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Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Helen Shiells, Bjoern O. Schelter, Peter Bentham, Thomas C. Baddeley, Christopher M. Rubino, Harish Ganesan, Jeffrey Hammel, Vesna Vuksanovic Orcid Logo, Roger T. Staff, Alison D. Murray, Luc Bracoud, Damon J. Wischik, Gernot Riedel, Serge Gauthier, Jianping Jia, Hans J. Moebius, Jiri Hardlund, Christopher M. Kipps, Karin Kook, John M.D. Storey, Charles R. Harrington, Claude M. Wischik

Journal of Alzheimer's Disease, Volume: 75, Issue: 2, Pages: 501 - 519

Swansea University Author: Vesna Vuksanovic Orcid Logo

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DOI (Published version): 10.3233/jad-191173

Abstract

Background:Hydromethylthionine is a potent inhibitor of pathological aggregation of tau and TDP-43 proteins.Objective:To compare hydromethylthionine treatment effects at two doses and to determine how drug exposure is related to treatment response in bvFTD.Methods:We undertook a 52-week Phase III st...

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Published in: Journal of Alzheimer's Disease
ISSN: 1387-2877 1875-8908
Published: IOS Press 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa60497
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Abstract: Background:Hydromethylthionine is a potent inhibitor of pathological aggregation of tau and TDP-43 proteins.Objective:To compare hydromethylthionine treatment effects at two doses and to determine how drug exposure is related to treatment response in bvFTD.Methods:We undertook a 52-week Phase III study in 220 bvFTD patients randomized to compare hydromethylthionine at 200 mg/day and 8 mg/day (intended as a control). The principal outcomes were change on the Addenbrookes Cognitive Examination – Revised (ACE-R), the Functional Activities Questionnaire (FAQ), and whole brain volume. Secondary outcomes included Modified Clinical Global Impression of Change (Modified-CGIC). A population pharmacokinetic exposure-response analysis was undertaken in 175 of the patients with available blood samples and outcome data using a discriminatory plasma assay for the parent drug.Results:There were no significant differences between the two doses as randomized. There were steep concentration-response relationships for plasma levels in the range 0.3–0.6 ng/ml at the 8 mg/day dose on clinical and MRI outcomes. There were significant exposure-dependent differences at 8 mg/day for FAQ, Modified-CGIC, and whole brain atrophy comparing patients with plasma levels greater than 0.346 ng/ml with having minimal drug exposure. The exposure-response is biphasic with worse outcomes at the high concentrations produced by 200 mg/day.Conclusions:Hydromethylthionine has a similar concentration-response profile for effects on clinical decline and brain atrophy at the 8 mg/day dose in bvFTD as recently reported in AD. Treatment responses in bvFTD are predicted to be maximal at doses in the range 20–60 mg/day. A confirmatory placebo-controlled trial is now planned.
Keywords: Behavioral variant frontotemporal dementia, clinical trials, hydromethylthionine, leucomethylthioninium, tau protein, TDP-43
College: Faculty of Medicine, Health and Life Sciences
Funders: The study was sponsored by TauRx Therapeutics (Singapore).
Issue: 2
Start Page: 501
End Page: 519

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