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The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment

Rachel Verdon, Vicki Stone, Fiona Murphy, Emily Christopher, Helinor Johnston, Shareen Doak Orcid Logo, Ulla Vogel, Andrea Haase, Ali Kermanizadeh Orcid Logo

Particle and Fibre Toxicology, Volume: 19, Issue: 1

Swansea University Author: Shareen Doak Orcid Logo

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DOI (Published version): 10.1186/s12989-022-00476-9

Abstract

The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these material attractive, might also contribute to hazards for people exposed to these materials. The...

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Published in: Particle and Fibre Toxicology
ISSN: 1743-8977
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59989
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spelling 2022-05-19T13:14:48.4006299 v2 59989 2022-05-10 The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment 8f70286908f67238a527a98cbf66d387 0000-0002-6753-1987 Shareen Doak Shareen Doak true false 2022-05-10 BMS The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these material attractive, might also contribute to hazards for people exposed to these materials. The physicochemical properties of NMs will impact their interaction with biological surroundings and influence their fate and their potential adverse effects such as genotoxicity. Due to the large and expanding number of NMs produced, their availability in different nanoforms (NFs) and their utilization in various formats, it is impossible for risk assessment to be conducted on an individual NF basis. Alternative methods, such as grouping are needed for streamlining hazard assessment. The GRACIOUS Framework provides a logical and science evidenced approach to group similar NFs, allowing read-across of hazard information from source NFs (or non-NFs) with adequate hazard data to target NFs that lack such data. Here, we propose a simple three-tiered testing strategy to gather evidence to determine whether different NFs are sufficiently similar with respect to their potential to induce genotoxicity, in order to be grouped. The tiered testing strategy includes simple in vitro models as well as a number of alternative more complex multi-cellular in vitro models to allow for a better understanding of secondary NM-induced DNA damage, something that has been more appropriate in vivo until recently. Journal Article Particle and Fibre Toxicology 19 1 Springer Science and Business Media LLC 1743-8977 Nanomaterials, Genotoxicity, Grouping, Tiered testing strategy, Alternative physiological multi-cellularmodels 7 5 2022 2022-05-07 10.1186/s12989-022-00476-9 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee This work has been fnancially supported by H2020 funded projects GRACIOUS [Grant code-760840] and PATROLS [Grant code-760813]. 2022-05-19T13:14:48.4006299 2022-05-10T09:08:47.2801496 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Rachel Verdon 1 Vicki Stone 2 Fiona Murphy 3 Emily Christopher 4 Helinor Johnston 5 Shareen Doak 0000-0002-6753-1987 6 Ulla Vogel 7 Andrea Haase 8 Ali Kermanizadeh 0000-0002-2989-9078 9 59989__24130__7f0cd1fd7b3949ee9ad4e3039d8d8086.pdf 59989.pdf 2022-05-19T13:12:47.4784473 Output 2263894 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
spellingShingle The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
Shareen Doak
title_short The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
title_full The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
title_fullStr The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
title_full_unstemmed The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
title_sort The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
author_id_str_mv 8f70286908f67238a527a98cbf66d387
author_id_fullname_str_mv 8f70286908f67238a527a98cbf66d387_***_Shareen Doak
author Shareen Doak
author2 Rachel Verdon
Vicki Stone
Fiona Murphy
Emily Christopher
Helinor Johnston
Shareen Doak
Ulla Vogel
Andrea Haase
Ali Kermanizadeh
format Journal article
container_title Particle and Fibre Toxicology
container_volume 19
container_issue 1
publishDate 2022
institution Swansea University
issn 1743-8977
doi_str_mv 10.1186/s12989-022-00476-9
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these material attractive, might also contribute to hazards for people exposed to these materials. The physicochemical properties of NMs will impact their interaction with biological surroundings and influence their fate and their potential adverse effects such as genotoxicity. Due to the large and expanding number of NMs produced, their availability in different nanoforms (NFs) and their utilization in various formats, it is impossible for risk assessment to be conducted on an individual NF basis. Alternative methods, such as grouping are needed for streamlining hazard assessment. The GRACIOUS Framework provides a logical and science evidenced approach to group similar NFs, allowing read-across of hazard information from source NFs (or non-NFs) with adequate hazard data to target NFs that lack such data. Here, we propose a simple three-tiered testing strategy to gather evidence to determine whether different NFs are sufficiently similar with respect to their potential to induce genotoxicity, in order to be grouped. The tiered testing strategy includes simple in vitro models as well as a number of alternative more complex multi-cellular in vitro models to allow for a better understanding of secondary NM-induced DNA damage, something that has been more appropriate in vivo until recently.
published_date 2022-05-07T04:17:43Z
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