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The pre-supplementary motor area achieves inhibitory control by modulating response thresholds

Noham Wolpe Orcid Logo, Frank H. Hezemans Orcid Logo, Charlotte L. Rae Orcid Logo, Jiaxiang Zhang Orcid Logo, James B. Rowe

Cortex, Volume: 152, Pages: 98 - 108

Swansea University Author: Jiaxiang Zhang Orcid Logo

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DOI (Published version): 10.1016/j.cortex.2022.03.018

Abstract

The pre-supplementary motor area (pre-SMA) is central for the initiation and inhibition of voluntary action. For the execution of action, the pre-SMA optimises the decision of which action to choose by adjusting the thresholds for the required evidence for each choice. However, it remains unclear ho...

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Published in: Cortex
ISSN: 0010-9452
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61348
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spelling 2022-10-11T11:58:50.4324979 v2 61348 2022-09-26 The pre-supplementary motor area achieves inhibitory control by modulating response thresholds 555e06e0ed9a87608f2d035b3bde3a87 0000-0002-4758-0394 Jiaxiang Zhang Jiaxiang Zhang true false 2022-09-26 SCS The pre-supplementary motor area (pre-SMA) is central for the initiation and inhibition of voluntary action. For the execution of action, the pre-SMA optimises the decision of which action to choose by adjusting the thresholds for the required evidence for each choice. However, it remains unclear how the pre-SMA contributes to action inhibition. Here, we use computational modelling of a stop/no-go task, performed by an adult with a focal lesion in the pre-SMA, and 52 age-matched controls. We show that the patient required more time to successfully inhibit an action (longer stop-signal reaction time) but was faster in terms of go reaction times. Computational modelling revealed that the patient's failure to stop was explained by a significantly lower response threshold for initiating an action, as compared to controls, suggesting that the patient needed less evidence before committing to an action. A similarly specific impairment was also observed for the decision of which action to choose. Together, our results suggest that dynamic threshold modulation may be a general mechanism by which the pre-SMA exerts its control over voluntary action. Journal Article Cortex 152 98 108 Elsevier BV 0010-9452 Pre-SMA; Inhibitory control; Voluntary action; Bayesian hierarchical modelling; Focal lesion 1 7 2022 2022-07-01 10.1016/j.cortex.2022.03.018 COLLEGE NANME Computer Science COLLEGE CODE SCS Swansea University This work was supported by the James S. McDonnell Foundation 21st Century Science Initiative (Scholar Award to JBR in Understanding Human Cognition) and the Wellcome Trust (103838). NW is funded by a National Institute for Health and Care Research (NIHR), Academic Clinical Fellowship (ACF-2019-14-013). JBR is supported by the Medical Research Council intramural programme (SUAG/051 G101400). FHH was supported by a Cambridge Trust Vice-Chancellor's Award and Fitzwilliam College Scholarship. 2022-10-11T11:58:50.4324979 2022-09-26T12:24:25.5462220 Faculty of Science and Engineering School of Mathematics and Computer Science - Computer Science Noham Wolpe 0000-0002-4652-7727 1 Frank H. Hezemans 0000-0003-0092-3289 2 Charlotte L. Rae 0000-0002-4503-4971 3 Jiaxiang Zhang 0000-0002-4758-0394 4 James B. Rowe 5 61348__25405__9eb5acf8504c42b49fd5f286ee7c903f.pdf 61348_VoR.pdf 2022-10-11T11:57:14.2378936 Output 1452318 application/pdf Version of Record true © 2022 The Author(s). This is an open access article under the CC BY license true eng http://creativecommons.org/licenses/by/4.0/
title The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
spellingShingle The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
Jiaxiang Zhang
title_short The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
title_full The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
title_fullStr The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
title_full_unstemmed The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
title_sort The pre-supplementary motor area achieves inhibitory control by modulating response thresholds
author_id_str_mv 555e06e0ed9a87608f2d035b3bde3a87
author_id_fullname_str_mv 555e06e0ed9a87608f2d035b3bde3a87_***_Jiaxiang Zhang
author Jiaxiang Zhang
author2 Noham Wolpe
Frank H. Hezemans
Charlotte L. Rae
Jiaxiang Zhang
James B. Rowe
format Journal article
container_title Cortex
container_volume 152
container_start_page 98
publishDate 2022
institution Swansea University
issn 0010-9452
doi_str_mv 10.1016/j.cortex.2022.03.018
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Mathematics and Computer Science - Computer Science{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Mathematics and Computer Science - Computer Science
document_store_str 1
active_str 0
description The pre-supplementary motor area (pre-SMA) is central for the initiation and inhibition of voluntary action. For the execution of action, the pre-SMA optimises the decision of which action to choose by adjusting the thresholds for the required evidence for each choice. However, it remains unclear how the pre-SMA contributes to action inhibition. Here, we use computational modelling of a stop/no-go task, performed by an adult with a focal lesion in the pre-SMA, and 52 age-matched controls. We show that the patient required more time to successfully inhibit an action (longer stop-signal reaction time) but was faster in terms of go reaction times. Computational modelling revealed that the patient's failure to stop was explained by a significantly lower response threshold for initiating an action, as compared to controls, suggesting that the patient needed less evidence before committing to an action. A similarly specific impairment was also observed for the decision of which action to choose. Together, our results suggest that dynamic threshold modulation may be a general mechanism by which the pre-SMA exerts its control over voluntary action.
published_date 2022-07-01T04:20:08Z
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score 11.037056

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