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Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study

Ruixin Zhu, Elli Jalo, Marta P. Silvestre Orcid Logo, Sally D. Poppitt, Teodora Handjieva-Darlenska, Svetoslav Handjiev, Maija Huttunen-Lenz, Kelly Mackintosh Orcid Logo, Gareth Stratton Orcid Logo, Santiago Navas-Carretero, Kirsi H. Pietiläinen, Elizabeth Simpson, Ian A. Macdonald, Roslyn Muirhead, Jennie Brand-Miller, Mikael Fogelholm, Kristine Færch Orcid Logo, J. Alfredo Martinez, Margriet S. Westerterp-Plantenga, Tanja C. Adam Orcid Logo, Anne Raben Orcid Logo

Diabetes Care, Volume: 45, Issue: 11, Pages: 2698 - 2708

Swansea University Authors: Kelly Mackintosh Orcid Logo, Gareth Stratton Orcid Logo

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DOI (Published version): 10.2337/dc22-0549

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OBJECTIVETo examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype.RESEARCH DESIGN AND METHODSThis post hoc analysis of the multicenter, randomized trial, PREVention of diabetes through lifestyle interv...

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Published in: Diabetes Care
ISSN: 0149-5992 1935-5548
Published: American Diabetes Association 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60245
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A Post Hoc Analysis of the PREVIEW Study</title><swanseaauthors><author><sid>bdb20e3f31bcccf95c7bc116070c4214</sid><ORCID>0000-0003-0355-6357</ORCID><firstname>Kelly</firstname><surname>Mackintosh</surname><name>Kelly Mackintosh</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>6d62b2ed126961bed81a94a2beba8a01</sid><ORCID>0000-0001-5618-0803</ORCID><firstname>Gareth</firstname><surname>Stratton</surname><name>Gareth Stratton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-06-15</date><deptcode>STSC</deptcode><abstract>OBJECTIVETo examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype.RESEARCH DESIGN AND METHODSThis post hoc analysis of the multicenter, randomized trial, PREVention of diabetes through lifestyle interventions and population studies In Europe and around the World (PREVIEW), included 1,510 participants with prediabetes (BMI &#x2021;25 kg m22; defined using oral glucose tolerance tests). Of these, 58% had isolated impaired fasting glucose (iIFG), 6% had isolated impaired glucose tolerance (iIGT), and 36% had IFG+IGT; 73% had normal hemoglobin A1c (HbA1c; &amp;lt;39 mmol mol21) and 25% had intermediate HbA1c (39&#x2013;47 mmol mol21). Participants underwent an 8-week diet-induced rapid weight loss, followed by a 148-week lifestyle-based weight maintenance intervention. Linear mixed models adjusted for intervention arm and other confounders were used.RESULTSIn the available-case and complete-case analyses, participants with IFG+IGT had greater sustained weight loss after lifestyle intervention (adjusted mean at 156 weeks 23.5% [95% CI, 24.7%, 22.3%]) than those with iIFG (mean 22.5% [23.6%, 21.3%]) relative to baseline (P 5 0.011). Participants with IFG+IGT and iIFG had similar cardiometabolic benefits from the lifestyle intervention. The differences in cardiometabolic benefits between those with iIGT and IFG+IGT were minor or inconsistent in different analyses. Participants with normal versus intermediate HbA1c had similar weight loss over 3 years and minor differences in cardiometabolic benefits during weight loss, whereas those with normal HbA1c had greater improvements in fasting glucose, 2-h glucose (adjusted between-group difference at 156 weeks 20.54 mmol L21 [95% CI 20.70, 20.39],P &amp;lt; 0.001), and triglycerides (difference 20.07 mmol L21 [20.11, 20.03], P &amp;lt; 0.001) during the lifestyle intervention.CONCLUSIONSIndividuals with iIFG and IFG+IGT had similar improvements in cardiometabolic health from a lifestyle intervention. Those with normal HbA1c had greater improvements than those with intermediate HbA1c.</abstract><type>Journal Article</type><journal>Diabetes Care</journal><volume>45</volume><journalNumber>11</journalNumber><paginationStart>2698</paginationStart><paginationEnd>2708</paginationEnd><publisher>American Diabetes Association</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0149-5992</issnPrint><issnElectronic>1935-5548</issnElectronic><keywords/><publishedDay>13</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-06-13</publishedDate><doi>10.2337/dc22-0549</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2023-01-04T15:03:46.6627187</lastEdited><Created>2022-06-15T08:24:39.9044301</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Ruixin</firstname><surname>Zhu</surname><order>1</order></author><author><firstname>Elli</firstname><surname>Jalo</surname><order>2</order></author><author><firstname>Marta P.</firstname><surname>Silvestre</surname><orcid>0000-0001-9327-2897</orcid><order>3</order></author><author><firstname>Sally D.</firstname><surname>Poppitt</surname><order>4</order></author><author><firstname>Teodora</firstname><surname>Handjieva-Darlenska</surname><order>5</order></author><author><firstname>Svetoslav</firstname><surname>Handjiev</surname><order>6</order></author><author><firstname>Maija</firstname><surname>Huttunen-Lenz</surname><order>7</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>8</order></author><author><firstname>Gareth</firstname><surname>Stratton</surname><orcid>0000-0001-5618-0803</orcid><order>9</order></author><author><firstname>Santiago</firstname><surname>Navas-Carretero</surname><order>10</order></author><author><firstname>Kirsi H.</firstname><surname>Pietil&#xE4;inen</surname><order>11</order></author><author><firstname>Elizabeth</firstname><surname>Simpson</surname><order>12</order></author><author><firstname>Ian A.</firstname><surname>Macdonald</surname><order>13</order></author><author><firstname>Roslyn</firstname><surname>Muirhead</surname><order>14</order></author><author><firstname>Jennie</firstname><surname>Brand-Miller</surname><order>15</order></author><author><firstname>Mikael</firstname><surname>Fogelholm</surname><order>16</order></author><author><firstname>Kristine</firstname><surname>F&#xE6;rch</surname><orcid>0000-0002-6127-0448</orcid><order>17</order></author><author><firstname>J. Alfredo</firstname><surname>Martinez</surname><order>18</order></author><author><firstname>Margriet S.</firstname><surname>Westerterp-Plantenga</surname><order>19</order></author><author><firstname>Tanja C.</firstname><surname>Adam</surname><orcid>0000-0002-7840-5003</orcid><order>20</order></author><author><firstname>Anne</firstname><surname>Raben</surname><orcid>0000-0001-5229-4491</orcid><order>21</order></author></authors><documents><document><filename>60245__24493__ce3c794f731447f8b42241399cd0ab70.pdf</filename><originalFilename>60245.pdf</originalFilename><uploaded>2022-07-07T18:03:06.9952356</uploaded><type>Output</type><contentLength>348534</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><copyrightCorrect>true</copyrightCorrect><language>eng</language></document><document><filename>60245__24494__f963c1a8600c4553aba8ac59d642a02f.pdf</filename><originalFilename>60245_SupplementalMaterial.pdf</originalFilename><uploaded>2022-07-07T18:04:12.4185829</uploaded><type>Output</type><contentLength>391274</contentLength><contentType>application/pdf</contentType><version>Supplemental material</version><cronfaStatus>true</cronfaStatus><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2023-01-04T15:03:46.6627187 v2 60245 2022-06-15 Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 2022-06-15 STSC OBJECTIVETo examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype.RESEARCH DESIGN AND METHODSThis post hoc analysis of the multicenter, randomized trial, PREVention of diabetes through lifestyle interventions and population studies In Europe and around the World (PREVIEW), included 1,510 participants with prediabetes (BMI ‡25 kg m22; defined using oral glucose tolerance tests). Of these, 58% had isolated impaired fasting glucose (iIFG), 6% had isolated impaired glucose tolerance (iIGT), and 36% had IFG+IGT; 73% had normal hemoglobin A1c (HbA1c; &lt;39 mmol mol21) and 25% had intermediate HbA1c (39–47 mmol mol21). Participants underwent an 8-week diet-induced rapid weight loss, followed by a 148-week lifestyle-based weight maintenance intervention. Linear mixed models adjusted for intervention arm and other confounders were used.RESULTSIn the available-case and complete-case analyses, participants with IFG+IGT had greater sustained weight loss after lifestyle intervention (adjusted mean at 156 weeks 23.5% [95% CI, 24.7%, 22.3%]) than those with iIFG (mean 22.5% [23.6%, 21.3%]) relative to baseline (P 5 0.011). Participants with IFG+IGT and iIFG had similar cardiometabolic benefits from the lifestyle intervention. The differences in cardiometabolic benefits between those with iIGT and IFG+IGT were minor or inconsistent in different analyses. Participants with normal versus intermediate HbA1c had similar weight loss over 3 years and minor differences in cardiometabolic benefits during weight loss, whereas those with normal HbA1c had greater improvements in fasting glucose, 2-h glucose (adjusted between-group difference at 156 weeks 20.54 mmol L21 [95% CI 20.70, 20.39],P &lt; 0.001), and triglycerides (difference 20.07 mmol L21 [20.11, 20.03], P &lt; 0.001) during the lifestyle intervention.CONCLUSIONSIndividuals with iIFG and IFG+IGT had similar improvements in cardiometabolic health from a lifestyle intervention. Those with normal HbA1c had greater improvements than those with intermediate HbA1c. Journal Article Diabetes Care 45 11 2698 2708 American Diabetes Association 0149-5992 1935-5548 13 6 2022 2022-06-13 10.2337/dc22-0549 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2023-01-04T15:03:46.6627187 2022-06-15T08:24:39.9044301 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Ruixin Zhu 1 Elli Jalo 2 Marta P. Silvestre 0000-0001-9327-2897 3 Sally D. Poppitt 4 Teodora Handjieva-Darlenska 5 Svetoslav Handjiev 6 Maija Huttunen-Lenz 7 Kelly Mackintosh 0000-0003-0355-6357 8 Gareth Stratton 0000-0001-5618-0803 9 Santiago Navas-Carretero 10 Kirsi H. Pietiläinen 11 Elizabeth Simpson 12 Ian A. Macdonald 13 Roslyn Muirhead 14 Jennie Brand-Miller 15 Mikael Fogelholm 16 Kristine Færch 0000-0002-6127-0448 17 J. Alfredo Martinez 18 Margriet S. Westerterp-Plantenga 19 Tanja C. Adam 0000-0002-7840-5003 20 Anne Raben 0000-0001-5229-4491 21 60245__24493__ce3c794f731447f8b42241399cd0ab70.pdf 60245.pdf 2022-07-07T18:03:06.9952356 Output 348534 application/pdf Accepted Manuscript true true eng 60245__24494__f963c1a8600c4553aba8ac59d642a02f.pdf 60245_SupplementalMaterial.pdf 2022-07-07T18:04:12.4185829 Output 391274 application/pdf Supplemental material true true eng
title Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
spellingShingle Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
Kelly Mackintosh
Gareth Stratton
title_short Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
title_full Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
title_fullStr Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
title_full_unstemmed Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
title_sort Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study
author_id_str_mv bdb20e3f31bcccf95c7bc116070c4214
6d62b2ed126961bed81a94a2beba8a01
author_id_fullname_str_mv bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
author Kelly Mackintosh
Gareth Stratton
author2 Ruixin Zhu
Elli Jalo
Marta P. Silvestre
Sally D. Poppitt
Teodora Handjieva-Darlenska
Svetoslav Handjiev
Maija Huttunen-Lenz
Kelly Mackintosh
Gareth Stratton
Santiago Navas-Carretero
Kirsi H. Pietiläinen
Elizabeth Simpson
Ian A. Macdonald
Roslyn Muirhead
Jennie Brand-Miller
Mikael Fogelholm
Kristine Færch
J. Alfredo Martinez
Margriet S. Westerterp-Plantenga
Tanja C. Adam
Anne Raben
format Journal article
container_title Diabetes Care
container_volume 45
container_issue 11
container_start_page 2698
publishDate 2022
institution Swansea University
issn 0149-5992
1935-5548
doi_str_mv 10.2337/dc22-0549
publisher American Diabetes Association
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
active_str 0
description OBJECTIVETo examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype.RESEARCH DESIGN AND METHODSThis post hoc analysis of the multicenter, randomized trial, PREVention of diabetes through lifestyle interventions and population studies In Europe and around the World (PREVIEW), included 1,510 participants with prediabetes (BMI ‡25 kg m22; defined using oral glucose tolerance tests). Of these, 58% had isolated impaired fasting glucose (iIFG), 6% had isolated impaired glucose tolerance (iIGT), and 36% had IFG+IGT; 73% had normal hemoglobin A1c (HbA1c; &lt;39 mmol mol21) and 25% had intermediate HbA1c (39–47 mmol mol21). Participants underwent an 8-week diet-induced rapid weight loss, followed by a 148-week lifestyle-based weight maintenance intervention. Linear mixed models adjusted for intervention arm and other confounders were used.RESULTSIn the available-case and complete-case analyses, participants with IFG+IGT had greater sustained weight loss after lifestyle intervention (adjusted mean at 156 weeks 23.5% [95% CI, 24.7%, 22.3%]) than those with iIFG (mean 22.5% [23.6%, 21.3%]) relative to baseline (P 5 0.011). Participants with IFG+IGT and iIFG had similar cardiometabolic benefits from the lifestyle intervention. The differences in cardiometabolic benefits between those with iIGT and IFG+IGT were minor or inconsistent in different analyses. Participants with normal versus intermediate HbA1c had similar weight loss over 3 years and minor differences in cardiometabolic benefits during weight loss, whereas those with normal HbA1c had greater improvements in fasting glucose, 2-h glucose (adjusted between-group difference at 156 weeks 20.54 mmol L21 [95% CI 20.70, 20.39],P &lt; 0.001), and triglycerides (difference 20.07 mmol L21 [20.11, 20.03], P &lt; 0.001) during the lifestyle intervention.CONCLUSIONSIndividuals with iIFG and IFG+IGT had similar improvements in cardiometabolic health from a lifestyle intervention. Those with normal HbA1c had greater improvements than those with intermediate HbA1c.
published_date 2022-06-13T04:18:12Z
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