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Does hippocampal volume explain performance differences on hippocampal-dependant tasks?

Ian A. Clark Orcid Logo, Anna M. Monk Orcid Logo, Victoria Hotchin Orcid Logo, Gloria Pizzamiglio, Alice Liefgreen, Martina F. Callaghan Orcid Logo, Eleanor A. Maguire Orcid Logo

NeuroImage, Volume: 221, Start page: 117211

Swansea University Author: Alice Liefgreen

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DOI (Published version): 10.1016/j.neuroimage.2020.117211

Abstract

Marked disparities exist across healthy individuals in their ability to imagine scenes, recall autobiographical memories, think about the future and navigate in the world. The importance of the hippocampus in supporting these critical cognitive functions has prompted the question of whether differen...

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Published in: NeuroImage
ISSN: 1053-8119
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa60558
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spelling 2022-08-19T11:45:10.4909834 v2 60558 2022-07-20 Does hippocampal volume explain performance differences on hippocampal-dependant tasks? 5a11aaeb0cd68f36ec54c5534dc541bd Alice Liefgreen Alice Liefgreen true false 2022-07-20 Marked disparities exist across healthy individuals in their ability to imagine scenes, recall autobiographical memories, think about the future and navigate in the world. The importance of the hippocampus in supporting these critical cognitive functions has prompted the question of whether differences in hippocampal grey matter volume could be one source of performance variability. Evidence to date has been somewhat mixed. In this study we sought to mitigate issues that commonly affect these types of studies. Data were collected from a large sample of 217 young, healthy adult participants, including whole brain structural MRI data (0.8 mm isotropic voxels) and widely-varying performance on scene imagination, autobiographical memory, future thinking and navigation tasks. We found little evidence that hippocampal grey matter volume was related to task performance in this healthy sample. This was the case using different analysis methods (voxel-based morphometry, partial correlations), when whole brain or hippocampal regions of interest were examined, when comparing different sub-groups (divided by gender, task performance, self-reported ability), and when using latent variables derived from across the cognitive tasks. Hippocampal grey matter volume may not, therefore, significantly influence performance on tasks known to require the hippocampus in healthy people. Perhaps only in extreme situations, as in the case of licensed London taxi drivers, are measurable ability-related hippocampus volume changes consistently exhibited. Journal Article NeuroImage 221 117211 Elsevier BV 1053-8119 Hippocampal volume; Scene construction; Autobiographical memory; Future thinking; Spatial navigation; Individual differences 1 11 2020 2020-11-01 10.1016/j.neuroimage.2020.117211 COLLEGE NANME COLLEGE CODE Swansea University The authors were supported by a Wellcome Principal Research Fellowship to E.A. Maguire (101759/Z/13/Z) and the Centre by a Strategic Award from Wellcome (203147/Z/16/Z). 2022-08-19T11:45:10.4909834 2022-07-20T14:11:28.4032565 Faculty of Humanities and Social Sciences Hilary Rodham Clinton School of Law Ian A. Clark 0000-0002-5678-2190 1 Anna M. Monk 0000-0001-9675-1308 2 Victoria Hotchin 0000-0002-4318-4925 3 Gloria Pizzamiglio 4 Alice Liefgreen 5 Martina F. Callaghan 0000-0003-0374-1659 6 Eleanor A. Maguire 0000-0002-9470-6324 7 60558__24967__a0e91d9074294729bbddf6e2fe0ab4e1.pdf 60558.pdf 2022-08-19T11:44:10.0765761 Output 1090133 application/pdf Version of Record true © 2020 The Author(s). This is an open access article under the CC BY license. true eng http://creativecommons.org/licenses/by/4.0/
title Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
spellingShingle Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
Alice Liefgreen
title_short Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
title_full Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
title_fullStr Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
title_full_unstemmed Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
title_sort Does hippocampal volume explain performance differences on hippocampal-dependant tasks?
author_id_str_mv 5a11aaeb0cd68f36ec54c5534dc541bd
author_id_fullname_str_mv 5a11aaeb0cd68f36ec54c5534dc541bd_***_Alice Liefgreen
author Alice Liefgreen
author2 Ian A. Clark
Anna M. Monk
Victoria Hotchin
Gloria Pizzamiglio
Alice Liefgreen
Martina F. Callaghan
Eleanor A. Maguire
format Journal article
container_title NeuroImage
container_volume 221
container_start_page 117211
publishDate 2020
institution Swansea University
issn 1053-8119
doi_str_mv 10.1016/j.neuroimage.2020.117211
publisher Elsevier BV
college_str Faculty of Humanities and Social Sciences
hierarchytype
hierarchy_top_id facultyofhumanitiesandsocialsciences
hierarchy_top_title Faculty of Humanities and Social Sciences
hierarchy_parent_id facultyofhumanitiesandsocialsciences
hierarchy_parent_title Faculty of Humanities and Social Sciences
department_str Hilary Rodham Clinton School of Law{{{_:::_}}}Faculty of Humanities and Social Sciences{{{_:::_}}}Hilary Rodham Clinton School of Law
document_store_str 1
active_str 0
description Marked disparities exist across healthy individuals in their ability to imagine scenes, recall autobiographical memories, think about the future and navigate in the world. The importance of the hippocampus in supporting these critical cognitive functions has prompted the question of whether differences in hippocampal grey matter volume could be one source of performance variability. Evidence to date has been somewhat mixed. In this study we sought to mitigate issues that commonly affect these types of studies. Data were collected from a large sample of 217 young, healthy adult participants, including whole brain structural MRI data (0.8 mm isotropic voxels) and widely-varying performance on scene imagination, autobiographical memory, future thinking and navigation tasks. We found little evidence that hippocampal grey matter volume was related to task performance in this healthy sample. This was the case using different analysis methods (voxel-based morphometry, partial correlations), when whole brain or hippocampal regions of interest were examined, when comparing different sub-groups (divided by gender, task performance, self-reported ability), and when using latent variables derived from across the cognitive tasks. Hippocampal grey matter volume may not, therefore, significantly influence performance on tasks known to require the hippocampus in healthy people. Perhaps only in extreme situations, as in the case of licensed London taxi drivers, are measurable ability-related hippocampus volume changes consistently exhibited.
published_date 2020-11-01T05:17:16Z
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