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Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers

Daniela Oliveira, Barbara P Correia, Sanjiv Sharma Orcid Logo, Felismina Teixeira Coelho Moreira

ACS Omega, Volume: 7, Issue: 43, Pages: 39039 - 39044

Swansea University Author: Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1021/acsomega.2c04789

Abstract

The skin interstitial fluid (ISF) contains biomarkers that complement other biofluids such as blood, sweat, saliva, and urine. It can be sampled in a minimally invasive manner and used either for point of care testing or real time, continuous monitoring of analytes, the latter using microneedle arra...

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Published in: ACS Omega
ISSN: 2470-1343 2470-1343
Published: American Chemical Society (ACS) 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61543
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spelling 2022-11-20T14:40:39.9477629 v2 61543 2022-10-13 Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2022-10-13 MEDE The skin interstitial fluid (ISF) contains biomarkers that complement other biofluids such as blood, sweat, saliva, and urine. It can be sampled in a minimally invasive manner and used either for point of care testing or real time, continuous monitoring of analytes, the latter using microneedle arrays. The analytes present in the skin ISF are indicative of both systemic and local (i.e., skin) physiology. In this paper, we describe combining microneedle technology with molecularly imprinted polymers to demonstrate the potential of transdermal electrochemical sensing. The molecularly imprinted polymer employed here is easy to produce; it can be thought of as plastic antibody. Its synthesis is scalable, and the resulting sensor has a short measurement time (6 min), with high accuracy and a low limit of detection. It provides the requisite specificity to detect the proinflammatory cytokine IL-6. IL-6 is present in the skin ISF with other cytokines and is implicated in many clinical states including neurodegenerative diseases and fatal pneumonia from SARSCoV 2. The ability to mass produce microneedle arrays and plastic antibodies will allow for low-cost transdermal sensing devices. The transdermal sensors were able to detect IL-6 at concentrations as low as 1 pg/mL in artificial skin ISF, indicating its utility for routine point of care, bloodless measurements in simpler settings, worldwide. Journal Article ACS Omega 7 43 39039 39044 American Chemical Society (ACS) 2470-1343 2470-1343 1 11 2022 2022-11-01 10.1021/acsomega.2c04789 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University Fundação para a Ciência e a Tecnologia - SFRH/BD/137832/2018 2022-11-20T14:40:39.9477629 2022-10-13T11:28:15.2571232 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Daniela Oliveira 1 Barbara P Correia 2 Sanjiv Sharma 0000-0003-3828-737X 3 Felismina Teixeira Coelho Moreira 4 61543__25579__7fe2ed1661ab4981a20a025e99ac980b.pdf 61543.pdf 2022-10-25T09:25:08.3263302 Output 3380169 application/pdf Version of Record true © 2022 The Authors. Creative Commons Attribution 4.0 International (CC BY 4.0) Published by American Chemical Society true eng https://creativecommons.org/licenses/by/4.0/
title Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
spellingShingle Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
Sanjiv Sharma
title_short Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
title_full Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
title_fullStr Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
title_full_unstemmed Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
title_sort Molecular Imprinted Polymers on Microneedle Arrays for Point of Care Transdermal Sampling and Sensing of Inflammatory Biomarkers
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 Daniela Oliveira
Barbara P Correia
Sanjiv Sharma
Felismina Teixeira Coelho Moreira
format Journal article
container_title ACS Omega
container_volume 7
container_issue 43
container_start_page 39039
publishDate 2022
institution Swansea University
issn 2470-1343
2470-1343
doi_str_mv 10.1021/acsomega.2c04789
publisher American Chemical Society (ACS)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
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description The skin interstitial fluid (ISF) contains biomarkers that complement other biofluids such as blood, sweat, saliva, and urine. It can be sampled in a minimally invasive manner and used either for point of care testing or real time, continuous monitoring of analytes, the latter using microneedle arrays. The analytes present in the skin ISF are indicative of both systemic and local (i.e., skin) physiology. In this paper, we describe combining microneedle technology with molecularly imprinted polymers to demonstrate the potential of transdermal electrochemical sensing. The molecularly imprinted polymer employed here is easy to produce; it can be thought of as plastic antibody. Its synthesis is scalable, and the resulting sensor has a short measurement time (6 min), with high accuracy and a low limit of detection. It provides the requisite specificity to detect the proinflammatory cytokine IL-6. IL-6 is present in the skin ISF with other cytokines and is implicated in many clinical states including neurodegenerative diseases and fatal pneumonia from SARSCoV 2. The ability to mass produce microneedle arrays and plastic antibodies will allow for low-cost transdermal sensing devices. The transdermal sensors were able to detect IL-6 at concentrations as low as 1 pg/mL in artificial skin ISF, indicating its utility for routine point of care, bloodless measurements in simpler settings, worldwide.
published_date 2022-11-01T04:20:26Z
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