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Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity

David M Williams, Matthew Staff, Steve Bain Orcid Logo, Thinzar Min

Endocrinology, Volume: 18, Issue: 1, Start page: 43

Swansea University Authors: Steve Bain Orcid Logo, Thinzar Min

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DOI (Published version): 10.17925/ee.2022.18.1.43

Abstract

There is an increasing prevalence of obesity worldwide, associated with significant morbidity and mortality, which frequently reduces quality of life and life expectancy. Consequently, there is a substantial and growing personal and economic burden necessitating the development of more effective the...

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Published in: Endocrinology
ISSN: 2752-5457 2752-5457
Published: Touch Medical Media, Ltd. 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60990
first_indexed 2022-08-31T14:05:12Z
last_indexed 2023-01-13T19:21:31Z
id cronfa60990
recordtype SURis
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spelling 2022-09-13T13:52:30.0838652 v2 60990 2022-08-31 Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false 27cba511a4800fefddb6885ffffdb8b2 Thinzar Min Thinzar Min true false 2022-08-31 MEDS There is an increasing prevalence of obesity worldwide, associated with significant morbidity and mortality, which frequently reduces quality of life and life expectancy. Consequently, there is a substantial and growing personal and economic burden necessitating the development of more effective therapies for obesity. Glucagon-like peptide-1 receptor analogues (GLP-1RAs) are licensed for the treatment of type 2 diabetes (T2D), and there is substantial evidence that these drugs not only improve cardiovascular outcomes but also promote weight loss. More recent evidence supports the use of the GLP-1RAs liraglutide and semaglutide in people with obesity without T2D. This article discusses the results of the major cardiovascular outcome trials for GLP-1RAs in people with T2D, the SCALE Obesity and Prediabetes study (Effect of liraglutide on body weight in non-diabetic obese subjects or overweight subjects with co-morbidities: SCALE™ - Obesity and Pre-diabetes; ClinicalTrials.gov identifier: NCT01272219; investigating liraglutide) and the STEP studies (Semaglutide treatment effect in people with obesity; assorted studies; investigating subcutaneous semaglutide). We also highlight the importance of a cost-effective approach to obesity pharmacotherapy. Clinicians should consider the use of GLP-1RAs in people with obesity, especially those with T2D or other obesity-related diseases, such as hypertension and dyslipidaemia. Ongoing trials, as well as clinical and cost-effectiveness appraisals, are anticipated over the next 12 months, and their findings may change the current landscape of obesity pharmacotherapy. [Abstract copyright: © Touch Medical Media 2022.] Journal Article Endocrinology 18 1 43 Touch Medical Media, Ltd. 2752-5457 2752-5457 obesity, liraglutide, weight management, weight loss, type 2 diabetes, semaglutide, overweight, diabetes mellitus, Glucagon-like peptide-1 (GLP-1) receptor analogue 17 3 2022 2022-03-17 10.17925/ee.2022.18.1.43 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2022-09-13T13:52:30.0838652 2022-08-31T14:58:25.9288791 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine David M Williams 1 Matthew Staff 2 Steve Bain 0000-0001-8519-4964 3 Thinzar Min 4
title Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
spellingShingle Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
Steve Bain
Thinzar Min
title_short Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
title_full Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
title_fullStr Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
title_full_unstemmed Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
title_sort Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
author_id_str_mv 5399f4c6e6a70f3608a084ddb938511a
27cba511a4800fefddb6885ffffdb8b2
author_id_fullname_str_mv 5399f4c6e6a70f3608a084ddb938511a_***_Steve Bain
27cba511a4800fefddb6885ffffdb8b2_***_Thinzar Min
author Steve Bain
Thinzar Min
author2 David M Williams
Matthew Staff
Steve Bain
Thinzar Min
format Journal article
container_title Endocrinology
container_volume 18
container_issue 1
container_start_page 43
publishDate 2022
institution Swansea University
issn 2752-5457
2752-5457
doi_str_mv 10.17925/ee.2022.18.1.43
publisher Touch Medical Media, Ltd.
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
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description There is an increasing prevalence of obesity worldwide, associated with significant morbidity and mortality, which frequently reduces quality of life and life expectancy. Consequently, there is a substantial and growing personal and economic burden necessitating the development of more effective therapies for obesity. Glucagon-like peptide-1 receptor analogues (GLP-1RAs) are licensed for the treatment of type 2 diabetes (T2D), and there is substantial evidence that these drugs not only improve cardiovascular outcomes but also promote weight loss. More recent evidence supports the use of the GLP-1RAs liraglutide and semaglutide in people with obesity without T2D. This article discusses the results of the major cardiovascular outcome trials for GLP-1RAs in people with T2D, the SCALE Obesity and Prediabetes study (Effect of liraglutide on body weight in non-diabetic obese subjects or overweight subjects with co-morbidities: SCALE™ - Obesity and Pre-diabetes; ClinicalTrials.gov identifier: NCT01272219; investigating liraglutide) and the STEP studies (Semaglutide treatment effect in people with obesity; assorted studies; investigating subcutaneous semaglutide). We also highlight the importance of a cost-effective approach to obesity pharmacotherapy. Clinicians should consider the use of GLP-1RAs in people with obesity, especially those with T2D or other obesity-related diseases, such as hypertension and dyslipidaemia. Ongoing trials, as well as clinical and cost-effectiveness appraisals, are anticipated over the next 12 months, and their findings may change the current landscape of obesity pharmacotherapy. [Abstract copyright: © Touch Medical Media 2022.]
published_date 2022-03-17T14:22:49Z
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