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Selection and inhibition mechanisms for human voluntary action decisions

Jiaxiang Zhang Orcid Logo, Laura E. Hughes, James B. Rowe

NeuroImage, Volume: 63, Issue: 1, Pages: 392 - 402

Swansea University Author: Jiaxiang Zhang Orcid Logo

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DOI (Published version): 10.1016/j.neuroimage.2012.06.058

Abstract

One can choose between action alternatives that have no apparent difference in their outcomes. Such voluntary action decisions are associated with widespread frontal–parietal activation, and a tendency to inhibit the repetition of a previous action. However, the mechanism of initiating voluntary act...

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Published in: NeuroImage
ISSN: 1053-8119
Published: Elsevier BV 2012
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URI: https://cronfa.swan.ac.uk/Record/cronfa61336
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spelling 2022-10-11T14:18:47.0349664 v2 61336 2022-09-26 Selection and inhibition mechanisms for human voluntary action decisions 555e06e0ed9a87608f2d035b3bde3a87 0000-0002-4758-0394 Jiaxiang Zhang Jiaxiang Zhang true false 2022-09-26 SCS One can choose between action alternatives that have no apparent difference in their outcomes. Such voluntary action decisions are associated with widespread frontal–parietal activation, and a tendency to inhibit the repetition of a previous action. However, the mechanism of initiating voluntary actions and the functions of different brain regions during this process remains largely unknown. Here, we combine computational modeling and functional magnetic resonance imaging to test the selection and inhibition mechanisms that mediate trial-to-trial voluntary action decisions. We fitted an optimized accumulator model to behavioral responses in a finger-tapping task in which participants were instructed to make chosen actions or specified actions. Model parameters derived from each individual were then applied to estimate the expected accumulated metabolic activity (EAA) engaged in every single trial. The EAA was associated with blood oxygenation level-dependent responses in a decision work that was maximal in the supplementary motor area and the caudal anterior cingulate cortex, consistent with a competitive accumulation-to-threshold mechanism for action decision by these regions. Furthermore, specific inhibition of the previous action's accumulator was related to the suppression of response repetition. This action-specific inhibition correlated with the activity of the right inferior frontal gyrus, when the option to repeat existed. Our findings suggest that human voluntary action decisions are mediated by complementary processes of intentional selection and inhibition. Journal Article NeuroImage 63 1 392 402 Elsevier BV 1053-8119 Decision making; Inhibition; Volition; Accumulation; fMRI; Modeling 15 10 2012 2012-10-15 10.1016/j.neuroimage.2012.06.058 COLLEGE NANME Computer Science COLLEGE CODE SCS Swansea University This work was supported by Medical Research Council intramural program (MC-A060-5PQ30) and the Welcome Trust (088324). 2022-10-11T14:18:47.0349664 2022-09-26T11:33:16.7292701 Faculty of Science and Engineering School of Mathematics and Computer Science - Computer Science Jiaxiang Zhang 0000-0002-4758-0394 1 Laura E. Hughes 2 James B. Rowe 3 61336__25411__c34113fbf1624210bb37262eb2050c13.pdf 61336_VoR.pdf 2022-10-11T14:12:17.6824335 Output 922961 application/pdf Version of Record true © 2012 Elsevier Inc. Open access under CC BY license. true eng https://creativecommons.org/licenses/by/3.0/
title Selection and inhibition mechanisms for human voluntary action decisions
spellingShingle Selection and inhibition mechanisms for human voluntary action decisions
Jiaxiang Zhang
title_short Selection and inhibition mechanisms for human voluntary action decisions
title_full Selection and inhibition mechanisms for human voluntary action decisions
title_fullStr Selection and inhibition mechanisms for human voluntary action decisions
title_full_unstemmed Selection and inhibition mechanisms for human voluntary action decisions
title_sort Selection and inhibition mechanisms for human voluntary action decisions
author_id_str_mv 555e06e0ed9a87608f2d035b3bde3a87
author_id_fullname_str_mv 555e06e0ed9a87608f2d035b3bde3a87_***_Jiaxiang Zhang
author Jiaxiang Zhang
author2 Jiaxiang Zhang
Laura E. Hughes
James B. Rowe
format Journal article
container_title NeuroImage
container_volume 63
container_issue 1
container_start_page 392
publishDate 2012
institution Swansea University
issn 1053-8119
doi_str_mv 10.1016/j.neuroimage.2012.06.058
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Mathematics and Computer Science - Computer Science{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Mathematics and Computer Science - Computer Science
document_store_str 1
active_str 0
description One can choose between action alternatives that have no apparent difference in their outcomes. Such voluntary action decisions are associated with widespread frontal–parietal activation, and a tendency to inhibit the repetition of a previous action. However, the mechanism of initiating voluntary actions and the functions of different brain regions during this process remains largely unknown. Here, we combine computational modeling and functional magnetic resonance imaging to test the selection and inhibition mechanisms that mediate trial-to-trial voluntary action decisions. We fitted an optimized accumulator model to behavioral responses in a finger-tapping task in which participants were instructed to make chosen actions or specified actions. Model parameters derived from each individual were then applied to estimate the expected accumulated metabolic activity (EAA) engaged in every single trial. The EAA was associated with blood oxygenation level-dependent responses in a decision work that was maximal in the supplementary motor area and the caudal anterior cingulate cortex, consistent with a competitive accumulation-to-threshold mechanism for action decision by these regions. Furthermore, specific inhibition of the previous action's accumulator was related to the suppression of response repetition. This action-specific inhibition correlated with the activity of the right inferior frontal gyrus, when the option to repeat existed. Our findings suggest that human voluntary action decisions are mediated by complementary processes of intentional selection and inhibition.
published_date 2012-10-15T04:20:07Z
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