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Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes

Hannah R. Dines, Jennifer Nixon, Sarah J. Lockey, Adam J. Herbert, Courtney Kipps, Charles R. Pedlar, Stephen H. Day, Shane Heffernan Orcid Logo, Mark R. Antrobus, Jon Brazier, Robert M. Erskine, Georgina K. Stebbings, Elliott C.R. Hall Orcid Logo, Alun G. Williams

Journal of Strength and Conditioning Research, Volume: 37, Issue: 4, Pages: 799 - 805

Swansea University Author: Shane Heffernan Orcid Logo

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DOI (Published version): 10.1519/jsc.0000000000004291

Abstract

Dines, HR, Nixon, J, Lockey, SJ, Herbert, AJ, Kipps, C, Pedlar, CR, Day, SH, Heffernan, SM, Antrobus, MR, Brazier, J, Erskine, RM, Stebbings, GK, Hall, ECR, and Williams, AG. Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runner...

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Published in: Journal of Strength and Conditioning Research
ISSN: 1064-8011
Published: Ovid Technologies (Wolters Kluwer Health) 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa60180
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Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than nonathletes. J Strength Cond Res XX(X): 000–000, 2022—Single-nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the association of 2 collagen gene SNPs with athlete status and performance in 1,429 Caucasian subjects, including 597 competitive runners (354 men and 243 women) and 832 nonathletes (490 men and 342 women). Genotyping for COL1A1 rs1800012 (C &gt; A) and COL5A1 rs12722 (C &gt; T) SNPs was performed by a real-time polymerase chain reaction. The numbers of “injury-resistant” alleles from each SNP, based on previous literature (rs1800012 A allele and rs12722 C allele), were combined as an injury-resistance score (RScore, 0–4; higher scores indicate injury resistance). Genotype frequencies, individually and combined as an RScore, were compared between cohorts and investigated for associations with performance using official race times. Runners had 1.34 times greater odds of being rs12722 CC homozygotes than nonathletes (19.7% vs. 15.5%, p = 0.020) with no difference in the rs1800012 genotype distribution (p = 0.659). Fewer runners had an RScore 0 of (18.5% vs. 24.7%) and more had an RScore of 4 (0.6% vs. 0.3%) than nonathletes (p &lt; 0.001). Competitive performance was not associated with the COL1A1 genotype (p = 0.933), COL5A1 genotype (p = 0.613), or RScore (p = 0.477). Although not associated directly with running performance among competitive runners, a higher combined frequency of injury-resistant COL1A1 rs1800012 A and COL5A1 rs12722 C alleles in competitive runners than nonathletes suggests these SNPs may be advantageous through a mechanism that supports, but does not directly enhance, running performance.</abstract><type>Journal Article</type><journal>Journal of Strength and Conditioning Research</journal><volume>37</volume><journalNumber>4</journalNumber><paginationStart>799</paginationStart><paginationEnd>805</paginationEnd><publisher>Ovid Technologies (Wolters Kluwer Health)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1064-8011</issnPrint><issnElectronic/><keywords>Sports, genomics, endurance, soft-tissue, performance</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-04-01</publishedDate><doi>10.1519/jsc.0000000000004291</doi><url>http://dx.doi.org/10.1519/jsc.0000000000004291</url><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2024-02-06T10:07:42.6113147</lastEdited><Created>2022-06-13T09:07:17.8225970</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Sport and Exercise Sciences</level></path><authors><author><firstname>Hannah R.</firstname><surname>Dines</surname><order>1</order></author><author><firstname>Jennifer</firstname><surname>Nixon</surname><order>2</order></author><author><firstname>Sarah J.</firstname><surname>Lockey</surname><order>3</order></author><author><firstname>Adam J.</firstname><surname>Herbert</surname><order>4</order></author><author><firstname>Courtney</firstname><surname>Kipps</surname><order>5</order></author><author><firstname>Charles R.</firstname><surname>Pedlar</surname><order>6</order></author><author><firstname>Stephen H.</firstname><surname>Day</surname><order>7</order></author><author><firstname>Shane</firstname><surname>Heffernan</surname><orcid>0000-0002-3297-9335</orcid><order>8</order></author><author><firstname>Mark R.</firstname><surname>Antrobus</surname><order>9</order></author><author><firstname>Jon</firstname><surname>Brazier</surname><order>10</order></author><author><firstname>Robert M.</firstname><surname>Erskine</surname><order>11</order></author><author><firstname>Georgina K.</firstname><surname>Stebbings</surname><order>12</order></author><author><firstname>Elliott C.R.</firstname><surname>Hall</surname><orcid>0000-0003-0540-0735</orcid><order>13</order></author><author><firstname>Alun G.</firstname><surname>Williams</surname><order>14</order></author></authors><documents><document><filename>60180__24454__96f6c9a8a71a41858ded10837d69b5ea.pdf</filename><originalFilename>60180.pdf</originalFilename><uploaded>2022-07-05T15:05:02.3427794</uploaded><type>Output</type><contentLength>381586</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2023-06-07T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution Non-Commercial License (CC-BY-NC)</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by-nc/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling v2 60180 2022-06-13 Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 2022-06-13 STSC Dines, HR, Nixon, J, Lockey, SJ, Herbert, AJ, Kipps, C, Pedlar, CR, Day, SH, Heffernan, SM, Antrobus, MR, Brazier, J, Erskine, RM, Stebbings, GK, Hall, ECR, and Williams, AG. Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than nonathletes. J Strength Cond Res XX(X): 000–000, 2022—Single-nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the association of 2 collagen gene SNPs with athlete status and performance in 1,429 Caucasian subjects, including 597 competitive runners (354 men and 243 women) and 832 nonathletes (490 men and 342 women). Genotyping for COL1A1 rs1800012 (C > A) and COL5A1 rs12722 (C > T) SNPs was performed by a real-time polymerase chain reaction. The numbers of “injury-resistant” alleles from each SNP, based on previous literature (rs1800012 A allele and rs12722 C allele), were combined as an injury-resistance score (RScore, 0–4; higher scores indicate injury resistance). Genotype frequencies, individually and combined as an RScore, were compared between cohorts and investigated for associations with performance using official race times. Runners had 1.34 times greater odds of being rs12722 CC homozygotes than nonathletes (19.7% vs. 15.5%, p = 0.020) with no difference in the rs1800012 genotype distribution (p = 0.659). Fewer runners had an RScore 0 of (18.5% vs. 24.7%) and more had an RScore of 4 (0.6% vs. 0.3%) than nonathletes (p < 0.001). Competitive performance was not associated with the COL1A1 genotype (p = 0.933), COL5A1 genotype (p = 0.613), or RScore (p = 0.477). Although not associated directly with running performance among competitive runners, a higher combined frequency of injury-resistant COL1A1 rs1800012 A and COL5A1 rs12722 C alleles in competitive runners than nonathletes suggests these SNPs may be advantageous through a mechanism that supports, but does not directly enhance, running performance. Journal Article Journal of Strength and Conditioning Research 37 4 799 805 Ovid Technologies (Wolters Kluwer Health) 1064-8011 Sports, genomics, endurance, soft-tissue, performance 1 4 2023 2023-04-01 10.1519/jsc.0000000000004291 http://dx.doi.org/10.1519/jsc.0000000000004291 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2024-02-06T10:07:42.6113147 2022-06-13T09:07:17.8225970 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Hannah R. Dines 1 Jennifer Nixon 2 Sarah J. Lockey 3 Adam J. Herbert 4 Courtney Kipps 5 Charles R. Pedlar 6 Stephen H. Day 7 Shane Heffernan 0000-0002-3297-9335 8 Mark R. Antrobus 9 Jon Brazier 10 Robert M. Erskine 11 Georgina K. Stebbings 12 Elliott C.R. Hall 0000-0003-0540-0735 13 Alun G. Williams 14 60180__24454__96f6c9a8a71a41858ded10837d69b5ea.pdf 60180.pdf 2022-07-05T15:05:02.3427794 Output 381586 application/pdf Accepted Manuscript true 2023-06-07T00:00:00.0000000 Released under the terms of a Creative Commons Attribution Non-Commercial License (CC-BY-NC) true eng https://creativecommons.org/licenses/by-nc/4.0/
title Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
spellingShingle Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
Shane Heffernan
title_short Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
title_full Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
title_fullStr Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
title_full_unstemmed Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
title_sort Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
author_id_str_mv 72c0b36891dfbec0378c0d0f7916e807
author_id_fullname_str_mv 72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan
author Shane Heffernan
author2 Hannah R. Dines
Jennifer Nixon
Sarah J. Lockey
Adam J. Herbert
Courtney Kipps
Charles R. Pedlar
Stephen H. Day
Shane Heffernan
Mark R. Antrobus
Jon Brazier
Robert M. Erskine
Georgina K. Stebbings
Elliott C.R. Hall
Alun G. Williams
format Journal article
container_title Journal of Strength and Conditioning Research
container_volume 37
container_issue 4
container_start_page 799
publishDate 2023
institution Swansea University
issn 1064-8011
doi_str_mv 10.1519/jsc.0000000000004291
publisher Ovid Technologies (Wolters Kluwer Health)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
url http://dx.doi.org/10.1519/jsc.0000000000004291
document_store_str 1
active_str 0
description Dines, HR, Nixon, J, Lockey, SJ, Herbert, AJ, Kipps, C, Pedlar, CR, Day, SH, Heffernan, SM, Antrobus, MR, Brazier, J, Erskine, RM, Stebbings, GK, Hall, ECR, and Williams, AG. Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than nonathletes. J Strength Cond Res XX(X): 000–000, 2022—Single-nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the association of 2 collagen gene SNPs with athlete status and performance in 1,429 Caucasian subjects, including 597 competitive runners (354 men and 243 women) and 832 nonathletes (490 men and 342 women). Genotyping for COL1A1 rs1800012 (C > A) and COL5A1 rs12722 (C > T) SNPs was performed by a real-time polymerase chain reaction. The numbers of “injury-resistant” alleles from each SNP, based on previous literature (rs1800012 A allele and rs12722 C allele), were combined as an injury-resistance score (RScore, 0–4; higher scores indicate injury resistance). Genotype frequencies, individually and combined as an RScore, were compared between cohorts and investigated for associations with performance using official race times. Runners had 1.34 times greater odds of being rs12722 CC homozygotes than nonathletes (19.7% vs. 15.5%, p = 0.020) with no difference in the rs1800012 genotype distribution (p = 0.659). Fewer runners had an RScore 0 of (18.5% vs. 24.7%) and more had an RScore of 4 (0.6% vs. 0.3%) than nonathletes (p < 0.001). Competitive performance was not associated with the COL1A1 genotype (p = 0.933), COL5A1 genotype (p = 0.613), or RScore (p = 0.477). Although not associated directly with running performance among competitive runners, a higher combined frequency of injury-resistant COL1A1 rs1800012 A and COL5A1 rs12722 C alleles in competitive runners than nonathletes suggests these SNPs may be advantageous through a mechanism that supports, but does not directly enhance, running performance.
published_date 2023-04-01T10:07:41Z
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