No Cover Image

Journal article 551 views 76 downloads

Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation

Ciara Durcan, Mokarram Hossain Orcid Logo, Grégory Chagnon, Djordje Peric Orcid Logo, Lara Bsiesy, Georges Karam, Edouard Girard

Biomechanics and Modeling in Mechanobiology, Volume: 21, Issue: 4, Pages: 1169 - 1186

Swansea University Authors: Mokarram Hossain Orcid Logo, Djordje Peric Orcid Logo

  • 59914.pdf

    PDF | Version of Record

    © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License

    Download (2.95MB)

Check full text

DOI (Published version): 10.1007/s10237-022-01583-4

Abstract

The oesophagus is a primarily mechanical organ whose material characterisation would aid in the investigation of its pathophysiology, help in the field of tissue engineering, and improve surgical simulations and the design of medical devices. However, the layer-dependent, anisotropic properties of t...

Full description

Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: Springer Science and Business Media LLC 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59914
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2022-04-28T08:57:23Z
last_indexed 2023-01-11T14:41:30Z
id cronfa59914
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2022-10-31T20:09:36.6941652</datestamp><bib-version>v2</bib-version><id>59914</id><entry>2022-04-28</entry><title>Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation</title><swanseaauthors><author><sid>140f4aa5c5ec18ec173c8542a7fddafd</sid><ORCID>0000-0002-4616-1104</ORCID><firstname>Mokarram</firstname><surname>Hossain</surname><name>Mokarram Hossain</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>9d35cb799b2542ad39140943a9a9da65</sid><ORCID>0000-0002-1112-301X</ORCID><firstname>Djordje</firstname><surname>Peric</surname><name>Djordje Peric</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-04-28</date><deptcode>GENG</deptcode><abstract>The oesophagus is a primarily mechanical organ whose material characterisation would aid in the investigation of its pathophysiology, help in the field of tissue engineering, and improve surgical simulations and the design of medical devices. However, the layer-dependent, anisotropic properties of the organ have not been investigated using human tissue, particularly in regard to its viscoelastic and stress-softening behaviour. Restrictions caused by the COVID-19 pandemic meant that freshhuman tissue was not available for dissection. Therefore, in this study, the layer-specific material properties of the human oesophagus were investigated through ex vivo experimentation of the embalmed muscularis propria layer. For this, a series of uniaxial tension cyclic tests with increasing stretch levels were conducted at two different strain rates. The muscular layers from three different cadaveric specimens were tested in both the longitudinal and circumferential directions. The results displayed highly nonlinear and anisotropic behaviour, with both time- and history-dependent stress-softening. The longitudinal direction was found to be stiffer than the circumferential direction at both strain rates. Strain rate-dependent behaviour was apparent, with an increase in strain rate resulting in an increase in stiffness in both directions. Histological analysis was carried out via various staining methods; the results of which were discussed with regard to the experimentally observed stress-stretch response. Finally, the behaviour of the muscularis propria was simulated using a matrix-fibre model able to capture the various mechanical phenomena exhibited, the fibre orientation of which was driven by the histological findings of the study.</abstract><type>Journal Article</type><journal>Biomechanics and Modeling in Mechanobiology</journal><volume>21</volume><journalNumber>4</journalNumber><paginationStart>1169</paginationStart><paginationEnd>1186</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1617-7959</issnPrint><issnElectronic>1617-7940</issnElectronic><keywords>Human oesophagus, Mechanical characterisation, Uniaxial tensile deformation, Visco-hyperelasticity, Anisotropy, Stress-softening</keywords><publishedDay>1</publishedDay><publishedMonth>8</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-08-01</publishedDate><doi>10.1007/s10237-022-01583-4</doi><url/><notes/><college>COLLEGE NANME</college><department>General Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>GENG</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>Swansea University Strategic Partnerships Research Scholarships (SUSPRS)</funders><projectreference/><lastEdited>2022-10-31T20:09:36.6941652</lastEdited><Created>2022-04-28T09:52:23.7888430</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering</level></path><authors><author><firstname>Ciara</firstname><surname>Durcan</surname><order>1</order></author><author><firstname>Mokarram</firstname><surname>Hossain</surname><orcid>0000-0002-4616-1104</orcid><order>2</order></author><author><firstname>Gr&#xE9;gory</firstname><surname>Chagnon</surname><order>3</order></author><author><firstname>Djordje</firstname><surname>Peric</surname><orcid>0000-0002-1112-301X</orcid><order>4</order></author><author><firstname>Lara</firstname><surname>Bsiesy</surname><order>5</order></author><author><firstname>Georges</firstname><surname>Karam</surname><order>6</order></author><author><firstname>Edouard</firstname><surname>Girard</surname><order>7</order></author></authors><documents><document><filename>59914__23923__dbea9cd8bf9e4262acb3019ed1a501e5.pdf</filename><originalFilename>59914.pdf</originalFilename><uploaded>2022-04-28T09:56:51.1210940</uploaded><type>Output</type><contentLength>3094030</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-10-31T20:09:36.6941652 v2 59914 2022-04-28 Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation 140f4aa5c5ec18ec173c8542a7fddafd 0000-0002-4616-1104 Mokarram Hossain Mokarram Hossain true false 9d35cb799b2542ad39140943a9a9da65 0000-0002-1112-301X Djordje Peric Djordje Peric true false 2022-04-28 GENG The oesophagus is a primarily mechanical organ whose material characterisation would aid in the investigation of its pathophysiology, help in the field of tissue engineering, and improve surgical simulations and the design of medical devices. However, the layer-dependent, anisotropic properties of the organ have not been investigated using human tissue, particularly in regard to its viscoelastic and stress-softening behaviour. Restrictions caused by the COVID-19 pandemic meant that freshhuman tissue was not available for dissection. Therefore, in this study, the layer-specific material properties of the human oesophagus were investigated through ex vivo experimentation of the embalmed muscularis propria layer. For this, a series of uniaxial tension cyclic tests with increasing stretch levels were conducted at two different strain rates. The muscular layers from three different cadaveric specimens were tested in both the longitudinal and circumferential directions. The results displayed highly nonlinear and anisotropic behaviour, with both time- and history-dependent stress-softening. The longitudinal direction was found to be stiffer than the circumferential direction at both strain rates. Strain rate-dependent behaviour was apparent, with an increase in strain rate resulting in an increase in stiffness in both directions. Histological analysis was carried out via various staining methods; the results of which were discussed with regard to the experimentally observed stress-stretch response. Finally, the behaviour of the muscularis propria was simulated using a matrix-fibre model able to capture the various mechanical phenomena exhibited, the fibre orientation of which was driven by the histological findings of the study. Journal Article Biomechanics and Modeling in Mechanobiology 21 4 1169 1186 Springer Science and Business Media LLC 1617-7959 1617-7940 Human oesophagus, Mechanical characterisation, Uniaxial tensile deformation, Visco-hyperelasticity, Anisotropy, Stress-softening 1 8 2022 2022-08-01 10.1007/s10237-022-01583-4 COLLEGE NANME General Engineering COLLEGE CODE GENG Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University Strategic Partnerships Research Scholarships (SUSPRS) 2022-10-31T20:09:36.6941652 2022-04-28T09:52:23.7888430 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Ciara Durcan 1 Mokarram Hossain 0000-0002-4616-1104 2 Grégory Chagnon 3 Djordje Peric 0000-0002-1112-301X 4 Lara Bsiesy 5 Georges Karam 6 Edouard Girard 7 59914__23923__dbea9cd8bf9e4262acb3019ed1a501e5.pdf 59914.pdf 2022-04-28T09:56:51.1210940 Output 3094030 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
spellingShingle Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
Mokarram Hossain
Djordje Peric
title_short Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
title_full Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
title_fullStr Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
title_full_unstemmed Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
title_sort Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation
author_id_str_mv 140f4aa5c5ec18ec173c8542a7fddafd
9d35cb799b2542ad39140943a9a9da65
author_id_fullname_str_mv 140f4aa5c5ec18ec173c8542a7fddafd_***_Mokarram Hossain
9d35cb799b2542ad39140943a9a9da65_***_Djordje Peric
author Mokarram Hossain
Djordje Peric
author2 Ciara Durcan
Mokarram Hossain
Grégory Chagnon
Djordje Peric
Lara Bsiesy
Georges Karam
Edouard Girard
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 21
container_issue 4
container_start_page 1169
publishDate 2022
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-022-01583-4
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
document_store_str 1
active_str 0
description The oesophagus is a primarily mechanical organ whose material characterisation would aid in the investigation of its pathophysiology, help in the field of tissue engineering, and improve surgical simulations and the design of medical devices. However, the layer-dependent, anisotropic properties of the organ have not been investigated using human tissue, particularly in regard to its viscoelastic and stress-softening behaviour. Restrictions caused by the COVID-19 pandemic meant that freshhuman tissue was not available for dissection. Therefore, in this study, the layer-specific material properties of the human oesophagus were investigated through ex vivo experimentation of the embalmed muscularis propria layer. For this, a series of uniaxial tension cyclic tests with increasing stretch levels were conducted at two different strain rates. The muscular layers from three different cadaveric specimens were tested in both the longitudinal and circumferential directions. The results displayed highly nonlinear and anisotropic behaviour, with both time- and history-dependent stress-softening. The longitudinal direction was found to be stiffer than the circumferential direction at both strain rates. Strain rate-dependent behaviour was apparent, with an increase in strain rate resulting in an increase in stiffness in both directions. Histological analysis was carried out via various staining methods; the results of which were discussed with regard to the experimentally observed stress-stretch response. Finally, the behaviour of the muscularis propria was simulated using a matrix-fibre model able to capture the various mechanical phenomena exhibited, the fibre orientation of which was driven by the histological findings of the study.
published_date 2022-08-01T04:17:35Z
_version_ 1763754172786671616
score 11.014224

Similar Items