64a49
a8ca972ac6cb6e3786557a13b6b5b059
2cb3d1d96a7870a84d2f758e865172e6
author_id_fullname_str_mv 22576ee8492628137b76a5b8cb68a384_***_Luke Roberts
75e331827c3379f6057bbea3d378a149_***_Amanda K. E. Hornsby
47b7dbda1a3bd6e687b52b0dcbad2eae_***_Alanna Thomas
73844ea9bb96bff6f83ffeffa8f64a49_***_Martina Sassi
a8ca972ac6cb6e3786557a13b6b5b059_***_Beth David
2cb3d1d96a7870a84d2f758e865172e6_***_Jeffrey Davies
author Luke Roberts
Amanda K. E. Hornsby
Alanna Thomas
Martina Sassi
Beth David
Jeffrey Davies
author2 Luke Roberts
Amanda K. E. Hornsby
Alanna Thomas
Martina Sassi
Aimee Kinzett
Nathan Hsiao
Beth David
Mark Good
Timothy Wells
Jeffrey Davies
format Journal article
container_title EMBO reports
container_volume 24
container_issue 12
publishDate 2023
institution Swansea University
issn 1469-221X
1469-3178
doi_str_mv 10.15252/embr.202357269
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
url http://dx.doi.org/10.15252/embr.202357269
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description New neurones are generated throughout life in the mammalian brain in a process known as adult hippocampal neurogenesis (AHN). Since this phenomenon grants a high degree of neuroplasticity influencing learning and memory, identifying factors that regulate AHN may be important for ameliorating age‐related cognitive decline. Calorie restriction (CR) has been shown to enhance AHN and improve memory, mediated by the stomach hormone, ghrelin. Intermittent fasting (IF), a dietary strategy offering more flexibility than conventional CR, has also been shown to promote aspects of AHN. The 5:2 diet is a popular form of IF; however, its effects on AHN are not well characterised. To address this, we quantified AHN in adolescent and adult wild‐type and ghrelin‐receptor‐deficient mice following 6 weeks on a 5:2 diet. We report an age‐related decline in neurogenic processes. However, the 5:2 diet does not increase AHN nor enhance memory performance, suggesting that this specific form of IF is ineffective in promoting brain plasticity to support learning.
published_date 2023-12-06T11:16:12Z
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