No Cover Image

Journal article 847 views 86 downloads

Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Siang Ing Lee Orcid Logo, Amaya Azcoaga-Lorenzo Orcid Logo, Utkarsh Agrawal Orcid Logo, Jonathan Kennedy, Adeniyi Francis Fagbamigbe Orcid Logo, Holly Hope Orcid Logo, Anuradhaa Subramanian Orcid Logo, Astha Anand Orcid Logo, Beck Taylor Orcid Logo, Catherine Nelson-Piercy Orcid Logo, Christine Damase-Michel Orcid Logo, Christopher Yau Orcid Logo, Francesca Crowe Orcid Logo, Gillian Santorelli Orcid Logo, Kelly-Ann Eastwood Orcid Logo, Zoe Vowles Orcid Logo, Maria Loane Orcid Logo, Ngawai Moss Orcid Logo, Peter Brocklehurst Orcid Logo, Rachel Plachcinski Orcid Logo, Shakila Thangaratinam Orcid Logo, Mairead Black Orcid Logo, Dermot O’Reilly Orcid Logo, Kathryn M. Abel Orcid Logo, Sinead Brophy Orcid Logo, Krishnarajah Nirantharakumar Orcid Logo, Colin McCowan Orcid Logo

BMC Pregnancy and Childbirth, Volume: 22, Issue: 1

Swansea University Authors: Jonathan Kennedy, Sinead Brophy Orcid Logo

  • 60754.pdf

    PDF | Version of Record

    © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License

    Download (1.07MB)

Check full text

DOI (Published version): 10.1186/s12884-022-04442-3

Abstract

BackgroundAlthough maternal death is rare in the United Kingdom, 90% of these women had multiple health/social problems. This study aims to estimate the prevalence of pre-existing multimorbidity (two or more long-term physical or mental health conditions) in pregnant women in the United Kingdom (Eng...

Full description

Published in: BMC Pregnancy and Childbirth
ISSN: 1471-2393
Published: Springer Science and Business Media LLC 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60754
first_indexed 2022-08-05T12:02:52Z
last_indexed 2023-01-13T19:21:07Z
id cronfa60754
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2022-08-25T13:39:47.6567242</datestamp><bib-version>v2</bib-version><id>60754</id><entry>2022-08-05</entry><title>Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study</title><swanseaauthors><author><sid>08163d1f58d7fefcb1c695bcc2e0ef68</sid><ORCID/><firstname>Jonathan</firstname><surname>Kennedy</surname><name>Jonathan Kennedy</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>84f5661b35a729f55047f9e793d8798b</sid><ORCID>0000-0001-7417-2858</ORCID><firstname>Sinead</firstname><surname>Brophy</surname><name>Sinead Brophy</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-08-05</date><deptcode>MEDS</deptcode><abstract>BackgroundAlthough maternal death is rare in the United Kingdom, 90% of these women had multiple health/social problems. This study aims to estimate the prevalence of pre-existing multimorbidity (two or more long-term physical or mental health conditions) in pregnant women in the United Kingdom (England, Northern Ireland, Wales and Scotland).Study designPregnant women aged 15&#x2013;49&#x2009;years with a conception date 1/1/2018 to 31/12/2018 were included in this population-based cross-sectional study, using routine healthcare datasets from primary care: Clinical Practice Research Datalink (CPRD, United Kingdom, n&#x2009;=&#x2009;37,641) and Secure Anonymized Information Linkage databank (SAIL, Wales, n&#x2009;=&#x2009;27,782), and secondary care: Scottish Morbidity Records with linked community prescribing data (SMR, Tayside and Fife, n&#x2009;=&#x2009;6099). Pre-existing multimorbidity preconception was defined from 79 long-term health conditions prioritised through a workshop with patient representatives and clinicians.ResultsThe prevalence of multimorbidity was 44.2% (95% CI 43.7&#x2013;44.7%), 46.2% (45.6&#x2013;46.8%) and 19.8% (18.8&#x2013;20.8%) in CPRD, SAIL and SMR respectively. When limited to health conditions that were active in the year before pregnancy, the prevalence of multimorbidity was still high (24.2% [23.8&#x2013;24.6%], 23.5% [23.0&#x2013;24.0%] and 17.0% [16.0 to 17.9%] in the respective datasets). Mental health conditions were highly prevalent and involved 70% of multimorbidity CPRD: multimorbidity with &#x2265;one mental health condition/s 31.3% [30.8&#x2013;31.8%]).After adjusting for age, ethnicity, gravidity, index of multiple deprivation, body mass index and smoking, logistic regression showed that pregnant women with multimorbidity were more likely to be older (CPRD England, adjusted OR 1.81 [95% CI 1.04&#x2013;3.17] 45&#x2013;49&#x2009;years vs 15&#x2013;19&#x2009;years), multigravid (1.68 [1.50&#x2013;1.89] gravidity &#x2265; five vs one), have raised body mass index (1.59 [1.44&#x2013;1.76], body mass index 30+ vs body mass index 18.5&#x2013;24.9) and smoked preconception (1.61 [1.46&#x2013;1.77) vs non-smoker).ConclusionMultimorbidity is prevalent in pregnant women in the United Kingdom, they are more likely to be older, multigravid, have raised body mass index and smoked preconception. Secondary care and community prescribing dataset may only capture the severe spectrum of health conditions. Research is needed urgently to quantify the consequences of maternal multimorbidity for both mothers and children.</abstract><type>Journal Article</type><journal>BMC Pregnancy and Childbirth</journal><volume>22</volume><journalNumber>1</journalNumber><paginationStart/><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1471-2393</issnElectronic><keywords>Multimorbidity, Multiple chronic conditions, Multiple long-term conditions, Pregnancy, Maternity,Epidemiology</keywords><publishedDay>11</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-02-11</publishedDate><doi>10.1186/s12884-022-04442-3</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>This work was funded by the Strategic Priority Fund &#x201C;Tackling multimorbidity at scale&#x201D; programme (grant number MR/W014432/1) delivered by the Medical Research Council and the National Institute for Health Research in partnership with the Economic and Social Research Council and in collaboration with the Engineering and Physical Sciences Research Council. BT was funded by the National Institute for Health Research (NIHR) West Midlands Applied Research Collaboration. AA and SIL were funded as NIHR Academic Clinical Fellows. The views expressed are those of the author and not necessarily those of the funders, the NIHR or the UK Department of Health and Social Care.</funders><projectreference/><lastEdited>2022-08-25T13:39:47.6567242</lastEdited><Created>2022-08-05T13:00:02.2907918</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Siang Ing</firstname><surname>Lee</surname><orcid>0000-0002-2332-5452</orcid><order>1</order></author><author><firstname>Amaya</firstname><surname>Azcoaga-Lorenzo</surname><orcid>0000-0003-3307-878x</orcid><order>2</order></author><author><firstname>Utkarsh</firstname><surname>Agrawal</surname><orcid>0000-0001-5181-6120</orcid><order>3</order></author><author><firstname>Jonathan</firstname><surname>Kennedy</surname><orcid/><order>4</order></author><author><firstname>Adeniyi Francis</firstname><surname>Fagbamigbe</surname><orcid>0000-0001-9184-8258</orcid><order>5</order></author><author><firstname>Holly</firstname><surname>Hope</surname><orcid>0000-0002-4834-6719</orcid><order>6</order></author><author><firstname>Anuradhaa</firstname><surname>Subramanian</surname><orcid>0000-0001-8875-7363</orcid><order>7</order></author><author><firstname>Astha</firstname><surname>Anand</surname><orcid>0000-0003-0494-321x</orcid><order>8</order></author><author><firstname>Beck</firstname><surname>Taylor</surname><orcid>0000-0002-3559-7922</orcid><order>9</order></author><author><firstname>Catherine</firstname><surname>Nelson-Piercy</surname><orcid>0000-0001-9311-1196</orcid><order>10</order></author><author><firstname>Christine</firstname><surname>Damase-Michel</surname><orcid>0000-0001-5018-0108</orcid><order>11</order></author><author><firstname>Christopher</firstname><surname>Yau</surname><orcid>0000-0001-7615-8523</orcid><order>12</order></author><author><firstname>Francesca</firstname><surname>Crowe</surname><orcid>0000-0003-4026-1726</orcid><order>13</order></author><author><firstname>Gillian</firstname><surname>Santorelli</surname><orcid>0000-0003-0427-1783</orcid><order>14</order></author><author><firstname>Kelly-Ann</firstname><surname>Eastwood</surname><orcid>0000-0003-3689-0490</orcid><order>15</order></author><author><firstname>Zoe</firstname><surname>Vowles</surname><orcid>0000-0001-6989-2180</orcid><order>16</order></author><author><firstname>Maria</firstname><surname>Loane</surname><orcid>0000-0002-1206-3637</orcid><order>17</order></author><author><firstname>Ngawai</firstname><surname>Moss</surname><orcid>0000-0001-9369-5072</orcid><order>18</order></author><author><firstname>Peter</firstname><surname>Brocklehurst</surname><orcid>0000-0002-9950-6751</orcid><order>19</order></author><author><firstname>Rachel</firstname><surname>Plachcinski</surname><orcid>0000-0001-9908-0773</orcid><order>20</order></author><author><firstname>Shakila</firstname><surname>Thangaratinam</surname><orcid>0000-0002-4254-460x</orcid><order>21</order></author><author><firstname>Mairead</firstname><surname>Black</surname><orcid>0000-0002-6841-8601</orcid><order>22</order></author><author><firstname>Dermot</firstname><surname>O&#x2019;Reilly</surname><orcid>0000-0002-9181-0652</orcid><order>23</order></author><author><firstname>Kathryn M.</firstname><surname>Abel</surname><orcid>0000-0003-3538-8896</orcid><order>24</order></author><author><firstname>Sinead</firstname><surname>Brophy</surname><orcid>0000-0001-7417-2858</orcid><order>25</order></author><author><firstname>Krishnarajah</firstname><surname>Nirantharakumar</surname><orcid>0000-0002-6816-1279</orcid><order>26</order></author><author><firstname>Colin</firstname><surname>McCowan</surname><orcid>0000-0002-9466-833x</orcid><order>27</order></author></authors><documents><document><filename>60754__24873__e4ac87c180344fbe9d8daf3a2ce1ef90.pdf</filename><originalFilename>60754.pdf</originalFilename><uploaded>2022-08-05T13:01:58.4959776</uploaded><type>Output</type><contentLength>1125021</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-08-25T13:39:47.6567242 v2 60754 2022-08-05 Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study 08163d1f58d7fefcb1c695bcc2e0ef68 Jonathan Kennedy Jonathan Kennedy true false 84f5661b35a729f55047f9e793d8798b 0000-0001-7417-2858 Sinead Brophy Sinead Brophy true false 2022-08-05 MEDS BackgroundAlthough maternal death is rare in the United Kingdom, 90% of these women had multiple health/social problems. This study aims to estimate the prevalence of pre-existing multimorbidity (two or more long-term physical or mental health conditions) in pregnant women in the United Kingdom (England, Northern Ireland, Wales and Scotland).Study designPregnant women aged 15–49 years with a conception date 1/1/2018 to 31/12/2018 were included in this population-based cross-sectional study, using routine healthcare datasets from primary care: Clinical Practice Research Datalink (CPRD, United Kingdom, n = 37,641) and Secure Anonymized Information Linkage databank (SAIL, Wales, n = 27,782), and secondary care: Scottish Morbidity Records with linked community prescribing data (SMR, Tayside and Fife, n = 6099). Pre-existing multimorbidity preconception was defined from 79 long-term health conditions prioritised through a workshop with patient representatives and clinicians.ResultsThe prevalence of multimorbidity was 44.2% (95% CI 43.7–44.7%), 46.2% (45.6–46.8%) and 19.8% (18.8–20.8%) in CPRD, SAIL and SMR respectively. When limited to health conditions that were active in the year before pregnancy, the prevalence of multimorbidity was still high (24.2% [23.8–24.6%], 23.5% [23.0–24.0%] and 17.0% [16.0 to 17.9%] in the respective datasets). Mental health conditions were highly prevalent and involved 70% of multimorbidity CPRD: multimorbidity with ≥one mental health condition/s 31.3% [30.8–31.8%]).After adjusting for age, ethnicity, gravidity, index of multiple deprivation, body mass index and smoking, logistic regression showed that pregnant women with multimorbidity were more likely to be older (CPRD England, adjusted OR 1.81 [95% CI 1.04–3.17] 45–49 years vs 15–19 years), multigravid (1.68 [1.50–1.89] gravidity ≥ five vs one), have raised body mass index (1.59 [1.44–1.76], body mass index 30+ vs body mass index 18.5–24.9) and smoked preconception (1.61 [1.46–1.77) vs non-smoker).ConclusionMultimorbidity is prevalent in pregnant women in the United Kingdom, they are more likely to be older, multigravid, have raised body mass index and smoked preconception. Secondary care and community prescribing dataset may only capture the severe spectrum of health conditions. Research is needed urgently to quantify the consequences of maternal multimorbidity for both mothers and children. Journal Article BMC Pregnancy and Childbirth 22 1 Springer Science and Business Media LLC 1471-2393 Multimorbidity, Multiple chronic conditions, Multiple long-term conditions, Pregnancy, Maternity,Epidemiology 11 2 2022 2022-02-11 10.1186/s12884-022-04442-3 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University This work was funded by the Strategic Priority Fund “Tackling multimorbidity at scale” programme (grant number MR/W014432/1) delivered by the Medical Research Council and the National Institute for Health Research in partnership with the Economic and Social Research Council and in collaboration with the Engineering and Physical Sciences Research Council. BT was funded by the National Institute for Health Research (NIHR) West Midlands Applied Research Collaboration. AA and SIL were funded as NIHR Academic Clinical Fellows. The views expressed are those of the author and not necessarily those of the funders, the NIHR or the UK Department of Health and Social Care. 2022-08-25T13:39:47.6567242 2022-08-05T13:00:02.2907918 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Siang Ing Lee 0000-0002-2332-5452 1 Amaya Azcoaga-Lorenzo 0000-0003-3307-878x 2 Utkarsh Agrawal 0000-0001-5181-6120 3 Jonathan Kennedy 4 Adeniyi Francis Fagbamigbe 0000-0001-9184-8258 5 Holly Hope 0000-0002-4834-6719 6 Anuradhaa Subramanian 0000-0001-8875-7363 7 Astha Anand 0000-0003-0494-321x 8 Beck Taylor 0000-0002-3559-7922 9 Catherine Nelson-Piercy 0000-0001-9311-1196 10 Christine Damase-Michel 0000-0001-5018-0108 11 Christopher Yau 0000-0001-7615-8523 12 Francesca Crowe 0000-0003-4026-1726 13 Gillian Santorelli 0000-0003-0427-1783 14 Kelly-Ann Eastwood 0000-0003-3689-0490 15 Zoe Vowles 0000-0001-6989-2180 16 Maria Loane 0000-0002-1206-3637 17 Ngawai Moss 0000-0001-9369-5072 18 Peter Brocklehurst 0000-0002-9950-6751 19 Rachel Plachcinski 0000-0001-9908-0773 20 Shakila Thangaratinam 0000-0002-4254-460x 21 Mairead Black 0000-0002-6841-8601 22 Dermot O’Reilly 0000-0002-9181-0652 23 Kathryn M. Abel 0000-0003-3538-8896 24 Sinead Brophy 0000-0001-7417-2858 25 Krishnarajah Nirantharakumar 0000-0002-6816-1279 26 Colin McCowan 0000-0002-9466-833x 27 60754__24873__e4ac87c180344fbe9d8daf3a2ce1ef90.pdf 60754.pdf 2022-08-05T13:01:58.4959776 Output 1125021 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
spellingShingle Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
Jonathan Kennedy
Sinead Brophy
title_short Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
title_full Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
title_fullStr Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
title_full_unstemmed Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
title_sort Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
author_id_str_mv 08163d1f58d7fefcb1c695bcc2e0ef68
84f5661b35a729f55047f9e793d8798b
author_id_fullname_str_mv 08163d1f58d7fefcb1c695bcc2e0ef68_***_Jonathan Kennedy
84f5661b35a729f55047f9e793d8798b_***_Sinead Brophy
author Jonathan Kennedy
Sinead Brophy
author2 Siang Ing Lee
Amaya Azcoaga-Lorenzo
Utkarsh Agrawal
Jonathan Kennedy
Adeniyi Francis Fagbamigbe
Holly Hope
Anuradhaa Subramanian
Astha Anand
Beck Taylor
Catherine Nelson-Piercy
Christine Damase-Michel
Christopher Yau
Francesca Crowe
Gillian Santorelli
Kelly-Ann Eastwood
Zoe Vowles
Maria Loane
Ngawai Moss
Peter Brocklehurst
Rachel Plachcinski
Shakila Thangaratinam
Mairead Black
Dermot O’Reilly
Kathryn M. Abel
Sinead Brophy
Krishnarajah Nirantharakumar
Colin McCowan
format Journal article
container_title BMC Pregnancy and Childbirth
container_volume 22
container_issue 1
publishDate 2022
institution Swansea University
issn 1471-2393
doi_str_mv 10.1186/s12884-022-04442-3
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description BackgroundAlthough maternal death is rare in the United Kingdom, 90% of these women had multiple health/social problems. This study aims to estimate the prevalence of pre-existing multimorbidity (two or more long-term physical or mental health conditions) in pregnant women in the United Kingdom (England, Northern Ireland, Wales and Scotland).Study designPregnant women aged 15–49 years with a conception date 1/1/2018 to 31/12/2018 were included in this population-based cross-sectional study, using routine healthcare datasets from primary care: Clinical Practice Research Datalink (CPRD, United Kingdom, n = 37,641) and Secure Anonymized Information Linkage databank (SAIL, Wales, n = 27,782), and secondary care: Scottish Morbidity Records with linked community prescribing data (SMR, Tayside and Fife, n = 6099). Pre-existing multimorbidity preconception was defined from 79 long-term health conditions prioritised through a workshop with patient representatives and clinicians.ResultsThe prevalence of multimorbidity was 44.2% (95% CI 43.7–44.7%), 46.2% (45.6–46.8%) and 19.8% (18.8–20.8%) in CPRD, SAIL and SMR respectively. When limited to health conditions that were active in the year before pregnancy, the prevalence of multimorbidity was still high (24.2% [23.8–24.6%], 23.5% [23.0–24.0%] and 17.0% [16.0 to 17.9%] in the respective datasets). Mental health conditions were highly prevalent and involved 70% of multimorbidity CPRD: multimorbidity with ≥one mental health condition/s 31.3% [30.8–31.8%]).After adjusting for age, ethnicity, gravidity, index of multiple deprivation, body mass index and smoking, logistic regression showed that pregnant women with multimorbidity were more likely to be older (CPRD England, adjusted OR 1.81 [95% CI 1.04–3.17] 45–49 years vs 15–19 years), multigravid (1.68 [1.50–1.89] gravidity ≥ five vs one), have raised body mass index (1.59 [1.44–1.76], body mass index 30+ vs body mass index 18.5–24.9) and smoked preconception (1.61 [1.46–1.77) vs non-smoker).ConclusionMultimorbidity is prevalent in pregnant women in the United Kingdom, they are more likely to be older, multigravid, have raised body mass index and smoked preconception. Secondary care and community prescribing dataset may only capture the severe spectrum of health conditions. Research is needed urgently to quantify the consequences of maternal multimorbidity for both mothers and children.
published_date 2022-02-11T08:13:32Z
_version_ 1821392463670018048
score 11.047523

Similar Items